GREMLIN Database
OPGE - Phosphoethanolamine transferase OpgE
UniProt: P75785 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13321
Length: 527 (468)
Sequences: 5687 (4833)
Seq/√Len: 223.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_F402_R5.8071.00
254_A465_K5.3261.00
479_Q493_P4.5471.00
290_N318_R4.0221.00
350_A411_S3.8291.00
244_F247_S3.7251.00
346_A407_Q3.4191.00
27_S31_N3.3421.00
240_D246_S3.3241.00
402_R406_D3.1881.00
295_Q355_Q3.0171.00
406_D409_R2.9751.00
220_V417_L2.8831.00
222_V419_Y2.8801.00
468_R494_F2.8661.00
224_G227_A2.7851.00
320_D323_Y2.7601.00
219_Y289_A2.7591.00
217_Q414_S2.6991.00
31_N34_L2.6501.00
476_F495_I2.6341.00
256_Y468_R2.6241.00
218_T415_F2.5511.00
219_Y481_T2.4721.00
289_A481_T2.3651.00
233_G242_T2.3591.00
405_Y417_L2.3101.00
124_V128_R2.2601.00
218_T357_Q2.2131.00
23_Y27_S2.2011.00
242_T246_S2.1821.00
455_S458_D2.1791.00
408_L417_L2.1711.00
249_N409_R2.1421.00
235_F252_I2.1281.00
24_F27_S2.1261.00
221_V358_L2.1141.00
31_N35_G2.1111.00
272_N284_N2.0871.00
222_V401_L2.0461.00
345_T361_L2.0041.00
344_M347_Q1.9931.00
348_V351_Q1.9861.00
305_I308_Y1.9851.00
406_D410_N1.9781.00
26_Q31_N1.9631.00
403_K406_D1.9561.00
275_V278_K1.9521.00
220_V415_F1.9261.00
416_S453_V1.8661.00
339_E403_K1.8431.00
215_K414_S1.8421.00
342_L346_A1.8151.00
375_Q396_Q1.7781.00
263_T362_H1.7751.00
380_T395_T1.7521.00
221_V418_V1.7401.00
27_S30_I1.7111.00
270_T420_F1.7111.00
23_Y26_Q1.7091.00
254_A463_V1.7041.00
338_D342_L1.6941.00
366_S393_T1.6941.00
243_P398_D1.6911.00
367_H422_D1.6801.00
140_T143_S1.6761.00
376_G379_E1.6761.00
26_Q29_L1.6761.00
175_P178_R1.6691.00
263_T267_L1.6521.00
245_A401_L1.6291.00
420_F470_A1.6271.00
233_G240_D1.6181.00
23_Y31_N1.5991.00
126_A130_K1.5971.00
299_F348_V1.5881.00
20_T26_Q1.5761.00
346_A411_S1.5691.00
444_Q447_F1.5591.00
217_Q416_S1.5561.00
227_A394_M1.5241.00
250_G254_A1.5231.00
399_D403_K1.5221.00
149_S152_T1.5101.00
407_Q411_S1.5001.00
26_Q30_I1.5001.00
288_L478_S1.4971.00
395_T399_D1.4891.00
407_Q410_N1.4851.00
30_I34_L1.4791.00
224_G397_T1.4691.00
227_A397_T1.4591.00
233_G246_S1.4481.00
418_V453_V1.4441.00
223_I267_L1.4341.00
346_A350_A1.4331.00
308_Y311_A1.4291.00
219_Y416_S1.4241.00
41_L45_A1.4111.00
218_T413_S1.4101.00
342_L363_L1.4041.00
170_K174_Y1.4021.00
26_Q33_G1.3991.00
244_F405_Y1.3931.00
339_E396_Q1.3881.00
436_Y439_H1.3861.00
404_L417_L1.3801.00
256_Y451_F1.3761.00
174_Y178_R1.3721.00
399_D402_R1.3701.00
250_G454_I1.3671.00
28_L32_L1.3631.00
231_A391_L1.3611.00
30_I33_G1.3601.00
239_W391_L1.3531.00
279_P283_D1.3481.00
224_G419_Y1.3461.00
347_Q351_Q1.3361.00
444_Q448_Q1.3341.00
403_K407_Q1.3241.00
98_M104_I1.3181.00
156_A163_W1.3131.00
19_W26_Q1.3121.00
178_R181_K1.2981.00
18_P26_Q1.2941.00
248_V402_R1.2941.00
26_Q34_L1.2821.00
196_R199_K1.2771.00
227_A232_L1.2771.00
158_V162_A1.2751.00
273_R475_G1.2731.00
378_Y399_D1.2671.00
219_Y358_L1.2581.00
28_L31_N1.2561.00
125_I129_R1.2551.00
137_R140_T1.2541.00
242_T245_A1.2531.00
197_M200_L1.2521.00
173_G176_V1.2391.00
25_L29_L1.2391.00
27_S34_L1.2381.00
310_T313_A1.2341.00
342_L404_L1.2251.00
244_F398_D1.2171.00
451_F473_F1.2151.00
244_F248_V1.2141.00
366_S394_M1.2131.00
421_S449_V1.2121.00
171_D174_Y1.2121.00
223_I420_F1.2001.00
39_S43_T1.1991.00
294_F356_P1.1981.00
19_W27_S1.1981.00
221_V270_T1.1971.00
285_F477_F1.1931.00
123_G127_I1.1911.00
297_W357_Q1.1891.00
99_E103_E1.1851.00
268_G274_V1.1841.00
400_L403_K1.1801.00
350_A407_Q1.1781.00
341_L361_L1.1771.00
303_G309_D1.1721.00
174_Y177_F1.1691.00
229_R448_Q1.1631.00
247_S402_R1.1591.00
265_K269_L1.1581.00
159_Q163_W1.1571.00
307_E310_T1.1511.00
309_D313_A1.1501.00
306_G311_A1.1501.00
39_S45_A1.1481.00
248_V405_Y1.1471.00
442_K446_N1.1431.00
100_E103_E1.1381.00
44_A48_A1.1351.00
227_A231_A1.1341.00
300_S308_Y1.1291.00
154_F157_P1.1291.00
343_D403_K1.1281.00
299_F359_I1.1281.00
178_R183_V1.1271.00
45_A49_I1.1271.00
227_A245_A1.1221.00
231_A394_M1.1191.00
181_K185_V1.1121.00
227_A242_T1.1121.00
416_S455_S1.1111.00
20_T27_S1.1091.00
101_S104_I1.1081.00
224_G401_L1.1061.00
155_V159_Q1.1051.00
221_V360_V1.1041.00
19_W23_Y1.1031.00
263_T367_H1.1021.00
263_T268_G1.0971.00
114_L118_F1.0971.00
121_A125_I1.0951.00
349_L408_L1.0931.00
375_Q378_Y1.0921.00
103_E107_I1.0871.00
311_A315_I1.0841.00
19_W24_F1.0821.00
251_L464_I1.0821.00
157_P160_N1.0811.00
298_W362_H1.0811.00
400_L404_L1.0761.00
297_W359_I1.0741.00
157_P164_G1.0731.00
228_R424_G1.0731.00
29_L33_G1.0701.00
405_Y409_R1.0681.00
443_Y446_N1.0671.00
255_D448_Q1.0661.00
305_I312_I1.0651.00
194_Q198_A1.0631.00
170_K173_G1.0571.00
157_P161_L1.0561.00
196_R200_L1.0551.00
308_Y312_I1.0551.00
61_Q65_V1.0531.00
160_N163_W1.0521.00
248_V409_R1.0521.00
253_F451_F1.0471.00
425_L431_G1.0471.00
147_V151_A1.0471.00
243_P248_V1.0451.00
244_F399_D1.0421.00
24_F31_N1.0411.00
112_S115_V1.0391.00
304_Q309_D1.0361.00
36_Y39_S1.0321.00
344_M348_V1.0321.00
223_I360_V1.0311.00
183_V186_N1.0311.00
161_L165_G1.0261.00
366_S397_T1.0261.00
292_A483_I1.0251.00
181_K184_I1.0191.00
309_D312_I1.0111.00
217_Q356_P1.0081.00
219_Y294_F1.0051.00
265_K268_G1.0031.00
201_S204_K1.0001.00
374_T379_E0.9981.00
157_P162_A0.9981.00
100_E104_I0.9981.00
178_R182_D0.9951.00
193_E196_R0.9931.00
39_S42_Y0.9931.00
20_T24_F0.9921.00
220_V357_Q0.9921.00
192_E200_L0.9881.00
23_Y28_L0.9871.00
223_I270_T0.9811.00
420_F473_F0.9801.00
21_A26_Q0.9751.00
161_L164_G0.9751.00
319_A322_V0.9731.00
177_F181_K0.9691.00
251_L495_I0.9651.00
255_D467_R0.9651.00
26_Q35_G0.9611.00
478_S483_I0.9581.00
347_Q350_A0.9581.00
159_Q162_A0.9561.00
27_S33_G0.9561.00
219_Y418_V0.9551.00
229_R235_F0.9521.00
216_Y292_A0.9511.00
24_F28_L0.9471.00
297_W348_V0.9451.00
416_S477_F0.9451.00
263_T422_D0.9441.00
207_W210_T0.9421.00
361_L404_L0.9421.00
225_E422_D0.9411.00
32_L35_G0.9401.00
21_A25_L0.9361.00
191_I197_M0.9331.00
160_N165_G0.9311.00
475_G491_K0.9311.00
142_D153_F0.9281.00
18_P28_L0.9281.00
270_T473_F0.9241.00
198_A201_S0.9221.00
16_F23_Y0.9210.99
186_N190_V0.9190.99
418_V477_F0.9170.99
371_C389_C0.9130.99
335_N364_M0.9050.99
122_L126_A0.9050.99
23_Y30_I0.9030.99
160_N164_G0.8960.99
228_R231_A0.8960.99
374_T392_Y0.8950.99
156_A165_G0.8950.99
110_W114_L0.8930.99
298_W312_I0.8900.99
136_A139_N0.8870.99
179_F182_D0.8860.99
317_K360_V0.8850.99
441_D444_Q0.8840.99
340_A343_D0.8830.99
259_A469_S0.8830.99
136_A142_D0.8810.99
289_A478_S0.8790.99
342_L397_T0.8740.99
158_V161_L0.8710.99
39_S52_L0.8710.99
250_G452_M0.8710.99
343_D407_Q0.8700.99
176_V185_V0.8680.99
426_A429_E0.8660.99
183_V187_N0.8630.99
30_I35_G0.8620.99
286_V317_K0.8610.99
161_L166_V0.8600.99
306_G309_D0.8570.99
405_Y419_Y0.8570.99
248_V452_M0.8560.99
303_G320_D0.8530.99
192_E196_R0.8520.99
306_G312_I0.8520.99
268_G272_N0.8520.99
180_A184_I0.8500.99
289_A358_L0.8480.99
365_G396_Q0.8460.99
150_V153_F0.8450.99
401_L419_Y0.8440.99
228_R234_A0.8410.99
195_E198_A0.8390.99
266_S269_L0.8390.99
168_K172_T0.8340.99
225_E367_H0.8330.99
99_E102_T0.8310.99
55_R58_P0.8290.99
345_T359_I0.8290.99
265_K273_R0.8270.99
419_Y452_M0.8250.99
237_G391_L0.8220.99
176_V180_A0.8200.99
20_T30_I0.8200.99
196_R201_S0.8200.99
219_Y477_F0.8150.99
374_T378_Y0.8140.99
198_A202_G0.8140.99
103_E106_T0.8120.99
221_V473_F0.8110.99
89_T92_A0.8090.99
311_A314_S0.8080.99
96_T100_E0.8060.99
152_T155_V0.8060.99
158_V163_W0.8050.99
370_A425_L0.8050.99
345_T349_L0.7990.99
163_W166_V0.7970.99
178_R184_I0.7940.99
162_A165_G0.7920.98
363_L397_T0.7920.98
479_Q496_S0.7890.98
185_V188_N0.7890.98
382_V385_K0.7890.98
100_E107_I0.7830.98
153_F157_P0.7830.98
319_A324_F0.7790.98
221_V420_F0.7780.98
28_L35_G0.7780.98
425_L428_K0.7780.98
23_Y34_L0.7770.98
80_Q112_S0.7750.98
156_A161_L0.7740.98
263_T273_R0.7730.98
182_D185_V0.7730.98
27_S32_L0.7730.98
259_A269_L0.7720.98
390_Y394_M0.7720.98
195_E199_K0.7710.98
25_L31_N0.7710.98
17_S21_A0.7710.98
156_A164_G0.7690.98
420_F449_V0.7690.98
117_L121_A0.7690.98
381_F392_Y0.7670.98
224_G342_L0.7670.98
138_W141_F0.7660.98
413_S456_S0.7640.98
381_F395_T0.7630.98
216_Y356_P0.7630.98
43_T46_F0.7620.98
388_S392_Y0.7610.98
294_F481_T0.7600.98
493_P496_S0.7600.98
175_P179_F0.7590.98
138_W142_D0.7590.98
172_T175_P0.7580.98
192_E197_M0.7570.98
18_P23_Y0.7570.98
66_G70_L0.7570.98
40_L44_A0.7570.98
227_A419_Y0.7570.98
174_Y179_F0.7550.98
124_V127_I0.7540.98
157_P165_G0.7520.98
271_L358_L0.7510.98
307_E314_S0.7500.98
48_A52_L0.7500.98
154_F158_V0.7500.98
304_Q308_Y0.7490.98
220_V404_L0.7490.98
339_E399_D0.7470.98
193_E200_L0.7470.98
349_L359_I0.7460.98
257_I448_Q0.7450.98
248_V401_L0.7450.98
264_Q268_G0.7450.98
22_F26_Q0.7450.98
191_I196_R0.7450.98
408_L412_G0.7440.98
158_V166_V0.7440.98
312_I317_K0.7440.98
280_Q283_D0.7420.98
146_L150_V0.7410.98
222_V342_L0.7410.98
241_N391_L0.7380.98
21_A27_S0.7360.98
59_R63_V0.7360.98
223_I362_H0.7350.98
179_F185_V0.7340.98
42_Y45_A0.7330.97
245_A452_M0.7330.97
28_L33_G0.7300.97
17_S24_F0.7280.97
263_T269_L0.7260.97
218_T416_S0.7240.97
26_Q32_L0.7240.97
345_T404_L0.7230.97
230_D445_Q0.7230.97
23_Y33_G0.7220.97
98_M101_S0.7210.97
17_S20_T0.7210.97
310_T314_S0.7210.97
197_M201_S0.7200.97
46_F50_L0.7180.97
308_Y313_A0.7160.97
401_L417_L0.7140.97
156_A160_N0.7140.97
343_D346_A0.7130.97
143_S146_L0.7090.97
227_A366_S0.7090.97
199_K202_G0.7090.97
337_K340_A0.7080.97
111_Y115_V0.7080.97
174_Y183_V0.7080.97
16_F26_Q0.7060.97
264_Q267_L0.7060.97
449_V470_A0.7050.97
177_F180_A0.7030.97
139_N142_D0.6980.97
363_L400_L0.6970.97
16_F27_S0.6970.97
392_Y395_T0.6950.97
285_F474_L0.6950.97
268_G273_R0.6940.97
365_G393_T0.6940.97
286_V296_T0.6910.96
451_F468_R0.6910.96
338_D341_L0.6910.96
367_H423_H0.6890.96
308_Y315_I0.6870.96
413_S457_D0.6860.96
297_W300_S0.6850.96
40_L48_A0.6830.96
186_N189_E0.6830.96
443_Y447_F0.6820.96
440_D443_Y0.6800.96
160_N166_V0.6800.96
221_V285_F0.6790.96
298_W302_Q0.6780.96
20_T23_Y0.6770.96
24_F35_G0.6760.96
178_R186_N0.6740.96
175_P185_V0.6720.96
293_G356_P0.6670.96
339_E343_D0.6660.96
126_A129_R0.6640.96
233_G241_N0.6630.95
396_Q399_D0.6620.95
342_L400_L0.6610.95
28_L34_L0.6600.95
311_A316_A0.6600.95
172_T176_V0.6600.95
427_F430_R0.6590.95
98_M102_T0.6590.95
305_I310_T0.6590.95
243_P246_S0.6510.95
319_A323_Y0.6510.95
120_F124_V0.6480.95
39_S44_A0.6460.95
18_P27_S0.6460.95
287_T291_R0.6450.95
175_P182_D0.6450.95
168_K174_Y0.6410.95
19_W31_N0.6400.95
141_F145_C0.6390.95
301_N336_T0.6390.95
244_F406_D0.6380.94
27_S35_G0.6370.94
179_F183_V0.6370.94
181_K186_N0.6350.94
358_L477_F0.6330.94
222_V417_L0.6310.94
113_Y117_L0.6310.94
142_D148_F0.6310.94
101_S105_L0.6290.94
251_L462_R0.6290.94
96_T104_I0.6260.94
112_S116_G0.6260.94
91_L95_S0.6240.94
346_A403_K0.6230.94
153_F156_A0.6220.94
463_V466_A0.6220.94
411_S415_F0.6220.94
46_F53_L0.6220.94
326_K331_E0.6220.94
75_Y85_P0.6210.94
273_R474_L0.6210.94
23_Y32_L0.6210.94
170_K175_P0.6200.94
254_A258_A0.6200.94
347_Q407_Q0.6170.93
113_Y128_R0.6160.93
304_Q307_E0.6160.93
305_I309_D0.6150.93
218_T411_S0.6150.93
301_N364_M0.6130.93
155_V161_L0.6130.93
155_V158_V0.6120.93
18_P31_N0.6110.93
192_E204_K0.6110.93
61_Q64_L0.6110.93
179_F186_N0.6100.93
158_V165_G0.6100.93
179_F184_I0.6080.93
261_G427_F0.6080.93
200_L204_K0.6070.93
240_D395_T0.6050.93
220_V349_L0.6040.93
168_K175_P0.6040.93
200_L203_M0.6040.93
254_A464_I0.6040.93
116_G120_F0.6040.93
149_S153_F0.6030.93
288_L291_R0.6030.93
170_K178_R0.6010.93
286_V358_L0.6000.92
272_N311_A0.6000.92
182_D186_N0.5970.92
374_T381_F0.5970.92
445_Q448_Q0.5970.92
19_W29_L0.5960.92
426_A446_N0.5960.92
242_T398_D0.5950.92
210_T495_I0.5950.92
250_G257_I0.5940.92
450_P453_V0.5940.92
43_T47_T0.5930.92
298_W301_N0.5910.92
62_K65_V0.5910.92
397_T400_L0.5910.92
159_Q166_V0.5900.92
45_A51_L0.5890.92
148_F152_T0.5880.92
20_T25_L0.5870.92
99_E104_I0.5860.92
217_Q294_F0.5850.92
25_L33_G0.5840.91
194_Q201_S0.5840.91
128_R131_K0.5840.91
271_L360_V0.5830.91
147_V157_P0.5820.91
169_L172_T0.5810.91
167_F170_K0.5800.91
253_F257_I0.5790.91
50_L53_L0.5790.91
39_S48_A0.5780.91
19_W22_F0.5780.91
385_K389_C0.5770.91
232_L235_F0.5760.91
143_S147_V0.5750.91
313_A316_A0.5740.91
266_S470_A0.5730.91
441_D445_Q0.5730.91
151_A155_V0.5730.91
88_N91_L0.5720.91
264_Q269_L0.5710.91
184_I187_N0.5710.91
199_K203_M0.5710.91
328_G331_E0.5700.90
263_T423_H0.5700.90
426_A431_G0.5700.90
92_A95_S0.5690.90
290_N296_T0.5690.90
307_E316_A0.5680.90
225_E366_S0.5680.90
41_L49_I0.5670.90
249_N254_A0.5670.90
225_E363_L0.5630.90
228_R390_Y0.5630.90
16_F31_N0.5630.90
307_E312_I0.5620.90
261_G266_S0.5610.90
474_L478_S0.5610.90
430_R445_Q0.5590.90
309_D314_S0.5590.90
155_V160_N0.5590.90
106_T109_P0.5580.90
25_L28_L0.5570.89
307_E311_A0.5570.89
306_G316_A0.5570.89
62_K66_G0.5560.89
86_N89_T0.5560.89
70_L74_C0.5560.89
179_F187_N0.5560.89
195_E201_S0.5550.89
38_F48_A0.5540.89
20_T31_N0.5530.89
48_A51_L0.5520.89
136_A140_T0.5520.89
269_L274_V0.5520.89
208_T211_A0.5510.89
441_D446_N0.5510.89
211_A214_P0.5500.89
19_W34_L0.5500.89
374_T393_T0.5500.89
104_I107_I0.5490.89
171_D175_P0.5490.89
133_N140_T0.5490.89
127_I131_K0.5480.89
217_Q455_S0.5480.89
38_F51_L0.5470.89
279_P282_Q0.5470.89
264_Q306_G0.5470.89
111_Y114_L0.5450.88
18_P25_L0.5450.88
169_L173_G0.5440.88
236_G391_L0.5440.88
21_A31_N0.5430.88
173_G179_F0.5430.88
152_T156_A0.5430.88
300_S362_H0.5420.88
123_G126_A0.5420.88
23_Y29_L0.5410.88
37_P41_L0.5390.88
224_G366_S0.5360.88
159_Q164_G0.5360.88
174_Y182_D0.5360.88
269_L363_L0.5360.88
38_F42_Y0.5350.87
378_Y381_F0.5340.87
39_S47_T0.5340.87
341_L400_L0.5330.87
272_N275_V0.5320.87
39_S50_L0.5320.87
22_F27_S0.5300.87
36_Y53_L0.5300.87
173_G177_F0.5300.87
178_R185_V0.5280.87
155_V165_G0.5280.87
458_D462_R0.5250.87
47_T51_L0.5250.87
127_I130_K0.5240.86
340_A344_M0.5230.86
226_S421_S0.5220.86
17_S31_N0.5220.86
425_L429_E0.5220.86
314_S317_K0.5210.86
302_Q362_H0.5200.86
252_I463_V0.5200.86
134_E137_R0.5200.86
176_V179_F0.5200.86
305_I311_A0.5190.86
157_P166_V0.5180.86
184_I188_N0.5180.86
312_I316_A0.5160.86
162_A166_V0.5160.86
171_D176_V0.5150.85
222_V404_L0.5140.85
233_G236_G0.5120.85
258_A424_G0.5120.85
326_K329_N0.5100.85
36_Y41_L0.5090.85
191_I203_M0.5080.85
267_L271_L0.5080.85
135_K139_N0.5080.85
327_E331_E0.5070.85
390_Y424_G0.5070.85
205_D208_T0.5060.84
21_A62_K0.5060.84
232_L363_L0.5030.84
179_F188_N0.5000.84
220_V345_T0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uorA 3 0.6262 100 0.529 Contact Map
2w5qA 1 0.6281 100 0.533 Contact Map
2w8dA 1 0.63 100 0.534 Contact Map
3lxqA 1 0.6129 100 0.538 Contact Map
4kavA 1 0.5636 100 0.541 Contact Map
4upkA 3 0.5806 100 0.547 Contact Map
4tn0A 1 0.5332 100 0.547 Contact Map
2vqrA 3 0.5787 100 0.548 Contact Map
4uphA 2 0.5769 100 0.551 Contact Map
4upiA 2 0.5787 100 0.552 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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