GREMLIN Database
YBHM - Uncharacterized protein YbhM
UniProt: P75769 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13669
Length: 237 (206)
Sequences: 3180 (2024)
Seq/√Len: 141.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_W180_R3.7311.00
168_M219_I3.5281.00
121_M180_R3.1271.00
57_Y61_G3.0341.00
135_R178_H2.7941.00
166_C223_I2.7651.00
112_T224_A2.5151.00
120_S173_S2.4141.00
169_I216_F2.3021.00
104_Y225_I2.2591.00
101_V106_I2.2491.00
30_G86_Y2.2291.00
63_L93_V2.2261.00
149_I164_I2.1661.00
109_V223_I2.1501.00
65_L69_G2.1321.00
34_T210_Y2.1221.00
119_I143_T2.0691.00
24_W121_M2.0681.00
179_G212_Y2.0501.00
159_R163_I2.0391.00
218_G222_A2.0231.00
69_G73_D1.9991.00
109_V220_L1.9871.00
68_Y72_K1.9181.00
151_V155_L1.9121.00
139_M143_T1.8951.00
22_G202_A1.8841.00
176_I216_F1.7981.00
138_I174_G1.7871.00
138_I178_H1.7331.00
163_I167_L1.7271.00
142_L146_A1.7041.00
146_A150_I1.7031.00
211_Y215_G1.6881.00
145_L168_M1.6731.00
61_G65_L1.6581.00
121_M125_L1.6461.00
111_S115_A1.6451.00
122_L126_L1.6381.00
182_K208_T1.6321.00
161_I222_A1.6281.00
60_I64_L1.6221.00
81_I84_V1.5941.00
127_F131_P1.5831.00
63_L96_V1.5831.00
28_A118_L1.5831.00
173_S216_F1.5791.00
112_T220_L1.5671.00
167_L171_L1.5461.00
179_G182_K1.5271.00
143_T147_L1.5241.00
63_L67_M1.4991.00
13_F17_A1.4941.00
166_C170_V1.4771.00
81_I85_I1.4701.00
84_V88_F1.4581.00
162_W223_I1.4471.00
115_A147_L1.4011.00
172_W211_Y1.3801.00
35_A111_S1.3781.00
69_G85_I1.3681.00
39_W43_Y1.3521.00
131_P177_S1.3371.00
37_L91_S1.3371.00
100_L218_G1.3331.00
105_A224_A1.3131.00
69_G72_K1.2941.00
124_G181_N1.2881.00
123_A127_F1.2821.00
182_K212_Y1.2531.00
83_G87_L1.2521.00
26_I83_G1.2491.00
97_V218_G1.2221.00
172_W215_G1.2191.00
62_L92_L1.2191.00
116_M120_S1.2151.00
123_A129_V1.2061.00
129_V133_S1.1811.00
219_I222_A1.1751.00
109_V112_T1.1731.00
209_L212_Y1.1520.99
107_I111_S1.1510.99
134_H138_I1.1310.99
127_F181_N1.1160.99
15_H187_A1.1100.99
133_S136_F1.0980.99
148_V164_I1.0960.99
152_N155_L1.0890.99
58_V61_G1.0880.99
89_L93_V1.0800.99
41_A46_I1.0570.99
152_N157_S1.0430.99
160_P164_I1.0410.99
142_L211_Y1.0340.99
145_L171_L1.0320.99
57_Y60_I1.0100.99
73_D81_I1.0050.99
73_D76_K1.0000.98
152_N156_M0.9980.98
129_V134_H0.9980.98
105_A109_V0.9970.98
18_R22_G0.9840.98
32_V36_G0.9810.98
105_A227_L0.9810.98
162_W166_C0.9730.98
83_G203_F0.9720.98
88_F92_L0.9710.98
112_T151_V0.9710.98
117_F213_F0.9640.98
117_F176_I0.9630.98
171_L175_I0.9620.98
179_G211_Y0.9510.98
56_M60_I0.9440.98
168_M172_W0.9420.98
137_I141_T0.9350.98
79_A83_G0.9330.98
59_A63_L0.9310.98
181_N185_E0.9040.97
112_T169_I0.9030.97
116_M216_F0.9020.97
183_L209_L0.8990.97
165_S222_A0.8960.97
150_I153_A0.8940.97
172_W179_G0.8930.97
66_C92_L0.8820.97
80_A84_V0.8800.97
116_M173_S0.8790.97
170_V174_G0.8750.96
142_L175_I0.8730.96
116_M119_I0.8700.96
16_E19_I0.8700.96
28_A32_V0.8630.96
27_T209_L0.8580.96
25_L29_L0.8550.96
165_S169_I0.8540.96
110_F114_G0.8510.96
139_M175_I0.8440.96
26_I203_F0.8420.96
146_A171_L0.8380.95
141_T171_L0.8350.95
29_L87_L0.8280.95
142_L216_F0.8240.95
37_L41_A0.8220.95
108_I224_A0.8210.95
144_G148_V0.8210.95
78_N81_I0.8200.95
146_A149_I0.8110.95
158_E161_I0.8110.95
30_G90_L0.8090.94
56_M96_V0.8080.94
208_T212_Y0.8030.94
120_S177_S0.8010.94
162_W165_S0.8000.94
70_L73_D0.8000.94
164_I167_L0.7980.94
22_G25_L0.7980.94
172_W175_I0.7970.94
137_I170_V0.7960.94
14_Q18_R0.7960.94
133_S137_I0.7930.94
93_V96_V0.7920.94
73_D85_I0.7900.94
29_L33_A0.7880.94
36_G40_G0.7820.93
156_M159_R0.7780.93
116_M220_L0.7760.93
58_V65_L0.7750.93
41_A50_K0.7730.93
220_L224_A0.7720.93
165_S219_I0.7630.93
105_A108_I0.7610.92
142_L215_G0.7610.92
133_S173_S0.7580.92
183_L205_G0.7540.92
222_A226_T0.7520.92
160_P163_I0.7460.92
100_L104_Y0.7440.92
40_G44_I0.7440.92
44_I47_T0.7390.91
171_L174_G0.7360.91
23_I183_L0.7350.91
140_M144_G0.7230.90
18_R21_N0.7230.90
177_S181_N0.7150.90
120_S131_P0.7120.90
186_L205_G0.7120.90
41_A98_A0.7090.90
86_Y90_L0.7080.90
209_L213_F0.7060.89
87_L90_L0.7050.89
46_I49_T0.7030.89
21_N25_L0.7030.89
142_L171_L0.7020.89
125_L180_R0.7000.89
142_L149_I0.6980.89
115_A119_I0.6970.89
145_L219_I0.6950.89
16_E187_A0.6930.89
33_A87_L0.6920.88
86_Y207_L0.6920.88
67_M71_S0.6850.88
183_L186_L0.6830.88
67_M89_L0.6810.88
104_Y218_G0.6800.88
35_A38_A0.6790.88
180_R209_L0.6780.87
219_I223_I0.6770.87
125_L184_L0.6700.87
157_S160_P0.6700.87
149_I166_C0.6670.87
63_L66_C0.6620.86
74_I204_T0.6610.86
77_I85_I0.6570.86
19_I23_I0.6510.85
175_I179_G0.6510.85
29_L32_V0.6480.85
26_I87_L0.6470.85
202_A205_G0.6460.85
172_W212_Y0.6440.85
70_L75_N0.6430.85
23_I205_G0.6380.84
66_C70_L0.6310.83
89_L207_L0.6310.83
175_I212_Y0.6260.83
47_T102_P0.6250.83
32_V136_F0.6220.83
64_L67_M0.6190.82
138_I141_T0.6190.82
48_A51_Y0.6120.82
124_G184_L0.6100.81
61_G64_L0.6090.81
143_T146_A0.6090.81
67_M207_L0.6050.81
120_S133_S0.6050.81
79_A200_R0.6040.81
147_L151_V0.6020.80
70_L74_I0.6010.80
142_L145_L0.6000.80
110_F213_F0.5980.80
12_D17_A0.5970.80
152_N164_I0.5950.80
109_V224_A0.5930.79
129_V181_N0.5910.79
59_A95_I0.5900.79
106_I221_A0.5900.79
215_G218_G0.5890.79
117_F209_L0.5850.79
142_L172_W0.5810.78
42_K102_P0.5790.78
71_S74_I0.5740.77
25_L28_A0.5740.77
14_Q17_A0.5710.77
119_I123_A0.5670.76
33_A90_L0.5660.76
168_M222_A0.5660.76
45_E48_A0.5650.76
113_A220_L0.5640.76
75_N78_N0.5620.76
122_L125_L0.5590.75
70_L85_I0.5590.75
123_A126_L0.5590.75
149_I153_A0.5580.75
215_G219_I0.5570.75
66_C89_L0.5570.75
164_I219_I0.5550.75
133_S177_S0.5540.75
116_M170_V0.5510.74
161_I165_S0.5500.74
30_G34_T0.5500.74
38_A98_A0.5470.74
13_F16_E0.5460.74
57_Y64_L0.5460.74
109_V113_A0.5440.73
30_G91_S0.5440.73
141_T182_K0.5420.73
135_R174_G0.5420.73
19_I202_A0.5410.73
33_A94_A0.5410.73
69_G76_K0.5390.73
159_R162_W0.5370.72
222_A225_I0.5350.72
31_L34_T0.5340.72
72_K75_N0.5330.72
178_H182_K0.5310.72
108_I161_I0.5280.71
19_I183_L0.5260.71
77_I81_I0.5260.71
145_L164_I0.5250.71
124_G131_P0.5230.71
105_A226_T0.5230.71
63_L89_L0.5210.70
135_R138_I0.5210.70
70_L77_I0.5190.70
66_C88_F0.5180.70
32_V114_G0.5170.70
139_M149_I0.5140.69
33_A37_L0.5090.68
48_A52_D0.5080.68
148_V152_N0.5060.68
133_S181_N0.5050.68
155_L158_E0.5050.68
74_I82_A0.5050.68
89_L211_Y0.5040.68
161_I164_I0.5020.67
170_V173_S0.5010.67
100_L106_I0.5010.67
73_D77_I0.5010.67
165_S168_M0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pgrA 1 0.8397 100 0.278 Contact Map
4i0uA 4 0.3249 37.2 0.941 Contact Map
4ev6A 3 0.3333 34.5 0.942 Contact Map
3brdD 1 0.0211 6.1 0.959 Contact Map
5a63B 1 0.4726 4.8 0.961 Contact Map
3giaA 1 0.7384 4.7 0.961 Contact Map
4qncA 2 0.3249 3.9 0.963 Contact Map
2wswA 3 0.2996 3.8 0.963 Contact Map
4gh4D 3 0.1392 3.7 0.963 Contact Map
2xq2A 2 0.7426 3.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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