GREMLIN Database
GNGF - Putative gluconeogenesis factor
UniProt: P75767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13667
Length: 302 (289)
Sequences: 1750 (1145)
Seq/√Len: 67.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_I162_Q5.1091.00
210_L213_T4.2801.00
141_I163_E3.9951.00
13_V183_A3.9031.00
185_L218_V3.8901.00
270_I275_V3.5521.00
186_I213_T3.4931.00
186_I210_L3.2761.00
38_I176_A3.1271.00
178_H182_E3.0511.00
139_M165_L2.9731.00
55_E102_K2.9441.00
9_L34_R2.8321.00
96_L100_M2.7281.00
11_R182_E2.7251.00
63_M115_I2.7241.00
270_I276_L2.6951.00
256_I293_A2.6651.00
57_G102_K2.5851.00
238_S241_A2.5551.00
48_T59_A2.5251.00
129_I176_A2.5171.00
178_H181_N2.4261.00
180_I206_I2.4241.00
270_I274_E2.3261.00
181_N209_A2.2751.00
47_S94_H2.2531.00
13_V36_T2.2421.00
272_I275_V2.2001.00
181_N212_R2.1601.00
208_Q212_R2.1371.00
143_D162_Q2.0891.00
271_V276_L2.0801.00
100_M118_I2.0651.00
177_V181_N2.0241.00
81_F118_I1.9651.00
83_Y106_H1.9461.00
220_I294_L1.9411.00
134_H171_P1.9311.00
271_V274_E1.8911.00
143_D160_P1.8611.00
13_V38_I1.8331.00
256_I294_L1.8211.00
236_L255_V1.7961.00
141_I165_L1.7281.00
205_E208_Q1.7201.00
235_K238_S1.6980.99
87_G92_S1.6890.99
172_A177_V1.6890.99
67_L128_L1.6850.99
9_L32_G1.6670.99
142_D145_G1.6660.99
234_L242_I1.6500.99
180_I209_A1.6470.99
63_M111_P1.6420.99
269_R275_V1.6340.99
139_M167_T1.6110.99
131_M206_I1.6000.99
176_A206_I1.5880.99
177_V206_I1.5700.99
72_T125_D1.5590.99
139_M149_Y1.5360.99
142_D148_V1.5150.99
240_L252_I1.4970.99
218_V294_L1.4960.99
272_I276_L1.4960.99
271_V275_V1.4890.99
10_D32_G1.4740.99
110_R113_E1.4600.98
287_R290_L1.4580.98
172_A176_A1.4440.98
194_Y234_L1.4370.98
213_T217_M1.4280.98
198_M242_I1.4190.98
162_Q245_Q1.4120.98
36_T129_I1.3970.98
241_A245_Q1.3950.98
221_G236_L1.3740.98
15_L200_I1.3700.98
11_R34_R1.3630.98
242_I246_Y1.3580.98
44_N153_N1.3560.97
58_I111_P1.3480.97
117_L120_N1.3140.97
174_R178_H1.3110.97
280_D284_R1.3020.97
147_E165_L1.3020.97
152_V155_D1.3010.97
96_L118_I1.2910.97
210_L217_M1.2830.96
42_T152_V1.2810.96
140_A161_I1.2760.96
287_R293_A1.2640.96
166_L190_P1.2540.96
234_L238_S1.2450.96
73_E78_S1.2390.96
144_Q159_T1.2260.95
141_I147_E1.2020.95
270_I273_Q1.1930.95
132_S136_V1.1930.95
269_R272_I1.1740.94
192_S226_E1.1520.94
275_V289_L1.1430.93
44_N137_D1.1380.93
46_G150_G1.1330.93
211_R251_V1.1260.93
216_P254_A1.1240.93
155_D226_E1.1150.93
25_L37_G1.1080.92
137_D149_Y1.1060.92
207_A211_R1.1000.92
15_L38_I1.0880.92
269_R276_L1.0860.92
36_T179_A1.0840.91
81_F100_M1.0760.91
207_A210_L1.0630.91
112_L175_E1.0560.90
219_Y243_M1.0350.89
194_Y242_I1.0310.89
96_L103_A1.0270.89
279_S282_P1.0220.89
188_I217_M1.0220.89
177_V209_A1.0190.89
61_G150_G1.0060.88
69_Q126_T0.9900.87
68_N82_E0.9880.87
80_M121_L0.9840.87
66_C96_L0.9820.87
80_M96_L0.9690.86
54_S90_E0.9640.86
127_H179_A0.9600.86
94_H150_G0.9510.85
190_P223_L0.9460.85
38_I131_M0.9410.84
226_E229_L0.9340.84
172_A205_E0.9340.84
116_N175_E0.9340.84
113_E117_L0.9320.84
16_G20_G0.9320.84
169_N204_K0.9310.84
286_D289_L0.9250.83
31_L295_E0.9210.83
10_D34_R0.9170.83
185_L294_L0.9080.82
225_R239_K0.9080.82
96_L107_L0.8910.81
100_M114_A0.8900.81
51_I57_G0.8900.81
170_V204_K0.8890.81
289_L293_A0.8880.81
244_E252_I0.8880.81
14_A21_L0.8870.81
65_N82_E0.8790.80
146_H159_T0.8770.80
24_V220_I0.8770.80
265_A268_E0.8750.80
269_R274_E0.8700.79
101_L202_L0.8700.79
58_I133_E0.8690.79
237_E241_A0.8680.79
9_L33_S0.8680.79
287_R291_H0.8670.79
224_G283_Y0.8670.79
49_G52_R0.8650.79
155_D192_S0.8650.79
288_Q292_N0.8650.79
186_I217_M0.8640.79
205_E209_A0.8600.79
22_G226_E0.8600.79
178_H212_R0.8590.79
46_G61_G0.8580.78
14_A23_R0.8560.78
264_S268_E0.8540.78
160_P238_S0.8530.78
14_A25_L0.8520.78
130_P195_T0.8500.78
149_Y167_T0.8460.77
278_A282_P0.8440.77
147_E167_T0.8420.77
49_G60_W0.8390.77
158_T210_L0.8350.77
12_V33_S0.8340.76
22_G65_N0.8300.76
105_D114_A0.8300.76
16_G25_L0.8290.76
57_G105_D0.8280.76
166_L202_L0.8250.76
256_I297_A0.8220.75
217_M252_I0.8200.75
231_A239_K0.8150.75
277_E280_D0.8120.75
177_V186_I0.8120.75
47_S81_F0.8080.74
66_C77_A0.8060.74
187_I220_I0.8060.74
278_A281_I0.8050.74
273_Q276_L0.8020.74
55_E89_G0.8010.74
58_I135_P0.8010.74
102_K106_H0.7980.73
152_V156_Q0.7940.73
64_R97_G0.7930.73
68_N71_I0.7880.72
86_G92_S0.7830.72
198_M236_L0.7810.72
136_V166_L0.7770.71
30_S288_Q0.7750.71
66_C100_M0.7730.71
201_L210_L0.7660.70
66_C151_E0.7650.70
42_T155_D0.7590.69
148_V171_P0.7590.69
95_N161_I0.7570.69
187_I218_V0.7540.69
96_L99_L0.7520.69
172_A206_I0.7500.69
243_M247_V0.7490.68
164_L199_P0.7480.68
103_A124_V0.7440.68
138_L247_V0.7430.68
50_R90_E0.7430.68
181_N213_T0.7430.68
260_K266_V0.7410.68
171_P205_E0.7370.67
41_T136_V0.7370.67
58_I66_C0.7370.67
197_L234_L0.7340.67
70_L201_L0.7320.67
254_A257_V0.7310.67
15_L186_I0.7280.66
76_V108_S0.7240.66
41_T192_S0.7240.66
198_M240_L0.7180.65
136_V170_V0.7040.64
67_L118_I0.7030.64
164_L246_Y0.7020.63
282_P294_L0.7010.63
178_H210_L0.6990.63
210_L251_V0.6990.63
15_L20_G0.6990.63
59_A203_L0.6970.63
84_R98_N0.6960.63
228_S232_A0.6940.63
89_G92_S0.6930.62
82_E257_V0.6930.62
198_M202_L0.6910.62
14_A187_I0.6880.62
111_P166_L0.6870.62
190_P215_A0.6870.62
24_V294_L0.6860.62
211_R250_K0.6860.62
76_V117_L0.6840.61
32_G66_C0.6820.61
185_L197_L0.6820.61
151_E258_G0.6800.61
61_G192_S0.6800.61
250_K255_V0.6790.61
51_I63_M0.6760.60
40_T48_T0.6760.60
283_Y291_H0.6750.60
177_V213_T0.6730.60
280_D283_Y0.6720.60
240_L244_E0.6700.60
21_L39_V0.6690.60
15_L176_A0.6680.60
128_L291_H0.6670.59
131_M200_I0.6660.59
207_A247_V0.6660.59
290_L297_A0.6640.59
60_W190_P0.6620.59
49_G94_H0.6610.59
256_I290_L0.6580.58
112_L129_I0.6580.58
39_V285_H0.6550.58
228_S231_A0.6550.58
164_L242_I0.6530.58
36_T183_A0.6510.58
239_K246_Y0.6500.58
140_A195_T0.6500.58
260_K292_N0.6470.57
104_L212_R0.6460.57
138_L151_E0.6450.57
142_D159_T0.6440.57
28_L175_E0.6410.56
231_A234_L0.6400.56
57_G218_V0.6400.56
42_T164_L0.6390.56
59_A131_M0.6380.56
148_V153_N0.6380.56
244_E250_K0.6370.56
110_R117_L0.6360.56
187_I294_L0.6350.56
40_T65_N0.6340.56
47_S50_R0.6330.56
41_T226_E0.6320.55
193_F229_L0.6310.55
15_L251_V0.6290.55
56_G100_M0.6280.55
178_H208_Q0.6280.55
181_N288_Q0.6260.55
278_A283_Y0.6260.55
155_D165_L0.6260.55
42_T136_V0.6220.54
48_T65_N0.6220.54
150_G192_S0.6190.54
220_I290_L0.6190.54
98_N196_S0.6180.54
106_H109_V0.6180.54
179_A183_A0.6170.54
55_E91_L0.6160.54
70_L168_P0.6140.53
43_D47_S0.6130.53
195_T201_L0.6120.53
61_G94_H0.6110.53
119_R124_V0.6100.53
182_E294_L0.6080.53
153_N194_Y0.6070.52
142_D157_L0.6020.52
72_T194_Y0.6020.52
133_E173_T0.6020.52
177_V214_P0.6020.52
272_I279_S0.5990.51
214_P259_P0.5990.51
212_R266_V0.5990.51
118_I154_I0.5990.51
284_R287_R0.5990.51
15_L188_I0.5980.51
243_M246_Y0.5970.51
9_L12_V0.5930.51
192_S239_K0.5930.51
141_I144_Q0.5930.51
68_N81_F0.5920.51
265_A296_K0.5910.51
236_L244_E0.5900.50
211_R249_K0.5900.50
41_T239_K0.5890.50
68_N78_S0.5880.50
44_N152_V0.5880.50
19_H50_R0.5860.50
94_H99_L0.5860.50
240_L255_V0.5840.50
44_N246_Y0.5820.49
110_R164_L0.5800.49
279_S289_L0.5800.49
112_L206_I0.5790.49
225_R238_S0.5780.49
193_F242_I0.5770.49
48_T60_W0.5770.49
111_P115_I0.5750.49
31_L291_H0.5740.49
119_R129_I0.5730.48
166_L205_E0.5730.48
54_S114_A0.5730.48
278_A293_A0.5720.48
254_A259_P0.5720.48
243_M252_I0.5720.48
286_D296_K0.5710.48
209_A212_R0.5680.48
177_V279_S0.5680.48
274_E296_K0.5680.48
211_R248_G0.5670.48
21_L192_S0.5660.48
221_G257_V0.5650.47
185_L216_P0.5630.47
58_I132_S0.5630.47
181_N211_R0.5620.47
254_A297_A0.5620.47
38_I172_A0.5610.47
154_I164_L0.5610.47
65_N192_S0.5570.47
261_V264_S0.5560.46
136_V177_V0.5550.46
50_R54_S0.5550.46
188_I252_I0.5520.46
49_G151_E0.5520.46
77_A121_L0.5510.46
17_G20_G0.5510.46
104_L122_L0.5500.46
153_N156_Q0.5490.46
15_L177_V0.5470.45
48_T202_L0.5470.45
46_G192_S0.5460.45
288_Q295_E0.5450.45
264_S267_K0.5450.45
180_I238_S0.5440.45
35_L234_L0.5410.45
240_L243_M0.5410.45
31_L288_Q0.5390.44
79_A107_L0.5390.44
50_R93_G0.5380.44
262_D273_Q0.5380.44
12_V56_G0.5380.44
49_G190_P0.5370.44
46_G94_H0.5370.44
22_G44_N0.5370.44
163_E206_I0.5360.44
29_S71_I0.5350.44
48_T61_G0.5340.44
166_L254_A0.5340.44
277_E281_I0.5340.44
261_V271_V0.5330.44
35_L81_F0.5320.44
19_H65_N0.5310.43
24_V248_G0.5300.43
182_E208_Q0.5300.43
84_R196_S0.5290.43
53_R56_G0.5290.43
207_A248_G0.5280.43
285_H291_H0.5270.43
101_L108_S0.5270.43
192_S195_T0.5260.43
71_I105_D0.5260.43
73_E176_A0.5260.43
29_S70_L0.5250.43
265_A272_I0.5230.43
46_G97_G0.5220.42
16_G37_G0.5180.42
64_R196_S0.5170.42
271_V286_D0.5170.42
21_L122_L0.5160.42
186_I209_A0.5140.41
180_I213_T0.5130.41
31_L81_F0.5110.41
217_M254_A0.5110.41
65_N226_E0.5100.41
61_G64_R0.5070.41
177_V260_K0.5070.41
48_T82_E0.5060.41
20_G49_G0.5030.40
263_V275_V0.5020.40
58_I105_D0.5020.40
63_M80_M0.5010.40
120_N297_A0.5000.40
281_I291_H0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p0yA 1 0.7219 100 0.167 Contact Map
2o2zA 2 0.957 100 0.171 Contact Map
2q7xA 2 0.9205 100 0.178 Contact Map
2ppvA 2 0.9702 100 0.182 Contact Map
3c3dA 2 0.8808 100 0.36 Contact Map
4pfsA 1 0.7483 84.6 0.954 Contact Map
1vl0A 3 0.8245 78.2 0.957 Contact Map
4rz3A 2 0.7715 77.6 0.958 Contact Map
4dzzA 2 0.6523 76.8 0.958 Contact Map
2ozeA 2 0.798 71.7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.