GREMLIN Database
YBIU - Uncharacterized protein YbiU
UniProt: P75791 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13326
Length: 421 (394)
Sequences: 410 (279)
Seq/√Len: 14.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_Q230_A7.1861.00
105_S145_A5.3871.00
228_N231_Q5.0371.00
96_R332_E4.6321.00
63_V91_K4.1741.00
225_F289_L4.0631.00
90_I158_A3.2850.99
163_N259_T3.2670.98
166_W237_A3.2130.98
79_R83_K3.1920.98
223_N231_Q2.7400.95
66_Y157_N2.6740.95
64_L82_I2.6280.94
378_V389_G2.5930.94
277_H327_S2.5680.93
271_P330_K2.5570.93
351_E357_G2.4370.92
142_W185_P2.4170.91
87_C278_V2.3700.90
217_Y311_L2.3120.89
353_Q357_G2.2440.88
104_Q108_D2.2410.88
54_K323_E2.2410.88
270_L330_K2.2000.87
137_I195_T2.1830.86
224_V289_L2.1750.86
101_G105_S2.1180.84
151_Q417_L2.1040.84
51_N92_G2.1020.84
387_S394_E2.0690.83
263_W274_G2.0560.82
385_G403_R2.0260.81
76_A80_E1.9890.80
167_T233_D1.9880.80
195_T198_K1.9770.80
94_F102_W1.9750.80
42_D45_T1.9740.80
36_F43_I1.9540.79
82_I88_A1.9300.78
42_D283_E1.8960.77
112_R402_G1.8440.75
84_R155_M1.8290.74
210_E229_L1.8210.74
70_K157_N1.7830.72
100_L107_L1.7740.72
277_H346_S1.7640.71
284_A344_I1.7620.71
40_S320_L1.7490.71
213_L248_V1.7480.71
365_A368_C1.7310.70
25_L308_G1.7290.70
182_V375_A1.6990.68
215_P219_R1.6940.68
116_D400_W1.6870.68
217_Y232_Y1.6730.67
93_H336_S1.6530.66
93_H185_P1.6480.66
222_A226_N1.6460.66
156_A181_S1.6430.66
185_P378_V1.6360.65
367_M372_L1.6330.65
353_Q359_V1.6290.65
303_C317_W1.6270.65
182_V367_M1.6130.64
50_I83_K1.6020.64
18_I248_V1.5950.63
43_I333_A1.5940.63
87_C343_V1.5780.62
140_I143_S1.5770.62
265_A270_L1.5760.62
28_Q92_G1.5750.62
39_L230_A1.5680.62
181_S368_C1.5660.62
190_R243_V1.5620.62
93_H221_F1.5460.61
108_D377_K1.5400.60
144_Q148_Q1.5280.60
17_A213_L1.5200.59
113_N402_G1.5100.59
75_T78_Q1.5080.59
129_T138_Y1.5060.59
195_T312_P1.4990.58
68_D111_D1.4860.58
266_L346_S1.4850.58
66_Y154_E1.4740.57
347_V359_V1.4670.57
363_P392_P1.4570.56
149_A362_I1.4300.55
87_C209_L1.4290.55
98_Q148_Q1.4150.54
210_E213_L1.4150.54
135_P250_N1.4150.54
137_I198_K1.4120.54
210_E308_G1.4030.53
59_A63_V1.4020.53
59_A225_F1.3960.53
106_M188_I1.3940.53
290_L293_L1.3930.53
235_W380_A1.3920.53
345_H359_V1.3830.52
374_Y388_P1.3790.52
103_D356_W1.3760.52
49_E52_A1.3690.51
225_F327_S1.3630.51
223_N228_N1.3370.50
61_W87_C1.3310.49
216_A239_H1.3310.49
203_H345_H1.3190.49
170_S236_H1.3110.48
85_R142_W1.3070.48
214_L244_E1.2980.47
187_R210_E1.2960.47
78_Q236_H1.2800.46
257_F389_G1.2720.46
369_E373_A1.2710.46
81_Q85_R1.2620.46
359_V362_I1.2580.45
375_A388_P1.2580.45
19_R23_H1.2510.45
353_Q356_W1.2510.45
78_Q235_W1.2460.45
44_A415_R1.2380.44
221_F232_Y1.2150.43
194_G362_I1.2150.43
135_P166_W1.2150.43
296_D299_E1.2100.43
130_L199_G1.2080.43
410_N413_G1.2060.43
305_V311_L1.2030.42
187_R254_C1.1950.42
312_P396_Y1.1910.42
54_K60_V1.1890.42
214_L388_P1.1880.42
202_A353_Q1.1870.42
24_A380_A1.1820.41
109_Y387_S1.1800.41
410_N414_K1.1760.41
65_S68_D1.1720.41
23_H97_E1.1690.41
272_G327_S1.1630.40
217_Y221_F1.1620.40
137_I312_P1.1570.40
382_L413_G1.1480.39
191_R263_W1.1450.39
406_L419_M1.1440.39
144_Q408_D1.1430.39
92_G99_A1.1410.39
203_H263_W1.1320.39
163_N336_S1.1320.39
142_W417_L1.1260.38
281_I324_A1.1260.38
198_K201_G1.1250.38
55_A284_A1.1220.38
95_P319_P1.1200.38
88_A278_V1.1190.38
238_A265_A1.1150.38
163_N338_W1.1110.38
52_A84_R1.1070.37
61_W323_E1.1050.37
395_D399_N1.0980.37
369_E413_G1.0950.37
34_Q38_Q1.0940.37
89_V325_L1.0910.37
106_M158_A1.0880.36
312_P394_E1.0810.36
89_V236_H1.0730.36
305_V317_W1.0690.35
56_Q60_V1.0670.35
412_H415_R1.0650.35
51_N323_E1.0620.35
220_V302_L1.0550.35
82_I374_Y1.0530.35
285_M293_L1.0530.35
166_W289_L1.0510.35
139_P198_K1.0500.35
208_A271_P1.0460.34
203_H359_V1.0450.34
363_P396_Y1.0430.34
234_P360_M1.0420.34
219_R328_I1.0400.34
331_L388_P1.0390.34
287_Y292_P1.0360.34
214_L235_W1.0340.34
268_D332_E1.0310.34
194_G331_L1.0300.34
347_V351_E1.0280.33
288_V313_V1.0270.33
76_A157_N1.0260.33
26_R32_V1.0230.33
33_Q68_D1.0200.33
24_A69_I1.0130.33
66_Y70_K1.0120.33
113_N346_S1.0100.33
103_D358_N1.0090.33
77_E81_Q1.0070.32
194_G271_P1.0060.32
137_I199_G1.0010.32
35_I53_L1.0000.32
178_P284_A0.9990.32
221_F311_L0.9890.32
103_D267_S0.9850.31
152_S190_R0.9800.31
225_F260_F0.9730.31
61_W353_Q0.9710.31
96_R268_D0.9700.31
45_T231_Q0.9620.30
57_G92_G0.9610.30
182_V388_P0.9590.30
71_A75_T0.9570.30
74_V361_Y0.9560.30
191_R347_V0.9560.30
134_R192_P0.9560.30
213_L229_L0.9540.30
33_Q323_E0.9540.30
113_N162_L0.9520.30
130_L357_G0.9500.30
405_T414_K0.9480.30
191_R345_H0.9420.29
275_L351_E0.9420.29
183_I417_L0.9400.29
110_L243_V0.9360.29
307_P317_W0.9360.29
203_H347_V0.9330.29
147_M417_L0.9330.29
108_D112_R0.9320.29
214_L218_Q0.9310.29
66_Y158_A0.9280.29
206_S210_E0.9280.29
102_W148_Q0.9260.29
292_P319_P0.9260.29
209_L302_L0.9230.29
142_W264_T0.9220.29
89_V328_I0.9200.28
36_F293_L0.9200.28
20_Q23_H0.9190.28
267_S363_P0.9150.28
19_R409_L0.9130.28
13_D16_A0.9100.28
198_K312_P0.9090.28
235_W351_E0.9070.28
209_L275_L0.9060.28
264_T338_W0.8990.28
372_L376_H0.8990.28
49_E53_L0.8980.27
153_E292_P0.8940.27
203_H274_G0.8890.27
156_A416_A0.8880.27
95_P101_G0.8880.27
108_D415_R0.8880.27
68_D332_E0.8820.27
302_L317_W0.8790.27
170_S173_K0.8770.27
218_Q303_C0.8710.26
32_V160_S0.8700.26
49_E419_M0.8670.26
232_Y256_V0.8650.26
149_A206_S0.8630.26
65_S92_G0.8620.26
50_I409_L0.8620.26
321_L344_I0.8610.26
387_S396_Y0.8610.26
109_Y166_W0.8600.26
23_H27_A0.8590.26
236_H239_H0.8590.26
44_A401_E0.8580.26
277_H348_A0.8570.26
275_L353_Q0.8570.26
96_R114_R0.8520.26
374_Y378_V0.8500.25
235_W281_I0.8490.25
15_K59_A0.8470.25
191_R274_G0.8430.25
74_V88_A0.8390.25
314_S393_R0.8380.25
176_F241_T0.8370.25
272_G418_G0.8360.25
351_E359_V0.8330.25
35_I227_G0.8300.25
250_N387_S0.8260.24
278_V360_M0.8230.24
264_T336_S0.8200.24
179_D299_E0.8200.24
218_Q400_W0.8170.24
76_A83_K0.8160.24
268_D273_Q0.8140.24
63_V260_F0.8130.24
217_Y244_E0.8120.24
234_P257_F0.8120.24
328_I331_L0.8110.24
53_L60_V0.8080.24
282_P409_L0.8070.24
130_L136_E0.8030.24
188_I403_R0.8030.24
185_P417_L0.8010.23
412_H417_L0.8010.23
140_I351_E0.7990.23
201_G392_P0.7980.23
157_N407_A0.7970.23
52_A98_Q0.7950.23
413_G416_A0.7900.23
217_Y350_V0.7880.23
39_L221_F0.7870.23
69_I271_P0.7870.23
45_T401_E0.7860.23
235_W277_H0.7860.23
183_I372_L0.7850.23
214_L302_L0.7840.23
143_S302_L0.7790.23
159_Q273_Q0.7790.23
143_S208_A0.7780.23
61_W147_M0.7770.23
336_S364_A0.7770.23
232_Y302_L0.7760.22
20_Q238_A0.7740.22
348_A365_A0.7740.22
43_I294_L0.7740.22
42_D230_A0.7730.22
44_A145_A0.7730.22
142_W210_E0.7700.22
263_W359_V0.7700.22
139_P312_P0.7690.22
92_G376_H0.7680.22
138_Y414_K0.7680.22
17_A229_L0.7660.22
375_A418_G0.7650.22
55_A97_E0.7640.22
368_C394_E0.7640.22
91_K109_Y0.7640.22
39_L252_T0.7620.22
346_S385_G0.7620.22
103_D266_L0.7610.22
92_G372_L0.7600.22
139_P393_R0.7600.22
305_V308_G0.7590.22
226_N231_Q0.7590.22
97_E101_G0.7580.22
23_H384_K0.7570.22
246_Y249_D0.7570.22
98_Q102_W0.7570.22
248_V415_R0.7550.22
139_P201_G0.7540.22
164_R179_D0.7530.22
148_Q372_L0.7520.22
230_A288_V0.7500.22
259_T279_V0.7490.21
312_P393_R0.7430.21
16_A20_Q0.7430.21
191_R203_H0.7410.21
105_S231_Q0.7360.21
39_L90_I0.7350.21
35_I290_L0.7350.21
141_Y162_L0.7320.21
273_Q349_P0.7310.21
14_H17_A0.7270.21
201_G312_P0.7270.21
348_A351_E0.7260.21
276_L361_Y0.7250.21
306_A315_E0.7250.21
139_P392_P0.7240.21
162_L202_A0.7240.21
293_L311_L0.7210.20
359_V397_E0.7190.20
95_P171_D0.7160.20
217_Y225_F0.7150.20
220_V380_A0.7150.20
24_A260_F0.7140.20
129_T338_W0.7130.20
294_L320_L0.7110.20
12_A373_A0.7100.20
33_Q417_L0.7070.20
61_W410_N0.7050.20
155_M344_I0.7050.20
134_R252_T0.7000.20
91_K142_W0.7000.20
12_A77_E0.6990.20
275_L389_G0.6980.20
56_Q59_A0.6980.20
61_W351_E0.6950.20
356_W359_V0.6940.20
193_P276_L0.6940.20
98_Q152_S0.6920.19
109_Y403_R0.6910.19
14_H209_L0.6890.19
76_A332_E0.6880.19
71_A314_S0.6860.19
106_M138_Y0.6860.19
204_T313_V0.6840.19
348_A400_W0.6840.19
66_Y194_G0.6790.19
226_N314_S0.6790.19
218_Q302_L0.6790.19
52_A56_Q0.6790.19
148_Q179_D0.6780.19
141_Y203_H0.6760.19
165_L256_V0.6760.19
177_N201_G0.6750.19
341_C356_W0.6730.19
15_K315_E0.6700.19
75_T80_E0.6690.19
326_T346_S0.6680.19
394_E403_R0.6670.19
38_Q221_F0.6650.19
16_A92_G0.6650.19
178_P260_F0.6640.19
374_Y385_G0.6630.18
20_Q69_I0.6630.18
168_F178_P0.6610.18
385_G394_E0.6590.18
289_L302_L0.6560.18
142_W187_R0.6530.18
397_E403_R0.6520.18
373_A376_H0.6510.18
33_Q37_N0.6500.18
136_E389_G0.6480.18
43_I290_L0.6470.18
269_M341_C0.6470.18
347_V362_I0.6440.18
38_Q90_I0.6430.18
65_S79_R0.6420.18
55_A108_D0.6410.18
232_Y377_K0.6390.18
88_A267_S0.6390.18
103_D190_R0.6380.18
185_P250_N0.6370.18
209_L260_F0.6370.18
129_T348_A0.6370.18
34_Q416_A0.6360.18
18_I94_F0.6360.18
143_S314_S0.6320.18
41_D44_A0.6320.18
382_L403_R0.6310.17
82_I328_I0.6290.17
21_M341_C0.6290.17
376_H379_K0.6290.17
214_L400_W0.6260.17
100_L103_D0.6250.17
195_T200_L0.6250.17
314_S411_I0.6240.17
82_I165_L0.6230.17
254_C403_R0.6230.17
198_K392_P0.6230.17
15_K23_H0.6230.17
182_V248_V0.6220.17
327_S348_A0.6220.17
347_V353_Q0.6200.17
54_K317_W0.6200.17
216_A372_L0.6190.17
257_F403_R0.6190.17
95_P104_Q0.6190.17
210_E307_P0.6180.17
76_A104_Q0.6150.17
252_T363_P0.6150.17
27_A98_Q0.6150.17
251_T400_W0.6150.17
91_K335_D0.6130.17
206_S285_M0.6110.17
245_E368_C0.6110.17
106_M355_G0.6110.17
200_L311_L0.6100.17
102_W382_L0.6070.17
192_P195_T0.6070.17
42_D229_L0.6070.17
103_D139_P0.6060.17
255_S304_G0.6060.17
362_I374_Y0.6050.17
215_P410_N0.6020.17
188_I313_V0.6010.17
351_E356_W0.6010.17
74_V220_V0.5990.16
185_P252_T0.5990.16
353_Q362_I0.5990.16
223_N285_M0.5980.16
32_V221_F0.5960.16
138_Y283_E0.5960.16
197_S236_H0.5960.16
234_P409_L0.5960.16
28_Q65_S0.5950.16
294_L319_P0.5940.16
144_Q147_M0.5940.16
254_C307_P0.5940.16
21_M40_S0.5920.16
43_I298_P0.5910.16
162_L193_P0.5910.16
139_P254_C0.5910.16
94_F152_S0.5890.16
189_R347_V0.5870.16
91_K171_D0.5870.16
50_I295_D0.5830.16
28_Q90_I0.5830.16
218_Q338_W0.5820.16
38_Q144_Q0.5800.16
147_M404_F0.5760.16
57_G229_L0.5760.16
179_D384_K0.5750.16
72_G237_A0.5750.16
42_D49_E0.5740.16
51_N69_I0.5740.16
382_L406_L0.5730.16
157_N373_A0.5730.16
225_F302_L0.5730.16
89_V156_A0.5730.16
50_I167_T0.5720.16
163_N260_F0.5710.16
177_N338_W0.5710.16
207_G318_H0.5710.16
273_Q294_L0.5710.16
51_N54_K0.5700.16
82_I87_C0.5690.16
30_G172_G0.5690.16
155_M217_Y0.5670.16
227_G416_A0.5640.15
132_A231_Q0.5640.15
163_N324_A0.5640.15
200_L254_C0.5640.15
143_S322_I0.5640.15
295_D368_C0.5630.15
382_L391_F0.5620.15
59_A79_R0.5610.15
64_L78_Q0.5590.15
155_M182_V0.5580.15
60_V166_W0.5580.15
35_I61_W0.5580.15
162_L338_W0.5580.15
92_G242_E0.5560.15
213_L254_C0.5550.15
59_A231_Q0.5550.15
17_A248_V0.5550.15
18_I213_L0.5530.15
25_L77_E0.5520.15
11_P94_F0.5500.15
32_V204_T0.5500.15
302_L345_H0.5490.15
147_M413_G0.5490.15
109_Y237_A0.5490.15
331_L363_P0.5470.15
373_A401_E0.5450.15
58_D90_I0.5440.15
163_N303_C0.5430.15
187_R229_L0.5430.15
164_R343_V0.5420.15
39_L142_W0.5420.15
69_I330_K0.5410.15
113_N140_I0.5360.15
224_V286_A0.5350.15
102_W404_F0.5350.15
368_C385_G0.5350.15
332_E395_D0.5340.15
70_K97_E0.5340.15
20_Q90_I0.5330.15
103_D392_P0.5330.15
204_T260_F0.5290.14
110_L343_V0.5280.14
234_P256_V0.5270.14
349_P387_S0.5260.14
34_Q315_E0.5260.14
250_N416_A0.5240.14
84_R248_V0.5230.14
181_S416_A0.5220.14
311_L320_L0.5210.14
214_L243_V0.5210.14
66_Y99_A0.5190.14
26_R297_V0.5180.14
52_A59_A0.5170.14
27_A151_Q0.5170.14
151_Q282_P0.5160.14
30_G179_D0.5160.14
206_S254_C0.5160.14
382_L385_G0.5150.14
131_S167_T0.5150.14
248_V252_T0.5140.14
253_K336_S0.5120.14
179_D295_D0.5110.14
95_P161_F0.5100.14
364_A368_C0.5100.14
110_L392_P0.5100.14
171_D411_I0.5100.14
141_Y201_G0.5090.14
194_G359_V0.5090.14
137_I253_K0.5080.14
410_N417_L0.5060.14
182_V243_V0.5060.14
166_W369_E0.5050.14
232_Y284_A0.5040.14
302_L305_V0.5030.14
51_N234_P0.5020.14
152_S248_V0.5020.14
67_A95_P0.5020.14
171_D239_H0.5020.14
78_Q81_Q0.5010.14
198_K393_R0.5010.14
149_A194_G0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dbnA 1 0.9549 100 0.27 Contact Map
4rgkA 2 0.981 100 0.301 Contact Map
4mhrA 2 0.658 99.8 0.888 Contact Map
2fctA 1 0.6508 99.4 0.921 Contact Map
3nnfA 2 0.6603 99.4 0.921 Contact Map
4xaaA 1 0.4917 99.4 0.922 Contact Map
4xabA 1 0.5558 99.4 0.922 Contact Map
4xbzA 4 0.658 99.4 0.923 Contact Map
3gjaA 3 0.5938 99.3 0.925 Contact Map
4nmiA 2 0.6437 99.3 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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