GREMLIN Database
ABRB - Protein AbrB
UniProt: P75747 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13310
Length: 348 (336)
Sequences: 1101 (882)
Seq/√Len: 48.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_A139_V5.0121.00
197_G202_L4.7711.00
17_S29_L3.9491.00
83_I320_M3.9391.00
275_G279_G3.6901.00
9_L37_G3.3991.00
236_Y302_T3.2651.00
193_A209_I3.2031.00
13_S241_W3.1621.00
27_A302_T2.8161.00
216_V220_G2.8091.00
30_L150_V2.7951.00
66_A214_G2.7811.00
214_G218_Q2.7481.00
134_A139_V2.7261.00
16_L33_P2.6721.00
195_T199_L2.5881.00
193_A197_G2.5721.00
109_P112_T2.3781.00
34_M243_I2.2921.00
18_I22_A2.2771.00
307_A317_I2.2561.00
125_M332_G2.2371.00
124_A236_Y2.2341.00
286_I291_A2.2271.00
300_L325_L2.1961.00
287_D290_T2.1501.00
13_S16_L2.1311.00
89_L264_L2.1161.00
236_Y301_D2.1031.00
121_G236_Y2.0981.00
193_A213_A2.0821.00
98_V265_S2.0821.00
116_G142_M2.0761.00
303_V317_I2.0561.00
31_L35_I2.0351.00
150_V298_G2.0321.00
101_L105_Y2.0030.99
17_S237_M1.8820.99
90_V321_Q1.8720.99
9_L13_S1.8340.99
62_G207_M1.8120.99
278_W282_R1.8030.99
295_T320_M1.7770.99
124_A302_T1.7760.99
250_Q321_Q1.7220.98
69_L243_I1.7200.98
129_A136_I1.7100.98
40_F45_I1.6910.98
25_L164_D1.6780.98
8_M196_V1.6740.98
39_I43_R1.6690.98
115_W305_V1.6390.98
207_M239_I1.6360.98
168_A171_Q1.6220.98
27_A236_Y1.6050.97
235_A269_L1.5850.97
236_Y305_V1.5840.97
100_W235_A1.5770.97
64_M205_G1.5740.97
192_V216_V1.5740.97
234_M263_L1.5680.97
195_T198_C1.5420.97
287_D294_A1.5420.97
302_T305_V1.5200.96
121_G302_T1.5150.96
122_A296_S1.5090.96
87_I91_T1.4940.96
337_R341_T1.4820.96
281_T288_F1.4720.96
314_M317_I1.4700.96
103_V110_G1.4620.96
313_D333_P1.4300.95
12_L40_F1.4300.95
30_L316_L1.4150.95
20_F31_L1.3950.94
68_N314_M1.3930.94
16_L20_F1.3880.94
155_V236_Y1.3610.93
279_G335_I1.3610.93
9_L147_V1.3600.93
25_L28_A1.3550.93
216_V219_S1.3540.93
170_N196_V1.3490.93
82_P268_A1.3450.93
121_G301_D1.3410.93
253_L257_R1.3300.93
29_L151_A1.3290.93
35_I152_G1.3100.92
121_G325_L1.3050.92
23_V263_L1.3040.92
62_G66_A1.3020.92
15_L18_I1.3000.92
197_G268_A1.2890.91
81_W121_G1.2880.91
271_A275_G1.2830.91
156_L160_M1.2810.91
27_A301_D1.2800.91
27_A30_L1.2760.91
149_F263_L1.2690.91
70_T119_P1.2580.90
41_S137_R1.2540.90
177_P216_V1.2530.90
94_S272_I1.2530.90
104_R199_L1.2510.90
99_G143_Q1.2410.90
184_L188_L1.2380.90
125_M328_I1.2370.90
115_W336_A1.2340.90
202_L209_I1.2310.89
112_T134_A1.2260.89
284_M291_A1.2260.89
80_N83_I1.2230.89
142_M147_V1.2170.89
140_A312_A1.2050.88
130_Q136_I1.1970.88
111_N141_F1.1960.88
103_V113_G1.1940.88
303_V310_S1.1770.87
20_F28_A1.1740.87
12_L25_L1.1720.87
181_I184_L1.1670.87
144_Y292_Y1.1500.86
17_S163_G1.1490.86
7_G48_Q1.1470.86
95_S317_I1.1450.86
27_A129_A1.1430.86
188_L275_G1.1400.85
58_Q318_M1.1400.85
34_M314_M1.1370.85
28_A54_F1.1340.85
36_A40_F1.1330.85
19_G22_A1.1310.85
116_G255_A1.1300.85
62_G120_G1.1240.85
95_S125_M1.1230.85
188_L192_V1.1220.84
149_F152_G1.1200.84
21_L29_L1.1100.84
43_R168_A1.1050.84
15_L56_A1.1010.83
69_L327_S1.0940.83
148_L219_S1.0900.83
176_F181_I1.0870.83
124_A301_D1.0860.82
31_L130_Q1.0850.82
13_S33_P1.0830.82
29_L302_T1.0820.82
20_F35_I1.0820.82
13_S37_G1.0780.82
63_C202_L1.0770.82
116_G154_A1.0740.82
99_G295_T1.0690.81
281_T306_I1.0630.81
17_S21_L1.0610.81
149_F270_L1.0570.81
93_L263_L1.0550.81
106_S261_Q1.0550.81
17_S157_V1.0510.80
326_F330_L1.0490.80
116_G291_A1.0480.80
14_L18_I1.0470.80
126_V316_L1.0440.80
118_S328_I1.0430.80
121_G239_I1.0430.80
121_G124_A1.0430.80
184_L311_N1.0390.80
59_A190_A1.0380.80
91_T135_D1.0350.79
249_K321_Q1.0330.79
131_D234_M1.0160.78
321_Q325_L1.0160.78
57_A238_A1.0120.78
333_P336_A1.0100.78
101_L264_L1.0040.77
154_A292_Y1.0020.77
90_V143_Q1.0020.77
141_F262_I0.9970.77
125_M296_S0.9890.76
217_L222_L0.9870.76
315_A335_I0.9840.76
99_G115_W0.9800.75
173_I282_R0.9750.75
51_R86_A0.9750.75
301_D306_I0.9670.74
15_L271_A0.9660.74
95_S321_Q0.9620.74
15_L282_R0.9580.74
50_P86_A0.9560.74
141_F251_I0.9550.74
240_G244_G0.9520.73
58_Q124_A0.9490.73
56_A271_A0.9490.73
53_A127_A0.9490.73
19_G89_L0.9410.72
11_V168_A0.9410.72
58_Q300_L0.9350.72
191_V195_T0.9330.72
278_W283_F0.9310.72
145_L259_L0.9250.71
66_A236_Y0.9240.71
118_S125_M0.9210.71
61_L65_I0.9130.70
123_A305_V0.9050.69
299_G329_L0.9040.69
27_A321_Q0.8970.69
35_I222_L0.8920.68
97_I234_M0.8900.68
87_I114_A0.8900.68
267_F271_A0.8870.68
202_L215_A0.8850.68
115_W247_F0.8830.68
112_T116_G0.8830.68
84_V317_I0.8820.67
143_Q154_A0.8770.67
91_T249_K0.8740.67
217_L221_Q0.8740.67
91_T204_S0.8740.67
46_T187_I0.8720.67
204_S308_A0.8700.66
80_N316_L0.8680.66
207_M299_G0.8650.66
9_L16_L0.8480.64
85_L216_V0.8480.64
75_T268_A0.8470.64
59_A194_G0.8420.64
25_L85_L0.8420.64
6_W9_L0.8400.64
99_G103_V0.8400.64
256_L260_P0.8390.64
61_L261_Q0.8340.63
121_G155_V0.8300.63
273_C296_S0.8280.63
118_S332_G0.8270.62
291_A321_Q0.8220.62
47_L245_L0.8150.61
50_P143_Q0.8140.61
185_L216_V0.8130.61
166_A180_S0.8110.61
113_G147_V0.8100.61
29_L293_L0.8080.61
53_A238_A0.8060.60
196_V267_F0.8030.60
89_L188_L0.8020.60
7_G11_V0.8010.60
99_G290_T0.7980.60
125_M134_A0.7980.60
29_L233_A0.7970.60
296_S303_V0.7970.60
96_A306_I0.7950.59
281_T292_Y0.7920.59
52_S216_V0.7880.59
187_I191_V0.7870.59
14_L24_H0.7850.58
85_L326_F0.7850.58
147_V301_D0.7850.58
24_H202_L0.7830.58
26_P240_G0.7800.58
36_A101_L0.7790.58
144_Y296_S0.7750.57
17_S119_P0.7730.57
213_A286_I0.7680.57
142_M262_I0.7660.57
202_L205_G0.7660.57
308_A321_Q0.7630.56
255_A315_A0.7600.56
215_A219_S0.7600.56
78_A82_P0.7590.56
80_N320_M0.7590.56
54_F304_A0.7580.56
10_C156_L0.7580.56
83_I316_L0.7560.56
36_A89_L0.7550.55
18_I271_A0.7510.55
161_M257_R0.7480.55
119_P328_I0.7470.55
280_L289_M0.7470.55
272_I276_M0.7470.55
189_L213_A0.7440.54
176_F216_V0.7430.54
179_V216_V0.7420.54
196_V223_I0.7360.54
196_V313_D0.7350.53
74_L78_A0.7340.53
95_S147_V0.7330.53
143_Q236_Y0.7320.53
90_V209_I0.7270.53
243_I313_D0.7250.52
17_S317_I0.7210.52
129_A163_G0.7180.52
8_M40_F0.7180.52
246_G266_I0.7170.52
84_V204_S0.7170.52
111_N116_G0.7150.51
338_F341_T0.7150.51
212_L316_L0.7120.51
154_A294_A0.7100.51
121_G299_G0.7090.51
192_V195_T0.7080.51
61_L232_L0.7060.51
29_L317_I0.7060.51
84_V320_M0.7040.50
45_I96_A0.7030.50
88_L91_T0.7010.50
144_Y306_I0.7000.50
194_G197_G0.7000.50
290_T312_A0.7000.50
267_F283_F0.6990.50
302_T309_G0.6990.50
54_F87_I0.6980.50
262_I317_I0.6960.50
114_A262_I0.6960.50
94_S123_A0.6960.50
180_S229_E0.6950.49
12_L35_I0.6940.49
160_M326_F0.6910.49
124_A320_M0.6900.49
143_Q161_M0.6890.49
57_A61_L0.6890.49
221_Q224_T0.6850.48
141_F151_A0.6850.48
74_L101_L0.6840.48
332_G339_I0.6820.48
99_G133_G0.6780.48
7_G165_N0.6770.48
81_W299_G0.6710.47
311_N335_I0.6710.47
32_G243_I0.6710.47
125_M336_A0.6700.47
337_R340_S0.6700.47
69_L156_L0.6700.47
234_M272_I0.6650.46
25_L89_L0.6630.46
112_T121_G0.6600.46
316_L320_M0.6600.46
34_M68_N0.6570.46
66_A262_I0.6570.46
109_P133_G0.6540.45
12_L157_V0.6510.45
116_G124_A0.6490.45
147_V308_A0.6470.45
13_S303_V0.6470.45
63_C214_G0.6460.45
76_T79_V0.6450.44
154_A266_I0.6450.44
86_A264_L0.6440.44
175_W279_G0.6430.44
61_L84_V0.6410.44
243_I301_D0.6410.44
265_S277_A0.6410.44
97_I141_F0.6400.44
278_W281_T0.6370.44
31_L152_G0.6360.44
7_G282_R0.6350.43
242_R246_G0.6340.43
147_V319_A0.6330.43
23_V74_L0.6330.43
263_L337_R0.6330.43
59_A189_L0.6320.43
289_M310_S0.6300.43
292_Y310_S0.6300.43
75_T188_L0.6280.43
279_G282_R0.6270.43
124_A277_A0.6260.43
182_N267_F0.6250.42
56_A60_I0.6240.42
174_V234_M0.6240.42
147_V151_A0.6210.42
61_L242_R0.6200.42
29_L147_V0.6200.42
10_C79_V0.6170.42
9_L40_F0.6150.41
192_V199_L0.6140.41
152_G290_T0.6140.41
95_S328_I0.6130.41
212_L331_T0.6130.41
253_L256_L0.6110.41
19_G249_K0.6100.41
155_V302_T0.6100.41
83_I295_T0.6080.41
15_L339_I0.6060.41
274_A288_F0.6060.41
266_I270_L0.6050.40
32_G36_A0.6050.40
17_S33_P0.6050.40
151_A301_D0.6040.40
125_M270_L0.6040.40
48_Q263_L0.6030.40
121_G269_L0.6020.40
36_A39_I0.6020.40
147_V294_A0.6010.40
236_Y325_L0.6000.40
300_L322_T0.5990.40
95_S121_G0.5980.40
6_W53_A0.5960.40
291_A333_P0.5960.40
162_L165_N0.5950.40
79_V277_A0.5950.40
116_G219_S0.5940.39
69_L304_A0.5940.39
273_C328_I0.5910.39
41_S145_L0.5900.39
20_F202_L0.5900.39
28_A284_M0.5850.39
115_W124_A0.5850.39
134_A335_I0.5850.39
112_T205_G0.5830.38
92_L322_T0.5810.38
114_A332_G0.5810.38
301_D328_I0.5800.38
144_Y302_T0.5790.38
144_Y304_A0.5790.38
14_L43_R0.5770.38
280_L309_G0.5770.38
246_G327_S0.5770.38
95_S118_S0.5760.38
143_Q326_F0.5740.38
30_L140_A0.5730.37
19_G160_M0.5700.37
154_A242_R0.5700.37
58_Q290_T0.5690.37
262_I295_T0.5690.37
204_S300_L0.5680.37
242_R302_T0.5670.37
216_V268_A0.5670.37
16_L40_F0.5670.37
132_Y139_V0.5650.37
192_V234_M0.5630.36
75_T104_R0.5630.36
73_I265_S0.5620.36
171_Q188_L0.5610.36
252_L326_F0.5610.36
59_A158_T0.5610.36
23_V36_A0.5590.36
42_M148_L0.5540.36
57_A235_A0.5530.36
138_L207_M0.5530.36
127_A283_F0.5530.36
243_I333_P0.5520.35
7_G167_E0.5510.35
212_L339_I0.5500.35
95_S239_I0.5480.35
68_N141_F0.5470.35
23_V77_L0.5470.35
31_L295_T0.5470.35
115_W134_A0.5460.35
114_A336_A0.5450.35
24_H69_L0.5440.35
93_L215_A0.5440.35
25_L294_A0.5440.35
169_V201_R0.5430.35
86_A285_H0.5430.35
59_A243_I0.5420.35
42_M326_F0.5420.35
135_D197_G0.5410.34
87_I320_M0.5400.34
290_T321_Q0.5380.34
90_V95_S0.5380.34
52_S234_M0.5380.34
195_T205_G0.5380.34
315_A320_M0.5370.34
16_L37_G0.5360.34
92_L163_G0.5330.34
41_S207_M0.5330.34
99_G296_S0.5330.34
19_G279_G0.5320.34
210_P213_A0.5320.34
98_V119_P0.5320.34
85_L279_G0.5300.33
192_V198_C0.5300.33
31_L306_I0.5300.33
205_G329_L0.5300.33
276_M339_I0.5270.33
18_I79_V0.5260.33
35_I321_Q0.5250.33
128_M315_A0.5240.33
13_S318_M0.5220.33
115_W132_Y0.5220.33
66_A155_V0.5210.33
102_L305_V0.5210.33
68_N218_Q0.5200.33
206_T300_L0.5200.33
108_L277_A0.5190.32
121_G329_L0.5180.32
268_A279_G0.5150.32
138_L255_A0.5150.32
42_M191_V0.5140.32
207_M255_A0.5130.32
65_I200_L0.5120.32
234_M257_R0.5110.32
86_A250_Q0.5110.32
217_L296_S0.5090.32
262_I315_A0.5090.32
130_Q305_V0.5090.32
177_P264_L0.5080.32
47_L60_I0.5070.31
16_L25_L0.5070.31
77_L84_V0.5060.31
54_F204_S0.5050.31
119_P243_I0.5040.31
6_W271_A0.5030.31
302_T306_I0.5010.31
11_V271_A0.5010.31
59_A234_M0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.8305 97.8 0.902 Contact Map
4n7wA 2 0.8362 97.8 0.903 Contact Map
4bwzA 2 0.9569 97 0.916 Contact Map
4czbA 2 0.9684 94.9 0.93 Contact Map
4cz8A 2 0.9368 94 0.933 Contact Map
3rlbA 1 0.4397 36.7 0.961 Contact Map
1zcdA 1 0.4655 18.1 0.967 Contact Map
3tuiA 2 0.5862 15.8 0.967 Contact Map
4huqS 1 0.4655 9.5 0.97 Contact Map
1pw4A 1 0.8448 8 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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