GREMLIN Database
YBHG - UPF0194 membrane protein YbhG
UniProt: P75777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13315
Length: 332 (269)
Sequences: 23881 (18588)
Seq/√Len: 1133.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_S74_E3.1051.00
71_V206_T2.8671.00
67_K212_D2.8261.00
278_G307_V2.5351.00
152_R156_D2.4041.00
128_Q132_N2.3431.00
74_E206_T2.3211.00
134_Q143_I2.2661.00
260_K274_H2.2601.00
59_A74_E2.2561.00
134_Q151_A2.2111.00
88_K199_E2.1921.00
67_K70_Q2.1221.00
77_H81_E2.1151.00
41_D244_R2.0961.00
275_G306_I2.0581.00
50_R204_D2.0561.00
155_R159_Q2.0321.00
95_Q192_Q2.0321.00
135_Q152_R2.0021.00
135_Q139_K1.9851.00
59_A71_V1.9121.00
65_A214_T1.9101.00
68_A212_D1.9041.00
71_V208_I1.8771.00
128_Q159_Q1.8651.00
262_L274_H1.8571.00
242_W305_R1.8521.00
138_W145_A1.8281.00
128_Q155_R1.8191.00
84_L199_E1.8151.00
216_L236_S1.8141.00
147_D150_N1.7881.00
244_R303_R1.7721.00
126_Y130_F1.7581.00
145_A149_E1.7501.00
138_W148_L1.7471.00
131_Y148_L1.7431.00
84_L195_L1.7401.00
91_V195_L1.7381.00
189_E192_Q1.7241.00
262_L272_P1.6911.00
131_Y135_Q1.6911.00
276_Q309_T1.6591.00
84_L88_K1.6521.00
85_M88_K1.6471.00
121_Q166_Q1.6411.00
81_E85_M1.6231.00
260_K276_Q1.5771.00
245_A323_V1.5691.00
276_Q307_V1.5621.00
131_Y155_R1.5561.00
261_V306_I1.5401.00
91_V95_Q1.5301.00
81_E202_L1.5251.00
196_A199_E1.5141.00
61_D64_D1.5091.00
245_A306_I1.4991.00
88_K195_L1.4931.00
131_Y152_R1.4781.00
284_A302_Y1.4771.00
86_Q194_Q1.4731.00
40_V243_V1.4491.00
279_F305_R1.4421.00
92_S95_Q1.4411.00
130_F150_N1.4331.00
148_L152_R1.4331.00
124_Y155_R1.4241.00
163_K166_Q1.4231.00
125_D129_N1.4171.00
243_V321_V1.4161.00
156_D159_Q1.4161.00
91_V192_Q1.4031.00
197_Q201_N1.3961.00
56_E76_D1.3801.00
83_A86_Q1.3771.00
83_A197_Q1.3741.00
227_N230_G1.3711.00
55_V220_V1.3711.00
150_N154_S1.3651.00
55_V73_G1.3601.00
22_G26_Y1.3601.00
21_G25_W1.3591.00
53_G75_L1.3541.00
121_Q162_L1.3431.00
98_Y188_L1.3251.00
162_L166_Q1.3031.00
23_Y27_Q1.2901.00
132_N136_G1.2821.00
65_A238_T1.2791.00
73_G207_L1.2711.00
56_E74_E1.2671.00
23_Y26_Y1.2651.00
195_L199_E1.2621.00
133_R149_E1.2591.00
240_P307_V1.2581.00
135_Q148_L1.2471.00
262_L326_G1.2451.00
154_S157_Q1.2401.00
85_M196_A1.2261.00
136_G140_S1.2251.00
192_Q196_A1.2251.00
146_N150_N1.2171.00
127_A158_A1.2161.00
83_A201_N1.2121.00
200_L204_D1.2101.00
124_Y128_Q1.2101.00
71_V74_E1.2031.00
159_Q163_K1.2021.00
209_A235_V1.2011.00
60_V70_Q1.2001.00
80_Y205_S1.1991.00
199_E203_Q1.1981.00
271_K314_A1.1731.00
215_L233_F1.1701.00
57_S222_P1.1681.00
90_G190_Q1.1671.00
264_Y324_Q1.1631.00
125_D128_Q1.1621.00
132_N135_Q1.1581.00
20_A24_W1.1581.00
136_G139_K1.1461.00
265_T321_V1.1411.00
248_D251_N1.1371.00
237_L240_P1.1341.00
72_L233_F1.1301.00
262_L324_Q1.1261.00
84_L202_L1.1261.00
213_G235_V1.1231.00
244_R305_R1.1201.00
246_Y303_R1.1191.00
88_K92_S1.1181.00
124_Y159_Q1.1151.00
124_Y162_L1.0931.00
43_R237_L1.0881.00
44_T234_T1.0851.00
90_G93_V1.0841.00
121_Q125_D1.0811.00
77_H205_S1.0771.00
19_V23_Y1.0751.00
130_F146_N1.0721.00
125_D156_D1.0701.00
91_V188_L1.0691.00
87_A191_A1.0581.00
86_Q90_G1.0571.00
49_F207_L1.0501.00
149_E152_R1.0421.00
218_R221_E1.0421.00
129_N149_E1.0321.00
46_N234_T1.0321.00
52_G228_E1.0291.00
95_Q188_L1.0231.00
94_A191_A1.0201.00
35_T324_Q1.0011.00
45_V211_S1.0001.00
154_S158_A0.9931.00
92_S189_E0.9931.00
93_V97_Q0.9921.00
50_R54_R0.9831.00
94_A97_Q0.9821.00
217_T234_T0.9821.00
62_E217_T0.9791.00
65_A212_D0.9771.00
274_H309_T0.9771.00
97_Q187_S0.9721.00
89_A193_A0.9631.00
152_R155_R0.9621.00
263_L308_V0.9571.00
264_Y272_P0.9491.00
73_G233_F0.9491.00
126_Y153_S0.9471.00
134_Q147_D0.9461.00
247_V255_A0.9461.00
256_Q259_R0.9441.00
40_V241_V0.9431.00
46_N231_T0.9411.00
157_Q161_T0.9411.00
73_G232_V0.9361.00
64_D70_Q0.9321.00
226_L232_V0.9301.00
281_S303_R0.9291.00
243_V263_L0.9271.00
58_L222_P0.9271.00
126_Y150_N0.9251.00
187_S190_Q0.9191.00
130_F134_Q0.9171.00
120_A123_A0.9151.00
35_T322_T0.9151.00
90_G194_Q0.9141.00
82_I200_L0.9101.00
60_V233_F0.9101.00
33_G324_Q0.9081.00
54_R225_V0.9081.00
78_K200_L0.9041.00
61_D218_R0.9031.00
209_A212_D0.8981.00
93_V187_S0.8971.00
90_G94_A0.8911.00
277_I304_L0.8901.00
161_T164_S0.8861.00
190_Q194_Q0.8841.00
265_T268_R0.8691.00
120_A158_A0.8671.00
252_L302_Y0.8581.00
268_R273_Y0.8511.00
87_A198_A0.8481.00
247_V304_L0.8461.00
77_H206_T0.8461.00
55_V226_L0.8441.00
188_L192_Q0.8341.00
151_A154_S0.8261.00
50_R79_P0.8231.00
40_V315_L0.8171.00
277_I306_I0.8171.00
58_L73_G0.8161.00
141_R145_A0.8141.00
218_R233_F0.8131.00
123_A157_Q0.8101.00
60_V215_L0.8051.00
95_Q98_Y0.8001.00
242_W307_V0.7991.00
83_A87_A0.7991.00
38_G321_V0.7971.00
129_N132_N0.7931.00
52_G227_N0.7911.00
56_E59_A0.7911.00
242_W278_G0.7871.00
255_A325_F0.7871.00
200_L203_Q0.7861.00
191_A194_Q0.7831.00
49_F226_L0.7821.00
246_Y301_V0.7811.00
74_E77_H0.7791.00
87_A90_G0.7791.00
82_I193_A0.7761.00
66_I72_L0.7741.00
56_E77_H0.7711.00
73_G218_R0.7691.00
263_L275_G0.7661.00
310_D313_D0.7621.00
68_A210_P0.7611.00
255_A277_I0.7601.00
264_Y322_T0.7601.00
84_L198_A0.7591.00
219_A234_T0.7551.00
83_A198_A0.7481.00
120_A165_A0.7471.00
95_Q99_D0.7451.00
143_I147_D0.7431.00
203_Q208_I0.7421.00
268_R271_K0.7411.00
87_A91_V0.7391.00
158_A161_T0.7391.00
264_Y270_D0.7381.00
211_S235_V0.7321.00
194_Q197_Q0.7311.00
153_S157_Q0.7271.00
243_V323_V0.7261.00
147_D151_A0.7251.00
198_A201_N0.7191.00
90_G187_S0.7171.00
60_V218_R0.7161.00
193_A196_A0.7141.00
138_W143_I0.7121.00
20_A23_Y0.7111.00
21_G26_Y0.7061.00
79_P83_A0.7041.00
88_K91_V0.7041.00
260_K326_G0.7001.00
126_Y129_N0.6991.00
49_F73_G0.6921.00
158_A162_L0.6901.00
134_Q146_N0.6891.00
49_F232_V0.6871.00
52_G225_V0.6861.00
127_A154_S0.6861.00
43_R221_E0.6861.00
31_D326_G0.6831.00
79_P201_N0.6761.00
285_E303_R0.6701.00
36_L245_A0.6641.00
82_I85_M0.6641.00
247_V325_F0.6601.00
161_T165_A0.6591.00
24_W27_Q0.6591.00
87_A195_L0.6591.00
12_V16_A0.6581.00
187_S191_A0.6571.00
214_T238_T0.6541.00
54_R76_D0.6531.00
80_Y198_A0.6531.00
16_A20_A0.6511.00
123_A126_Y0.6481.00
135_Q138_W0.6441.00
241_V317_Q0.6431.00
47_L210_P0.6431.00
81_E84_L0.6421.00
79_P200_L0.6401.00
257_P280_V0.6381.00
316_R319_M0.6371.00
22_G25_W0.6351.00
47_L233_F0.6331.00
278_G305_R0.6281.00
51_V80_Y0.6251.00
144_S147_D0.6231.00
94_A98_Y0.6221.00
77_H202_L0.6201.00
123_A154_S0.6181.00
191_A195_L0.6171.00
46_N224_T0.6141.00
263_L321_V0.6141.00
86_Q197_Q0.6121.00
286_F300_L0.6091.00
145_A148_L0.6061.00
60_V64_D0.6051.00
9_G13_V0.6051.00
42_I240_P0.6031.00
80_Y84_L0.6031.00
201_N204_D0.6001.00
267_G319_M0.5971.00
51_V201_N0.5941.00
59_A70_Q0.5941.00
126_Y154_S0.5941.00
261_V275_G0.5941.00
42_I242_W0.5931.00
268_R319_M0.5881.00
130_F151_A0.5881.00
65_A313_D0.5871.00
192_Q195_L0.5871.00
196_A200_L0.5841.00
9_G12_V0.5841.00
145_A152_R0.5841.00
90_G191_A0.5831.00
285_E299_D0.5781.00
62_E218_R0.5771.00
236_S317_Q0.5711.00
18_V21_G0.5691.00
127_A151_A0.5691.00
36_L247_V0.5681.00
130_F154_S0.5671.00
123_A127_A0.5671.00
249_E320_P0.5661.00
17_A21_G0.5651.00
78_K203_Q0.5611.00
21_G24_W0.5571.00
159_Q162_L0.5571.00
245_A325_F0.5551.00
20_A26_Y0.5541.00
245_A304_L0.5531.00
127_A130_F0.5481.00
138_W141_R0.5441.00
219_A231_T0.5431.00
257_P278_G0.5421.00
160_A163_K0.5411.00
49_F52_G0.5401.00
82_I197_Q0.5391.00
40_V321_V0.5371.00
207_L232_V0.5371.00
246_Y287_T0.5341.00
284_A300_L0.5341.00
32_N254_Q0.5331.00
48_S225_V0.5321.00
258_G276_Q0.5311.00
153_S160_A0.5311.00
120_A162_L0.5301.00
263_L306_I0.5291.00
302_Y319_M0.5291.00
62_E305_R0.5271.00
197_Q200_L0.5261.00
143_I148_L0.5261.00
142_T146_N0.5241.00
58_L218_R0.5231.00
251_N254_Q0.5221.00
203_Q206_T0.5221.00
44_T236_S0.5191.00
306_I323_V0.5171.00
93_V161_T0.5171.00
123_A161_T0.5171.00
212_D239_R0.5161.00
56_E222_P0.5141.00
51_V204_D0.5141.00
80_Y201_N0.5141.00
146_N149_E0.5141.00
87_A194_Q0.5131.00
39_N300_L0.5131.00
133_R146_N0.5121.00
243_V308_V0.5121.00
186_A189_E0.5101.00
85_M193_A0.5101.00
132_N155_R0.5091.00
231_T234_T0.5071.00
269_P273_Y0.5071.00
45_V235_V0.5071.00
202_L205_S0.5061.00
69_G208_I0.5061.00
49_F75_L0.5061.00
96_A186_A0.5041.00
270_D273_Y0.5031.00
36_L323_V0.5031.00
263_L323_V0.5021.00
89_A92_S0.5011.00
82_I86_Q0.5001.00
121_Q124_Y0.5001.00
198_A202_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkoB 1 0.8584 100 0.28 Contact Map
4dk0A 5 0.8042 100 0.356 Contact Map
3fppA 3 0.7831 100 0.359 Contact Map
2f1mA 2 0.6988 100 0.38 Contact Map
3lnnA 6 0.7952 100 0.406 Contact Map
1vf7A 5 0.6777 100 0.432 Contact Map
4l8jA 2 0.7259 100 0.437 Contact Map
3ne5B 3 0.6566 100 0.449 Contact Map
4kkuA 1 0.5452 100 0.525 Contact Map
2k32A 1 0.3464 99.8 0.657 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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