GREMLIN Database
RLMF - Ribosomal RNA large subunit methyltransferase F
UniProt: P75782 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13319
Length: 308 (286)
Sequences: 816 (577)
Seq/√Len: 34.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_I181_A8.2641.00
263_L290_I5.4101.00
122_G130_F5.2281.00
233_I254_V4.8391.00
264_Y277_K4.3591.00
140_L159_L4.2211.00
131_T179_Y3.9121.00
278_K289_F3.3821.00
13_R125_E3.2571.00
169_F236_M3.0981.00
112_V132_G3.0641.00
53_K70_D3.0431.00
45_D48_N2.7371.00
123_V156_A2.6711.00
280_M289_F2.6701.00
99_G102_P2.6391.00
84_A121_I2.5161.00
192_A220_Q2.5101.00
117_I121_I2.4871.00
75_F136_S2.3850.99
19_D22_T2.3760.99
134_E140_L2.3680.99
112_V116_C2.3550.99
90_L181_A2.3450.99
90_L183_L2.3350.99
27_N54_A2.3000.99
26_V62_H2.2680.99
190_D194_A2.2350.99
33_F51_A2.2010.99
233_I252_S2.0810.99
230_V259_N2.0270.98
116_C143_A2.0160.98
274_K293_T1.9660.98
11_R92_D1.9270.98
107_I130_F1.9160.97
87_I122_G1.8760.97
189_H214_L1.8550.97
17_R41_E1.8330.97
133_S172_I1.8320.97
237_I260_L1.8100.96
119_P130_F1.7410.95
90_L107_I1.7400.95
248_M295_M1.7140.95
22_T62_H1.7080.95
29_E57_K1.6950.95
107_I183_L1.6300.94
181_A251_T1.5880.93
87_I126_Y1.5810.92
116_C147_I1.5800.92
144_Q147_I1.5730.92
182_T236_M1.5690.92
116_C157_I1.5560.92
93_L291_A1.5440.92
137_S161_R1.5440.92
237_I290_I1.5390.91
166_G235_K1.5100.91
199_S203_R1.5030.90
147_I159_L1.4980.90
260_L290_I1.4920.90
198_G214_L1.4770.90
139_A220_Q1.4740.89
173_I243_F1.4670.89
272_A275_V1.4550.89
216_F223_L1.4530.89
248_M293_T1.4300.88
231_T235_K1.4240.88
272_A294_F1.4240.88
234_K266_A1.4220.88
14_H63_F1.4160.88
112_V133_S1.4130.87
61_A66_V1.4120.87
160_R177_E1.4010.87
173_I179_Y1.3850.86
121_I125_E1.3650.85
30_L58_A1.3520.85
90_L289_F1.3480.85
91_A126_Y1.3340.84
117_I239_E1.3140.83
34_L37_T1.3070.83
122_G128_W1.2820.82
90_L290_I1.2700.81
64_Y84_A1.2640.81
285_K288_R1.2620.81
266_A270_V1.2550.80
238_E266_A1.2500.80
54_A57_K1.2480.80
142_S146_I1.2320.79
34_L42_Q1.2290.79
24_C34_L1.2200.78
254_V263_L1.2180.78
189_H198_G1.2040.77
106_S131_T1.1990.77
107_I122_G1.1960.77
102_P105_A1.1830.76
106_S129_R1.1790.76
115_N132_G1.1770.76
36_L42_Q1.1760.76
20_L24_C1.1670.75
218_G223_L1.1620.75
84_A88_H1.1530.74
89_H289_F1.1480.74
9_H12_N1.1470.74
144_Q148_S1.1360.73
184_C252_S1.1360.73
131_T160_R1.1280.73
79_P218_G1.1090.71
95_A99_G1.0970.70
120_L154_N1.0920.70
193_A197_A1.0710.69
19_D127_G1.0640.68
29_E54_A1.0590.68
255_S285_K1.0590.68
37_T43_S1.0510.67
65_A124_H1.0480.67
93_L249_W1.0400.66
85_D282_Q1.0360.66
75_F219_Q1.0340.66
93_L251_T1.0340.66
134_E172_I1.0300.65
132_G177_E1.0230.65
143_A146_I1.0180.65
75_F138_Q1.0030.63
173_I182_T1.0020.63
88_H126_Y1.0000.63
192_A221_Q0.9970.63
139_A221_Q0.9940.63
230_V234_K0.9940.63
21_A31_R0.9910.62
237_I270_V0.9910.62
87_I119_P0.9880.62
169_F182_T0.9820.62
264_Y275_V0.9810.62
8_L89_H0.9730.61
27_N62_H0.9710.61
192_A196_R0.9660.60
87_I121_I0.9620.60
85_D280_M0.9610.60
260_L264_Y0.9540.59
255_S288_R0.9480.59
167_A170_N0.9350.58
260_L279_E0.9300.57
136_S220_Q0.9230.57
80_V117_I0.9200.57
182_T247_V0.9190.57
95_A100_T0.9140.56
115_N142_S0.9130.56
46_F52_V0.9130.56
50_L73_D0.9130.56
189_H256_R0.9100.56
71_I115_N0.9100.56
145_A149_S0.9050.55
280_M291_A0.9040.55
233_I263_L0.9030.55
87_I183_L0.8970.55
235_K238_E0.8950.55
173_I247_V0.8890.54
57_K70_D0.8850.54
132_G159_L0.8810.53
79_P216_F0.8780.53
178_Q248_M0.8780.53
145_A148_S0.8780.53
85_D89_H0.8650.52
169_F250_F0.8630.52
281_A289_F0.8610.52
20_L34_L0.8600.52
262_P290_I0.8570.51
68_N120_L0.8540.51
254_V260_L0.8530.51
130_F183_L0.8520.51
85_D202_K0.8450.50
237_I263_L0.8420.50
123_V157_I0.8330.49
167_A239_E0.8300.49
110_I291_A0.8270.49
120_L152_G0.8240.49
70_D284_Q0.8200.48
275_V298_E0.8180.48
105_A180_D0.8150.48
226_E231_T0.8140.48
82_G253_L0.8120.48
85_D278_K0.8120.48
280_M288_R0.8060.47
198_G205_N0.8060.47
243_F250_F0.8050.47
183_L251_T0.8040.47
280_M285_K0.8030.47
130_F181_A0.8030.47
136_S221_Q0.8020.47
261_P266_A0.8010.47
97_A248_M0.8000.47
180_D248_M0.7970.46
204_R212_D0.7950.46
47_A177_E0.7890.46
92_D251_T0.7860.45
75_F221_Q0.7840.45
115_N146_I0.7810.45
236_M247_V0.7800.45
262_P266_A0.7740.44
42_Q139_A0.7680.44
107_I134_E0.7680.44
69_W88_H0.7670.44
13_R88_H0.7640.44
226_E284_Q0.7620.43
214_L256_R0.7510.42
251_T291_A0.7490.42
277_K290_I0.7480.42
260_L263_L0.7470.42
68_N149_S0.7470.42
56_N215_N0.7440.42
165_S239_E0.7440.42
168_I179_Y0.7420.42
105_A138_Q0.7350.41
17_R84_A0.7350.41
116_C130_F0.7340.41
14_H18_Y0.7330.41
112_V121_I0.7320.41
88_H92_D0.7320.41
142_S290_I0.7310.41
35_T38_P0.7290.41
14_H71_I0.7290.41
104_N251_T0.7240.40
259_N273_V0.7230.40
71_I282_Q0.7220.40
84_A91_A0.7210.40
27_N57_K0.7210.40
11_R91_A0.7200.40
120_L145_A0.7200.40
191_S202_K0.7180.40
80_V107_I0.7160.40
50_L104_N0.7150.39
136_S194_A0.7150.39
80_V213_A0.7120.39
170_N243_F0.7100.39
49_P159_L0.7100.39
11_R150_N0.7080.39
56_N216_F0.7050.39
63_F121_I0.7040.39
140_L161_R0.7030.39
72_P114_A0.7020.38
120_L157_I0.6970.38
56_N162_Q0.6960.38
241_K244_A0.6950.38
162_Q239_E0.6930.38
147_I157_I0.6930.38
35_T41_E0.6920.38
85_D88_H0.6870.37
239_E277_K0.6830.37
147_I266_A0.6790.37
24_C31_R0.6760.36
24_C293_T0.6750.36
97_A274_K0.6740.36
21_A34_L0.6730.36
105_A248_M0.6730.36
77_C82_G0.6730.36
280_M287_S0.6660.36
85_D253_L0.6660.36
21_A42_Q0.6630.35
278_K288_R0.6610.35
184_C236_M0.6600.35
164_E245_K0.6580.35
274_K298_E0.6560.35
170_N242_G0.6540.35
56_N288_R0.6530.35
143_A147_I0.6530.35
281_A284_Q0.6510.34
77_C216_F0.6490.34
120_L140_L0.6490.34
103_A154_N0.6470.34
50_L159_L0.6460.34
85_D288_R0.6450.34
77_C202_K0.6450.34
134_E157_I0.6450.34
205_N255_S0.6440.34
66_V124_H0.6420.34
91_A95_A0.6410.34
202_K218_G0.6380.33
134_E169_F0.6380.33
148_S164_E0.6370.33
56_N80_V0.6350.33
18_Y56_N0.6340.33
117_I272_A0.6340.33
18_Y58_A0.6340.33
87_I251_T0.6320.33
278_K285_K0.6290.33
233_I237_I0.6290.33
183_L261_P0.6280.33
198_G256_R0.6270.33
116_C122_G0.6270.33
31_R137_S0.6240.32
145_A158_R0.6180.32
132_G139_A0.6170.32
114_A139_A0.6160.32
168_I235_K0.6140.32
43_S199_S0.6140.32
116_C119_P0.6140.32
25_Q65_A0.6130.32
173_I246_Q0.6120.32
90_L265_R0.6090.31
179_Y233_I0.6090.31
90_L261_P0.6080.31
273_V293_T0.6070.31
80_V194_A0.6060.31
38_P281_A0.6060.31
260_L277_K0.6050.31
116_C290_I0.6040.31
152_G155_R0.6040.31
82_G255_S0.6040.31
14_H84_A0.6030.31
44_V77_C0.6020.31
22_T141_S0.5990.31
216_F285_K0.5980.30
79_P82_G0.5950.30
87_I282_Q0.5940.30
219_Q246_Q0.5940.30
197_A200_E0.5930.30
225_C231_T0.5920.30
14_H64_Y0.5900.30
181_A276_V0.5880.30
262_P271_G0.5870.30
163_K176_N0.5850.30
65_A89_H0.5850.30
7_G121_I0.5840.30
85_D92_D0.5830.29
253_L289_F0.5820.29
90_L272_A0.5810.29
31_R261_P0.5800.29
244_A250_F0.5790.29
119_P122_G0.5780.29
160_R174_H0.5780.29
133_S170_N0.5770.29
148_S154_N0.5760.29
131_T158_R0.5720.29
21_A24_C0.5690.28
127_G239_E0.5690.28
221_Q272_A0.5690.28
84_A125_E0.5690.28
169_F243_F0.5690.28
281_A287_S0.5680.28
121_I251_T0.5660.28
65_A98_S0.5660.28
24_C30_L0.5640.28
88_H282_Q0.5620.28
197_A231_T0.5610.28
178_Q235_K0.5590.28
66_V221_Q0.5580.28
132_G251_T0.5580.28
110_I236_M0.5570.28
19_D96_E0.5570.28
33_F50_L0.5560.28
71_I260_L0.5550.28
74_G144_Q0.5550.28
118_Y253_L0.5520.27
133_S157_I0.5520.27
25_Q296_N0.5510.27
144_Q235_K0.5500.27
34_L39_A0.5450.27
89_H278_K0.5440.27
235_K261_P0.5440.27
13_R106_S0.5440.27
233_I244_A0.5430.27
236_M251_T0.5430.27
135_T193_A0.5430.27
68_N146_I0.5420.27
167_A175_K0.5420.27
30_L139_A0.5420.27
85_D285_K0.5420.27
95_A102_P0.5410.27
215_N224_W0.5410.27
108_L179_Y0.5410.27
94_L105_A0.5400.27
210_K287_S0.5400.27
182_T244_A0.5400.27
263_L284_Q0.5380.26
255_S287_S0.5380.26
109_D185_N0.5370.26
168_I231_T0.5370.26
108_L131_T0.5370.26
217_G255_S0.5360.26
120_L124_H0.5350.26
115_N139_A0.5330.26
32_Q48_N0.5330.26
15_H251_T0.5330.26
29_E32_Q0.5310.26
106_S158_R0.5310.26
85_D289_F0.5290.26
12_N88_H0.5290.26
41_E55_L0.5260.26
104_N274_K0.5260.26
124_H193_A0.5240.25
20_L217_G0.5240.25
89_H254_V0.5240.25
44_V66_V0.5230.25
7_G281_A0.5230.25
7_G89_H0.5220.25
56_N79_P0.5210.25
51_A254_V0.5210.25
35_T290_I0.5210.25
14_H20_L0.5200.25
60_L117_I0.5200.25
14_H219_Q0.5200.25
215_N285_K0.5200.25
71_I217_G0.5190.25
40_G150_N0.5190.25
134_E244_A0.5190.25
53_K71_I0.5190.25
216_F224_W0.5180.25
134_E158_R0.5170.25
255_S259_N0.5170.25
106_S175_K0.5150.25
49_P212_D0.5150.25
34_L44_V0.5130.25
33_F54_A0.5120.25
254_V259_N0.5110.25
143_A263_L0.5100.25
55_L211_D0.5100.25
157_I200_E0.5100.25
258_E281_A0.5060.24
88_H91_A0.5060.24
140_L144_Q0.5060.24
122_G131_T0.5060.24
152_G174_H0.5050.24
77_C223_L0.5030.24
29_E70_D0.5030.24
18_Y255_S0.5020.24
71_I280_M0.5020.24
141_S144_Q0.5010.24
49_P70_D0.5010.24
212_D290_I0.5000.24
106_S179_Y0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h00A 1 0.7403 100 0.743 Contact Map
3evzA 1 0.6364 99.9 0.815 Contact Map
2b3tA 1 0.8084 99.4 0.88 Contact Map
1nv8A 1 0.7695 99.4 0.881 Contact Map
3m70A 1 0.8247 99.4 0.883 Contact Map
2pjdA 1 0.776 99.2 0.894 Contact Map
4dzrA 2 0.4903 99.2 0.894 Contact Map
4c4aA 1 0.8929 99.1 0.896 Contact Map
3lpmA 2 0.6266 99.1 0.898 Contact Map
2ozvA 2 0.5649 99 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.