ABRB - ECOLI - GREMLIN Contacts

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ABRB - Protein AbrB

UniProt:	P75747	Sequences: MPVLQWGMLCVLSLLLSIGFLAVHLPAALLLGPMIAGIIFSMRGITLQLPRSAFLAAQAILGCMIAQNLTGSILTTLAVNWPIVLAILLVTLLSSAIVGWLLVRYSSLPGNTGAWGSSPGGAAAMVAMAQDYGADIRLVAFMQYLRVLFVAGAAVLVTRMMLGDNAEAVNQHIVWFPPVSINLLLTILLAVVAGTVGCLLRLPSGTMLIPMLAGAVLQSGQLITIELPEWLLAMAYMAIGWRIGLGFDKQILLRALRPLPQILLSIFALLAICAGMAWGLTRFMHIDFMTAYLATSPGGLDTVAVIAAGSNADMALIMAMQTLRLFSILLTGPAIARFISTYAPKRSA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13310
Length:	348 (336)
Sequences:	1101 (882)
Seq/√Len:	48.1

ECOLI - ABRB
BACSU - YHJN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_A	139_V	5.012	1.00
197_G	202_L	4.771	1.00
17_S	29_L	3.949	1.00
83_I	320_M	3.939	1.00
275_G	279_G	3.690	1.00
9_L	37_G	3.399	1.00
236_Y	302_T	3.265	1.00
193_A	209_I	3.203	1.00
13_S	241_W	3.162	1.00
27_A	302_T	2.816	1.00
216_V	220_G	2.809	1.00
30_L	150_V	2.795	1.00
66_A	214_G	2.781	1.00
214_G	218_Q	2.748	1.00
134_A	139_V	2.726	1.00
16_L	33_P	2.672	1.00
195_T	199_L	2.588	1.00
193_A	197_G	2.572	1.00
109_P	112_T	2.378	1.00
34_M	243_I	2.292	1.00
18_I	22_A	2.277	1.00
307_A	317_I	2.256	1.00
125_M	332_G	2.237	1.00
124_A	236_Y	2.234	1.00
286_I	291_A	2.227	1.00
300_L	325_L	2.196	1.00
287_D	290_T	2.150	1.00
13_S	16_L	2.131	1.00
89_L	264_L	2.116	1.00
236_Y	301_D	2.103	1.00
121_G	236_Y	2.098	1.00
193_A	213_A	2.082	1.00
98_V	265_S	2.082	1.00
116_G	142_M	2.076	1.00
303_V	317_I	2.056	1.00
31_L	35_I	2.035	1.00
150_V	298_G	2.032	1.00
101_L	105_Y	2.003	0.99
17_S	237_M	1.882	0.99
90_V	321_Q	1.872	0.99
9_L	13_S	1.834	0.99
62_G	207_M	1.812	0.99
278_W	282_R	1.803	0.99
295_T	320_M	1.777	0.99
124_A	302_T	1.776	0.99
250_Q	321_Q	1.722	0.98
69_L	243_I	1.720	0.98
129_A	136_I	1.710	0.98
40_F	45_I	1.691	0.98
25_L	164_D	1.678	0.98
8_M	196_V	1.674	0.98
39_I	43_R	1.669	0.98
115_W	305_V	1.639	0.98
207_M	239_I	1.636	0.98
168_A	171_Q	1.622	0.98
27_A	236_Y	1.605	0.97
235_A	269_L	1.585	0.97
236_Y	305_V	1.584	0.97
100_W	235_A	1.577	0.97
64_M	205_G	1.574	0.97
192_V	216_V	1.574	0.97
234_M	263_L	1.568	0.97
195_T	198_C	1.542	0.97
287_D	294_A	1.542	0.97
302_T	305_V	1.520	0.96
121_G	302_T	1.515	0.96
122_A	296_S	1.509	0.96
87_I	91_T	1.494	0.96
337_R	341_T	1.482	0.96
281_T	288_F	1.472	0.96
314_M	317_I	1.470	0.96
103_V	110_G	1.462	0.96
313_D	333_P	1.430	0.95
12_L	40_F	1.430	0.95
30_L	316_L	1.415	0.95
20_F	31_L	1.395	0.94
68_N	314_M	1.393	0.94
16_L	20_F	1.388	0.94
155_V	236_Y	1.361	0.93
279_G	335_I	1.361	0.93
9_L	147_V	1.360	0.93
25_L	28_A	1.355	0.93
216_V	219_S	1.354	0.93
170_N	196_V	1.349	0.93
82_P	268_A	1.345	0.93
121_G	301_D	1.341	0.93
253_L	257_R	1.330	0.93
29_L	151_A	1.329	0.93
35_I	152_G	1.310	0.92
121_G	325_L	1.305	0.92
23_V	263_L	1.304	0.92
62_G	66_A	1.302	0.92
15_L	18_I	1.300	0.92
197_G	268_A	1.289	0.91
81_W	121_G	1.288	0.91
271_A	275_G	1.283	0.91
156_L	160_M	1.281	0.91
27_A	301_D	1.280	0.91
27_A	30_L	1.276	0.91
149_F	263_L	1.269	0.91
70_T	119_P	1.258	0.90
41_S	137_R	1.254	0.90
177_P	216_V	1.253	0.90
94_S	272_I	1.253	0.90
104_R	199_L	1.251	0.90
99_G	143_Q	1.241	0.90
184_L	188_L	1.238	0.90
125_M	328_I	1.237	0.90
115_W	336_A	1.234	0.90
202_L	209_I	1.231	0.89
112_T	134_A	1.226	0.89
284_M	291_A	1.226	0.89
80_N	83_I	1.223	0.89
142_M	147_V	1.217	0.89
140_A	312_A	1.205	0.88
130_Q	136_I	1.197	0.88
111_N	141_F	1.196	0.88
103_V	113_G	1.194	0.88
303_V	310_S	1.177	0.87
20_F	28_A	1.174	0.87
12_L	25_L	1.172	0.87
181_I	184_L	1.167	0.87
144_Y	292_Y	1.150	0.86
17_S	163_G	1.149	0.86
7_G	48_Q	1.147	0.86
95_S	317_I	1.145	0.86
27_A	129_A	1.143	0.86
188_L	275_G	1.140	0.85
58_Q	318_M	1.140	0.85
34_M	314_M	1.137	0.85
28_A	54_F	1.134	0.85
36_A	40_F	1.133	0.85
19_G	22_A	1.131	0.85
116_G	255_A	1.130	0.85
62_G	120_G	1.124	0.85
95_S	125_M	1.123	0.85
188_L	192_V	1.122	0.84
149_F	152_G	1.120	0.84
21_L	29_L	1.110	0.84
43_R	168_A	1.105	0.84
15_L	56_A	1.101	0.83
69_L	327_S	1.094	0.83
148_L	219_S	1.090	0.83
176_F	181_I	1.087	0.83
124_A	301_D	1.086	0.82
31_L	130_Q	1.085	0.82
13_S	33_P	1.083	0.82
29_L	302_T	1.082	0.82
20_F	35_I	1.082	0.82
13_S	37_G	1.078	0.82
63_C	202_L	1.077	0.82
116_G	154_A	1.074	0.82
99_G	295_T	1.069	0.81
281_T	306_I	1.063	0.81
17_S	21_L	1.061	0.81
149_F	270_L	1.057	0.81
93_L	263_L	1.055	0.81
106_S	261_Q	1.055	0.81
17_S	157_V	1.051	0.80
326_F	330_L	1.049	0.80
116_G	291_A	1.048	0.80
14_L	18_I	1.047	0.80
126_V	316_L	1.044	0.80
118_S	328_I	1.043	0.80
121_G	239_I	1.043	0.80
121_G	124_A	1.043	0.80
184_L	311_N	1.039	0.80
59_A	190_A	1.038	0.80
91_T	135_D	1.035	0.79
249_K	321_Q	1.033	0.79
131_D	234_M	1.016	0.78
321_Q	325_L	1.016	0.78
57_A	238_A	1.012	0.78
333_P	336_A	1.010	0.78
101_L	264_L	1.004	0.77
154_A	292_Y	1.002	0.77
90_V	143_Q	1.002	0.77
141_F	262_I	0.997	0.77
125_M	296_S	0.989	0.76
217_L	222_L	0.987	0.76
315_A	335_I	0.984	0.76
99_G	115_W	0.980	0.75
173_I	282_R	0.975	0.75
51_R	86_A	0.975	0.75
301_D	306_I	0.967	0.74
15_L	271_A	0.966	0.74
95_S	321_Q	0.962	0.74
15_L	282_R	0.958	0.74
50_P	86_A	0.956	0.74
141_F	251_I	0.955	0.74
240_G	244_G	0.952	0.73
58_Q	124_A	0.949	0.73
56_A	271_A	0.949	0.73
53_A	127_A	0.949	0.73
19_G	89_L	0.941	0.72
11_V	168_A	0.941	0.72
58_Q	300_L	0.935	0.72
191_V	195_T	0.933	0.72
278_W	283_F	0.931	0.72
145_L	259_L	0.925	0.71
66_A	236_Y	0.924	0.71
118_S	125_M	0.921	0.71
61_L	65_I	0.913	0.70
123_A	305_V	0.905	0.69
299_G	329_L	0.904	0.69
27_A	321_Q	0.897	0.69
35_I	222_L	0.892	0.68
97_I	234_M	0.890	0.68
87_I	114_A	0.890	0.68
267_F	271_A	0.887	0.68
202_L	215_A	0.885	0.68
115_W	247_F	0.883	0.68
112_T	116_G	0.883	0.68
84_V	317_I	0.882	0.67
143_Q	154_A	0.877	0.67
91_T	249_K	0.874	0.67
217_L	221_Q	0.874	0.67
91_T	204_S	0.874	0.67
46_T	187_I	0.872	0.67
204_S	308_A	0.870	0.66
80_N	316_L	0.868	0.66
207_M	299_G	0.865	0.66
9_L	16_L	0.848	0.64
85_L	216_V	0.848	0.64
75_T	268_A	0.847	0.64
59_A	194_G	0.842	0.64
25_L	85_L	0.842	0.64
6_W	9_L	0.840	0.64
99_G	103_V	0.840	0.64
256_L	260_P	0.839	0.64
61_L	261_Q	0.834	0.63
121_G	155_V	0.830	0.63
273_C	296_S	0.828	0.63
118_S	332_G	0.827	0.62
291_A	321_Q	0.822	0.62
47_L	245_L	0.815	0.61
50_P	143_Q	0.814	0.61
185_L	216_V	0.813	0.61
166_A	180_S	0.811	0.61
113_G	147_V	0.810	0.61
29_L	293_L	0.808	0.61
53_A	238_A	0.806	0.60
196_V	267_F	0.803	0.60
89_L	188_L	0.802	0.60
7_G	11_V	0.801	0.60
99_G	290_T	0.798	0.60
125_M	134_A	0.798	0.60
29_L	233_A	0.797	0.60
296_S	303_V	0.797	0.60
96_A	306_I	0.795	0.59
281_T	292_Y	0.792	0.59
52_S	216_V	0.788	0.59
187_I	191_V	0.787	0.59
14_L	24_H	0.785	0.58
85_L	326_F	0.785	0.58
147_V	301_D	0.785	0.58
24_H	202_L	0.783	0.58
26_P	240_G	0.780	0.58
36_A	101_L	0.779	0.58
144_Y	296_S	0.775	0.57
17_S	119_P	0.773	0.57
213_A	286_I	0.768	0.57
142_M	262_I	0.766	0.57
202_L	205_G	0.766	0.57
308_A	321_Q	0.763	0.56
255_A	315_A	0.760	0.56
215_A	219_S	0.760	0.56
78_A	82_P	0.759	0.56
80_N	320_M	0.759	0.56
54_F	304_A	0.758	0.56
10_C	156_L	0.758	0.56
83_I	316_L	0.756	0.56
36_A	89_L	0.755	0.55
18_I	271_A	0.751	0.55
161_M	257_R	0.748	0.55
119_P	328_I	0.747	0.55
280_L	289_M	0.747	0.55
272_I	276_M	0.747	0.55
189_L	213_A	0.744	0.54
176_F	216_V	0.743	0.54
179_V	216_V	0.742	0.54
196_V	223_I	0.736	0.54
196_V	313_D	0.735	0.53
74_L	78_A	0.734	0.53
95_S	147_V	0.733	0.53
143_Q	236_Y	0.732	0.53
90_V	209_I	0.727	0.53
243_I	313_D	0.725	0.52
17_S	317_I	0.721	0.52
129_A	163_G	0.718	0.52
8_M	40_F	0.718	0.52
246_G	266_I	0.717	0.52
84_V	204_S	0.717	0.52
111_N	116_G	0.715	0.51
338_F	341_T	0.715	0.51
212_L	316_L	0.712	0.51
154_A	294_A	0.710	0.51
121_G	299_G	0.709	0.51
192_V	195_T	0.708	0.51
61_L	232_L	0.706	0.51
29_L	317_I	0.706	0.51
84_V	320_M	0.704	0.50
45_I	96_A	0.703	0.50
88_L	91_T	0.701	0.50
144_Y	306_I	0.700	0.50
194_G	197_G	0.700	0.50
290_T	312_A	0.700	0.50
267_F	283_F	0.699	0.50
302_T	309_G	0.699	0.50
54_F	87_I	0.698	0.50
262_I	317_I	0.696	0.50
114_A	262_I	0.696	0.50
94_S	123_A	0.696	0.50
180_S	229_E	0.695	0.49
12_L	35_I	0.694	0.49
160_M	326_F	0.691	0.49
124_A	320_M	0.690	0.49
143_Q	161_M	0.689	0.49
57_A	61_L	0.689	0.49
221_Q	224_T	0.685	0.48
141_F	151_A	0.685	0.48
74_L	101_L	0.684	0.48
332_G	339_I	0.682	0.48
99_G	133_G	0.678	0.48
7_G	165_N	0.677	0.48
81_W	299_G	0.671	0.47
311_N	335_I	0.671	0.47
32_G	243_I	0.671	0.47
125_M	336_A	0.670	0.47
337_R	340_S	0.670	0.47
69_L	156_L	0.670	0.47
234_M	272_I	0.665	0.46
25_L	89_L	0.663	0.46
112_T	121_G	0.660	0.46
316_L	320_M	0.660	0.46
34_M	68_N	0.657	0.46
66_A	262_I	0.657	0.46
109_P	133_G	0.654	0.45
12_L	157_V	0.651	0.45
116_G	124_A	0.649	0.45
147_V	308_A	0.647	0.45
13_S	303_V	0.647	0.45
63_C	214_G	0.646	0.45
76_T	79_V	0.645	0.44
154_A	266_I	0.645	0.44
86_A	264_L	0.644	0.44
175_W	279_G	0.643	0.44
61_L	84_V	0.641	0.44
243_I	301_D	0.641	0.44
265_S	277_A	0.641	0.44
97_I	141_F	0.640	0.44
278_W	281_T	0.637	0.44
31_L	152_G	0.636	0.44
7_G	282_R	0.635	0.43
242_R	246_G	0.634	0.43
147_V	319_A	0.633	0.43
23_V	74_L	0.633	0.43
263_L	337_R	0.633	0.43
59_A	189_L	0.632	0.43
289_M	310_S	0.630	0.43
292_Y	310_S	0.630	0.43
75_T	188_L	0.628	0.43
279_G	282_R	0.627	0.43
124_A	277_A	0.626	0.43
182_N	267_F	0.625	0.42
56_A	60_I	0.624	0.42
174_V	234_M	0.624	0.42
147_V	151_A	0.621	0.42
61_L	242_R	0.620	0.42
29_L	147_V	0.620	0.42
10_C	79_V	0.617	0.42
9_L	40_F	0.615	0.41
192_V	199_L	0.614	0.41
152_G	290_T	0.614	0.41
95_S	328_I	0.613	0.41
212_L	331_T	0.613	0.41
253_L	256_L	0.611	0.41
19_G	249_K	0.610	0.41
155_V	302_T	0.610	0.41
83_I	295_T	0.608	0.41
15_L	339_I	0.606	0.41
274_A	288_F	0.606	0.41
266_I	270_L	0.605	0.40
32_G	36_A	0.605	0.40
17_S	33_P	0.605	0.40
151_A	301_D	0.604	0.40
125_M	270_L	0.604	0.40
48_Q	263_L	0.603	0.40
121_G	269_L	0.602	0.40
36_A	39_I	0.602	0.40
147_V	294_A	0.601	0.40
236_Y	325_L	0.600	0.40
300_L	322_T	0.599	0.40
95_S	121_G	0.598	0.40
6_W	53_A	0.596	0.40
291_A	333_P	0.596	0.40
162_L	165_N	0.595	0.40
79_V	277_A	0.595	0.40
116_G	219_S	0.594	0.39
69_L	304_A	0.594	0.39
273_C	328_I	0.591	0.39
41_S	145_L	0.590	0.39
20_F	202_L	0.590	0.39
28_A	284_M	0.585	0.39
115_W	124_A	0.585	0.39
134_A	335_I	0.585	0.39
112_T	205_G	0.583	0.38
92_L	322_T	0.581	0.38
114_A	332_G	0.581	0.38
301_D	328_I	0.580	0.38
144_Y	302_T	0.579	0.38
144_Y	304_A	0.579	0.38
14_L	43_R	0.577	0.38
280_L	309_G	0.577	0.38
246_G	327_S	0.577	0.38
95_S	118_S	0.576	0.38
143_Q	326_F	0.574	0.38
30_L	140_A	0.573	0.37
19_G	160_M	0.570	0.37
154_A	242_R	0.570	0.37
58_Q	290_T	0.569	0.37
262_I	295_T	0.569	0.37
204_S	300_L	0.568	0.37
242_R	302_T	0.567	0.37
216_V	268_A	0.567	0.37
16_L	40_F	0.567	0.37
132_Y	139_V	0.565	0.37
192_V	234_M	0.563	0.36
75_T	104_R	0.563	0.36
73_I	265_S	0.562	0.36
171_Q	188_L	0.561	0.36
252_L	326_F	0.561	0.36
59_A	158_T	0.561	0.36
23_V	36_A	0.559	0.36
42_M	148_L	0.554	0.36
57_A	235_A	0.553	0.36
138_L	207_M	0.553	0.36
127_A	283_F	0.553	0.36
243_I	333_P	0.552	0.35
7_G	167_E	0.551	0.35
212_L	339_I	0.550	0.35
95_S	239_I	0.548	0.35
68_N	141_F	0.547	0.35
23_V	77_L	0.547	0.35
31_L	295_T	0.547	0.35
115_W	134_A	0.546	0.35
114_A	336_A	0.545	0.35
24_H	69_L	0.544	0.35
93_L	215_A	0.544	0.35
25_L	294_A	0.544	0.35
169_V	201_R	0.543	0.35
86_A	285_H	0.543	0.35
59_A	243_I	0.542	0.35
42_M	326_F	0.542	0.35
135_D	197_G	0.541	0.34
87_I	320_M	0.540	0.34
290_T	321_Q	0.538	0.34
90_V	95_S	0.538	0.34
52_S	234_M	0.538	0.34
195_T	205_G	0.538	0.34
315_A	320_M	0.537	0.34
16_L	37_G	0.536	0.34
92_L	163_G	0.533	0.34
41_S	207_M	0.533	0.34
99_G	296_S	0.533	0.34
19_G	279_G	0.532	0.34
210_P	213_A	0.532	0.34
98_V	119_P	0.532	0.34
85_L	279_G	0.530	0.33
192_V	198_C	0.530	0.33
31_L	306_I	0.530	0.33
205_G	329_L	0.530	0.33
276_M	339_I	0.527	0.33
18_I	79_V	0.526	0.33
35_I	321_Q	0.525	0.33
128_M	315_A	0.524	0.33
13_S	318_M	0.522	0.33
115_W	132_Y	0.522	0.33
66_A	155_V	0.521	0.33
102_L	305_V	0.521	0.33
68_N	218_Q	0.520	0.33
206_T	300_L	0.520	0.33
108_L	277_A	0.519	0.32
121_G	329_L	0.518	0.32
268_A	279_G	0.515	0.32
138_L	255_A	0.515	0.32
42_M	191_V	0.514	0.32
207_M	255_A	0.513	0.32
65_I	200_L	0.512	0.32
234_M	257_R	0.511	0.32
86_A	250_Q	0.511	0.32
217_L	296_S	0.509	0.32
262_I	315_A	0.509	0.32
130_Q	305_V	0.509	0.32
177_P	264_L	0.508	0.32
47_L	60_I	0.507	0.31
16_L	25_L	0.507	0.31
77_L	84_V	0.506	0.31
54_F	204_S	0.505	0.31
119_P	243_I	0.504	0.31
6_W	271_A	0.503	0.31
302_T	306_I	0.501	0.31
11_V	271_A	0.501	0.31
59_A	234_M	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zuxA	1	0.8305	97.8	0.902	Contact Map
4n7wA	2	0.8362	97.8	0.903	Contact Map
4bwzA	2	0.9569	97	0.916	Contact Map
4czbA	2	0.9684	94.9	0.93	Contact Map
4cz8A	2	0.9368	94	0.933	Contact Map
3rlbA	1	0.4397	36.7	0.961	Contact Map
1zcdA	1	0.4655	18.1	0.967	Contact Map
3tuiA	2	0.5862	15.8	0.967	Contact Map
4huqS	1	0.4655	9.5	0.97	Contact Map
1pw4A	1	0.8448	8	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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