GREMLIN Database
SUPH - Sugar phosphatase YbiV
UniProt: P75792 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13327
Length: 271 (256)
Sequences: 10940 (8923)
Seq/√Len: 557.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_D257_N4.2341.00
17_D251_N3.4531.00
212_A226_A3.0851.00
223_L229_S2.7881.00
4_K209_N2.7821.00
249_D252_H2.7771.00
22_N253_E2.7311.00
25_R253_E2.5421.00
200_L210_V2.5271.00
224_K242_I2.4071.00
197_S225_M2.4041.00
237_E241_Q2.3911.00
16_N20_T2.3881.00
8_T40_F2.3661.00
25_R260_Q2.3621.00
44_S51_L2.1851.00
207_P225_M2.1381.00
191_H221_E1.9971.00
80_F198_R1.9571.00
220_A239_I1.9321.00
217_G238_N1.8791.00
229_S244_R1.8401.00
231_A243_A1.8391.00
32_E35_K1.8201.00
24_P28_A1.8101.00
220_A242_I1.7941.00
217_G236_A1.7861.00
30_Y40_F1.7851.00
32_E260_Q1.7831.00
3_V211_V1.7631.00
85_T88_E1.7331.00
74_E77_K1.7311.00
206_S209_N1.7251.00
33_L38_I1.7151.00
248_D252_H1.7091.00
198_R202_R1.7041.00
5_V41_V1.6771.00
7_V196_I1.6711.00
237_E240_K1.6701.00
197_S201_K1.6641.00
27_M57_E1.6471.00
32_E36_R1.6441.00
228_Y245_Y1.6191.00
198_R201_K1.6051.00
228_Y244_R1.5991.00
230_F258_V1.5921.00
193_A225_M1.5661.00
196_I222_M1.5661.00
194_N197_S1.5651.00
245_Y262_V1.5301.00
82_G198_R1.5241.00
39_K203_W1.5031.00
96_L151_L1.5011.00
3_V38_I1.4991.00
25_R257_N1.4821.00
22_N26_F1.4821.00
239_I242_I1.4751.00
28_A32_E1.4611.00
10_M15_L1.4531.00
34_K61_E1.4451.00
212_A222_M1.4371.00
26_F253_E1.4281.00
91_I172_I1.4251.00
213_I255_A1.4241.00
208_Q227_R1.4231.00
8_T213_I1.4151.00
27_M31_Q1.3991.00
245_Y258_V1.3751.00
162_I166_H1.3601.00
3_V228_Y1.3251.00
220_A224_K1.3131.00
88_E91_I1.3121.00
7_V43_A1.3101.00
78_Q81_H1.3081.00
29_Q256_L1.3071.00
231_A235_A1.3051.00
86_R90_R1.3041.00
3_V209_N1.3011.00
213_I258_V1.2971.00
233_G249_D1.2791.00
207_P210_V1.2741.00
223_L239_I1.2681.00
82_G187_I1.2471.00
81_H145_V1.2411.00
200_L207_P1.2391.00
240_K246_A1.2321.00
120_E124_A1.2311.00
29_Q260_Q1.2301.00
258_V262_V1.2211.00
174_K221_E1.2191.00
138_D141_E1.2111.00
238_N241_Q1.2051.00
120_E123_V1.1961.00
22_N25_R1.1911.00
157_Q160_L1.1871.00
31_Q35_K1.1851.00
71_L78_Q1.1841.00
6_I259_I1.1781.00
25_R29_Q1.1721.00
245_Y261_A1.1711.00
6_I33_L1.1701.00
81_H147_F1.1591.00
16_N251_N1.1501.00
5_V205_L1.1481.00
41_V199_L1.1391.00
211_V262_V1.1351.00
63_S203_W1.1341.00
255_A259_I1.1331.00
34_K62_I1.1301.00
174_K189_G1.1261.00
210_V226_A1.1181.00
65_V195_G1.1171.00
88_E173_M1.1141.00
212_A223_L1.1041.00
41_V63_S1.1031.00
72_V198_R1.1021.00
247_T258_V1.1021.00
5_V200_L1.0781.00
6_I38_I1.0701.00
159_P177_T1.0631.00
153_L157_Q1.0581.00
256_L260_Q1.0571.00
31_Q34_K1.0571.00
159_P163_D1.0561.00
17_D250_N1.0431.00
232_M254_G1.0391.00
7_V210_V1.0381.00
234_N250_N1.0371.00
176_V186_I1.0331.00
207_P227_R1.0311.00
10_M54_F1.0301.00
24_P27_M1.0291.00
230_F247_T1.0271.00
230_F245_Y1.0261.00
247_T254_G1.0231.00
191_H194_N1.0201.00
257_N261_A1.0141.00
258_V261_A1.0131.00
236_A239_I1.0081.00
72_V80_F1.0061.00
193_A221_E1.0021.00
226_A229_S0.9991.00
31_Q59_K0.9931.00
200_L225_M0.9921.00
82_G189_G0.9891.00
83_E145_V0.9891.00
196_I226_A0.9881.00
187_I190_L0.9871.00
211_V230_F0.9871.00
148_K184_D0.9851.00
216_S236_A0.9801.00
5_V210_V0.9741.00
90_R94_G0.9741.00
14_F30_Y0.9731.00
81_H109_L0.9731.00
14_F26_F0.9731.00
197_S207_P0.9691.00
70_A190_L0.9571.00
233_G240_K0.9561.00
211_V228_Y0.9541.00
257_N260_Q0.9541.00
211_V258_V0.9391.00
231_A239_I0.9371.00
199_L203_W0.9361.00
171_G188_P0.9351.00
160_L164_K0.9331.00
48_Y66_A0.9321.00
160_L163_D0.9321.00
235_A240_K0.9271.00
217_G220_A0.9261.00
88_E172_I0.9181.00
8_T255_A0.9161.00
28_A31_Q0.9161.00
233_G248_D0.9151.00
200_L205_L0.9131.00
52_I76_G0.9111.00
163_D166_H0.9091.00
238_N242_I0.8991.00
66_A71_L0.8991.00
100_K164_K0.8981.00
73_Y78_Q0.8861.00
7_V41_V0.8831.00
248_D254_G0.8811.00
72_V195_G0.8761.00
153_L158_I0.8741.00
33_L40_F0.8641.00
44_S66_A0.8641.00
91_I94_G0.8521.00
48_Y73_Y0.8511.00
52_I56_P0.8501.00
200_L227_R0.8491.00
63_S199_L0.8461.00
232_M247_T0.8411.00
186_I191_H0.8401.00
26_F256_L0.8361.00
16_N22_N0.8341.00
84_L187_I0.8291.00
65_V199_L0.8281.00
73_Y76_G0.8261.00
79_L202_R0.8251.00
6_I211_V0.8221.00
95_E100_K0.8221.00
212_A229_S0.8191.00
43_A65_V0.8181.00
210_V227_R0.8131.00
95_E169_L0.8081.00
29_Q32_E0.8081.00
210_V225_M0.8031.00
25_R256_L0.7981.00
227_R244_R0.7981.00
39_K63_S0.7971.00
139_Y142_I0.7921.00
223_L242_I0.7911.00
63_S74_E0.7911.00
87_H91_I0.7901.00
159_P162_I0.7861.00
94_G140_Q0.7821.00
233_G252_H0.7811.00
98_K115_S0.7771.00
175_P185_L0.7751.00
99_D164_K0.7741.00
162_I177_T0.7731.00
8_T14_F0.7701.00
26_F29_Q0.7671.00
10_M42_V0.7661.00
47_Q67_E0.7581.00
91_I95_E0.7571.00
83_E147_F0.7571.00
66_A73_Y0.7561.00
38_I211_V0.7551.00
194_N198_R0.7521.00
248_D261_A0.7521.00
33_L259_I0.7481.00
137_K140_Q0.7451.00
95_E164_K0.7421.00
197_S200_L0.7261.00
18_A251_N0.7231.00
209_N227_R0.7201.00
51_L66_A0.7191.00
223_L243_A0.7191.00
127_A130_Y0.7161.00
235_A239_I0.7151.00
196_I212_A0.6991.00
232_M235_A0.6991.00
111_S134_K0.6971.00
48_Y52_I0.6961.00
14_F21_Y0.6951.00
91_I169_L0.6951.00
164_K167_V0.6941.00
68_N184_D0.6911.00
174_K191_H0.6881.00
77_K202_R0.6871.00
109_L145_V0.6871.00
190_L194_N0.6861.00
245_Y257_N0.6851.00
86_R145_V0.6841.00
42_V51_L0.6811.00
89_S146_L0.6801.00
51_L64_F0.6791.00
16_N250_N0.6781.00
43_A222_M0.6771.00
71_L147_F0.6741.00
172_I188_P0.6731.00
108_G144_D0.6701.00
215_D235_A0.6671.00
25_R28_A0.6641.00
221_E224_K0.6641.00
10_M51_L0.6631.00
108_G146_L0.6621.00
94_G99_D0.6591.00
70_A187_I0.6551.00
78_Q109_L0.6551.00
228_Y258_V0.6531.00
213_I247_T0.6491.00
220_A223_L0.6471.00
12_G232_M0.6471.00
174_K188_P0.6471.00
14_F250_N0.6441.00
253_E256_L0.6411.00
121_A124_A0.6411.00
95_E99_D0.6401.00
213_I230_F0.6361.00
229_S239_I0.6361.00
122_F125_L0.6341.00
150_S184_D0.6331.00
163_D167_V0.6331.00
55_F64_F0.6311.00
245_Y248_D0.6281.00
174_K186_I0.6261.00
100_K160_L0.6231.00
72_V199_L0.6211.00
86_R143_D0.6201.00
193_A197_S0.6171.00
229_S243_A0.6151.00
10_M14_F0.6151.00
179_G216_S0.6121.00
123_V127_A0.6111.00
6_I213_I0.6101.00
234_N249_D0.6091.00
109_L144_D0.6091.00
247_T257_N0.6081.00
39_K62_I0.6081.00
87_H90_R0.6081.00
232_M250_N0.6051.00
242_I245_Y0.6031.00
42_V55_F0.6031.00
101_Q157_Q0.6031.00
105_V150_S0.5991.00
137_K141_E0.5971.00
74_E79_L0.5941.00
215_D232_M0.5911.00
217_G239_I0.5901.00
5_V199_L0.5891.00
234_N240_K0.5891.00
94_G98_K0.5891.00
106_A146_L0.5881.00
126_M130_Y0.5871.00
126_M129_H0.5871.00
90_R140_Q0.5851.00
109_L147_F0.5841.00
108_G111_S0.5831.00
74_E202_R0.5811.00
248_D258_V0.5770.99
136_V139_Y0.5770.99
121_A125_L0.5770.99
189_G194_N0.5760.99
253_E257_N0.5740.99
43_A68_N0.5730.99
231_A242_I0.5720.99
256_L259_I0.5720.99
26_F30_Y0.5710.99
71_L109_L0.5710.99
14_F42_V0.5700.99
148_K178_S0.5690.99
239_I243_A0.5680.99
175_P183_I0.5680.99
72_V202_R0.5680.99
4_K38_I0.5670.99
16_N253_E0.5660.99
60_D63_S0.5660.99
156_E160_L0.5660.99
119_P122_F0.5650.99
29_Q33_L0.5640.99
51_L54_F0.5630.99
93_I106_A0.5620.99
21_Y27_M0.5610.99
205_L227_R0.5590.99
129_H133_L0.5560.99
52_I55_F0.5520.99
89_S93_I0.5520.99
158_I162_I0.5520.99
38_I209_N0.5520.99
28_A260_Q0.5500.99
15_L250_N0.5480.99
158_I183_I0.5480.99
3_V39_K0.5480.99
169_L172_I0.5470.99
22_N256_L0.5470.99
67_E147_F0.5450.99
5_V39_K0.5430.99
124_A127_A0.5420.99
53_S56_P0.5410.99
42_V62_I0.5340.99
67_E70_A0.5330.99
134_K137_K0.5300.99
213_I259_I0.5300.99
53_S57_E0.5250.99
98_K104_F0.5230.99
230_F244_R0.5230.99
166_H170_D0.5230.99
34_K59_K0.5200.99
82_G190_L0.5170.99
128_K131_H0.5150.99
30_Y259_I0.5130.99
33_L256_L0.5130.99
3_V6_I0.5080.99
158_I177_T0.5070.99
7_V200_L0.5060.99
152_N182_F0.5050.99
196_I200_L0.5050.99
132_R135_P0.5030.99
205_L210_V0.5020.99
125_L129_H0.5010.99
166_H175_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgvA 3 0.9446 100 0.223 Contact Map
3l7yA 1 0.9668 100 0.223 Contact Map
1rlmA 1 0.9926 100 0.231 Contact Map
1nrwA 1 0.9483 100 0.24 Contact Map
2b30A 2 0.9631 100 0.241 Contact Map
3daoA 1 0.9631 100 0.246 Contact Map
1rkqA 1 0.9705 100 0.25 Contact Map
4qjbA 1 0.9668 100 0.253 Contact Map
1nf2A 4 0.9705 100 0.258 Contact Map
2pq0A 1 0.9483 100 0.263 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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