GREMLIN Database
DTPD - Dipeptide permease D
UniProt: P75742 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13304
Length: 493 (463)
Sequences: 4697 (2986)
Seq/√Len: 138.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_A173_L4.1131.00
361_I386_V3.4031.00
363_T461_Q3.3811.00
280_F390_A3.3081.00
68_L73_L3.2991.00
460_D463_T3.2751.00
73_L78_A3.2411.00
313_F377_L3.2111.00
44_D297_R3.1671.00
350_L393_F2.9931.00
88_I109_I2.9011.00
301_R307_T2.8811.00
68_L72_V2.6691.00
320_A385_A2.6221.00
92_V106_S2.5471.00
398_A418_Y2.5151.00
92_V109_I2.4881.00
473_V477_W2.4861.00
162_Q311_A2.4811.00
460_D464_W2.4691.00
381_V385_A2.4261.00
302_D307_T2.4201.00
24_S90_H2.3941.00
73_L81_L2.3791.00
34_L292_S2.3591.00
87_A179_I2.3551.00
82_G116_L2.3481.00
292_S295_I2.3411.00
295_I380_M2.3191.00
459_F463_T2.3141.00
18_Q22_Y2.2491.00
84_L88_I2.2461.00
327_F331_V2.2371.00
343_R346_G2.2081.00
51_F288_G2.2051.00
354_L389_F2.2051.00
290_S295_I2.1801.00
193_T196_R2.1191.00
163_E310_T2.0951.00
334_E338_G2.0881.00
459_F462_I2.0551.00
261_Q265_K2.0521.00
80_M186_L2.0471.00
21_E118_K2.0451.00
204_R207_N2.0401.00
140_F403_T2.0351.00
93_L106_S2.0141.00
25_F55_C1.9921.00
76_R189_N1.9901.00
324_C389_F1.9731.00
281_W395_D1.9451.00
361_I382_L1.9401.00
94_G175_A1.9231.00
33_I37_T1.9191.00
353_G472_L1.9141.00
18_Q21_E1.8951.00
200_K203_L1.8941.00
208_F212_N1.8811.00
316_I381_V1.8461.00
62_P69_A1.8191.00
61_T64_L1.7971.00
472_L476_I1.7681.00
125_L139_G1.7281.00
228_T231_F1.7161.00
469_C473_V1.6941.00
327_F330_W1.6831.00
331_V335_S1.6801.00
101_S105_L1.6721.00
18_Q118_K1.6681.00
42_Y50_L1.6651.00
474_L478_L1.6551.00
323_L327_F1.6451.00
44_D293_L1.6431.00
145_A322_M1.6331.00
368_W371_M1.6281.00
86_M117_F1.6261.00
166_S169_M1.6221.00
353_G357_A1.6171.00
317_N388_G1.6091.00
196_R201_K1.5851.00
250_V254_I1.5771.00
250_V253_K1.5591.00
309_P312_M1.5491.00
61_T111_V1.5471.00
360_C464_W1.5421.00
196_R199_N1.5391.00
461_Q464_W1.5291.00
251_L254_I1.5281.00
242_V246_I1.5171.00
91_V175_A1.5141.00
189_N194_H1.5031.00
122_S419_M1.5011.00
89_G110_I1.4971.00
38_N167_W1.4951.00
212_N216_L1.4891.00
199_N207_N1.4851.00
152_I322_M1.4781.00
34_L310_T1.4581.00
253_K256_R1.4551.00
357_A386_V1.4381.00
317_N321_V1.4371.00
277_S422_S1.4251.00
143_M147_G1.4251.00
256_R259_E1.4191.00
159_G311_A1.4121.00
43_N46_H1.4091.00
203_L207_N1.4081.00
169_M172_G1.4051.00
302_D305_G1.4041.00
480_Q483_K1.3981.00
358_G387_M1.3961.00
239_A242_V1.3931.00
376_S379_L1.3871.00
227_I231_F1.3841.00
282_A426_A1.3841.00
468_A472_L1.3831.00
465_G470_V1.3821.00
211_P215_W1.3801.00
36_L51_F1.3781.00
235_W238_Y1.3581.00
100_P104_Y1.3571.00
301_R310_T1.3561.00
335_S340_R1.3551.00
19_I146_A1.3551.00
330_W334_E1.3531.00
145_A325_G1.3471.00
229_I232_W1.3451.00
202_V206_T1.3431.00
237_V240_L1.3361.00
262_K265_K1.3361.00
211_P214_G1.3311.00
161_A165_Y1.3291.00
375_S379_L1.3191.00
176_V180_A1.2981.00
362_L383_G1.2971.00
367_R371_M1.2941.00
356_S469_C1.2921.00
459_F464_W1.2891.00
320_A388_G1.2861.00
87_A91_V1.2851.00
292_S296_D1.2811.00
158_C161_A1.2711.00
106_S110_I1.2701.00
198_V201_K1.2591.00
462_I465_G1.2571.00
49_E435_D1.2551.00
13_Y188_G1.2481.00
35_Y96_S1.2461.00
33_I47_A1.2421.00
284_A287_G1.2381.00
27_G158_C1.2311.00
366_A369_S1.2301.00
206_T210_L1.2261.00
127_E403_T1.2241.00
89_G93_L1.2221.00
472_L475_M1.2221.00
442_F445_S1.2211.00
279_L471_G1.2141.00
354_L390_A1.2011.00
321_V391_E1.2011.00
204_R208_F1.2011.00
201_K206_T1.1961.00
144_Y391_E1.1941.00
298_F374_H1.1901.00
65_G115_G1.1901.00
33_I293_L1.1871.00
148_N317_N1.1841.00
81_L84_L1.1811.00
22_Y118_K1.1801.00
480_Q484_F1.1761.00
114_Y118_K1.1740.99
89_G113_G1.1710.99
157_A173_L1.1710.99
412_G416_G1.1680.99
207_N260_N1.1640.99
19_I149_V1.1520.99
342_V350_L1.1510.99
114_Y117_F1.1490.99
183_V187_C1.1440.99
395_D399_M1.1420.99
236_S240_L1.1390.99
159_G312_M1.1380.99
224_P229_I1.1320.99
462_I467_L1.1290.99
36_L103_L1.1290.99
225_A228_T1.1240.99
477_W481_A1.1170.99
210_L214_G1.1170.99
147_G419_M1.1150.99
137_D400_S1.1150.99
385_A389_F1.1140.99
243_A246_I1.1090.99
247_G251_L1.1080.99
18_Q143_M1.1060.99
301_R309_P1.1050.99
214_G218_V1.1030.99
348_F394_I1.1010.99
129_Y139_G1.1010.99
290_S294_Y1.0990.99
118_K419_M1.0960.99
199_N203_L1.0930.99
365_S379_L1.0900.99
87_A182_L1.0880.99
75_N127_E1.0870.99
86_M114_Y1.0860.99
42_Y100_P1.0820.99
20_W177_G1.0820.99
478_L481_A1.0750.99
240_L243_A1.0680.99
207_N211_P1.0650.99
201_K207_N1.0640.99
122_S143_M1.0630.99
224_P228_T1.0620.99
468_A475_M1.0590.99
151_S318_A1.0570.99
58_V61_T1.0560.99
221_V226_L1.0550.99
200_K208_F1.0550.99
96_S102_F1.0540.99
21_E26_Y1.0510.99
314_Q318_A1.0510.99
22_Y25_F1.0500.99
306_Y312_M1.0500.99
251_L255_Y1.0480.99
241_I245_I1.0460.99
35_Y103_L1.0450.99
203_L212_N1.0420.99
243_A247_G1.0410.99
328_L331_V1.0370.99
218_V222_A1.0350.99
237_V241_I1.0340.99
73_L77_M1.0340.99
238_Y241_I1.0320.99
349_A476_I1.0310.99
223_T227_I1.0270.99
66_G412_G1.0260.99
356_S360_C1.0210.99
259_E263_Q1.0180.99
144_Y321_V1.0170.99
29_R51_F1.0160.99
7_Q11_I1.0150.99
287_G387_M1.0120.98
18_Q117_F1.0120.98
194_H197_G1.0100.98
68_L78_A1.0080.98
29_R285_Q1.0070.98
227_I230_L1.0050.98
202_V205_A1.0040.98
43_N47_A1.0010.98
255_Y259_E0.9970.98
291_I295_I0.9950.98
156_I312_M0.9890.98
208_F261_Q0.9870.98
231_F235_W0.9850.98
122_S415_T0.9840.98
147_G399_M0.9780.98
282_A429_L0.9770.98
349_A472_L0.9750.98
58_V111_V0.9720.98
235_W240_L0.9710.98
172_G176_V0.9710.98
187_C190_R0.9710.98
226_L231_F0.9700.98
346_G479_Y0.9650.98
38_N163_E0.9650.98
22_Y26_Y0.9650.98
125_L128_L0.9610.98
37_T293_L0.9590.98
226_L229_I0.9580.98
49_E431_G0.9530.98
144_Y148_N0.9500.98
247_G250_V0.9440.98
126_G403_T0.9430.98
223_T229_I0.9400.98
470_V473_V0.9360.98
256_R260_N0.9320.97
160_Y165_Y0.9310.97
356_S472_L0.9300.97
229_I233_K0.9300.97
61_T115_G0.9260.97
470_V477_W0.9240.97
395_D418_Y0.9230.97
221_V227_I0.9230.97
246_I250_V0.9230.97
218_V243_A0.9210.97
42_Y46_H0.9200.97
228_T233_K0.9170.97
299_V380_M0.9170.97
209_L212_N0.9150.97
351_G394_I0.9150.97
468_A471_G0.9140.97
469_C472_L0.9130.97
52_S430_A0.9130.97
364_L368_W0.9130.97
215_W218_V0.9130.97
291_I383_G0.9110.97
200_K210_L0.9110.97
472_L480_Q0.9050.97
436_Q440_A0.9050.97
287_G391_E0.9030.97
321_V326_V0.9030.97
199_N202_V0.9020.97
325_G396_P0.9000.97
461_Q465_G0.9000.97
215_W255_Y0.8970.97
215_W222_A0.8950.97
244_T247_G0.8890.97
284_A388_G0.8890.97
224_P227_I0.8880.97
207_N210_L0.8870.97
37_T44_D0.8870.97
59_Y118_K0.8860.97
277_S418_Y0.8840.96
66_G416_G0.8840.96
34_L38_N0.8820.96
212_N215_W0.8800.96
239_A243_A0.8800.96
208_F211_P0.8760.96
295_I299_V0.8740.96
330_W333_K0.8690.96
300_N374_H0.8690.96
15_V146_A0.8680.96
172_G175_A0.8600.96
335_S342_V0.8580.96
223_T226_L0.8580.96
160_Y164_E0.8560.96
395_D398_A0.8560.96
117_F121_V0.8540.96
88_I92_V0.8530.96
475_M479_Y0.8520.96
122_S399_M0.8500.96
324_C392_L0.8500.96
324_C327_F0.8490.96
153_I156_I0.8490.96
20_W23_F0.8480.96
246_I249_G0.8480.96
50_L104_Y0.8470.96
333_K336_V0.8460.95
143_M399_M0.8440.95
320_A381_V0.8440.95
280_F321_V0.8440.95
245_I248_L0.8410.95
325_G329_A0.8410.95
328_L389_F0.8400.95
20_W121_V0.8370.95
334_E337_A0.8340.95
283_F468_A0.8330.95
308_V377_L0.8310.95
391_E395_D0.8310.95
8_P11_I0.8280.95
249_G253_K0.8260.95
200_K207_N0.8250.95
168_A172_G0.8250.95
253_K257_K0.8240.95
59_Y419_M0.8210.95
357_A361_I0.8160.95
205_A208_F0.8140.94
206_T209_L0.8140.94
227_I233_K0.8070.94
19_I147_G0.8070.94
122_S147_G0.8020.94
46_H49_E0.8010.94
284_A395_D0.7990.94
224_P230_L0.7990.94
209_L213_W0.7980.94
57_L428_Y0.7970.94
238_Y247_G0.7960.94
63_I416_G0.7950.94
208_F215_W0.7950.94
336_V341_T0.7930.94
335_S338_G0.7930.94
80_M83_A0.7910.94
94_G172_G0.7890.93
21_E178_M0.7880.93
308_V312_M0.7880.93
354_L386_V0.7840.93
324_C385_A0.7840.93
349_A475_M0.7810.93
85_L112_C0.7800.93
463_T468_A0.7800.93
316_I320_A0.7780.93
87_A175_A0.7750.93
400_S404_R0.7740.93
213_W216_L0.7700.93
336_V339_N0.7700.93
348_F398_A0.7690.93
217_L220_L0.7680.93
138_G329_A0.7680.93
193_T197_G0.7660.92
22_Y147_G0.7640.92
284_A317_N0.7620.92
212_N261_Q0.7600.92
401_Q482_L0.7600.92
232_W237_V0.7600.92
283_F387_M0.7590.92
254_I267_L0.7590.92
467_L471_G0.7580.92
152_I318_A0.7570.92
163_E311_A0.7540.92
429_L432_V0.7530.92
273_L348_F0.7470.91
362_L365_S0.7470.91
201_K208_F0.7470.91
283_F355_M0.7450.91
432_V436_Q0.7420.91
21_E25_F0.7390.91
143_M391_E0.7370.91
346_G349_A0.7360.91
274_T402_I0.7350.91
291_I384_L0.7300.91
225_A229_I0.7290.90
239_A246_I0.7280.90
345_W479_Y0.7270.90
31_L170_G0.7260.90
285_Q427_N0.7260.90
361_I383_G0.7250.90
332_V336_V0.7250.90
121_V147_G0.7230.90
33_I48_Y0.7230.90
437_T462_I0.7220.90
285_Q423_G0.7220.90
437_T441_S0.7220.90
70_D74_G0.7200.90
426_A429_L0.7180.90
228_T232_W0.7170.90
98_I102_F0.7170.90
280_F394_I0.7160.90
126_G140_F0.7150.90
287_G358_G0.7120.89
48_Y293_L0.7060.89
37_T296_D0.7060.89
159_G162_Q0.7050.89
90_H178_M0.7040.89
287_G384_L0.7040.89
204_R212_N0.7030.89
157_A160_Y0.7020.89
238_Y242_V0.7020.89
317_N391_E0.7020.89
162_Q167_W0.7020.89
408_P411_T0.7000.89
273_L401_Q0.7000.89
143_M406_E0.6990.89
270_I402_I0.6990.89
248_L251_L0.6990.89
370_A373_G0.6980.88
278_M426_A0.6980.88
363_T366_A0.6970.88
34_L297_R0.6960.88
236_S239_A0.6960.88
67_F72_V0.6950.88
155_P315_S0.6940.88
338_G341_T0.6930.88
299_V377_L0.6920.88
200_K206_T0.6910.88
79_V185_F0.6890.88
281_W284_A0.6870.88
230_L235_W0.6860.88
80_M182_L0.6860.88
444_A470_V0.6850.88
48_Y437_T0.6850.88
121_V124_L0.6840.87
185_F189_N0.6840.87
78_A116_L0.6830.87
18_Q147_G0.6820.87
77_M81_L0.6770.87
198_V202_V0.6750.87
209_L228_T0.6720.87
160_Y311_A0.6720.87
249_G256_R0.6710.86
63_I67_F0.6700.86
127_E411_T0.6690.86
288_G292_S0.6680.86
34_L37_T0.6670.86
230_L233_K0.6660.86
55_C58_V0.6660.86
287_G317_N0.6650.86
162_Q165_Y0.6640.86
140_F273_L0.6630.86
90_H94_G0.6630.86
13_Y191_H0.6610.86
202_V208_F0.6600.86
301_R377_L0.6600.86
21_E286_Q0.6590.85
238_Y244_T0.6570.85
224_P231_F0.6570.85
199_N206_T0.6560.85
230_L236_S0.6560.85
119_S123_C0.6540.85
65_G129_Y0.6530.85
7_Q129_Y0.6530.85
476_I479_Y0.6520.85
334_E339_N0.6520.85
33_I292_S0.6500.85
156_I315_S0.6500.85
221_V228_T0.6490.85
355_M358_G0.6480.85
18_Q27_G0.6470.84
473_V476_I0.6460.84
83_A178_M0.6450.84
239_A323_L0.6450.84
58_V120_N0.6450.84
144_Y317_N0.6440.84
473_V481_A0.6430.84
64_L426_A0.6420.84
25_F118_K0.6420.84
215_W219_L0.6410.84
409_G416_G0.6400.84
120_N412_G0.6400.84
193_T199_N0.6370.83
122_S395_D0.6360.83
433_I462_I0.6350.83
31_L36_L0.6340.83
80_M84_L0.6330.83
117_F120_N0.6330.83
148_N151_S0.6330.83
332_V341_T0.6320.83
140_F406_E0.6320.83
152_I319_F0.6320.83
282_A433_I0.6320.83
15_V19_I0.6310.83
226_L230_L0.6300.83
471_G474_L0.6270.83
148_N395_D0.6260.82
142_L145_A0.6260.82
336_V340_R0.6250.82
94_G182_L0.6250.82
212_N241_I0.6250.82
35_Y329_A0.6240.82
472_L477_W0.6240.82
42_Y104_Y0.6230.82
479_Y482_L0.6230.82
224_P232_W0.6220.82
337_A340_R0.6210.82
123_C415_T0.6200.82
293_L296_D0.6190.82
434_A437_T0.6190.82
148_N318_A0.6190.82
363_T367_R0.6180.82
69_A79_V0.6180.82
328_L392_L0.6170.82
474_L477_W0.6170.82
293_L297_R0.6160.81
9_R12_Y0.6140.81
242_V247_G0.6140.81
57_L111_V0.6130.81
169_M174_A0.6130.81
212_N231_F0.6120.81
290_S293_L0.6110.81
59_Y148_N0.6110.81
207_N212_N0.6100.81
212_N217_L0.6080.81
349_A353_G0.6070.80
7_Q10_A0.6060.80
219_L222_A0.6050.80
148_N391_E0.6040.80
223_T228_T0.6030.80
249_G252_A0.6030.80
120_N174_A0.5960.79
24_S114_Y0.5960.79
365_S375_S0.5950.79
30_A155_P0.5940.79
60_V427_N0.5930.79
22_Y114_Y0.5930.79
286_Q290_S0.5910.79
87_A145_A0.5910.79
24_S28_M0.5910.79
280_F317_N0.5900.79
461_Q475_M0.5900.79
253_K258_A0.5890.78
91_V95_A0.5870.78
141_S329_A0.5850.78
203_L206_T0.5850.78
83_A174_A0.5840.78
217_L223_T0.5810.78
12_Y16_A0.5800.77
163_E309_P0.5790.77
162_Q166_S0.5770.77
54_Y58_V0.5770.77
21_E27_G0.5770.77
117_F122_S0.5760.77
432_V435_D0.5760.77
31_L44_D0.5750.77
56_S428_Y0.5750.77
23_F156_I0.5740.77
363_T463_T0.5730.77
130_E193_T0.5700.76
124_L128_L0.5700.76
260_N263_Q0.5700.76
249_G254_I0.5690.76
60_V426_A0.5680.76
68_L116_L0.5670.76
144_Y147_G0.5660.76
372_Y375_S0.5660.76
217_L221_V0.5650.76
216_L221_V0.5650.76
351_G390_A0.5640.75
144_Y314_Q0.5640.75
22_Y27_G0.5640.75
216_L219_L0.5640.75
52_S431_G0.5630.75
281_W426_A0.5630.75
218_V221_V0.5620.75
10_A13_Y0.5620.75
186_L189_N0.5620.75
258_A262_K0.5620.75
441_S444_A0.5610.75
265_K268_G0.5590.75
86_M110_I0.5590.75
90_H175_A0.5590.75
226_L232_W0.5590.75
117_F143_M0.5580.75
50_L108_A0.5570.75
157_A161_A0.5560.74
475_M482_L0.5550.74
207_N253_K0.5530.74
59_Y317_N0.5520.74
220_L224_P0.5520.74
283_F463_T0.5510.74
477_W480_Q0.5510.74
25_F29_R0.5510.74
471_G475_M0.5500.74
439_Q443_D0.5490.73
236_S243_A0.5490.73
239_A247_G0.5490.73
97_E100_P0.5480.73
319_F323_L0.5440.73
205_A264_R0.5430.73
85_L106_S0.5420.73
18_Q26_Y0.5410.72
227_I232_W0.5400.72
18_Q25_F0.5400.72
49_E52_S0.5390.72
22_Y143_M0.5390.72
306_Y309_P0.5370.72
145_A326_V0.5370.72
317_N387_M0.5370.72
199_N208_F0.5360.72
49_E53_A0.5350.72
288_G387_M0.5350.72
104_Y108_A0.5350.72
35_Y97_E0.5350.72
81_L186_L0.5340.71
242_V259_E0.5330.71
436_Q439_Q0.5330.71
378_P382_L0.5330.71
27_G74_G0.5330.71
394_I418_Y0.5320.71
250_V255_Y0.5310.71
344_I426_A0.5290.71
283_F362_L0.5290.71
279_L282_A0.5280.71
350_L354_L0.5280.71
201_K204_R0.5270.70
225_A230_L0.5270.70
74_G78_A0.5260.70
293_L314_Q0.5260.70
165_Y309_P0.5260.70
188_G192_F0.5250.70
154_A313_F0.5240.70
88_I164_E0.5230.70
111_V426_A0.5230.70
21_E117_F0.5230.70
127_E195_T0.5230.70
321_V325_G0.5220.70
23_F177_G0.5190.69
354_L393_F0.5190.69
209_L215_W0.5180.69
294_Y299_V0.5180.69
360_C363_T0.5180.69
40_L460_D0.5180.69
129_Y484_F0.5170.69
301_R313_F0.5170.69
217_L222_A0.5170.69
270_I277_S0.5160.69
332_V339_N0.5150.69
213_W271_V0.5140.69
391_E398_A0.5130.68
22_Y178_M0.5120.68
167_W171_F0.5120.68
351_G355_M0.5110.68
225_A231_F0.5100.68
26_Y318_A0.5100.68
223_T232_W0.5090.68
286_Q359_F0.5080.68
10_A14_V0.5070.68
86_M90_H0.5060.67
365_S383_G0.5050.67
276_F352_L0.5050.67
38_N296_D0.5050.67
137_D347_K0.5040.67
188_G191_H0.5020.67
118_K122_S0.5020.67
200_K212_N0.5010.67
65_G120_N0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oh3A 2 0.9655 100 0.52 Contact Map
4uvmA 1 0.9635 100 0.531 Contact Map
4q65A 1 0.8783 100 0.585 Contact Map
4tphA 2 0.8844 100 0.635 Contact Map
4ikvA 1 0.9432 100 0.64 Contact Map
4xnjA 1 0.9148 100 0.654 Contact Map
4w6vA 1 0.931 100 0.74 Contact Map
3wdoA 1 0.8093 99.9 0.776 Contact Map
2cfqA 1 0.8256 99.9 0.776 Contact Map
1pw4A 1 0.8256 99.9 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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