GREMLIN Database
YBFF - Esterase YbfF
UniProt: P75736 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11776
Length: 254 (237)
Sequences: 58340 (48477)
Seq/√Len: 3148.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_T108_K4.7861.00
51_R70_D4.6351.00
35_L245_L3.6111.00
113_D206_S3.0061.00
72_V98_L2.9101.00
204_G230_A2.9071.00
240_K243_A2.8021.00
84_T107_D2.6521.00
227_H247_A2.6371.00
112_I244_V2.6131.00
82_K107_D2.6021.00
12_N44_N2.5781.00
92_G114_I2.4531.00
199_L251_Y2.4361.00
229_I247_A2.4051.00
75_L83_A2.3241.00
76_D105_R2.2501.00
98_L102_A2.2301.00
42_D249_R2.1631.00
218_L224_A2.1141.00
69_Q101_L2.0611.00
204_G228_V2.0591.00
72_V102_A2.0591.00
85_F95_V2.0491.00
84_T110_V2.0231.00
232_A240_K1.9371.00
72_V105_R1.9061.00
18_P46_I1.8981.00
95_V109_L1.8911.00
23_H53_H1.8861.00
72_V76_D1.8551.00
99_T109_L1.8101.00
38_D245_L1.7531.00
43_H84_T1.7461.00
48_V71_L1.7081.00
110_V248_I1.6731.00
97_A101_L1.6671.00
23_H50_M1.6641.00
211_E228_V1.6611.00
199_L227_H1.6331.00
71_L98_L1.6331.00
198_A221_F1.6011.00
18_P44_N1.5901.00
65_P101_L1.5771.00
84_T252_L1.5561.00
247_A250_R1.5491.00
246_R250_R1.5461.00
102_A105_R1.5411.00
17_S84_T1.5361.00
50_M94_A1.5361.00
216_D220_Q1.5341.00
18_P80_I1.5331.00
22_V50_M1.5271.00
22_V95_V1.5121.00
21_L86_I1.4971.00
27_G31_N1.4651.00
98_L106_I1.4631.00
36_A47_Q1.4521.00
190_K193_A1.4031.00
46_I74_T1.3851.00
111_A114_I1.3851.00
26_F53_H1.3691.00
76_D102_A1.3651.00
204_G231_G1.3501.00
63_N66_A1.3391.00
29_L49_D1.3341.00
29_L55_L1.3281.00
80_I83_A1.3231.00
68_A97_A1.3201.00
88_H237_H1.3201.00
38_D41_N1.3171.00
26_F89_S1.3161.00
17_S107_D1.3081.00
243_A247_A1.2961.00
21_L45_I1.2951.00
98_L105_R1.2881.00
75_L80_I1.2821.00
13_Q16_N1.2741.00
38_D249_R1.2721.00
74_T78_Q1.2661.00
48_V74_T1.2631.00
215_D219_A1.2621.00
22_V71_L1.2601.00
20_V75_L1.2491.00
229_I232_A1.2451.00
202_P214_R1.2261.00
49_D54_G1.2191.00
110_V199_L1.1921.00
97_A100_A1.1901.00
96_M111_A1.1701.00
221_F224_A1.1641.00
244_V248_I1.1441.00
100_A190_K1.1231.00
211_E215_D1.1211.00
83_A106_I1.1201.00
201_I229_I1.1111.00
192_P220_Q1.1061.00
75_L98_L1.1041.00
243_A246_R1.0991.00
16_N44_N1.0891.00
232_A236_V1.0881.00
38_D242_D1.0861.00
31_N237_H1.0771.00
86_I112_I1.0641.00
29_L47_Q1.0561.00
216_D219_A1.0511.00
46_I78_Q1.0471.00
201_I247_A1.0451.00
12_N16_N1.0361.00
40_V45_I1.0311.00
89_S234_H1.0241.00
232_A239_E1.0231.00
109_L198_A1.0211.00
68_A94_A1.0211.00
215_D228_V1.0181.00
88_H235_W1.0171.00
19_I43_H1.0141.00
20_V83_A1.0081.00
202_P211_E0.9931.00
83_A105_R0.9771.00
233_G239_E0.9761.00
242_D246_R0.9751.00
34_V37_R0.9741.00
160_Q164_K0.9671.00
72_V101_L0.9651.00
229_I240_K0.9631.00
17_S43_H0.9621.00
112_I237_H0.9621.00
225_R247_A0.9611.00
86_I248_I0.9561.00
202_P226_A0.9501.00
20_V71_L0.9491.00
18_P43_H0.9461.00
33_G47_Q0.9441.00
202_P228_V0.9441.00
19_I86_I0.9421.00
205_N231_G0.9401.00
125_D129_A0.9401.00
229_I243_A0.9371.00
11_Q14_H0.9351.00
218_L226_A0.9321.00
215_D226_A0.9211.00
43_H252_L0.9131.00
23_H48_V0.9131.00
17_S82_K0.9081.00
65_P97_A0.8981.00
176_P180_D0.8841.00
29_L48_V0.8791.00
19_I45_I0.8791.00
24_G89_S0.8781.00
174_N177_V0.8751.00
99_T106_I0.8711.00
97_A190_K0.8691.00
160_Q163_L0.8681.00
22_V85_F0.8611.00
87_G95_V0.8591.00
22_V48_V0.8541.00
50_M90_M0.8451.00
87_G92_G0.8451.00
72_V75_L0.8441.00
14_H44_N0.8431.00
36_A40_V0.8411.00
214_R226_A0.8361.00
199_L225_R0.8351.00
227_H250_R0.8351.00
200_F224_A0.8201.00
68_A101_L0.8191.00
85_F98_L0.8161.00
215_D218_L0.8141.00
73_D77_A0.8051.00
108_K197_P0.8031.00
17_S108_K0.7981.00
227_H243_A0.7911.00
156_E160_Q0.7851.00
146_A150_R0.7851.00
112_I236_V0.7801.00
36_A45_I0.7791.00
66_A69_Q0.7751.00
127_I131_I0.7741.00
212_Q215_D0.7741.00
50_M53_H0.7731.00
79_Q82_K0.7701.00
113_D236_V0.7671.00
201_I244_V0.7611.00
25_L90_M0.7591.00
106_I196_H0.7591.00
128_F131_I0.7571.00
128_F132_N0.7571.00
18_P83_A0.7571.00
26_F90_M0.7491.00
177_V180_D0.7481.00
69_Q73_D0.7451.00
178_L181_Q0.7441.00
50_M67_M0.7441.00
44_N80_I0.7441.00
21_L32_L0.7381.00
37_R40_V0.7381.00
143_Q146_A0.7371.00
46_I80_I0.7351.00
143_Q147_A0.7341.00
141_T144_Q0.7341.00
67_M90_M0.7341.00
231_G240_K0.7331.00
20_V85_F0.7311.00
113_D202_P0.7291.00
110_V252_L0.7281.00
194_W198_A0.7271.00
49_D55_L0.7251.00
41_N249_R0.7241.00
30_D33_G0.7241.00
171_W174_N0.7231.00
73_D76_D0.7231.00
69_Q72_V0.7191.00
86_I110_V0.7181.00
108_K252_L0.7161.00
181_Q184_H0.7151.00
35_L38_D0.7131.00
144_Q148_I0.7071.00
156_E159_I0.7061.00
241_P245_L0.7041.00
161_F165_S0.7011.00
148_I152_H0.7001.00
140_Q144_Q0.6951.00
161_F164_K0.6941.00
194_W221_F0.6941.00
159_I163_L0.6941.00
19_I39_L0.6911.00
108_K251_Y0.6901.00
81_D105_R0.6861.00
12_N15_N0.6861.00
68_A98_L0.6831.00
126_E129_A0.6831.00
142_R146_A0.6821.00
129_A132_N0.6811.00
43_H249_R0.6791.00
37_R41_N0.6781.00
85_F106_I0.6771.00
51_R67_M0.6761.00
203_G236_V0.6751.00
21_L39_L0.6751.00
50_M71_L0.6691.00
87_G91_G0.6671.00
127_I134_V0.6631.00
185_I188_W0.6621.00
113_D203_G0.6621.00
165_S168_D0.6611.00
74_T77_A0.6601.00
96_M116_P0.6601.00
195_D222_P0.6591.00
127_I130_A0.6561.00
49_D56_S0.6521.00
111_A200_F0.6511.00
99_T196_H0.6501.00
225_R250_R0.6481.00
88_H112_I0.6461.00
172_R176_P0.6451.00
88_H113_D0.6451.00
200_F226_A0.6411.00
147_A150_R0.6381.00
31_N88_H0.6371.00
21_L47_Q0.6321.00
96_M114_I0.6311.00
245_L249_R0.6221.00
19_I84_T0.6181.00
35_L244_V0.6171.00
93_K115_A0.6111.00
83_A107_D0.6101.00
99_T194_W0.6091.00
15_N44_N0.6071.00
69_Q102_A0.6061.00
89_S235_W0.6051.00
139_A145_A0.6041.00
11_Q16_N0.6021.00
75_L105_R0.6011.00
42_D45_I0.5991.00
162_L166_F0.5981.00
200_F218_L0.5981.00
204_G211_E0.5941.00
230_A243_A0.5921.00
100_A193_A0.5901.00
65_P69_Q0.5891.00
173_F177_V0.5881.00
138_D141_T0.5881.00
13_Q44_N0.5871.00
130_A134_V0.5861.00
165_S169_G0.5801.00
83_A98_L0.5801.00
144_Q147_A0.5761.00
140_Q143_Q0.5751.00
159_I162_L0.5741.00
128_F135_S0.5721.00
59_D62_M0.5721.00
19_I252_L0.5721.00
149_M153_L0.5701.00
32_L36_A0.5701.00
176_P179_W0.5701.00
180_D183_P0.5691.00
246_R249_R0.5681.00
64_Y97_A0.5671.00
189_E192_P0.5591.00
90_M94_A0.5581.00
201_I227_H0.5581.00
23_H32_L0.5531.00
68_A72_V0.5511.00
126_E130_A0.5511.00
129_A133_A0.5501.00
213_Y216_D0.5481.00
32_L35_L0.5471.00
121_V125_D0.5471.00
127_I132_N0.5461.00
138_D142_R0.5411.00
184_H187_G0.5401.00
27_G235_W0.5361.00
101_L190_K0.5341.00
32_L86_I0.5341.00
177_V181_Q0.5331.00
82_K105_R0.5331.00
164_K167_V0.5321.00
28_S53_H0.5311.00
110_V201_I0.5311.00
150_R153_L0.5301.00
131_I134_V0.5281.00
33_G37_R0.5271.00
64_Y94_A0.5251.00
174_N181_Q0.5241.00
147_A151_Q0.5221.00
214_R218_L0.5201.00
67_M94_A0.5201.00
126_E132_N0.5191.00
22_V94_A0.5181.00
200_F214_R0.5171.00
51_R59_D0.5171.00
237_H244_V0.5161.00
102_A106_I0.5161.00
11_Q47_Q0.5161.00
181_Q185_I0.5161.00
158_V162_L0.5151.00
92_G111_A0.5141.00
158_V161_F0.5131.00
142_R145_A0.5131.00
108_K199_L0.5111.00
114_I217_L0.5111.00
139_A143_Q0.5101.00
236_V244_V0.5091.00
30_D55_L0.5071.00
149_M152_H0.5041.00
25_L53_H0.5041.00
202_P209_V0.5041.00
110_V251_Y0.5041.00
179_W183_P0.5031.00
11_Q29_L0.5021.00
178_L182_Y0.5021.00
57_P62_M0.5021.00
52_N62_M0.5011.00
145_A148_I0.5011.00
248_I252_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bf7A 1 1 100 0.116 Contact Map
4inzA 1 1 100 0.14 Contact Map
1ehyA 1 0.9724 100 0.143 Contact Map
3oosA 1 0.9921 100 0.147 Contact Map
3om8A 4 0.9921 100 0.165 Contact Map
2pujA 4 0.9764 100 0.17 Contact Map
2xuaA 2 0.9882 100 0.173 Contact Map
1iupA 2 0.9606 100 0.173 Contact Map
4psuA 1 0.9882 100 0.178 Contact Map
2wueA 4 0.9921 100 0.182 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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