GREMLIN Database
YBFL - Putative protein YbfL
UniProt: P75741 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13417
Length: 378 (354)
Sequences: 502 (429)
Seq/√Len: 22.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_V206_F5.7381.00
265_S282_R4.4481.00
181_A193_F3.8591.00
152_I177_Q3.6971.00
160_N183_K3.4581.00
183_K187_Q3.3641.00
18_Q21_K3.1791.00
49_D356_R3.1191.00
149_S154_A2.9050.99
73_T76_R2.8390.99
238_H261_C2.8150.99
261_C295_F2.7960.99
168_I288_A2.7720.99
324_I333_F2.5090.98
171_T175_G2.4640.98
261_C286_S2.4580.98
259_K286_S2.4300.98
155_I175_G2.4280.98
32_L64_F2.4090.98
104_D133_S2.3820.98
18_Q22_V2.3030.97
197_G203_N2.2870.97
237_L264_V2.2820.97
25_K28_G2.2690.97
261_C299_I2.2540.97
33_T74_I2.2430.97
14_P85_K2.2280.96
318_N321_D2.2120.96
105_V170_T2.1880.96
185_Q256_G2.1870.96
42_E358_M2.1760.96
155_I180_I2.1540.96
194_A282_R2.0750.95
195_V200_G2.0690.95
155_I171_T2.0370.94
19_A22_V2.0340.94
190_D287_S2.0030.93
175_G180_I1.9860.93
168_I192_L1.9770.93
55_L59_K1.9380.92
128_V338_H1.9310.92
32_L55_L1.9230.92
33_T336_I1.9120.92
156_P180_I1.8860.91
239_I262_V1.8800.91
184_I189_G1.8740.91
112_T127_H1.7880.89
238_H263_A1.7810.89
48_E52_E1.7760.88
64_F67_G1.7680.88
54_H365_R1.7660.88
13_I89_C1.7600.88
139_V338_H1.7580.88
38_I340_A1.7390.87
165_K188_G1.7390.87
74_I78_V1.7350.87
264_V281_V1.7200.87
238_H296_A1.7190.87
149_S174_M1.6930.86
312_R345_T1.6860.86
116_S125_A1.6780.85
115_H321_D1.6720.85
347_D370_S1.6660.85
322_C333_F1.6590.85
150_N174_M1.6450.84
317_M358_M1.6410.84
29_I77_V1.6290.84
126_I144_K1.6210.83
71_H75_A1.6090.83
106_I131_A1.5970.82
13_I30_L1.5880.82
10_I89_C1.5840.82
316_V353_G1.5770.81
347_D371_V1.5640.81
32_L51_G1.5490.80
170_T302_H1.5430.80
6_L10_I1.5420.80
238_H292_A1.5340.80
24_H76_R1.5190.79
182_E186_K1.5170.79
53_T363_M1.5070.78
149_S152_I1.4900.78
131_A158_L1.4820.77
36_A41_A1.4760.77
347_D367_Y1.4620.76
48_E68_I1.4590.76
288_A295_F1.4370.75
106_I189_G1.4150.74
195_V285_I1.4120.74
137_S345_T1.4110.74
176_C282_R1.4080.73
156_P175_G1.4080.73
6_L30_L1.4060.73
156_P171_T1.4040.73
75_A324_I1.4030.73
203_N207_E1.4010.73
156_P174_M1.3930.73
55_L64_F1.3730.71
33_T78_V1.3690.71
13_I66_N1.3580.71
113_L334_S1.3490.70
357_K367_Y1.3370.69
46_D355_R1.3260.69
146_D149_S1.3250.69
130_S305_V1.3180.68
111_K319_E1.3060.68
238_H295_F1.3010.67
46_D359_R1.2980.67
42_E355_R1.2660.65
171_T174_M1.2660.65
171_T193_F1.2600.65
353_G367_Y1.2570.64
355_R359_R1.2560.64
144_K331_E1.2550.64
313_L338_H1.2540.64
195_V202_L1.2520.64
182_E255_K1.2480.64
145_T149_S1.2430.64
334_S338_H1.2390.63
139_V309_L1.2350.63
224_A237_L1.2230.62
87_H91_I1.2220.62
166_G188_G1.2120.62
304_H308_K1.2110.62
261_C288_A1.2100.61
130_S338_H1.2040.61
319_E337_R1.2030.61
106_I164_I1.1880.60
222_S239_I1.1850.60
288_A291_T1.1690.59
32_L74_I1.1670.59
189_G317_M1.1670.59
154_A180_I1.1650.58
28_G63_D1.1630.58
209_K243_V1.1630.58
53_T364_D1.1610.58
296_A299_I1.1600.58
171_T180_I1.1600.58
338_H341_I1.1540.58
153_T180_I1.1480.57
358_M362_A1.1470.57
293_E297_T1.1460.57
118_D323_K1.1430.57
243_V246_E1.1430.57
246_E251_T1.1360.57
44_W78_V1.1320.56
113_L319_E1.1320.56
149_S153_T1.1300.56
221_D292_A1.1200.55
51_G64_F1.1160.55
164_I336_I1.1130.55
57_F368_L1.1130.55
229_S281_V1.1100.55
10_I13_I1.1100.55
44_W50_F1.1090.55
41_A47_I1.1090.55
174_M180_I1.1040.54
263_A299_I1.1040.54
179_D182_E1.1020.54
241_C244_P1.0940.54
209_K246_E1.0860.53
291_T294_K1.0860.53
55_L63_D1.0830.53
86_F90_F1.0820.53
112_T116_S1.0810.53
192_L299_I1.0800.53
197_G364_D1.0780.53
33_T37_V1.0670.52
130_S231_G1.0670.52
352_A356_R1.0630.51
157_E286_S1.0580.51
74_I336_I1.0500.51
365_R368_L1.0400.50
127_H142_Q1.0390.50
207_E211_P1.0310.49
69_P111_K1.0280.49
189_G278_E1.0260.49
150_N177_Q1.0190.48
149_S156_P1.0130.48
49_D360_K1.0130.48
138_L342_N1.0120.48
24_H28_G1.0110.48
310_H314_D1.0090.48
16_Y80_C1.0060.48
116_S126_I1.0000.47
28_G59_K0.9950.47
169_I293_E0.9900.46
86_F188_G0.9810.46
113_L128_V0.9800.46
48_E71_H0.9780.46
236_R300_R0.9770.46
43_S46_D0.9530.44
226_S233_E0.9470.43
58_L362_A0.9450.43
319_E334_S0.9430.43
313_L357_K0.9370.43
177_Q180_I0.9240.42
347_D357_K0.9240.42
24_H62_G0.9240.42
51_G68_I0.9230.42
87_H338_H0.9160.41
358_M363_M0.9120.41
327_G330_A0.9090.41
306_E314_D0.9060.41
106_I140_I0.9030.41
31_L61_Y0.9020.40
177_Q206_F0.9010.40
199_Q231_G0.8970.40
42_E46_D0.8950.40
359_R363_M0.8920.40
314_D320_D0.8820.39
106_I183_K0.8780.39
55_L62_G0.8740.39
83_P331_E0.8740.39
127_H174_M0.8680.38
112_T125_A0.8620.38
191_Y257_L0.8550.37
108_I131_A0.8540.37
32_L62_G0.8530.37
30_L167_K0.8500.37
148_K280_T0.8480.37
36_A47_I0.8470.37
139_V342_N0.8420.37
326_R330_A0.8380.36
266_F279_M0.8380.36
197_G200_G0.8330.36
13_I81_I0.8320.36
209_K247_L0.8300.36
262_V281_V0.8290.36
42_E353_G0.8290.36
233_E268_S0.8280.36
59_K63_D0.8270.36
305_V308_K0.8260.36
153_T156_P0.8240.35
180_I184_I0.8200.35
227_E344_L0.8190.35
51_G55_L0.8180.35
335_G338_H0.8160.35
333_F339_I0.8090.34
311_W315_V0.8060.34
200_G247_L0.8060.34
189_G247_L0.8050.34
267_R278_E0.8030.34
303_W306_E0.8000.34
348_K357_K0.7970.34
150_N180_I0.7950.34
70_V80_C0.7940.34
24_H31_L0.7910.33
43_S336_I0.7890.33
240_V259_K0.7890.33
113_L338_H0.7890.33
126_I353_G0.7850.33
199_Q285_I0.7840.33
153_T197_G0.7830.33
260_L281_V0.7820.33
353_G356_R0.7820.33
148_K177_Q0.7810.33
31_L65_E0.7770.32
186_K362_A0.7760.32
268_S277_P0.7750.32
367_Y370_S0.7750.32
155_I174_M0.7740.32
239_I264_V0.7730.32
13_I206_F0.7720.32
130_S280_T0.7700.32
129_I155_I0.7700.32
199_Q254_W0.7700.32
222_S237_L0.7680.32
78_V210_F0.7670.32
334_S337_R0.7660.32
223_Y293_E0.7630.32
33_T36_A0.7630.32
89_C200_G0.7600.31
310_H320_D0.7570.31
132_F304_H0.7570.31
153_T177_Q0.7550.31
341_I354_L0.7550.31
90_F342_N0.7490.31
361_A368_L0.7480.31
31_L64_F0.7460.31
67_G159_L0.7460.31
227_E305_V0.7460.31
26_L77_V0.7430.30
141_G155_I0.7420.30
178_K253_E0.7420.30
250_F255_K0.7390.30
168_I298_A0.7380.30
64_F74_I0.7360.30
194_A284_Y0.7320.30
363_M368_L0.7290.30
35_F168_I0.7280.30
192_L252_F0.7270.30
228_K233_E0.7260.29
105_V134_T0.7250.29
111_K302_H0.7210.29
10_I255_K0.7210.29
24_H66_N0.7200.29
160_N187_Q0.7190.29
225_M286_S0.7180.29
84_A87_H0.7180.29
231_G269_I0.7170.29
52_E56_D0.7160.29
166_G169_I0.7150.29
189_G199_Q0.7130.29
240_V288_A0.7130.29
184_I344_L0.7120.29
54_H363_M0.7110.29
223_Y296_A0.7110.29
212_L216_N0.7100.29
241_C246_E0.7090.28
50_F299_I0.7040.28
176_C193_F0.7030.28
345_T348_K0.7030.28
35_F102_D0.7010.28
344_L371_V0.7010.28
343_I346_N0.7000.28
75_A357_K0.6990.28
58_L61_Y0.6970.28
9_H92_N0.6950.28
7_M10_I0.6940.28
45_E75_A0.6930.28
48_E51_G0.6930.28
210_F262_V0.6900.27
74_I301_N0.6870.27
153_T158_L0.6850.27
97_C141_G0.6850.27
184_I304_H0.6840.27
259_K288_A0.6830.27
41_A46_D0.6810.27
105_V298_A0.6810.27
127_H181_A0.6760.27
129_I149_S0.6760.27
308_K345_T0.6750.27
295_F299_I0.6730.27
306_E320_D0.6710.26
57_F347_D0.6630.26
194_A299_I0.6620.26
43_S117_Y0.6610.26
264_V305_V0.6600.26
177_Q254_W0.6600.26
16_Y183_K0.6570.26
314_D319_E0.6560.26
302_H310_H0.6540.25
208_E244_P0.6520.25
6_L327_G0.6510.25
45_E71_H0.6510.25
24_H233_E0.6490.25
177_Q183_K0.6490.25
128_V142_Q0.6480.25
147_K225_M0.6470.25
191_Y283_Y0.6460.25
109_D172_D0.6460.25
23_E27_S0.6460.25
44_W75_A0.6450.25
78_V167_K0.6430.25
261_C284_Y0.6420.25
192_L286_S0.6420.25
72_D300_R0.6410.25
58_L292_A0.6380.25
152_I174_M0.6370.25
240_V290_L0.6340.24
164_I169_I0.6340.24
252_F255_K0.6340.24
236_R302_H0.6340.24
185_Q188_G0.6310.24
46_D50_F0.6310.24
201_R299_I0.6310.24
361_A367_Y0.6290.24
24_H83_P0.6290.24
128_V334_S0.6280.24
127_H150_N0.6270.24
44_W93_W0.6270.24
178_K251_T0.6270.24
38_I365_R0.6260.24
112_T194_A0.6250.24
64_F70_V0.6240.24
209_K241_C0.6240.24
10_I195_V0.6220.24
162_L342_N0.6220.24
188_G197_G0.6200.24
88_E182_E0.6200.24
50_F195_V0.6190.24
255_K291_T0.6180.24
153_T175_G0.6180.24
94_M97_C0.6180.24
38_I58_L0.6180.24
75_A79_S0.6180.24
192_L288_A0.6170.24
192_L290_L0.6170.24
151_E172_D0.6160.24
166_G287_S0.6160.24
328_N332_L0.6140.23
66_N304_H0.6140.23
301_N333_F0.6140.23
222_S356_R0.6140.23
139_V312_R0.6130.23
235_I268_S0.6120.23
116_S123_R0.6110.23
348_K353_G0.6090.23
149_S177_Q0.6070.23
144_K149_S0.6070.23
6_L34_I0.6060.23
348_K367_Y0.6050.23
66_N285_I0.6040.23
324_I329_A0.6030.23
106_I141_G0.6030.23
172_D196_K0.6010.23
94_M342_N0.6010.23
178_K199_Q0.6000.23
39_S205_A0.6000.23
198_N314_D0.5990.23
54_H364_D0.5990.23
9_H43_S0.5990.23
31_L57_F0.5980.23
234_E300_R0.5980.23
124_G135_M0.5980.23
172_D306_E0.5960.23
90_F232_R0.5950.23
132_F284_Y0.5940.22
85_K137_S0.5940.22
331_E372_L0.5930.22
225_M299_I0.5920.22
26_L234_E0.5910.22
6_L353_G0.5890.22
50_F284_Y0.5890.22
138_L311_W0.5880.22
44_W51_G0.5840.22
284_Y299_I0.5830.22
224_A278_E0.5800.22
35_F274_K0.5790.22
13_I18_Q0.5790.22
25_K64_F0.5790.22
18_Q74_I0.5790.22
225_M233_E0.5780.22
169_I207_E0.5770.22
229_S266_F0.5770.22
150_N156_P0.5750.22
149_S180_I0.5740.22
138_L257_L0.5720.21
47_I112_T0.5690.21
56_D104_D0.5660.21
216_N276_E0.5650.21
149_S175_G0.5650.21
127_H159_L0.5640.21
16_Y159_L0.5640.21
42_E81_I0.5630.21
200_G206_F0.5630.21
236_R257_L0.5630.21
84_A145_T0.5630.21
111_K115_H0.5620.21
23_E34_I0.5620.21
87_H238_H0.5620.21
105_V167_K0.5620.21
143_I247_L0.5610.21
145_T205_A0.5600.21
206_F254_W0.5600.21
28_G67_G0.5590.21
238_H299_I0.5590.21
362_A368_L0.5570.21
332_L344_L0.5570.21
353_G371_V0.5570.21
154_A174_M0.5560.21
138_L186_K0.5550.21
111_K314_D0.5540.21
132_F285_I0.5530.21
205_A208_E0.5530.21
83_P313_L0.5520.21
210_F256_G0.5520.21
115_H125_A0.5520.21
159_L183_K0.5520.21
38_I181_A0.5510.20
114_R280_T0.5510.20
17_R26_L0.5510.20
164_I236_R0.5510.20
230_H299_I0.5510.20
134_T257_L0.5500.20
55_L58_L0.5480.20
135_M160_N0.5480.20
90_F144_K0.5460.20
111_K236_R0.5450.20
59_K368_L0.5440.20
170_T192_L0.5430.20
166_G190_D0.5390.20
34_I203_N0.5380.20
24_H325_R0.5340.20
46_D356_R0.5340.20
39_S60_Q0.5330.20
109_D151_E0.5330.20
114_R318_N0.5330.20
62_G159_L0.5320.20
203_N329_A0.5320.20
9_H89_C0.5300.20
152_I183_K0.5300.20
211_P241_C0.5280.19
325_R330_A0.5270.19
260_L312_R0.5270.19
282_R358_M0.5270.19
330_A341_I0.5260.19
11_S305_V0.5260.19
224_A235_I0.5250.19
269_I277_P0.5240.19
7_M11_S0.5210.19
81_I185_Q0.5200.19
83_P332_L0.5200.19
237_L281_V0.5190.19
109_D196_K0.5180.19
306_E310_H0.5170.19
205_A241_C0.5160.19
266_F277_P0.5150.19
109_D306_E0.5150.19
142_Q191_Y0.5110.19
160_N182_E0.5110.19
33_T41_A0.5100.19
111_K198_N0.5100.19
266_F275_K0.5100.19
45_E356_R0.5100.19
89_C96_D0.5090.19
49_D359_R0.5080.19
203_N299_I0.5070.19
356_R360_K0.5070.19
194_A295_F0.5070.19
129_I301_N0.5040.18
360_K367_Y0.5040.18
163_D189_G0.5030.18
97_C366_N0.5020.18
296_A305_V0.5020.18
316_V339_I0.5010.18
300_R319_E0.5010.18
9_H12_I0.5010.18
29_I32_L0.5000.18
290_L295_F0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8651 98.5 0.919 Contact Map
2abkA 1 0.3571 57.9 0.969 Contact Map
1ornA 1 0.3598 42.6 0.972 Contact Map
4unfA 1 0.373 38.5 0.972 Contact Map
1keaA 2 0.3519 23.9 0.975 Contact Map
4r3uC 1 0.336 21.1 0.976 Contact Map
3us6A 1 0.3677 15.2 0.977 Contact Map
4uobA 1 0.3651 13.9 0.978 Contact Map
1pdnC 1 0.1825 13.4 0.978 Contact Map
2d74B 1 0.3307 12.7 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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