GREMLIN Database
YBIX - PKHD-type hydroxylase YbiX
UniProt: P75779 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13316
Length: 225 (223)
Sequences: 725 (497)
Seq/√Len: 33.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_D165_R6.5001.00
114_L151_L4.2371.00
118_L149_L4.1461.00
7_G148_D3.7381.00
74_A151_L3.5081.00
88_Q167_V3.3661.00
116_A175_I3.3401.00
74_A114_L3.2891.00
184_K221_E3.1731.00
69_L189_F3.0691.00
11_P122_D2.8331.00
4_H148_D2.6221.00
10_S13_D2.6001.00
112_T155_S2.5991.00
37_G93_Y2.5111.00
145_P148_D2.5091.00
116_A149_L2.5061.00
180_R224_E2.3810.99
44_Q91_E2.3330.99
201_R207_E2.3230.99
44_Q86_R2.2940.99
27_V31_V2.1800.99
56_L84_F2.1430.99
121_S170_A2.1400.99
2_M133_V2.1120.99
13_D66_Q2.1060.99
95_F159_C2.0020.98
116_A173_M1.9480.98
37_G99_G1.9350.97
30_R33_T1.9260.97
33_T37_G1.9220.97
97_V213_N1.9150.97
194_N210_S1.7790.96
201_R205_S1.6420.93
77_R176_Q1.6340.93
22_E169_V1.6110.93
130_E143_K1.5960.92
9_L63_A1.5780.92
95_F134_N1.5720.92
21_L56_L1.5310.91
80_S83_L1.5270.91
17_F56_L1.5200.90
40_V94_G1.5170.90
114_L175_I1.4940.90
44_Q88_Q1.4790.89
20_Q55_A1.4610.88
193_N196_Q1.4550.88
93_Y102_R1.4450.88
37_G83_L1.4380.88
2_M150_V1.4210.87
83_L102_R1.4200.87
70_F175_I1.3950.86
137_F156_S1.3810.85
19_E23_Q1.3800.85
187_M214_L1.3630.85
122_D125_S1.3360.83
17_F59_E1.3290.83
199_K204_E1.3290.83
179_I188_L1.3230.83
52_L56_L1.3210.83
42_N92_T1.3180.83
102_R112_T1.3080.82
135_D140_H1.3070.82
8_V118_L1.2920.81
183_K221_E1.2910.81
134_N139_Q1.2820.81
209_L213_N1.2710.80
16_R59_E1.2300.78
184_K224_E1.2290.78
141_R161_T1.2210.77
13_D63_A1.2180.77
203_G206_E1.1830.75
199_K208_I1.1760.75
19_E22_E1.1750.75
121_S169_V1.1740.75
100_A219_L1.1560.73
210_S214_L1.1540.73
27_V47_D1.1530.73
63_A66_Q1.1500.73
197_S207_E1.1480.73
33_T99_G1.1390.72
115_S154_S1.1150.71
214_L221_E1.1130.71
17_F120_L1.1100.70
142_V156_S1.1020.70
77_R178_M1.1000.70
191_L194_N1.0950.69
64_V70_F1.0920.69
217_N220_R1.0830.68
118_L173_M1.0750.68
133_V140_H1.0670.67
194_N214_L1.0650.67
59_E63_A1.0550.66
80_S93_Y1.0450.66
203_G208_I1.0420.65
4_H145_P1.0370.65
42_N91_E1.0220.64
133_V156_S1.0140.63
104_H107_N1.0140.63
83_L93_Y1.0040.62
137_F140_H1.0030.62
172_F216_H1.0000.62
123_P143_K0.9910.61
178_M223_S0.9900.61
10_S14_V0.9790.61
75_L215_Y0.9780.60
8_V149_L0.9740.60
69_L193_N0.9640.59
132_V159_C0.9500.58
86_R167_V0.9450.58
20_Q52_L0.9440.58
14_V18_R0.9420.58
61_L65_N0.9410.57
197_S201_R0.9310.57
85_N170_A0.9280.56
20_Q56_L0.9190.56
202_Y208_I0.9110.55
184_K222_W0.9090.55
211_L216_H0.9070.55
192_D215_Y0.9020.54
20_Q59_E0.8970.54
88_Q127_D0.8930.53
121_S125_S0.8900.53
137_F155_S0.8870.53
80_S112_T0.8770.52
85_N172_F0.8760.52
77_R106_Q0.8720.52
75_L179_I0.8650.51
7_G12_Q0.8610.51
68_A72_A0.8610.51
176_Q224_E0.8600.51
69_L150_V0.8570.50
9_L17_F0.8520.50
82_P173_M0.8510.50
47_D50_S0.8500.50
44_Q167_V0.8490.50
21_L84_F0.8480.50
75_L85_N0.8450.49
16_R20_Q0.8440.49
54_A58_N0.8430.49
22_E167_V0.8380.49
88_Q169_V0.8340.49
16_R55_A0.8270.48
33_T40_V0.8230.48
53_Y57_Q0.8220.48
197_S210_S0.8200.47
119_F123_P0.8160.47
93_Y99_G0.8120.47
42_N203_G0.8100.47
18_R84_F0.8010.46
31_V93_Y0.7960.45
144_L189_F0.7950.45
36_Q209_L0.7940.45
49_R54_A0.7930.45
30_R40_V0.7920.45
91_E114_L0.7890.45
14_V171_S0.7870.45
24_A46_V0.7860.45
26_W91_E0.7840.44
6_P148_D0.7840.44
199_K214_L0.7800.44
130_E161_T0.7800.44
62_N108_G0.7800.44
60_V63_A0.7780.44
48_T53_Y0.7700.43
57_Q60_V0.7680.43
181_D184_K0.7660.43
196_Q199_K0.7640.43
154_S176_Q0.7630.43
204_E209_L0.7620.43
102_R209_L0.7550.42
138_G156_S0.7550.42
17_F52_L0.7540.42
11_P14_V0.7530.42
37_G80_S0.7470.41
85_N216_H0.7370.41
61_L104_H0.7330.40
30_R38_A0.7310.40
77_R109_W0.7310.40
19_E52_L0.7290.40
123_P145_P0.7280.40
134_N190_E0.7280.40
95_F161_T0.7260.40
103_S109_W0.7230.39
35_A208_I0.7120.39
82_P116_A0.7100.38
67_H72_A0.7000.38
65_N79_L0.6970.37
75_L82_P0.6970.37
112_T135_D0.6930.37
207_E210_S0.6920.37
204_E208_I0.6910.37
104_H108_G0.6870.37
26_W99_G0.6860.36
39_Q203_G0.6830.36
85_N195_I0.6830.36
20_Q51_T0.6810.36
157_L176_Q0.6780.36
38_A200_S0.6780.36
91_E157_L0.6730.35
173_M213_N0.6710.35
71_F116_A0.6680.35
38_A127_D0.6680.35
134_N159_C0.6660.35
86_R170_A0.6630.35
88_Q91_E0.6620.35
138_G179_I0.6600.34
18_R22_E0.6580.34
50_S104_H0.6560.34
110_M179_I0.6510.34
22_E120_L0.6500.34
35_A141_R0.6490.34
8_V67_H0.6490.34
48_T102_R0.6480.34
35_A199_K0.6470.34
4_H150_V0.6440.33
97_V154_S0.6430.33
99_G102_R0.6430.33
151_L175_I0.6430.33
149_L173_M0.6390.33
122_D145_P0.6370.33
195_I216_H0.6360.33
101_V223_S0.6310.32
57_Q173_M0.6250.32
22_E86_R0.6240.32
33_T93_Y0.6210.32
132_V161_T0.6210.32
3_Y186_A0.6200.32
18_R125_S0.6190.31
178_M219_L0.6170.31
78_T89_N0.6160.31
190_E213_N0.6140.31
45_Q100_A0.6140.31
157_L209_L0.6130.31
83_L92_T0.6130.31
97_V202_Y0.6120.31
26_W171_S0.6120.31
132_V141_R0.6100.31
135_D138_G0.6090.31
150_V189_F0.6070.31
21_L27_V0.6010.30
202_Y205_S0.5990.30
92_T159_C0.5990.30
16_R19_E0.5980.30
85_N173_M0.5970.30
106_Q109_W0.5970.30
139_Q186_A0.5960.30
91_E167_V0.5960.30
86_R91_E0.5930.30
91_E102_R0.5920.30
6_P69_L0.5900.29
194_N202_Y0.5890.29
35_A203_G0.5860.29
193_N199_K0.5860.29
26_W87_Y0.5840.29
48_T106_Q0.5840.29
89_N163_V0.5820.29
39_Q204_E0.5810.29
102_R135_D0.5800.29
5_I59_E0.5770.29
110_M170_A0.5760.28
17_F20_Q0.5750.28
56_L120_L0.5740.28
5_I149_L0.5740.28
121_S167_V0.5720.28
80_S110_M0.5720.28
2_M142_V0.5710.28
183_K186_A0.5710.28
2_M156_S0.5690.28
39_Q71_F0.5680.28
23_Q132_V0.5670.28
52_L55_A0.5670.28
61_L178_M0.5660.28
91_E203_G0.5650.28
62_N95_F0.5640.28
112_T148_D0.5640.28
178_M199_K0.5630.28
180_R222_W0.5630.28
45_Q192_D0.5630.28
17_F66_Q0.5580.27
55_A134_N0.5570.27
197_S202_Y0.5570.27
65_N77_R0.5550.27
84_F146_A0.5530.27
53_Y139_Q0.5530.27
23_Q169_V0.5530.27
15_A125_S0.5520.27
6_P63_A0.5520.27
199_K205_S0.5490.27
119_F144_L0.5490.27
198_L201_R0.5480.27
8_V74_A0.5470.27
137_F142_V0.5460.26
95_F139_Q0.5460.26
116_A151_L0.5450.26
95_F157_L0.5440.26
69_L219_L0.5430.26
21_L204_E0.5400.26
61_L79_L0.5400.26
150_V200_S0.5390.26
179_I200_S0.5370.26
179_I224_E0.5370.26
89_N162_P0.5360.26
41_K98_D0.5360.26
75_L192_D0.5360.26
8_V25_E0.5360.26
114_L155_S0.5350.26
21_L178_M0.5340.26
81_T110_M0.5330.26
57_Q65_N0.5310.25
83_L114_L0.5280.25
16_R201_R0.5280.25
170_A175_I0.5270.25
60_V132_V0.5270.25
77_R90_N0.5260.25
142_V188_L0.5260.25
50_S112_T0.5230.25
87_Y170_A0.5190.25
72_A198_L0.5140.24
134_N189_F0.5130.24
7_G197_S0.5110.24
73_A151_L0.5050.24
5_I25_E0.5050.24
80_S171_S0.5050.24
71_F103_S0.5050.24
99_G133_V0.5040.24
181_D221_E0.5030.24
84_F192_D0.5030.24
119_F126_Y0.5030.24
39_Q42_N0.5020.24
32_T167_V0.5020.24
4_H140_H0.5010.24
46_V53_Y0.5000.24
90_N176_Q0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dkqA 4 0.9956 100 0.452 Contact Map
2rg4A 4 0.72 100 0.702 Contact Map
3itqA 2 0.6978 99.9 0.739 Contact Map
2jigA 1 0.7556 99.9 0.741 Contact Map
3kt7A 2 0.8844 99.9 0.748 Contact Map
3w20A 2 0.7689 99.9 0.752 Contact Map
4nhxA 1 0.9067 99.9 0.763 Contact Map
4j25A 2 0.7422 99.9 0.781 Contact Map
4bqyA 1 0.8044 99.8 0.79 Contact Map
4xaaA 1 0.7422 98.7 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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