GNGF - ECOLI - GREMLIN Contacts

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GNGF - Putative gluconeogenesis factor

UniProt:	P75767	Sequences: MRNRTLADLDRVVALGGGHGLGRVLSSLSSLGSRLTGIVTTTDNGGSTGRIRRSEGGIAWGDMRNCLNQLITEPSVASAMFEYRFGGNGELSGHNLGNLMLKALDHLSVRPLEAINLIRNLLKVDTHLIPMSEHPVDLMAIDDQGHEVYGEVNIDQLTTPIQELLLTPNVPATREAVHAINEADLIIIGPGSFYTSLMPILLLKEIAQALRRTPAPMVYIGNLGRELSLPAANLKLESKLAIMEQYVGKKVIDAVIVGPKVDVSAVKERIVIQEVLEASDIPYRHDRQLLHNALEKALQALG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13667
Length:	302 (289)
Sequences:	1750 (1145)
Seq/√Len:	67.3

ECOLI - GNGF
BACSU - GNGF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_I	162_Q	5.109	1.00
210_L	213_T	4.280	1.00
141_I	163_E	3.995	1.00
13_V	183_A	3.903	1.00
185_L	218_V	3.890	1.00
270_I	275_V	3.552	1.00
186_I	213_T	3.493	1.00
186_I	210_L	3.276	1.00
38_I	176_A	3.127	1.00
178_H	182_E	3.051	1.00
139_M	165_L	2.973	1.00
55_E	102_K	2.944	1.00
9_L	34_R	2.832	1.00
96_L	100_M	2.728	1.00
11_R	182_E	2.725	1.00
63_M	115_I	2.724	1.00
270_I	276_L	2.695	1.00
256_I	293_A	2.665	1.00
57_G	102_K	2.585	1.00
238_S	241_A	2.555	1.00
48_T	59_A	2.525	1.00
129_I	176_A	2.517	1.00
178_H	181_N	2.426	1.00
180_I	206_I	2.424	1.00
270_I	274_E	2.326	1.00
181_N	209_A	2.275	1.00
47_S	94_H	2.253	1.00
13_V	36_T	2.242	1.00
272_I	275_V	2.200	1.00
181_N	212_R	2.160	1.00
208_Q	212_R	2.137	1.00
143_D	162_Q	2.089	1.00
271_V	276_L	2.080	1.00
100_M	118_I	2.065	1.00
177_V	181_N	2.024	1.00
81_F	118_I	1.965	1.00
83_Y	106_H	1.946	1.00
220_I	294_L	1.941	1.00
134_H	171_P	1.931	1.00
271_V	274_E	1.891	1.00
143_D	160_P	1.861	1.00
13_V	38_I	1.833	1.00
256_I	294_L	1.821	1.00
236_L	255_V	1.796	1.00
141_I	165_L	1.728	1.00
205_E	208_Q	1.720	1.00
235_K	238_S	1.698	0.99
87_G	92_S	1.689	0.99
172_A	177_V	1.689	0.99
67_L	128_L	1.685	0.99
9_L	32_G	1.667	0.99
142_D	145_G	1.666	0.99
234_L	242_I	1.650	0.99
180_I	209_A	1.647	0.99
63_M	111_P	1.642	0.99
269_R	275_V	1.634	0.99
139_M	167_T	1.611	0.99
131_M	206_I	1.600	0.99
176_A	206_I	1.588	0.99
177_V	206_I	1.570	0.99
72_T	125_D	1.559	0.99
139_M	149_Y	1.536	0.99
142_D	148_V	1.515	0.99
240_L	252_I	1.497	0.99
218_V	294_L	1.496	0.99
272_I	276_L	1.496	0.99
271_V	275_V	1.489	0.99
10_D	32_G	1.474	0.99
110_R	113_E	1.460	0.98
287_R	290_L	1.458	0.98
172_A	176_A	1.444	0.98
194_Y	234_L	1.437	0.98
213_T	217_M	1.428	0.98
198_M	242_I	1.419	0.98
162_Q	245_Q	1.412	0.98
36_T	129_I	1.397	0.98
241_A	245_Q	1.395	0.98
221_G	236_L	1.374	0.98
15_L	200_I	1.370	0.98
11_R	34_R	1.363	0.98
242_I	246_Y	1.358	0.98
44_N	153_N	1.356	0.97
58_I	111_P	1.348	0.97
117_L	120_N	1.314	0.97
174_R	178_H	1.311	0.97
280_D	284_R	1.302	0.97
147_E	165_L	1.302	0.97
152_V	155_D	1.301	0.97
96_L	118_I	1.291	0.97
210_L	217_M	1.283	0.96
42_T	152_V	1.281	0.96
140_A	161_I	1.276	0.96
287_R	293_A	1.264	0.96
166_L	190_P	1.254	0.96
234_L	238_S	1.245	0.96
73_E	78_S	1.239	0.96
144_Q	159_T	1.226	0.95
141_I	147_E	1.202	0.95
270_I	273_Q	1.193	0.95
132_S	136_V	1.193	0.95
269_R	272_I	1.174	0.94
192_S	226_E	1.152	0.94
275_V	289_L	1.143	0.93
44_N	137_D	1.138	0.93
46_G	150_G	1.133	0.93
211_R	251_V	1.126	0.93
216_P	254_A	1.124	0.93
155_D	226_E	1.115	0.93
25_L	37_G	1.108	0.92
137_D	149_Y	1.106	0.92
207_A	211_R	1.100	0.92
15_L	38_I	1.088	0.92
269_R	276_L	1.086	0.92
36_T	179_A	1.084	0.91
81_F	100_M	1.076	0.91
207_A	210_L	1.063	0.91
112_L	175_E	1.056	0.90
219_Y	243_M	1.035	0.89
194_Y	242_I	1.031	0.89
96_L	103_A	1.027	0.89
279_S	282_P	1.022	0.89
188_I	217_M	1.022	0.89
177_V	209_A	1.019	0.89
61_G	150_G	1.006	0.88
69_Q	126_T	0.990	0.87
68_N	82_E	0.988	0.87
80_M	121_L	0.984	0.87
66_C	96_L	0.982	0.87
80_M	96_L	0.969	0.86
54_S	90_E	0.964	0.86
127_H	179_A	0.960	0.86
94_H	150_G	0.951	0.85
190_P	223_L	0.946	0.85
38_I	131_M	0.941	0.84
226_E	229_L	0.934	0.84
172_A	205_E	0.934	0.84
116_N	175_E	0.934	0.84
113_E	117_L	0.932	0.84
16_G	20_G	0.932	0.84
169_N	204_K	0.931	0.84
286_D	289_L	0.925	0.83
31_L	295_E	0.921	0.83
10_D	34_R	0.917	0.83
185_L	294_L	0.908	0.82
225_R	239_K	0.908	0.82
96_L	107_L	0.891	0.81
100_M	114_A	0.890	0.81
51_I	57_G	0.890	0.81
170_V	204_K	0.889	0.81
289_L	293_A	0.888	0.81
244_E	252_I	0.888	0.81
14_A	21_L	0.887	0.81
65_N	82_E	0.879	0.80
146_H	159_T	0.877	0.80
24_V	220_I	0.877	0.80
265_A	268_E	0.875	0.80
269_R	274_E	0.870	0.79
101_L	202_L	0.870	0.79
58_I	133_E	0.869	0.79
237_E	241_A	0.868	0.79
9_L	33_S	0.868	0.79
287_R	291_H	0.867	0.79
224_G	283_Y	0.867	0.79
49_G	52_R	0.865	0.79
155_D	192_S	0.865	0.79
288_Q	292_N	0.865	0.79
186_I	217_M	0.864	0.79
205_E	209_A	0.860	0.79
22_G	226_E	0.860	0.79
178_H	212_R	0.859	0.79
46_G	61_G	0.858	0.78
14_A	23_R	0.856	0.78
264_S	268_E	0.854	0.78
160_P	238_S	0.853	0.78
14_A	25_L	0.852	0.78
130_P	195_T	0.850	0.78
149_Y	167_T	0.846	0.77
278_A	282_P	0.844	0.77
147_E	167_T	0.842	0.77
49_G	60_W	0.839	0.77
158_T	210_L	0.835	0.77
12_V	33_S	0.834	0.76
22_G	65_N	0.830	0.76
105_D	114_A	0.830	0.76
16_G	25_L	0.829	0.76
57_G	105_D	0.828	0.76
166_L	202_L	0.825	0.76
256_I	297_A	0.822	0.75
217_M	252_I	0.820	0.75
231_A	239_K	0.815	0.75
277_E	280_D	0.812	0.75
177_V	186_I	0.812	0.75
47_S	81_F	0.808	0.74
66_C	77_A	0.806	0.74
187_I	220_I	0.806	0.74
278_A	281_I	0.805	0.74
273_Q	276_L	0.802	0.74
55_E	89_G	0.801	0.74
58_I	135_P	0.801	0.74
102_K	106_H	0.798	0.73
152_V	156_Q	0.794	0.73
64_R	97_G	0.793	0.73
68_N	71_I	0.788	0.72
86_G	92_S	0.783	0.72
198_M	236_L	0.781	0.72
136_V	166_L	0.777	0.71
30_S	288_Q	0.775	0.71
66_C	100_M	0.773	0.71
201_L	210_L	0.766	0.70
66_C	151_E	0.765	0.70
42_T	155_D	0.759	0.69
148_V	171_P	0.759	0.69
95_N	161_I	0.757	0.69
187_I	218_V	0.754	0.69
96_L	99_L	0.752	0.69
172_A	206_I	0.750	0.69
243_M	247_V	0.749	0.68
164_L	199_P	0.748	0.68
103_A	124_V	0.744	0.68
138_L	247_V	0.743	0.68
50_R	90_E	0.743	0.68
181_N	213_T	0.743	0.68
260_K	266_V	0.741	0.68
171_P	205_E	0.737	0.67
41_T	136_V	0.737	0.67
58_I	66_C	0.737	0.67
197_L	234_L	0.734	0.67
70_L	201_L	0.732	0.67
254_A	257_V	0.731	0.67
15_L	186_I	0.728	0.66
76_V	108_S	0.724	0.66
41_T	192_S	0.724	0.66
198_M	240_L	0.718	0.65
136_V	170_V	0.704	0.64
67_L	118_I	0.703	0.64
164_L	246_Y	0.702	0.63
282_P	294_L	0.701	0.63
178_H	210_L	0.699	0.63
210_L	251_V	0.699	0.63
15_L	20_G	0.699	0.63
59_A	203_L	0.697	0.63
84_R	98_N	0.696	0.63
228_S	232_A	0.694	0.63
89_G	92_S	0.693	0.62
82_E	257_V	0.693	0.62
198_M	202_L	0.691	0.62
14_A	187_I	0.688	0.62
111_P	166_L	0.687	0.62
190_P	215_A	0.687	0.62
24_V	294_L	0.686	0.62
211_R	250_K	0.686	0.62
76_V	117_L	0.684	0.61
32_G	66_C	0.682	0.61
185_L	197_L	0.682	0.61
151_E	258_G	0.680	0.61
61_G	192_S	0.680	0.61
250_K	255_V	0.679	0.61
51_I	63_M	0.676	0.60
40_T	48_T	0.676	0.60
283_Y	291_H	0.675	0.60
177_V	213_T	0.673	0.60
280_D	283_Y	0.672	0.60
240_L	244_E	0.670	0.60
21_L	39_V	0.669	0.60
15_L	176_A	0.668	0.60
128_L	291_H	0.667	0.59
131_M	200_I	0.666	0.59
207_A	247_V	0.666	0.59
290_L	297_A	0.664	0.59
60_W	190_P	0.662	0.59
49_G	94_H	0.661	0.59
256_I	290_L	0.658	0.58
112_L	129_I	0.658	0.58
39_V	285_H	0.655	0.58
228_S	231_A	0.655	0.58
164_L	242_I	0.653	0.58
36_T	183_A	0.651	0.58
239_K	246_Y	0.650	0.58
140_A	195_T	0.650	0.58
260_K	292_N	0.647	0.57
104_L	212_R	0.646	0.57
138_L	151_E	0.645	0.57
142_D	159_T	0.644	0.57
28_L	175_E	0.641	0.56
231_A	234_L	0.640	0.56
57_G	218_V	0.640	0.56
42_T	164_L	0.639	0.56
59_A	131_M	0.638	0.56
148_V	153_N	0.638	0.56
244_E	250_K	0.637	0.56
110_R	117_L	0.636	0.56
187_I	294_L	0.635	0.56
40_T	65_N	0.634	0.56
47_S	50_R	0.633	0.56
41_T	226_E	0.632	0.55
193_F	229_L	0.631	0.55
15_L	251_V	0.629	0.55
56_G	100_M	0.628	0.55
178_H	208_Q	0.628	0.55
181_N	288_Q	0.626	0.55
278_A	283_Y	0.626	0.55
155_D	165_L	0.626	0.55
42_T	136_V	0.622	0.54
48_T	65_N	0.622	0.54
150_G	192_S	0.619	0.54
220_I	290_L	0.619	0.54
98_N	196_S	0.618	0.54
106_H	109_V	0.618	0.54
179_A	183_A	0.617	0.54
55_E	91_L	0.616	0.54
70_L	168_P	0.614	0.53
43_D	47_S	0.613	0.53
195_T	201_L	0.612	0.53
61_G	94_H	0.611	0.53
119_R	124_V	0.610	0.53
182_E	294_L	0.608	0.53
153_N	194_Y	0.607	0.52
142_D	157_L	0.602	0.52
72_T	194_Y	0.602	0.52
133_E	173_T	0.602	0.52
177_V	214_P	0.602	0.52
272_I	279_S	0.599	0.51
214_P	259_P	0.599	0.51
212_R	266_V	0.599	0.51
118_I	154_I	0.599	0.51
284_R	287_R	0.599	0.51
15_L	188_I	0.598	0.51
243_M	246_Y	0.597	0.51
9_L	12_V	0.593	0.51
192_S	239_K	0.593	0.51
141_I	144_Q	0.593	0.51
68_N	81_F	0.592	0.51
265_A	296_K	0.591	0.51
236_L	244_E	0.590	0.50
211_R	249_K	0.590	0.50
41_T	239_K	0.589	0.50
68_N	78_S	0.588	0.50
44_N	152_V	0.588	0.50
19_H	50_R	0.586	0.50
94_H	99_L	0.586	0.50
240_L	255_V	0.584	0.50
44_N	246_Y	0.582	0.49
110_R	164_L	0.580	0.49
279_S	289_L	0.580	0.49
112_L	206_I	0.579	0.49
225_R	238_S	0.578	0.49
193_F	242_I	0.577	0.49
48_T	60_W	0.577	0.49
111_P	115_I	0.575	0.49
31_L	291_H	0.574	0.49
119_R	129_I	0.573	0.48
166_L	205_E	0.573	0.48
54_S	114_A	0.573	0.48
278_A	293_A	0.572	0.48
254_A	259_P	0.572	0.48
243_M	252_I	0.572	0.48
286_D	296_K	0.571	0.48
209_A	212_R	0.568	0.48
177_V	279_S	0.568	0.48
274_E	296_K	0.568	0.48
211_R	248_G	0.567	0.48
21_L	192_S	0.566	0.48
221_G	257_V	0.565	0.47
185_L	216_P	0.563	0.47
58_I	132_S	0.563	0.47
181_N	211_R	0.562	0.47
254_A	297_A	0.562	0.47
38_I	172_A	0.561	0.47
154_I	164_L	0.561	0.47
65_N	192_S	0.557	0.47
261_V	264_S	0.556	0.46
136_V	177_V	0.555	0.46
50_R	54_S	0.555	0.46
188_I	252_I	0.552	0.46
49_G	151_E	0.552	0.46
77_A	121_L	0.551	0.46
17_G	20_G	0.551	0.46
104_L	122_L	0.550	0.46
153_N	156_Q	0.549	0.46
15_L	177_V	0.547	0.45
48_T	202_L	0.547	0.45
46_G	192_S	0.546	0.45
288_Q	295_E	0.545	0.45
264_S	267_K	0.545	0.45
180_I	238_S	0.544	0.45
35_L	234_L	0.541	0.45
240_L	243_M	0.541	0.45
31_L	288_Q	0.539	0.44
79_A	107_L	0.539	0.44
50_R	93_G	0.538	0.44
262_D	273_Q	0.538	0.44
12_V	56_G	0.538	0.44
49_G	190_P	0.537	0.44
46_G	94_H	0.537	0.44
22_G	44_N	0.537	0.44
163_E	206_I	0.536	0.44
29_S	71_I	0.535	0.44
48_T	61_G	0.534	0.44
166_L	254_A	0.534	0.44
277_E	281_I	0.534	0.44
261_V	271_V	0.533	0.44
35_L	81_F	0.532	0.44
19_H	65_N	0.531	0.43
24_V	248_G	0.530	0.43
182_E	208_Q	0.530	0.43
84_R	196_S	0.529	0.43
53_R	56_G	0.529	0.43
207_A	248_G	0.528	0.43
285_H	291_H	0.527	0.43
101_L	108_S	0.527	0.43
192_S	195_T	0.526	0.43
71_I	105_D	0.526	0.43
73_E	176_A	0.526	0.43
29_S	70_L	0.525	0.43
265_A	272_I	0.523	0.43
46_G	97_G	0.522	0.42
16_G	37_G	0.518	0.42
64_R	196_S	0.517	0.42
271_V	286_D	0.517	0.42
21_L	122_L	0.516	0.42
186_I	209_A	0.514	0.41
180_I	213_T	0.513	0.41
31_L	81_F	0.511	0.41
217_M	254_A	0.511	0.41
65_N	226_E	0.510	0.41
61_G	64_R	0.507	0.41
177_V	260_K	0.507	0.41
48_T	82_E	0.506	0.41
20_G	49_G	0.503	0.40
263_V	275_V	0.502	0.40
58_I	105_D	0.502	0.40
63_M	80_M	0.501	0.40
120_N	297_A	0.500	0.40
281_I	291_H	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p0yA	1	0.7219	100	0.167	Contact Map
2o2zA	2	0.957	100	0.171	Contact Map
2q7xA	2	0.9205	100	0.178	Contact Map
2ppvA	2	0.9702	100	0.182	Contact Map
3c3dA	2	0.8808	100	0.36	Contact Map
4pfsA	1	0.7483	84.6	0.954	Contact Map
1vl0A	3	0.8245	78.2	0.957	Contact Map
4rz3A	2	0.7715	77.6	0.958	Contact Map
4dzzA	2	0.6523	76.8	0.958	Contact Map
2ozeA	2	0.798	71.7	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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