GREMLIN Database
GSIA - Glutathione import ATP-binding protein GsiA
UniProt: P75796 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13472
Length: 623 (468)
Sequences: 123 (115)
Seq/√Len: 5.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
601_S609_H2.9810.73
236_A239_V2.9300.71
598_A604_C2.8780.70
233_A254_E2.8360.69
134_H139_R2.7110.65
602_L609_H2.6460.63
241_V256_I2.6100.62
583_S598_A2.6060.62
579_R587_P2.6060.62
285_R291_S2.5610.60
583_S596_E2.4640.57
582_L587_P2.4010.55
569_V603_Q2.3620.54
604_C608_G2.2870.51
584_D587_P2.2700.51
226_T454_P2.2580.50
288_P294_H2.2370.50
592_L598_A2.2210.49
589_N602_L2.1890.48
587_P595_E2.1620.47
573_S584_D2.1400.46
461_P472_I2.1280.46
355_L410_P2.1050.45
583_S587_P2.0990.45
253_V452_L2.0950.45
580_V583_S2.0930.45
583_S590_I2.0880.45
359_S492_S2.0860.45
590_I598_A2.0850.44
584_D595_E2.0790.44
583_S604_C2.0500.43
597_V603_Q2.0270.43
285_R288_P2.0070.42
601_S605_V1.9990.42
600_V604_C1.9780.41
154_R191_I1.9740.41
576_R590_I1.9530.40
198_A490_A1.9090.39
588_S596_E1.9010.39
317_R370_L1.8950.38
581_L592_L1.8880.38
349_P354_S1.8520.37
604_C607_P1.8500.37
588_S601_S1.8450.37
285_R292_L1.8180.36
573_S582_L1.8030.35
600_V608_G1.7900.35
581_L587_P1.7890.35
579_R584_D1.7810.35
585_D598_A1.7790.35
286_R299_A1.7740.35
592_L595_E1.7670.34
580_V604_C1.7650.34
577_P581_L1.7440.34
600_V603_Q1.7360.33
586_L594_G1.7350.33
242_M245_G1.7090.33
211_I520_I1.6990.32
586_L601_S1.6980.32
173_M291_S1.6930.32
587_P590_I1.6880.32
194_E471_R1.6740.32
590_I606_G1.6670.31
173_M285_R1.6620.31
135_Q239_V1.6560.31
424_I443_V1.6250.30
339_A455_E1.6020.30
457_A516_A1.6020.30
574_R607_P1.5980.29
583_S599_A1.5930.29
347_L372_R1.5930.29
354_S498_I1.5930.29
104_A108_M1.5860.29
288_P291_S1.5820.29
354_S532_H1.5770.29
214_L220_M1.5740.29
577_P590_I1.5530.28
194_E197_T1.5470.28
197_T492_S1.5430.28
579_R603_Q1.5400.28
569_V575_Q1.5380.28
567_V602_L1.5320.28
572_P588_S1.5270.28
244_Q560_T1.5240.27
418_Q426_E1.5240.27
405_F471_R1.5210.27
289_L296_A1.5180.27
588_S594_G1.4950.27
587_P602_L1.4890.27
576_R579_R1.4880.26
579_R583_S1.4840.26
580_V590_I1.4660.26
589_N605_V1.4660.26
288_P527_V1.4620.26
590_I594_G1.4610.26
287_F291_S1.4590.26
582_L597_V1.4550.26
207_I466_G1.4500.26
420_I472_I1.4450.25
579_R588_S1.4250.25
473_C481_N1.4220.25
580_V596_E1.4150.25
590_I595_E1.4110.25
169_L291_S1.4080.24
228_D515_I1.4050.24
577_P587_P1.4040.24
596_E604_C1.4000.24
605_V609_H1.4000.24
579_R601_S1.3910.24
585_D609_H1.3910.24
567_V570_A1.3900.24
583_S588_S1.3810.24
577_P582_L1.3800.24
589_N595_E1.3630.23
598_A605_V1.3590.23
559_Y597_V1.3590.23
586_L592_L1.3590.23
166_P177_V1.3540.23
572_P587_P1.3520.23
127_I140_E1.3490.23
197_T515_I1.3460.23
562_K581_L1.3440.23
593_R599_A1.3410.23
192_A467_G1.3350.23
161_I164_R1.3320.23
206_Q231_V1.3300.23
198_A492_S1.3250.22
582_L590_I1.3230.22
597_V606_G1.3220.22
590_I593_R1.3110.22
578_Q598_A1.3110.22
410_P473_C1.3090.22
585_D594_G1.3070.22
589_N603_Q1.2790.21
227_H467_G1.2770.21
583_S586_L1.2640.21
572_P583_S1.2540.21
585_D590_I1.2500.21
297_K300_P1.2490.21
117_L120_V1.2490.21
580_V600_V1.2450.21
587_P596_E1.2290.20
171_G408_Q1.2290.20
587_P594_G1.2230.20
581_L585_D1.2200.20
198_A502_I1.2130.20
198_A493_A1.2110.20
588_S595_E1.2090.20
239_V347_L1.2080.20
199_L405_F1.2040.20
580_V588_S1.2030.20
210_L260_P1.2000.20
356_V534_V1.1990.20
572_P586_L1.1990.20
266_R461_P1.1940.20
598_A607_P1.1930.20
169_L173_M1.1930.20
580_V598_A1.1930.20
155_I493_A1.1880.19
285_R527_V1.1870.19
173_M288_P1.1820.19
595_E599_A1.1740.19
581_L584_D1.1730.19
585_D601_S1.1720.19
230_G313_V1.1720.19
127_I134_H1.1670.19
405_F546_G1.1660.19
597_V601_S1.1600.19
562_K609_H1.1560.19
589_N599_A1.1550.19
447_L466_G1.1510.19
113_P487_A1.1510.19
580_V594_G1.1500.19
602_L605_V1.1490.19
288_P292_L1.1450.19
592_L605_V1.1410.18
577_P595_E1.1390.18
206_Q450_V1.1350.18
127_I139_R1.1350.18
589_N597_V1.1350.18
587_P598_A1.1340.18
565_A601_S1.1320.18
568_P580_V1.1310.18
225_I241_V1.1280.18
591_H601_S1.1270.18
105_D112_E1.1270.18
573_S607_P1.1160.18
175_Q288_P1.1160.18
104_A112_E1.1130.18
567_V575_Q1.1080.18
231_V515_I1.1000.18
448_E493_A1.0990.18
602_L606_G1.0990.18
575_Q597_V1.0980.18
580_V587_P1.0960.18
228_D523_D1.0940.18
579_R589_N1.0900.17
228_D359_S1.0820.17
562_K589_N1.0800.17
384_N471_R1.0760.17
452_L546_G1.0760.17
228_D466_G1.0740.17
579_R591_H1.0740.17
603_Q607_P1.0700.17
598_A609_H1.0690.17
197_T228_D1.0690.17
450_V468_Q1.0680.17
579_R592_L1.0650.17
283_Y364_S1.0640.17
590_I596_E1.0630.17
108_M112_E1.0620.17
577_P584_D1.0600.17
204_Q369_A1.0590.17
591_H604_C1.0570.17
223_I335_R1.0560.17
585_D599_A1.0550.17
584_D598_A1.0510.17
194_E494_L1.0470.17
584_D602_L1.0460.17
585_D589_N1.0460.17
181_M354_S1.0440.17
599_A603_Q1.0440.17
568_P600_V1.0430.17
589_N593_R1.0400.17
584_D594_G1.0390.17
370_L475_A1.0390.17
240_L299_A1.0360.16
562_K583_S1.0330.16
591_H609_H1.0320.16
182_A354_S1.0310.16
595_E604_C1.0300.16
581_L602_L1.0280.16
289_L292_L1.0240.16
163_S580_V1.0240.16
568_P573_S1.0230.16
584_D605_V1.0170.16
584_D588_S1.0170.16
183_L194_E1.0170.16
592_L600_V1.0150.16
282_D287_F1.0120.16
194_E228_D1.0110.16
568_P599_A1.0090.16
573_S609_H1.0060.16
575_Q590_I1.0040.16
575_Q585_D1.0030.16
226_T448_E1.0010.16
197_T207_I1.0010.16
580_V597_V0.9980.16
597_V602_L0.9940.16
170_S200_D0.9910.16
357_G362_G0.9910.16
357_G363_K0.9910.16
357_G488_D0.9910.16
357_G489_E0.9910.16
357_G495_D0.9910.16
357_G522_H0.9910.16
495_D522_H0.9910.16
170_S193_D0.9910.16
172_G522_H0.9910.16
172_G200_D0.9910.16
170_S522_H0.9910.16
170_S495_D0.9910.16
193_D362_G0.9910.16
193_D357_G0.9910.16
193_D489_E0.9910.16
193_D495_D0.9910.16
193_D522_H0.9910.16
170_S357_G0.9910.16
170_S362_G0.9910.16
193_D200_D0.9910.16
193_D363_K0.9910.16
170_S363_K0.9910.16
170_S488_D0.9910.16
193_D488_D0.9910.16
170_S489_E0.9910.16
362_G488_D0.9910.16
200_D357_G0.9910.16
488_D522_H0.9910.16
200_D488_D0.9910.16
489_E522_H0.9910.16
172_G488_D0.9910.16
200_D489_E0.9910.16
172_G489_E0.9910.16
363_K522_H0.9910.16
363_K495_D0.9910.16
363_K489_E0.9910.16
489_E495_D0.9910.16
363_K488_D0.9910.16
362_G522_H0.9910.16
488_D495_D0.9910.16
200_D495_D0.9910.16
200_D362_G0.9910.16
172_G193_D0.9910.16
362_G489_E0.9910.16
200_D363_K0.9910.16
172_G357_G0.9910.16
172_G362_G0.9910.16
172_G495_D0.9910.16
362_G495_D0.9910.16
172_G363_K0.9910.16
200_D522_H0.9910.16
206_Q466_G0.9910.16
564_L567_V0.9900.16
197_T471_R0.9890.16
594_G599_A0.9890.16
226_T493_A0.9840.16
380_E578_Q0.9820.15
592_L601_S0.9810.15
178_M503_I0.9800.15
106_M109_I0.9800.15
347_L403_I0.9800.15
183_L211_I0.9790.15
567_V596_E0.9790.15
194_E466_G0.9780.15
579_R608_G0.9780.15
483_K524_M0.9750.15
595_E607_P0.9710.15
462_H601_S0.9660.15
587_P591_H0.9650.15
571_E578_Q0.9640.15
591_H599_A0.9620.15
578_Q581_L0.9590.15
581_L591_H0.9580.15
562_K578_Q0.9570.15
596_E608_G0.9550.15
590_I609_H0.9540.15
142_A184_S0.9520.15
578_Q582_L0.9500.15
197_T523_D0.9460.15
132_R139_R0.9440.15
599_A608_G0.9430.15
593_R605_V0.9400.15
309_D459_R0.9400.15
593_R596_E0.9370.15
575_Q580_V0.9360.15
271_A347_L0.9320.15
573_S601_S0.9310.15
570_A596_E0.9280.15
176_R379_G0.9260.15
593_R598_A0.9250.15
152_Q493_A0.9250.15
242_M367_G0.9250.15
196_T227_H0.9240.14
371_L486_I0.9240.14
285_R296_A0.9230.14
197_T466_G0.9200.14
525_A548_R0.9150.14
582_L596_E0.9130.14
589_N592_L0.9120.14
352_T479_A0.9110.14
290_I296_A0.9100.14
592_L596_E0.9090.14
586_L590_I0.9080.14
231_V523_D0.9050.14
206_Q359_S0.9040.14
199_L546_G0.9040.14
577_P589_N0.9020.14
226_T366_T0.9000.14
569_V584_D0.9000.14
581_L599_A0.8990.14
197_T359_S0.8970.14
596_E601_S0.8960.14
587_P604_C0.8960.14
562_K582_L0.8950.14
584_D592_L0.8950.14
573_S581_L0.8930.14
231_V405_F0.8910.14
173_M409_D0.8900.14
492_S515_I0.8900.14
152_Q155_I0.8890.14
570_A600_V0.8880.14
571_E599_A0.8830.14
588_S593_R0.8830.14
582_L593_R0.8820.14
229_M524_M0.8790.14
570_A574_R0.8770.14
291_S448_E0.8760.14
198_A515_I0.8750.14
359_S515_I0.8680.14
569_V594_G0.8660.14
286_R311_E0.8650.14
581_L586_L0.8650.14
174_R409_D0.8640.14
588_S602_L0.8630.14
152_Q297_K0.8620.13
195_P466_G0.8590.13
149_M354_S0.8580.13
593_R607_P0.8580.13
413_S517_Y0.8540.13
584_D590_I0.8530.13
190_L194_E0.8520.13
584_D607_P0.8500.13
575_Q595_E0.8500.13
583_S595_E0.8490.13
569_V579_R0.8480.13
383_F401_R0.8450.13
203_I256_I0.8450.13
584_D589_N0.8450.13
581_L598_A0.8450.13
594_G609_H0.8440.13
574_R585_D0.8430.13
577_P600_V0.8430.13
582_L607_P0.8420.13
595_E602_L0.8380.13
571_E579_R0.8380.13
569_V580_V0.8370.13
444_A493_A0.8350.13
539_L588_S0.8290.13
197_T206_Q0.8270.13
589_N596_E0.8250.13
592_L602_L0.8240.13
569_V600_V0.8220.13
242_M250_T0.8210.13
228_D231_V0.8160.13
223_I298_Q0.8140.13
587_P603_Q0.8140.13
573_S591_H0.8140.13
570_A577_P0.8140.13
579_R597_V0.8120.13
561_R564_L0.8110.13
567_V600_V0.8100.13
565_A607_P0.8080.13
287_F290_I0.8050.13
588_S597_V0.8050.13
590_I597_V0.8040.13
461_P485_I0.8030.13
275_L302_I0.8000.13
586_L600_V0.7970.13
196_T368_R0.7950.12
570_A603_Q0.7930.12
237_D559_Y0.7910.12
573_S598_A0.7890.12
589_N609_H0.7880.12
579_R599_A0.7880.12
583_S605_V0.7870.12
285_R289_L0.7780.12
600_V607_P0.7770.12
579_R607_P0.7730.12
581_L608_G0.7730.12
567_V607_P0.7720.12
581_L589_N0.7700.12
595_E598_A0.7700.12
197_T231_V0.7670.12
585_D603_Q0.7640.12
288_P296_A0.7610.12
574_R596_E0.7590.12
569_V599_A0.7570.12
282_D291_S0.7560.12
582_L598_A0.7540.12
582_L595_E0.7530.12
578_Q600_V0.7510.12
574_R604_C0.7500.12
586_L602_L0.7480.12
292_L406_I0.7480.12
190_L466_G0.7460.12
581_L609_H0.7460.12
569_V576_R0.7460.12
359_S466_G0.7440.12
562_K594_G0.7420.12
310_G459_R0.7410.12
375_E596_E0.7400.12
194_E365_T0.7390.12
586_L603_Q0.7380.12
227_H466_G0.7370.12
570_A595_E0.7370.12
568_P596_E0.7360.12
310_G321_T0.7350.12
581_L588_S0.7330.12
287_F292_L0.7310.12
195_P467_G0.7310.12
571_E598_A0.7310.12
572_P606_G0.7310.12
169_L294_H0.7300.12
570_A599_A0.7280.12
576_R606_G0.7270.12
579_R602_L0.7250.11
227_H447_L0.7250.11
579_R595_E0.7240.11
583_S594_G0.7240.11
583_S589_N0.7210.11
568_P598_A0.7210.11
586_L606_G0.7200.11
235_I562_K0.7200.11
585_D595_E0.7190.11
601_S608_G0.7190.11
572_P605_V0.7160.11
152_Q300_P0.7160.11
195_P502_I0.7140.11
590_I607_P0.7120.11
581_L597_V0.7090.11
206_Q471_R0.7090.11
576_R584_D0.7060.11
297_K304_Q0.7060.11
476_R536_V0.7060.11
231_V471_R0.7040.11
575_Q604_C0.7040.11
293_E568_P0.7020.11
593_R602_L0.7020.11
295_P474_I0.7010.11
502_I505_L0.6980.11
593_R597_V0.6970.11
596_E600_V0.6960.11
562_K575_Q0.6940.11
223_I518_L0.6930.11
560_T590_I0.6920.11
569_V589_N0.6910.11
187_P487_A0.6890.11
584_D591_H0.6880.11
575_Q602_L0.6880.11
282_D289_L0.6870.11
575_Q583_S0.6860.11
135_Q140_E0.6860.11
194_E490_A0.6840.11
379_G408_Q0.6840.11
575_Q586_L0.6830.11
207_I515_I0.6810.11
104_A111_Q0.6790.11
300_P304_Q0.6780.11
105_D109_I0.6780.11
575_Q588_S0.6770.11
149_M187_P0.6770.11
466_G515_I0.6760.11
149_M455_E0.6760.11
585_D596_E0.6750.11
580_V586_L0.6720.11
199_L490_A0.6690.11
583_S609_H0.6690.11
206_Q515_I0.6680.11
183_L195_P0.6650.11
492_S502_I0.6640.11
175_Q470_Q0.6630.11
597_V609_H0.6620.11
582_L606_G0.6610.11
465_S522_H0.6590.11
200_D465_S0.6590.11
193_D465_S0.6590.11
362_G465_S0.6590.11
172_G465_S0.6590.11
170_S465_S0.6590.11
465_S495_D0.6590.11
363_K465_S0.6590.11
357_G465_S0.6590.11
465_S489_E0.6590.11
465_S488_D0.6590.11
577_P597_V0.6590.11
188_A509_L0.6580.11
317_R600_V0.6580.11
572_P580_V0.6550.11
585_D608_G0.6520.11
207_I227_H0.6520.11
588_S609_H0.6510.11
594_G602_L0.6480.10
343_V567_V0.6460.10
581_L593_R0.6460.10
588_S592_L0.6460.10
107_A158_A0.6450.10
241_V526_V0.6440.10
564_L570_A0.6430.10
598_A603_Q0.6410.10
292_L299_A0.6400.10
367_G482_P0.6390.10
288_P407_F0.6390.10
573_S608_G0.6360.10
457_A500_G0.6350.10
506_L517_Y0.6340.10
199_L485_I0.6340.10
581_L595_E0.6320.10
575_Q584_D0.6300.10
572_P579_R0.6280.10
583_S602_L0.6280.10
226_T444_A0.6280.10
177_V281_L0.6270.10
360_G488_D0.6260.10
360_G489_E0.6260.10
360_G363_K0.6260.10
357_G360_G0.6260.10
200_D360_G0.6260.10
360_G495_D0.6260.10
291_S294_H0.6260.10
193_D360_G0.6260.10
170_S360_G0.6260.10
360_G522_H0.6260.10
172_G360_G0.6260.10
573_S580_V0.6250.10
573_S579_R0.6250.10
603_Q609_H0.6240.10
571_E575_Q0.6240.10
196_T228_D0.6220.10
572_P598_A0.6210.10
145_E526_V0.6160.10
596_E605_V0.6130.10
177_V266_R0.6130.10
574_R595_E0.6110.10
567_V572_P0.6110.10
586_L598_A0.6110.10
600_V605_V0.6050.10
493_A505_L0.6040.10
170_S408_Q0.6030.10
408_Q522_H0.6030.10
408_Q489_E0.6030.10
408_Q488_D0.6030.10
193_D408_Q0.6030.10
408_Q495_D0.6030.10
357_G408_Q0.6030.10
172_G408_Q0.6030.10
363_K408_Q0.6030.10
200_D408_Q0.6030.10
362_G408_Q0.6030.10
383_F402_D0.6010.10
158_A598_A0.5990.10
169_L285_R0.5990.10
581_L596_E0.5980.10
155_I300_P0.5980.10
581_L604_C0.5970.10
573_S594_G0.5900.10
578_Q605_V0.5900.10
579_R590_I0.5890.10
498_I516_A0.5880.10
221_G461_P0.5880.10
179_I227_H0.5850.10
567_V591_H0.5850.10
599_A607_P0.5840.10
579_R598_A0.5830.10
580_V601_S0.5820.10
591_H598_A0.5800.10
410_P517_Y0.5800.10
587_P609_H0.5780.10
581_L594_G0.5770.10
135_Q139_R0.5750.10
194_E523_D0.5750.10
578_Q590_I0.5750.10
599_A605_V0.5730.10
576_R600_V0.5720.10
575_Q589_N0.5720.10
572_P578_Q0.5720.10
578_Q591_H0.5690.10
285_R290_I0.5690.10
149_M177_V0.5670.10
574_R606_G0.5670.10
230_G361_S0.5660.09
198_A359_S0.5640.09
232_V443_V0.5640.09
584_D599_A0.5620.09
589_N600_V0.5610.09
576_R603_Q0.5600.09
313_V516_A0.5600.09
592_L597_V0.5590.09
109_I112_E0.5590.09
150_L464_F0.5590.09
586_L589_N0.5570.09
577_P596_E0.5560.09
287_F296_A0.5560.09
127_I132_R0.5540.09
596_E603_Q0.5540.09
365_T490_A0.5530.09
178_M355_L0.5530.09
317_R380_E0.5510.09
169_L175_Q0.5510.09
575_Q601_S0.5500.09
149_M308_V0.5500.09
270_A315_R0.5490.09
282_D296_A0.5480.09
597_V605_V0.5460.09
356_V478_L0.5440.09
577_P599_A0.5440.09
590_I600_V0.5430.09
345_F517_Y0.5390.09
304_Q356_V0.5350.09
593_R604_C0.5310.09
569_V592_L0.5310.09
335_R469_R0.5310.09
483_K520_I0.5300.09
100_H104_A0.5300.09
582_L594_G0.5290.09
572_P576_R0.5280.09
321_T369_A0.5280.09
474_I520_I0.5260.09
405_F491_V0.5260.09
406_I527_V0.5260.09
263_P418_Q0.5260.09
224_F236_A0.5240.09
123_V134_H0.5220.09
577_P605_V0.5210.09
272_V403_I0.5210.09
589_N598_A0.5210.09
588_S603_Q0.5190.09
573_S604_C0.5170.09
568_P604_C0.5160.09
585_D588_S0.5150.09
569_V586_L0.5140.09
198_A228_D0.5130.09
598_A606_G0.5110.09
212_K592_L0.5080.09
582_L586_L0.5070.09
588_S608_G0.5070.09
359_S523_D0.5070.09
178_M464_F0.5040.09
364_S537_M0.5040.09
508_D592_L0.5030.09
572_P595_E0.5020.09
578_Q586_L0.5000.09
355_L481_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4finA 2 0.8058 100 0.491 Contact Map
4q9hA 1 0.8299 100 0.499 Contact Map
4f4cA 1 0.8058 100 0.504 Contact Map
2iw3A 2 0.7368 100 0.519 Contact Map
1yqtA 1 0.8202 100 0.551 Contact Map
3bk7A 1 0.8427 100 0.552 Contact Map
3ozxA 1 0.8186 100 0.558 Contact Map
3j16B 1 0.8636 100 0.57 Contact Map
3ux8A 2 0.7175 100 0.58 Contact Map
2vf7A 2 0.7897 100 0.603 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0137 seconds.