GREMLIN Database
YBHI - Inner membrane protein YbhI
UniProt: P75763 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13665
Length: 477 (408)
Sequences: 9079 (6158)
Seq/√Len: 304.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_K80_A4.7851.00
123_T126_G4.4681.00
347_E351_E4.1881.00
105_T316_D4.0891.00
80_A342_K3.2441.00
281_A302_V3.0361.00
272_K276_G3.0261.00
195_F205_L2.9581.00
115_L119_K2.8121.00
94_F327_L2.7501.00
135_D153_V2.7331.00
443_K447_L2.6951.00
441_D444_S2.6811.00
260_G263_E2.6601.00
217_S220_G2.6281.00
180_M434_I2.6231.00
363_G366_A2.6191.00
313_T316_D2.5691.00
115_L118_G2.5411.00
42_A60_A2.5121.00
102_A306_M2.4541.00
36_F345_F2.4541.00
315_E320_N2.4311.00
33_W37_G2.4091.00
444_S447_L2.3211.00
98_T303_M2.3041.00
275_L279_V2.2901.00
223_L227_L2.2211.00
136_L229_G2.2111.00
125_L241_Y2.1801.00
44_V48_I2.0871.00
181_M185_M2.0721.00
348_W352_V2.0521.00
280_L284_G2.0121.00
157_I183_I2.0111.00
269_I273_M2.0031.00
277_V302_V1.9921.00
111_R115_L1.9811.00
267_M271_E1.9671.00
95_S303_M1.9611.00
222_A226_G1.9521.00
131_T157_I1.9321.00
376_I453_T1.9131.00
38_I63_A1.8971.00
261_L265_G1.8781.00
287_F291_L1.8771.00
375_I391_M1.8521.00
189_T232_M1.8281.00
41_A45_G1.8181.00
338_S342_K1.8151.00
283_L287_F1.8121.00
412_A464_G1.8111.00
462_T466_W1.8031.00
238_L242_T1.7741.00
219_G223_L1.7701.00
193_M229_G1.7701.00
137_V141_A1.7561.00
61_V82_L1.7541.00
232_M456_T1.7461.00
242_T245_P1.7271.00
369_V461_I1.7101.00
95_S299_A1.7071.00
454_I458_L1.7061.00
373_L457_F1.6941.00
267_M270_R1.6901.00
362_H366_A1.6711.00
102_A274_L1.6611.00
220_G407_M1.6561.00
99_L281_A1.6541.00
111_R271_E1.6351.00
268_K271_E1.6291.00
272_K275_L1.6171.00
45_G48_I1.6111.00
38_I60_A1.6011.00
196_T218_W1.5971.00
135_D187_T1.5931.00
265_G271_E1.5851.00
45_G56_V1.5841.00
365_V465_V1.5831.00
277_V305_T1.5681.00
220_G223_L1.5621.00
372_F416_S1.5541.00
273_M276_G1.5481.00
139_A190_T1.5341.00
38_I64_S1.5291.00
38_I67_V1.5291.00
276_G280_L1.5281.00
94_F98_T1.5171.00
230_I234_L1.5141.00
62_A304_A1.5111.00
277_V281_A1.5101.00
425_H435_F1.4981.00
64_S339_L1.4831.00
90_T327_L1.4751.00
377_V381_F1.4701.00
32_A345_F1.4661.00
186_V190_T1.4561.00
85_Y331_G1.4541.00
120_I130_V1.4501.00
352_V355_N1.4461.00
279_V283_L1.4431.00
277_V306_M1.4411.00
51_F55_V1.4401.00
132_V186_V1.4401.00
270_R273_M1.4311.00
263_E267_M1.4081.00
34_V75_A1.3981.00
51_F56_V1.3951.00
287_F290_S1.3911.00
380_F453_T1.3871.00
101_A104_V1.3841.00
460_H464_G1.3761.00
446_W450_A1.3751.00
129_Y237_P1.3691.00
34_V67_V1.3681.00
388_I417_N1.3641.00
104_V321_K1.3591.00
35_L339_L1.3541.00
193_M226_G1.3531.00
122_N126_G1.3521.00
67_V75_A1.3491.00
235_V455_L1.3431.00
423_V453_T1.3431.00
54_P325_N1.3281.00
259_A263_E1.3261.00
259_A262_A1.3221.00
184_Y434_I1.3211.00
121_G126_G1.3031.00
255_T259_A1.2971.00
340_L346_F1.2931.00
274_L278_F1.2831.00
52_P56_V1.2821.00
239_V242_T1.2791.00
340_L345_F1.2701.00
238_L241_Y1.2661.00
450_A454_I1.2661.00
262_A265_G1.2631.00
463_L467_W1.2631.00
101_A322_G1.2601.00
32_A348_W1.2561.00
379_Y384_G1.2471.00
341_S347_E1.2361.00
132_V182_S1.2251.00
190_T233_L1.2231.00
39_Y42_A1.2041.00
37_G41_A1.2041.00
254_K258_K1.2031.00
261_L267_M1.2011.00
227_L463_L1.1991.00
268_K272_K1.1991.00
277_V285_W1.1981.00
261_L264_L1.1951.00
278_F285_W1.1941.00
124_T178_Y1.1931.00
61_V332_G1.1871.00
36_F40_L1.1821.00
274_L277_V1.1781.00
280_L305_T1.1761.00
63_A67_V1.1741.00
190_T197_A1.1721.00
180_M440_N1.1721.00
42_A56_V1.1711.00
244_Y448_V1.1691.00
154_L433_V1.1681.00
273_M277_V1.1671.00
80_A83_S1.1661.00
65_M81_V1.1611.00
412_A416_S1.1571.00
41_A63_A1.1551.00
35_L64_S1.1551.00
145_N191_S1.1441.00
228_P459_V1.1441.00
351_E355_N1.1381.00
395_F413_L1.1341.00
67_V74_G1.1321.00
263_E266_P1.1301.00
131_T160_V1.1171.00
273_M309_L1.1041.00
40_L44_V1.1001.00
443_K446_W1.0971.00
132_V236_T1.0961.00
144_S147_A1.0901.00
457_F461_I1.0841.00
136_L233_L1.0841.00
191_S198_M1.0741.00
208_I410_A1.0711.00
88_G296_S1.0651.00
38_I42_A1.0631.00
373_L377_V1.0611.00
462_T465_V1.0591.00
161_A179_L1.0521.00
404_A409_T1.0511.00
378_R387_Y1.0481.00
235_V459_V1.0441.00
266_P269_I1.0381.00
436_G439_Y1.0351.00
273_M285_W1.0321.00
330_Y385_S1.0311.00
392_L410_A1.0281.00
83_S338_S1.0231.00
265_G269_I1.0221.00
257_A261_L1.0191.00
338_S341_S1.0161.00
118_G258_K1.0121.00
58_L328_I1.0051.00
231_I459_V0.9981.00
274_L285_W0.9921.00
226_G230_I0.9911.00
88_G294_D0.9871.00
372_F412_A0.9871.00
84_G335_G0.9821.00
149_A187_T0.9781.00
350_A354_K0.9761.00
39_Y340_L0.9761.00
200_G418_S0.9741.00
101_A321_K0.9721.00
384_G427_G0.9681.00
274_L281_A0.9661.00
93_V385_S0.9641.00
380_F420_G0.9531.00
273_M311_I0.9521.00
155_P159_S0.9491.00
425_H432_P0.9491.00
191_S194_F0.9481.00
110_K114_Y0.9441.00
255_T258_K0.9441.00
77_K81_V0.9431.00
132_V233_L0.9421.00
423_V446_W0.9391.00
393_P396_A0.9381.00
276_G279_V0.9231.00
348_W351_E0.9221.00
373_L461_I0.9221.00
239_V455_L0.9221.00
384_G420_G0.9181.00
42_A336_L0.9141.00
146_T198_M0.9111.00
458_L462_T0.9081.00
195_F222_A0.9071.00
269_I272_K0.9061.00
95_S300_I0.9041.00
184_Y431_G0.9041.00
383_S386_A0.9031.00
264_L267_M0.9021.00
200_G385_S0.9011.00
151_G433_V0.8991.00
396_A400_N0.8981.00
189_T236_T0.8981.00
181_M448_V0.8921.00
396_A399_A0.8921.00
351_E354_K0.8841.00
424_T427_G0.8831.00
81_V335_G0.8831.00
277_V284_G0.8821.00
400_N406_L0.8791.00
239_V243_M0.8771.00
415_F460_H0.8741.00
61_V335_G0.8731.00
148_R187_T0.8731.00
140_P193_M0.8701.00
134_L153_V0.8701.00
103_F108_L0.8691.00
285_W299_A0.8681.00
111_R114_Y0.8671.00
385_S429_A0.8671.00
376_I457_F0.8611.00
284_G301_V0.8591.00
194_F197_A0.8531.00
200_G428_G0.8531.00
282_L285_W0.8531.00
45_G59_I0.8521.00
35_L75_A0.8511.00
375_I413_L0.8461.00
192_Y229_G0.8461.00
284_G298_V0.8431.00
198_M201_N0.8421.00
294_D297_T0.8411.00
144_S385_S0.8361.00
57_L332_G0.8351.00
451_V454_I0.8341.00
75_A339_L0.8341.00
146_T191_S0.8331.00
42_A46_L0.8321.00
203_L392_L0.8321.00
310_G313_T0.8311.00
204_A414_L0.8301.00
453_T456_T0.8301.00
117_I160_V0.8291.00
166_S179_L0.8281.00
57_L61_V0.8281.00
380_F423_V0.8271.00
281_A284_G0.8261.00
111_R265_G0.8251.00
260_G264_L0.8221.00
380_F427_G0.8211.00
385_S428_G0.8191.00
449_G452_L0.8151.00
273_M281_A0.8141.00
44_V50_P0.8141.00
423_V450_A0.8101.00
99_L306_M0.8091.00
371_I413_L0.8081.00
133_F137_V0.8071.00
77_K342_K0.8051.00
138_L148_R0.8051.00
199_A385_S0.8051.00
47_V50_P0.8031.00
275_L283_L0.7961.00
279_V282_L0.7961.00
190_T194_F0.7951.00
76_F335_G0.7911.00
128_G179_L0.7881.00
180_M183_I0.7860.99
200_G388_I0.7860.99
203_L385_S0.7850.99
397_M400_N0.7830.99
74_G77_K0.7830.99
334_I389_V0.7830.99
242_T246_P0.7810.99
207_M392_L0.7800.99
203_L389_V0.7800.99
323_G326_T0.7750.99
383_S420_G0.7750.99
125_L237_P0.7740.99
374_S378_R0.7720.99
221_W411_L0.7720.99
368_F412_A0.7710.99
277_V282_L0.7710.99
444_S448_V0.7680.99
95_S296_S0.7660.99
184_Y430_A0.7650.99
87_S206_K0.7600.99
37_G40_L0.7600.99
392_L396_A0.7590.99
271_E278_F0.7590.99
281_A285_W0.7590.99
204_A388_I0.7570.99
90_T331_G0.7570.99
159_S163_A0.7560.99
313_T317_V0.7530.99
154_L180_M0.7530.99
385_S388_I0.7520.99
35_L343_V0.7520.99
379_Y420_G0.7520.99
363_G370_I0.7510.99
195_F202_I0.7480.99
157_I179_L0.7480.99
379_Y427_G0.7460.99
59_I304_A0.7440.99
45_G50_P0.7440.99
266_P270_R0.7430.99
193_M197_A0.7420.99
39_Y336_L0.7420.99
364_N368_F0.7390.99
201_N221_W0.7390.99
110_K260_G0.7370.99
222_A227_L0.7360.99
375_I417_N0.7340.99
46_L57_L0.7340.99
234_L238_L0.7320.99
299_A302_V0.7320.99
369_V373_L0.7310.99
377_V453_T0.7280.99
260_G267_M0.7280.99
375_I416_S0.7260.99
139_A145_N0.7230.99
193_M222_A0.7220.99
54_P61_V0.7220.99
53_E57_L0.7200.99
59_I62_A0.7180.99
146_T383_S0.7180.99
256_I259_A0.7170.99
91_W331_G0.7170.99
76_F80_A0.7150.99
198_M418_S0.7140.99
240_I244_Y0.7110.99
257_A260_G0.7110.99
226_G229_G0.7110.99
192_Y419_Y0.7060.99
221_W414_L0.7050.99
137_V140_P0.7040.99
326_T385_S0.7040.99
218_W222_A0.7030.99
52_P55_V0.7020.99
228_P232_M0.7000.99
184_Y188_K0.7000.99
232_M419_Y0.6990.99
236_T452_L0.6970.99
145_N197_A0.6970.99
260_G265_G0.6960.99
90_T330_Y0.6950.99
411_L415_F0.6940.99
58_L332_G0.6900.99
59_I63_A0.6890.99
264_L271_E0.6890.99
303_M307_L0.6870.99
260_G266_P0.6860.99
293_V298_V0.6860.99
204_A392_L0.6850.99
89_T93_V0.6850.99
129_Y133_F0.6850.99
188_K422_M0.6840.99
263_E269_I0.6840.99
372_F457_F0.6840.99
233_L237_P0.6830.99
396_A410_A0.6830.99
200_G330_Y0.6830.99
288_S291_L0.6780.99
273_M287_F0.6770.99
227_L230_I0.6740.98
46_L333_I0.6730.98
267_M272_K0.6650.98
225_A415_F0.6640.98
240_I448_V0.6640.98
397_M401_V0.6630.98
140_P194_F0.6620.98
261_L266_P0.6610.98
287_F292_G0.6610.98
139_A191_S0.6600.98
192_Y418_S0.6580.98
365_V369_V0.6570.98
258_K262_A0.6540.98
84_G338_S0.6540.98
65_M297_T0.6530.98
149_A434_I0.6520.98
64_S67_V0.6510.98
92_L299_A0.6480.98
53_E56_V0.6480.98
254_K257_A0.6470.98
53_E383_S0.6470.98
81_V84_G0.6400.98
303_M317_V0.6400.98
75_A343_V0.6390.98
375_I387_Y0.6380.98
94_F322_G0.6350.98
178_Y246_P0.6350.98
145_N148_R0.6310.98
331_G335_G0.6300.98
224_A463_L0.6290.98
149_A430_A0.6290.98
379_Y383_S0.6290.98
208_I215_Q0.6280.98
46_L56_V0.6260.98
272_K277_V0.6250.97
101_A105_T0.6240.97
135_D148_R0.6240.97
83_S87_S0.6240.97
49_K435_F0.6230.97
419_Y456_T0.6230.97
236_T240_I0.6220.97
383_S387_Y0.6220.97
67_V76_F0.6200.97
451_V455_L0.6200.97
370_I374_S0.6130.97
103_F274_L0.6130.97
93_V97_F0.6120.97
78_T82_L0.6080.97
182_S240_I0.6070.97
92_L144_S0.6060.97
367_F402_S0.6050.97
422_M431_G0.6040.97
31_L34_V0.6040.97
282_L286_I0.6040.97
64_S336_L0.6030.97
43_I381_F0.6020.97
284_G305_T0.6020.97
88_G206_K0.6010.97
78_T81_V0.6010.97
205_L215_Q0.6010.97
188_K430_A0.6000.97
135_D183_I0.5990.97
181_M449_G0.5990.97
230_I233_L0.5980.97
263_E270_R0.5980.97
93_V330_Y0.5970.97
266_P271_E0.5970.97
257_A267_M0.5970.97
408_L465_V0.5960.97
145_N199_A0.5940.97
264_L269_I0.5940.97
259_A264_L0.5940.97
372_F460_H0.5920.97
205_L216_I0.5920.97
384_G387_Y0.5900.96
145_N198_M0.5900.96
103_F106_T0.5890.96
131_T135_D0.5880.96
265_G268_K0.5860.96
113_A160_V0.5830.96
265_G270_R0.5830.96
229_G234_L0.5830.96
340_L343_V0.5820.96
35_L39_Y0.5810.96
224_A468_W0.5800.96
35_L340_L0.5800.96
231_I235_V0.5790.96
227_L231_I0.5770.96
403_G406_L0.5770.96
32_A35_L0.5740.96
189_T233_L0.5740.96
191_S200_G0.5740.96
198_M428_G0.5730.96
218_W221_W0.5720.96
76_F339_L0.5720.96
378_R381_F0.5710.96
96_A299_A0.5700.96
62_A300_I0.5670.96
148_R153_V0.5660.96
353_F374_S0.5640.95
253_N259_A0.5640.95
144_S148_R0.5630.95
369_V457_F0.5620.95
201_N418_S0.5620.95
85_Y91_W0.5610.95
130_V206_K0.5600.95
145_N188_K0.5600.95
76_F342_K0.5600.95
182_S186_V0.5590.95
277_V280_L0.5580.95
99_L302_V0.5550.95
154_L434_I0.5550.95
92_L145_N0.5530.95
227_L467_W0.5530.95
32_A36_F0.5530.95
354_K398_L0.5520.95
274_L282_L0.5520.95
61_V65_M0.5510.95
388_I413_L0.5510.95
428_G431_G0.5510.95
34_V38_I0.5500.95
420_G427_G0.5500.95
216_I221_W0.5490.95
188_K428_G0.5460.95
431_G449_G0.5450.95
78_T297_T0.5450.95
145_N187_T0.5450.95
400_N403_G0.5450.95
169_E178_Y0.5450.95
247_E250_K0.5430.94
145_N196_T0.5390.94
104_V109_G0.5390.94
139_A142_T0.5380.94
78_T296_S0.5380.94
258_K261_L0.5360.94
110_K163_A0.5360.94
262_A271_E0.5350.94
96_A430_A0.5350.94
379_Y413_L0.5340.94
363_G398_L0.5340.94
340_L390_A0.5340.94
280_L285_W0.5330.94
135_D186_V0.5330.94
39_Y46_L0.5320.94
204_A410_A0.5310.94
92_L199_A0.5310.94
139_A148_R0.5300.94
200_G430_A0.5290.94
414_L418_S0.5290.94
52_P325_N0.5280.94
100_S326_T0.5270.94
139_A197_A0.5250.93
194_F431_G0.5250.93
45_G51_F0.5250.93
145_N200_G0.5240.93
408_L412_A0.5240.93
101_A320_N0.5230.93
245_P249_K0.5230.93
343_V393_P0.5230.93
128_G237_P0.5230.93
234_L237_P0.5230.93
49_K52_P0.5210.93
45_G60_A0.5200.93
456_T459_V0.5200.93
453_T457_F0.5200.93
125_L129_Y0.5190.93
55_V59_I0.5190.93
158_N162_V0.5180.93
92_L96_A0.5170.93
399_A406_L0.5170.93
35_L38_I0.5170.93
365_V461_I0.5170.93
272_K278_F0.5160.93
114_Y265_G0.5160.93
256_I260_G0.5150.93
259_A265_G0.5150.93
427_G431_G0.5150.93
295_E299_A0.5140.93
278_F282_L0.5140.93
187_T427_G0.5140.93
275_L278_F0.5140.93
60_A64_S0.5120.93
284_G288_S0.5120.93
256_I262_A0.5120.93
371_I395_F0.5100.92
231_I463_L0.5100.92
105_T313_T0.5090.92
100_S144_S0.5090.92
200_G417_N0.5080.92
272_K287_F0.5080.92
199_A429_A0.5070.92
272_K279_V0.5070.92
301_V305_T0.5060.92
464_G468_W0.5060.92
301_V304_A0.5050.92
221_W285_W0.5050.92
128_G178_Y0.5050.92
280_L287_F0.5050.92
278_F287_F0.5030.92
66_V301_V0.5030.92
201_N205_L0.5010.92
79_T83_S0.5010.92
461_I465_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8994 100 0.373 Contact Map
4r1iA 2 0.9057 100 0.672 Contact Map
4r0cA 3 0.8763 99.9 0.722 Contact Map
2ksfA 1 0.2222 11.4 0.97 Contact Map
2rddB 1 0.0755 7.6 0.972 Contact Map
4pd6A 3 0.7547 6.9 0.972 Contact Map
1ldfA 3 0.4696 6.1 0.973 Contact Map
3tdsE 3 0.478 5.6 0.974 Contact Map
3giaA 1 0.4717 5.1 0.974 Contact Map
3qe7A 2 0.4759 4.6 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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