GREMLIN Database
ZITB - Zinc transporter ZitB
UniProt: P75757 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13662
Length: 313 (276)
Sequences: 10347 (7100)
Seq/√Len: 427.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_P188_I3.7091.00
255_L287_I3.1151.00
199_R203_R3.0861.00
240_H256_H3.0731.00
210_N215_G2.9731.00
229_M255_L2.8431.00
228_R279_H2.5151.00
38_G127_I2.4851.00
228_R280_Y2.4371.00
106_V191_I2.4331.00
36_V51_A2.3531.00
76_T83_W2.3461.00
229_M272_I2.3001.00
107_W111_E2.2501.00
176_I185_A2.2491.00
145_G154_R2.1441.00
126_A130_A2.1301.00
95_A205_L2.1091.00
86_L213_L2.1011.00
39_G48_L2.0731.00
237_R260_I2.0571.00
264_D267_A2.0311.00
206_K210_N1.9791.00
223_A227_R1.9621.00
125_M171_I1.9481.00
79_H83_W1.9461.00
274_H278_D1.9421.00
18_A72_R1.9211.00
224_E279_H1.8881.00
266_D288_Q1.8821.00
106_V194_S1.8021.00
233_I275_Y1.7801.00
85_R214_E1.7801.00
257_V272_I1.7461.00
111_E115_T1.7351.00
37_V41_L1.7291.00
222_I244_V1.7221.00
175_L179_W1.7081.00
105_I190_S1.7021.00
233_I272_I1.6811.00
228_R275_Y1.6541.00
53_H159_H1.6421.00
62_L66_L1.6261.00
22_L26_G1.6021.00
191_I195_L1.5981.00
36_V40_F1.5831.00
173_A189_L1.5821.00
267_A271_Q1.5761.00
103_I107_W1.5651.00
195_L199_R1.5561.00
18_A69_Q1.5481.00
238_N258_Q1.5361.00
233_I271_Q1.5271.00
275_Y279_H1.5161.00
125_M175_L1.5161.00
27_V134_A1.5091.00
143_H146_S1.5071.00
176_I180_T1.5071.00
202_W206_K1.4861.00
240_H290_E1.4581.00
109_A190_S1.4581.00
265_H289_M1.4541.00
154_R207_D1.4491.00
110_I114_R1.4331.00
35_E54_M1.4201.00
203_R206_K1.4181.00
22_L65_L1.4121.00
169_G189_L1.4001.00
81_F254_T1.4001.00
261_P293_P1.3931.00
218_V221_D1.3911.00
271_Q275_Y1.3851.00
122_G178_I1.3771.00
136_I140_W1.3661.00
29_A58_T1.3611.00
184_P187_P1.3581.00
104_L107_W1.3501.00
269_L288_Q1.3371.00
244_V253_M1.3361.00
224_E228_R1.3321.00
76_T79_H1.3301.00
221_D224_E1.3261.00
129_V133_L1.3231.00
140_W143_H1.3221.00
269_L273_Q1.3221.00
259_V268_L1.3181.00
266_D269_L1.3031.00
214_E252_V1.2761.00
253_M282_I1.2741.00
223_A226_K1.2661.00
256_H290_E1.2661.00
125_M178_I1.2661.00
175_L178_I1.2631.00
156_A159_H1.2581.00
45_L109_A1.2531.00
42_S124_M1.2511.00
243_H284_H1.2471.00
137_L140_W1.2471.00
217_P244_V1.2281.00
67_A90_A1.2281.00
113_F187_P1.2211.00
99_V201_A1.2021.00
31_F35_E1.1911.00
42_S123_M1.1841.00
102_T198_L1.1801.00
242_V255_L1.1791.00
32_M55_L1.1751.00
265_H269_L1.1701.00
70_F86_L1.1621.00
125_M174_A1.1621.00
39_G51_A1.1621.00
132_L171_I1.1611.00
273_Q277_M1.1601.00
133_L137_L1.1561.00
129_V171_I1.1511.00
113_F184_P1.1471.00
224_E280_Y1.1451.00
79_H210_N1.1371.00
78_R83_W1.1331.00
26_G30_G1.1321.00
64_A155_A1.1111.00
224_E227_R1.1071.00
144_H147_E1.0971.00
25_F58_T1.0961.00
227_R232_E1.0961.00
63_F90_A1.0951.00
263_H267_A1.0951.00
144_H148_E1.0861.00
23_Y141_L1.0851.00
253_M285_A1.0841.00
19_R23_Y1.0841.00
36_V48_L1.0821.00
233_I268_L1.0811.00
27_V138_S1.0771.00
88_T211_E1.0761.00
219_S223_A1.0751.00
99_V202_W1.0681.00
124_M174_A1.0581.00
84_L250_K1.0581.00
123_M126_A1.0561.00
50_D167_S1.0551.00
32_M36_V1.0511.00
95_A204_L1.0501.00
32_M51_A1.0491.00
168_V172_I1.0441.00
117_R120_E1.0371.00
106_V110_I1.0341.00
108_E111_E1.0291.00
50_D53_H1.0181.00
225_L244_V1.0171.00
265_H268_L1.0141.00
266_D291_Y1.0131.00
240_H258_Q1.0071.00
24_A138_S1.0041.00
113_F191_I1.0041.00
270_D274_H0.9971.00
25_F65_L0.9971.00
69_Q72_R0.9961.00
126_A129_V0.9951.00
87_T150_N0.9941.00
269_L289_M0.9931.00
70_F73_R0.9891.00
235_E264_D0.9841.00
45_L112_R0.9791.00
276_L282_I0.9791.00
16_N147_E0.9781.00
143_H157_A0.9781.00
214_E245_W0.9761.00
182_W185_A0.9741.00
214_E247_V0.9731.00
137_L141_L0.9651.00
80_T216_A0.9591.00
96_I100_V0.9541.00
157_A161_L0.9541.00
64_A152_N0.9531.00
40_F48_L0.9491.00
135_N138_S0.9411.00
232_E275_Y0.9371.00
16_N19_R0.9351.00
25_F62_L0.9271.00
89_L213_L0.9271.00
33_L37_V0.9251.00
266_D290_E0.9241.00
99_V198_L0.9201.00
45_L190_S0.9181.00
99_V103_I0.9171.00
109_A191_I0.9141.00
273_Q288_Q0.9131.00
31_F134_A0.9121.00
275_Y278_D0.9091.00
136_I161_L0.9021.00
259_V289_M0.8971.00
270_D273_Q0.8941.00
29_A33_L0.8941.00
269_L272_I0.8901.00
145_G148_E0.8881.00
217_P220_L0.8861.00
276_L285_A0.8801.00
139_F157_A0.8761.00
66_L70_F0.8711.00
138_S160_V0.8661.00
18_A65_L0.8601.00
217_P251_P0.8561.00
34_V130_A0.8551.00
78_R215_G0.8551.00
28_T54_M0.8511.00
159_H163_D0.8491.00
108_E112_R0.8471.00
110_I191_I0.8451.00
188_I192_L0.8411.00
241_H256_H0.8401.00
85_R245_W0.8391.00
247_V252_V0.8381.00
185_A189_L0.8361.00
92_F205_L0.8271.00
211_E246_M0.8271.00
53_H57_D0.8261.00
216_A222_I0.8261.00
241_H284_H0.8251.00
45_L108_E0.8201.00
258_Q292_Q0.8151.00
259_V265_H0.8151.00
236_V257_V0.8111.00
128_A171_I0.8031.00
235_E268_L0.8011.00
81_F245_W0.7901.00
239_V242_V0.7891.00
237_R292_Q0.7831.00
125_M129_V0.7821.00
36_V55_L0.7801.00
173_A185_A0.7771.00
138_S142_L0.7671.00
177_I180_T0.7601.00
269_L287_I0.7591.00
56_T101_I0.7591.00
104_L108_E0.7581.00
28_T57_D0.7581.00
222_I226_K0.7541.00
89_L93_V0.7541.00
100_V107_W0.7471.00
221_D251_P0.7431.00
46_A189_L0.7401.00
71_S87_T0.7361.00
228_R233_I0.7341.00
100_V104_L0.7321.00
44_S186_D0.7311.00
155_A204_L0.7311.00
239_V255_L0.7311.00
268_L272_I0.7291.00
225_L253_M0.7291.00
288_Q291_Y0.7281.00
226_K239_V0.7271.00
233_I236_V0.7241.00
78_R210_N0.7231.00
189_L193_V0.7211.00
32_M54_M0.7211.00
111_E114_R0.7181.00
34_V127_I0.7171.00
132_L168_V0.7161.00
40_F51_A0.7141.00
139_F143_H0.7131.00
158_L161_L0.7131.00
228_R232_E0.7121.00
128_A131_G0.7121.00
229_M239_V0.7051.00
272_I287_I0.7051.00
39_G42_S0.7031.00
162_G200_S0.7021.00
243_H254_T0.7001.00
154_R158_L0.6991.00
35_E51_A0.6981.00
32_M58_T0.6981.00
92_F96_I0.6951.00
68_V152_N0.6941.00
138_S141_L0.6911.00
112_R117_R0.6901.00
38_G123_M0.6861.00
257_V289_M0.6841.00
272_I275_Y0.6741.00
60_A64_A0.6731.00
264_D271_Q0.6731.00
145_G157_A0.6711.00
53_H98_L0.6711.00
225_L276_L0.6701.00
282_I285_A0.6671.00
135_N160_V0.6651.00
24_A61_L0.6641.00
89_L209_V0.6621.00
266_D270_D0.6621.00
24_A160_V0.6621.00
236_V239_V0.6610.99
235_E271_Q0.6610.99
151_L211_E0.6590.99
196_L200_S0.6580.99
199_R202_W0.6580.99
217_P221_D0.6570.99
66_L69_Q0.6570.99
24_A142_L0.6530.99
131_G135_N0.6510.99
61_L156_A0.6510.99
246_M251_P0.6500.99
254_T284_H0.6470.99
18_A22_L0.6460.99
55_L59_A0.6440.99
232_E236_V0.6410.99
24_A156_A0.6400.99
111_E117_R0.6340.99
176_I179_W0.6340.99
135_N142_L0.6330.99
220_L244_V0.6320.99
277_M285_A0.6310.99
261_P292_Q0.6300.99
246_M249_E0.6250.99
119_V122_G0.6230.99
92_F208_S0.6230.99
267_A270_D0.6230.99
229_M257_V0.6220.99
124_M131_G0.6190.99
134_A138_S0.6150.99
235_E260_I0.6150.99
271_Q274_H0.6140.99
139_F161_L0.6130.99
22_L25_F0.6120.99
60_A97_A0.6100.99
80_T243_H0.6100.99
276_L287_I0.6100.99
100_V103_I0.6100.99
91_A152_N0.6080.99
59_A62_L0.6080.99
192_L196_L0.6050.99
265_H291_Y0.6030.99
20_R141_L0.6020.99
216_A244_V0.6020.99
60_A159_H0.6010.99
139_F160_V0.6010.99
210_N218_V0.6000.99
166_G173_A0.5990.99
273_Q285_A0.5990.99
159_H162_G0.5980.99
35_E131_G0.5980.99
151_L207_D0.5940.99
47_L98_L0.5910.99
35_E50_D0.5910.99
217_P222_I0.5900.99
91_A204_L0.5890.99
65_L69_Q0.5860.99
37_V40_F0.5860.99
130_A137_L0.5850.99
102_T201_A0.5840.99
141_L144_H0.5820.99
234_P271_Q0.5780.99
101_I104_L0.5750.99
120_E123_M0.5740.99
229_M236_V0.5730.99
26_G29_A0.5720.99
81_F243_H0.5720.99
21_L64_A0.5690.98
69_Q73_R0.5680.98
92_F212_L0.5680.98
54_M166_G0.5660.98
165_L168_V0.5630.98
36_V52_G0.5630.98
124_M128_A0.5630.98
86_L90_A0.5630.98
142_L156_A0.5610.98
142_L160_V0.5600.98
170_A173_A0.5590.98
92_F209_V0.5590.98
135_N139_F0.5580.98
136_I164_L0.5570.98
161_L165_L0.5520.98
21_L25_F0.5490.98
109_A194_S0.5480.98
237_R259_V0.5470.98
149_K154_R0.5470.98
130_A134_A0.5430.98
169_G193_V0.5410.98
25_F61_L0.5410.98
45_L49_A0.5380.98
189_L192_L0.5380.98
178_I181_G0.5360.98
43_G117_R0.5350.98
45_L48_L0.5340.98
109_A187_P0.5310.98
63_F93_V0.5310.98
23_Y27_V0.5310.98
28_T160_V0.5300.98
180_T185_A0.5290.98
31_F138_S0.5280.98
227_R279_H0.5270.98
17_N153_V0.5270.98
121_G178_I0.5260.98
154_R157_A0.5240.97
242_V253_M0.5220.97
118_P183_T0.5210.97
183_T187_P0.5200.97
74_P83_W0.5200.97
132_L136_I0.5190.97
172_I176_I0.5180.97
166_G193_V0.5170.97
91_A208_S0.5170.97
167_S170_A0.5160.97
216_A246_M0.5150.97
112_R116_P0.5140.97
196_L199_R0.5100.97
103_I198_L0.5090.97
124_M173_A0.5080.97
23_Y26_G0.5070.97
28_T135_N0.5070.97
79_H215_G0.5040.97
20_R144_H0.5030.97
198_L202_W0.5020.97
113_F188_I0.5020.97
32_M52_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.9297 100 0.18 Contact Map
3h90A 3 0.8882 100 0.217 Contact Map
2zztA 2 0.246 99.6 0.767 Contact Map
3bypA 2 0.246 99.4 0.793 Contact Map
3w61A 2 0.2428 99.2 0.811 Contact Map
2jsxA 1 0.3035 83.1 0.933 Contact Map
3rlbA 1 0.4952 78.2 0.936 Contact Map
4tkrA 2 0.492 67.4 0.941 Contact Map
2ko1A 2 0.278 59.2 0.944 Contact Map
4dveA 3 0.5335 56.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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