GREMLIN Database
YBHN - Inner membrane protein YbhN
UniProt: P75770 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13670
Length: 318 (287)
Sequences: 3764 (3023)
Seq/√Len: 178.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_V29_V3.5151.00
57_L225_L3.3791.00
35_D38_E2.7491.00
21_I25_V2.7291.00
105_G108_M2.6951.00
224_W228_G2.5581.00
40_W44_R2.5241.00
24_I28_V2.5021.00
261_A265_A2.4461.00
105_G109_R2.4361.00
227_L280_A2.4231.00
54_A287_L2.3921.00
47_N50_A2.3281.00
64_I218_V2.3281.00
178_Y182_C2.2601.00
119_P122_T2.2091.00
67_C211_I2.2021.00
134_N216_W2.2021.00
60_V218_V2.1741.00
106_I109_R2.1741.00
84_Q116_L2.1681.00
70_L74_F2.1381.00
50_A225_L2.1091.00
99_L104_G2.0681.00
53_S225_L2.0671.00
277_I281_L2.0641.00
232_N235_F2.0181.00
260_E285_R2.0051.00
86_M90_F1.9461.00
105_G113_Y1.9401.00
253_P285_R1.9191.00
81_A84_Q1.8611.00
243_S247_G1.8371.00
68_Y134_N1.8331.00
68_Y130_S1.8241.00
66_G86_M1.8181.00
65_Y134_N1.8141.00
64_I211_I1.8121.00
259_L285_R1.8081.00
20_F24_I1.7891.00
101_T104_G1.7711.00
166_I170_G1.7021.00
64_I214_V1.6991.00
52_L56_G1.6971.00
54_A226_L1.6711.00
203_K207_A1.6611.00
49_V53_S1.6451.00
57_L218_V1.6441.00
69_D126_I1.6401.00
40_W43_I1.6351.00
162_T166_I1.6311.00
90_F299_C1.6251.00
50_A53_S1.6141.00
78_H118_L1.6121.00
63_L82_K1.5971.00
145_I241_L1.5671.00
250_V258_V1.5631.00
23_V27_L1.5481.00
281_L285_R1.5351.00
29_V32_K1.5351.00
55_V287_L1.5301.00
66_G85_V1.5141.00
106_I131_I1.4981.00
71_L207_A1.4971.00
80_L85_V1.4921.00
16_T20_F1.4861.00
165_R169_I1.4741.00
131_I134_N1.4671.00
259_L284_Y1.4671.00
294_L298_I1.4501.00
223_I263_F1.4421.00
82_K86_M1.4391.00
273_S276_T1.4271.00
25_V28_V1.4261.00
58_V287_L1.4251.00
71_L211_I1.4111.00
25_V30_Y1.4101.00
286_V290_F1.4041.00
95_F99_L1.3871.00
298_I302_L1.3821.00
19_F23_V1.3771.00
66_G82_K1.3741.00
46_Y229_Q1.3651.00
137_G212_S1.3641.00
94_A297_L1.3591.00
23_V26_L1.3551.00
67_C70_L1.3401.00
239_V266_L1.3341.00
207_A210_L1.3261.00
68_Y212_S1.3211.00
134_N212_S1.3091.00
68_Y131_I1.3091.00
46_Y283_A1.3061.00
48_R52_L1.3041.00
54_A222_I1.3001.00
56_G60_V1.2881.00
46_Y50_A1.2851.00
97_L293_L1.2851.00
73_R118_L1.2771.00
92_C109_R1.2761.00
243_S262_V1.2721.00
130_S134_N1.2541.00
103_V106_I1.2531.00
163_T167_L1.2501.00
246_A262_V1.2351.00
83_R87_L1.2241.00
18_L25_V1.2141.00
264_I278_I1.2091.00
180_W184_F1.2031.00
28_V31_A1.1971.00
71_L204_F1.1931.00
173_M176_A1.1901.00
219_M288_Y1.1891.00
240_L244_S1.1821.00
104_G109_R1.1821.00
247_G255_G1.1611.00
94_A296_A1.1541.00
16_T19_F1.1491.00
72_A208_Q1.1461.00
180_W183_A1.1451.00
108_M113_Y1.1391.00
170_G174_I1.1291.00
79_K83_R1.1151.00
96_N105_G1.1071.00
168_G172_L1.0951.00
164_L167_L1.0951.00
162_T165_R1.0891.00
265_A268_A1.0851.00
50_A54_A1.0751.00
134_N215_N1.0721.00
105_G110_Y1.0671.00
102_W105_G1.0571.00
221_A233_Y1.0551.00
225_L229_Q1.0501.00
272_T277_I1.0481.00
41_K44_R1.0441.00
99_L107_G1.0371.00
13_K16_T1.0341.00
22_A26_L1.0320.99
224_W233_Y1.0310.99
78_H122_T1.0300.99
91_I95_F1.0290.99
62_Y90_F1.0290.99
253_P281_L1.0250.99
220_G237_L1.0190.99
251_H258_V1.0180.99
264_I277_I1.0170.99
28_V32_K1.0150.99
263_F281_L1.0130.99
210_L214_V1.0070.99
224_W236_V1.0000.99
55_V291_I0.9980.99
262_V265_A0.9970.99
53_S56_G0.9890.99
177_V180_W0.9860.99
14_I18_L0.9830.99
94_A100_S0.9810.99
184_F189_H0.9800.99
285_R288_Y0.9770.99
58_V219_M0.9770.99
65_Y215_N0.9670.99
17_W21_I0.9660.99
38_E275_G0.9650.99
109_R113_Y0.9630.99
78_H119_P0.9610.99
38_E41_K0.9580.99
201_S204_F0.9470.99
70_L85_V0.9450.99
169_I173_M0.9440.99
253_P259_L0.9380.99
69_D284_Y0.9380.99
190_M194_G0.9350.99
260_E281_L0.9340.99
92_C131_I0.9320.99
108_M112_L0.9320.99
263_F267_L0.9310.99
54_A229_Q0.9250.99
243_S255_G0.9240.99
89_S215_N0.9200.99
240_L243_S0.9140.99
205_A208_Q0.9090.99
220_G224_W0.9030.99
88_V112_L0.9030.99
202_W206_L0.8990.99
222_I284_Y0.8970.99
263_F280_A0.8960.99
69_D109_R0.8910.99
167_L171_L0.8910.99
70_L82_K0.8890.98
168_G171_L0.8820.98
18_L22_A0.8810.98
43_I283_A0.8750.98
65_Y131_I0.8740.98
183_A189_H0.8710.98
87_L302_L0.8710.98
206_L210_L0.8690.98
179_L182_C0.8600.98
223_I280_A0.8570.98
175_I184_F0.8560.98
62_Y93_Y0.8540.98
284_Y288_Y0.8530.98
50_A228_G0.8490.98
227_L272_T0.8490.98
138_Y142_A0.8430.98
22_A27_L0.8330.98
38_E42_V0.8330.98
85_V89_S0.8290.98
68_Y215_N0.8290.98
141_L217_M0.8290.98
184_F188_R0.8250.98
165_R168_G0.8240.98
217_M221_A0.8220.97
133_T208_Q0.8220.97
58_V222_I0.8210.97
243_S263_F0.8200.97
23_V31_A0.8200.97
175_I179_L0.8190.97
145_I238_G0.8170.97
23_V28_V0.8100.97
27_L30_Y0.8080.97
105_G131_I0.8030.97
252_I281_L0.8020.97
252_I262_V0.8010.97
141_L241_L0.8010.97
114_S120_G0.8010.97
69_D106_I0.8000.97
26_L29_V0.7970.97
89_S134_N0.7940.97
127_F131_I0.7880.97
239_V243_S0.7880.97
73_R126_I0.7880.97
250_V253_P0.7830.97
110_Y113_Y0.7800.97
239_V267_L0.7790.97
99_L103_V0.7760.96
106_I113_Y0.7750.96
166_I169_I0.7750.96
247_G250_V0.7720.96
252_I258_V0.7630.96
215_N219_M0.7620.96
243_S258_V0.7620.96
256_I284_Y0.7610.96
226_L229_Q0.7600.96
74_F79_K0.7570.96
212_S220_G0.7550.96
120_G123_I0.7490.96
27_L31_A0.7480.96
173_M177_V0.7440.95
57_L60_V0.7430.95
32_K35_D0.7410.95
221_A224_W0.7410.95
102_W106_I0.7340.95
65_Y69_D0.7340.95
138_Y216_W0.7320.95
97_L292_P0.7280.95
46_Y54_A0.7240.95
90_F295_L0.7230.95
26_L30_Y0.7220.95
234_F238_G0.7180.95
13_K210_L0.7180.95
55_V157_W0.7170.95
100_S215_N0.7160.94
93_Y284_Y0.7160.94
149_G153_L0.7150.94
19_F22_A0.7140.94
91_I112_L0.7140.94
144_I148_A0.7130.94
216_W219_M0.7110.94
171_L174_I0.7100.94
65_Y89_S0.7070.94
15_L140_L0.7060.94
97_L289_Y0.7060.94
175_I178_Y0.7030.94
61_S97_L0.7030.94
50_A229_Q0.7020.94
96_N106_I0.6990.94
259_L281_L0.6960.94
221_A225_L0.6960.94
48_R51_L0.6950.94
120_G124_T0.6940.93
41_K45_D0.6940.93
109_R131_I0.6940.93
174_I178_Y0.6940.93
69_D131_I0.6920.93
100_S104_G0.6910.93
195_Q198_V0.6900.93
69_D281_L0.6880.93
168_G183_A0.6870.93
297_L301_L0.6820.93
130_S252_I0.6820.93
140_L209_M0.6810.93
19_F29_V0.6800.93
113_Y127_F0.6770.93
126_I290_F0.6770.93
68_Y109_R0.6760.93
52_L151_V0.6760.93
299_C303_L0.6760.93
210_L217_M0.6730.92
109_R263_F0.6720.92
302_L305_S0.6720.92
65_Y216_W0.6710.92
98_T254_A0.6700.92
110_Y127_F0.6690.92
98_T293_L0.6680.92
252_I285_R0.6650.92
57_L221_A0.6650.92
276_T279_A0.6640.92
32_K179_L0.6630.92
264_I281_L0.6620.92
102_W108_M0.6610.92
88_V92_C0.6610.92
167_L184_F0.6590.92
208_Q281_L0.6590.92
118_L122_T0.6590.92
212_S216_W0.6570.92
288_Y292_P0.6550.91
168_G184_F0.6540.91
49_V52_L0.6530.91
14_I56_G0.6520.91
173_M180_W0.6510.91
20_F23_V0.6500.91
197_L200_P0.6470.91
131_I250_V0.6460.91
146_F150_V0.6440.91
167_L179_L0.6430.91
179_L183_A0.6430.91
25_V32_K0.6410.91
249_I289_Y0.6410.91
96_N104_G0.6380.90
168_G174_I0.6360.90
285_R289_Y0.6330.90
101_T109_R0.6330.90
106_I110_Y0.6330.90
65_Y130_S0.6300.90
37_E42_V0.6270.90
227_L236_V0.6260.89
295_L299_C0.6220.89
107_G282_L0.6210.89
95_F108_M0.6210.89
113_Y123_I0.6210.89
254_A259_L0.6200.89
47_N52_L0.6180.89
254_A289_Y0.6180.89
91_I299_C0.6160.89
103_V109_R0.6130.88
135_W219_M0.6120.88
170_G178_Y0.6120.88
233_Y237_L0.6120.88
176_A180_W0.6100.88
202_W232_N0.6080.88
143_G147_T0.6080.88
292_P295_L0.6060.88
72_A130_S0.6050.88
290_F294_L0.6050.88
20_F25_V0.6030.88
194_G197_L0.6000.87
145_I149_G0.5970.87
193_K197_L0.5940.87
256_I285_R0.5930.87
100_S250_V0.5930.87
133_T212_S0.5910.87
223_I244_S0.5890.86
213_S217_M0.5890.86
20_F27_L0.5890.86
98_T104_G0.5880.86
177_V181_F0.5790.86
244_S247_G0.5780.85
75_Y201_S0.5760.85
263_F285_R0.5750.85
249_I300_Y0.5750.85
62_Y288_Y0.5670.84
166_I198_V0.5660.84
104_G263_F0.5660.84
156_H159_V0.5650.84
219_M222_I0.5630.84
76_C122_T0.5630.84
58_V62_Y0.5610.84
264_I268_A0.5600.84
36_W40_W0.5590.83
212_S215_N0.5550.83
165_R181_F0.5550.83
246_A266_L0.5530.83
127_F215_N0.5520.83
168_G176_A0.5520.83
134_N138_Y0.5500.82
92_C96_N0.5490.82
53_S57_L0.5490.82
193_K198_V0.5480.82
72_A220_G0.5480.82
244_S263_F0.5470.82
96_N259_L0.5470.82
218_V222_I0.5470.82
62_Y222_I0.5460.82
92_C105_G0.5440.82
88_V109_R0.5420.82
44_R48_R0.5410.81
102_W109_R0.5410.81
267_L277_I0.5400.81
168_G181_F0.5400.81
141_L213_S0.5390.81
100_S251_H0.5380.81
169_I178_Y0.5370.81
177_V183_A0.5360.81
88_V111_R0.5330.81
17_W20_F0.5320.80
48_R301_L0.5300.80
126_I260_E0.5300.80
107_G289_Y0.5290.80
218_V221_A0.5280.80
176_A184_F0.5280.80
16_T30_Y0.5240.79
16_T24_I0.5240.79
55_V59_V0.5240.79
237_L241_L0.5230.79
163_T166_I0.5220.79
69_D130_S0.5220.79
65_Y102_W0.5170.78
212_S223_I0.5160.78
96_N131_I0.5130.78
204_F208_Q0.5120.78
37_E40_W0.5080.77
12_K16_T0.5070.77
59_V86_M0.5070.77
89_S292_P0.5060.77
15_L40_W0.5060.77
292_P296_A0.5050.77
173_M228_G0.5050.77
109_R137_G0.5000.76
58_V284_Y0.5000.76
135_W148_A0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.8648 60.8 0.932 Contact Map
2rddB 1 0.1069 39 0.94 Contact Map
4n7wA 2 0.8616 21.8 0.947 Contact Map
2zy9A 2 0.4245 10.8 0.954 Contact Map
3wdoA 1 0.9371 7.4 0.958 Contact Map
2kluA 1 0.1384 6.4 0.959 Contact Map
2l2tA 2 0.1352 5.9 0.959 Contact Map
3qe7A 2 0.7233 5.8 0.959 Contact Map
2kncA 1 0.1541 5.6 0.96 Contact Map
4u9nA 2 0.4277 5.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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