GREMLIN Database
CHIP - Chitoporin
UniProt: P75733 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13659
Length: 468 (403)
Sequences: 1921 (1206)
Seq/√Len: 60.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_G180_F4.9461.00
429_L457_V4.1511.00
47_Y70_S4.1301.00
39_S78_F3.9301.00
34_G37_D3.8991.00
299_G307_D3.7551.00
89_L140_F3.4651.00
149_A174_A3.4591.00
291_A315_V3.4341.00
194_W222_H3.4311.00
133_L199_K3.0511.00
238_A250_Y3.0361.00
230_F236_L2.8871.00
41_L78_F2.8541.00
145_V178_A2.8151.00
46_Y163_H2.7061.00
363_Y368_W2.7061.00
377_A411_L2.5711.00
240_F250_Y2.5381.00
314_W355_K2.5311.00
267_T298_F2.5251.00
236_L254_A2.5221.00
82_Y146_W2.5211.00
190_F226_A2.5091.00
47_Y72_W2.4981.00
427_F461_V2.4951.00
52_R456_D2.4101.00
185_A188_L2.3641.00
172_Q196_N2.3011.00
45_I72_W2.2721.00
258_F267_T2.1871.00
188_L228_Y2.1801.00
429_L459_F2.1321.00
344_D380_V2.1071.00
355_K384_D2.0881.00
306_V361_A2.0581.00
248_D277_K2.0511.00
100_A129_S2.0301.00
121_D128_K2.0011.00
305_V367_N1.9781.00
273_G290_T1.9401.00
431_F457_V1.9301.00
193_M223_S1.9161.00
412_D428_K1.9151.00
342_W356_A1.8831.00
266_T299_G1.8651.00
55_K455_R1.8631.00
271_F290_T1.8591.00
237_E253_K1.8581.00
345_N432_T1.8481.00
188_L226_A1.8081.00
297_T309_R1.8071.00
197_E208_E1.8051.00
302_A308_L1.8031.00
374_A414_V1.8011.00
51_E68_S1.8011.00
32_A37_D1.7560.99
242_Q277_K1.7450.99
49_Q68_S1.7430.99
45_I74_A1.7420.99
291_A340_D1.7410.99
175_E223_S1.7320.99
405_E437_H1.7290.99
357_V383_W1.7130.99
151_Y172_Q1.7110.99
256_Y267_T1.7100.99
352_N386_K1.6940.99
287_Y319_G1.6670.99
159_L195_T1.6540.99
417_I427_F1.6530.99
425_T463_A1.6450.99
234_F256_Y1.6400.99
144_P180_F1.6370.99
257_K264_P1.6310.99
33_E84_A1.6260.99
374_A416_T1.6090.99
310_L359_F1.5980.99
416_T426_M1.5830.99
152_I175_E1.5550.99
194_W220_Y1.5490.98
43_G465_F1.5310.98
145_V180_F1.5300.98
365_L413_A1.5090.98
88_G139_K1.5080.98
73_N98_E1.5040.98
238_A252_A1.5000.98
135_K151_Y1.4980.98
41_L467_I1.4910.98
159_L324_F1.4900.98
278_V285_D1.4780.98
371_P418_Q1.4770.98
145_V176_A1.4740.98
433_E455_R1.4630.98
242_Q248_D1.4610.98
269_Y296_L1.4580.98
154_P195_T1.4440.98
279_D283_V1.4370.97
44_G464_P1.3990.97
153_Q161_A1.3930.97
105_S125_S1.3880.97
180_F185_A1.3860.97
33_E38_D1.3790.97
31_R34_G1.3780.97
172_Q197_E1.3730.97
111_I114_S1.3660.97
364_D372_G1.3570.96
362_M376_G1.3510.96
48_W460_M1.3300.96
226_A238_A1.3290.96
82_Y141_K1.3240.96
208_E217_K1.3240.96
98_E166_F1.3230.96
21_M26_A1.3190.96
43_G76_L1.3110.96
122_E125_S1.3090.96
227_K237_E1.3060.96
355_K383_W1.3040.96
34_G84_A1.3020.95
353_G386_K1.2990.95
28_P32_A1.2970.95
103_G107_H1.2910.95
143_G178_A1.2840.95
93_A97_I1.2780.95
266_T301_R1.2700.95
299_G309_R1.2690.95
276_D282_S1.2690.95
19_T22_S1.2640.95
435_D455_R1.2600.95
208_E219_D1.2600.95
406_E434_Y1.2540.94
218_V243_A1.2530.94
376_G412_D1.2530.94
121_D125_S1.2500.94
71_T166_F1.2440.94
305_V368_W1.2420.94
157_Q251_F1.2370.94
144_P186_G1.2290.94
45_I465_F1.2260.94
427_F459_F1.2260.94
354_E382_A1.2240.94
221_L243_A1.2210.94
320_Q353_G1.2190.94
426_M462_I1.2150.93
229_D235_V1.2130.93
104_D107_H1.2130.93
177_G189_S1.2000.93
233_N259_D1.2000.93
412_D430_H1.2000.93
224_F240_F1.1930.93
361_A377_A1.1860.93
45_I99_M1.1840.93
404_I437_H1.1840.93
305_V363_Y1.1840.93
71_T113_F1.1710.92
25_M28_P1.1670.92
313_T356_A1.1610.92
44_G75_N1.1610.92
407_S433_E1.1560.92
82_Y148_R1.1510.91
338_R341_I1.1500.91
57_V60_G1.1490.91
158_T161_A1.1470.91
158_T239_A1.1460.91
74_A97_I1.1430.91
179_N189_S1.1420.91
15_I22_S1.1370.91
282_S285_D1.1300.91
27_M32_A1.1180.90
353_G384_D1.1120.90
218_V246_Y1.1090.90
381_Y405_E1.1040.90
311_E358_F1.1010.90
80_S88_G1.1010.90
323_Y348_D1.1000.90
191_S227_K1.0870.89
378_S412_D1.0810.89
152_I195_T1.0750.88
414_V426_M1.0740.88
54_R67_L1.0670.88
338_R342_W1.0630.88
36_I39_S1.0620.88
409_Y433_E1.0610.88
403_T437_H1.0590.88
257_K266_T1.0540.87
360_G376_G1.0510.87
111_I115_K1.0500.87
20_A23_G1.0470.87
421_R424_G1.0410.87
240_F248_D1.0390.87
87_F142_Y1.0380.87
363_Y367_N1.0370.87
137_A152_I1.0330.86
357_V381_Y1.0290.86
71_T114_S1.0280.86
255_S268_S1.0260.86
29_E32_A1.0150.85
22_S25_M1.0140.85
275_R290_T1.0130.85
144_P179_N1.0070.85
227_K235_V1.0060.85
334_S340_D1.0060.85
13_L16_A1.0050.85
38_D81_G1.0010.85
175_E191_S1.0000.84
147_A176_A0.9940.84
68_S107_H0.9800.83
334_S338_R0.9800.83
253_K268_S0.9770.83
14_A23_G0.9650.82
27_M30_A0.9640.82
461_V466_T0.9610.82
173_G195_T0.9590.82
356_A380_V0.9530.82
26_A29_E0.9500.81
22_S28_P0.9500.81
133_L151_Y0.9420.81
252_A271_F0.9320.80
188_L230_F0.9310.80
89_L142_Y0.9210.79
24_F28_P0.9210.79
98_E101_E0.9200.79
410_S432_T0.9180.79
94_F134_Y0.9140.79
163_H462_I0.9130.79
459_F462_I0.9120.79
270_Q295_A0.9100.78
134_Y168_P0.9060.78
295_A341_I0.9040.78
35_F81_G0.9030.78
292_W316_K0.9020.78
23_G28_P0.9010.78
93_A136_A0.9010.78
121_D124_W0.9000.78
156_G239_A0.8940.77
191_S239_A0.8920.77
382_A406_E0.8910.77
375_I413_A0.8910.77
154_P171_Y0.8910.77
264_P301_R0.8900.77
379_Y409_Y0.8900.77
248_D290_T0.8890.77
34_G38_D0.8850.76
225_G239_A0.8830.76
334_S339_L0.8820.76
345_N456_D0.8810.76
185_A190_F0.8800.76
339_L342_W0.8770.76
23_G27_M0.8760.76
66_N107_H0.8760.76
360_G378_S0.8720.75
115_K128_K0.8700.75
263_S300_Y0.8680.75
123_D128_K0.8670.75
216_T246_Y0.8660.75
404_I439_D0.8660.75
187_A229_D0.8570.74
310_L381_Y0.8570.74
365_L375_I0.8490.73
268_S300_Y0.8490.73
56_D59_D0.8460.73
337_G341_I0.8450.73
224_F242_Q0.8440.73
43_G74_A0.8430.73
276_D319_G0.8390.73
151_Y170_T0.8380.72
21_M24_F0.8330.72
297_T311_E0.8320.72
298_F310_L0.8310.72
19_T28_P0.8300.72
69_H127_D0.8300.72
342_W358_F0.8250.71
19_T24_F0.8250.71
259_D262_G0.8230.71
233_N258_F0.8220.71
141_K144_P0.8210.71
80_S139_K0.8210.71
20_A26_A0.8210.71
363_Y370_L0.8180.71
343_W348_D0.8160.70
320_Q434_Y0.8150.70
137_A148_R0.8140.70
16_A23_G0.8130.70
98_E131_I0.8130.70
362_M378_S0.8110.70
52_R430_H0.8110.70
49_Q70_S0.8100.70
417_I422_A0.8070.70
97_I132_S0.8060.69
242_Q245_G0.8020.69
43_G190_F0.8020.69
82_Y139_K0.8000.69
46_Y165_S0.7990.69
24_F27_M0.7970.69
409_Y431_F0.7950.68
94_F168_P0.7950.68
198_Y209_F0.7930.68
35_F39_S0.7920.68
24_F36_I0.7910.68
29_E33_E0.7890.68
199_K206_M0.7880.68
125_S128_K0.7850.67
379_Y407_S0.7840.67
31_R84_A0.7830.67
338_R343_W0.7820.67
85_D88_G0.7800.67
376_G411_L0.7750.66
90_D157_Q0.7750.66
71_T127_D0.7720.66
148_R152_I0.7710.66
102_N106_S0.7710.66
196_N290_T0.7700.66
278_V287_Y0.7670.66
39_S81_G0.7670.66
251_F295_A0.7670.66
274_T322_G0.7640.65
309_R360_G0.7620.65
285_D352_N0.7620.65
312_G355_K0.7610.65
351_A385_A0.7600.65
22_S427_F0.7550.64
425_T461_V0.7540.64
30_A34_G0.7530.64
249_Q274_T0.7530.64
159_L171_Y0.7510.64
94_F151_Y0.7510.64
145_V148_R0.7500.64
240_F277_K0.7460.63
336_N339_L0.7450.63
385_A434_Y0.7420.63
336_N343_W0.7410.63
272_Y350_N0.7390.63
94_F99_M0.7390.63
213_D216_T0.7360.62
210_Y214_K0.7350.62
389_T401_N0.7350.62
196_N220_Y0.7330.62
37_D84_A0.7320.62
138_A233_N0.7300.62
21_M29_E0.7300.62
23_G26_A0.7290.62
149_A196_N0.7290.62
275_R288_D0.7290.62
360_G428_K0.7260.61
211_Q216_T0.7240.61
147_A174_A0.7230.61
172_Q206_M0.7210.61
376_G410_S0.7210.61
25_M29_E0.7200.61
387_P401_N0.7200.61
130_G204_L0.7180.61
339_L343_W0.7170.60
22_S26_A0.7170.60
309_R428_K0.7160.60
146_W179_N0.7150.60
96_A168_P0.7150.60
223_S239_A0.7110.60
27_M34_G0.7110.60
132_S199_K0.7090.60
72_W114_S0.7070.59
290_T316_K0.7060.59
289_G321_Q0.7060.59
292_W314_W0.7060.59
100_A114_S0.7050.59
19_T23_G0.7050.59
288_D303_A0.7040.59
354_E406_E0.7020.59
340_D343_W0.7020.59
321_Q340_D0.6980.58
342_W410_S0.6980.58
87_F140_F0.6960.58
192_Y222_H0.6950.58
286_L319_G0.6900.57
53_D57_V0.6900.57
161_A171_Y0.6880.57
69_H202_W0.6860.57
97_I465_F0.6780.56
196_N219_D0.6770.56
409_Y455_R0.6750.56
42_T466_T0.6750.56
148_R233_N0.6730.56
310_L357_V0.6710.55
105_S109_N0.6710.55
383_W405_E0.6700.55
258_F261_A0.6680.55
21_M28_P0.6670.55
363_Y413_A0.6670.55
97_I130_G0.6650.55
334_S342_W0.6640.55
260_I265_L0.6640.55
222_H244_E0.6630.54
287_Y322_G0.6620.54
21_M25_M0.6620.54
434_Y452_Q0.6610.54
76_L467_I0.6600.54
373_F413_A0.6580.54
411_L433_E0.6570.54
162_P336_N0.6560.54
349_F408_A0.6560.54
123_D232_N0.6560.54
320_Q401_N0.6560.54
156_G223_S0.6560.54
137_A151_Y0.6530.53
163_H167_M0.6520.53
154_P161_A0.6520.53
27_M31_R0.6510.53
211_Q456_D0.6500.53
144_P178_A0.6490.53
214_K246_Y0.6480.53
50_R456_D0.6470.53
114_S131_I0.6460.53
385_A404_I0.6450.52
307_D362_M0.6440.52
370_L413_A0.6400.52
301_R307_D0.6370.52
170_T199_K0.6360.51
365_L368_W0.6340.51
55_K407_S0.6340.51
162_P201_P0.6340.51
164_W201_P0.6340.51
190_F233_N0.6320.51
23_G244_E0.6310.51
239_A270_Q0.6310.51
354_E372_G0.6260.50
267_T299_G0.6260.50
342_W348_D0.6260.50
262_G302_A0.6250.50
321_Q352_N0.6250.50
252_A260_I0.6230.50
229_D232_N0.6220.50
358_F378_S0.6210.50
20_A24_F0.6200.50
199_K204_L0.6180.49
314_W384_D0.6170.49
96_A133_L0.6170.49
158_T272_Y0.6170.49
19_T286_L0.6150.49
177_G370_L0.6150.49
211_Q214_K0.6130.49
80_S385_A0.6120.49
243_A247_I0.6110.49
196_N222_H0.6110.49
69_H407_S0.6090.48
155_T160_L0.6090.48
45_I467_I0.6090.48
384_D402_R0.6060.48
85_D90_D0.6050.48
164_W343_W0.6040.48
154_P173_G0.6030.48
411_L431_F0.6020.48
13_L28_P0.6020.48
25_M36_I0.6010.48
158_T223_S0.6010.48
94_F170_T0.6000.47
142_Y308_L0.6000.47
272_Y291_A0.5990.47
274_T287_Y0.5990.47
109_N125_S0.5970.47
101_E306_V0.5970.47
57_V452_Q0.5970.47
193_M313_T0.5960.47
40_T466_T0.5960.47
405_E465_F0.5940.47
187_A421_R0.5940.47
82_Y88_G0.5930.47
345_N348_D0.5900.46
269_Y298_F0.5890.46
73_N166_F0.5880.46
346_R432_T0.5880.46
187_A231_K0.5880.46
110_E114_S0.5880.46
219_D244_E0.5860.46
352_N387_P0.5840.46
109_N112_A0.5830.46
430_H458_K0.5830.46
381_Y386_K0.5820.45
52_R428_K0.5820.45
189_S227_K0.5820.45
383_W403_T0.5820.45
159_L198_Y0.5820.45
180_F187_A0.5800.45
169_G334_S0.5790.45
30_A37_D0.5790.45
362_M428_K0.5780.45
313_T342_W0.5770.45
285_D288_D0.5770.45
255_S266_T0.5760.45
19_T27_M0.5750.45
85_D361_A0.5750.45
14_A22_S0.5740.45
128_K422_A0.5740.45
308_L361_A0.5740.45
163_H168_P0.5740.45
87_F277_K0.5740.45
373_F415_Y0.5740.45
69_H111_I0.5720.44
240_F274_T0.5700.44
378_S410_S0.5690.44
334_S343_W0.5690.44
158_T310_L0.5680.44
139_K228_Y0.5680.44
82_Y86_M0.5660.44
95_T134_Y0.5660.44
432_T456_D0.5660.44
208_E216_T0.5660.44
367_N370_L0.5660.44
86_M229_D0.5650.44
16_A19_T0.5650.44
31_R36_I0.5640.43
25_M43_G0.5620.43
154_P159_L0.5620.43
256_Y298_F0.5620.43
152_I422_A0.5620.43
257_K301_R0.5600.43
174_A192_Y0.5580.43
80_S89_L0.5580.43
315_V340_D0.5570.43
156_G191_S0.5570.43
51_E66_N0.5560.43
319_G322_G0.5560.43
260_I263_S0.5550.42
243_A324_F0.5550.42
179_N229_D0.5540.42
174_A196_N0.5540.42
21_M32_A0.5530.42
416_T420_G0.5520.42
227_K245_G0.5510.42
154_P249_Q0.5510.42
366_K371_P0.5510.42
69_H113_F0.5460.41
177_G191_S0.5460.41
322_G434_Y0.5450.41
26_A36_I0.5430.41
366_K372_G0.5430.41
145_V185_A0.5430.41
41_L156_G0.5430.41
115_K132_S0.5420.41
58_T437_H0.5420.41
232_N310_L0.5420.41
26_A32_A0.5400.41
345_N410_S0.5400.41
150_G173_G0.5390.41
31_R37_D0.5390.41
271_F316_K0.5390.41
230_F234_F0.5390.41
254_A308_L0.5380.41
75_N167_M0.5380.41
239_A337_G0.5370.40
170_T260_I0.5360.40
79_Q370_L0.5350.40
29_E36_I0.5350.40
53_D66_N0.5340.40
14_A25_M0.5340.40
264_P286_L0.5330.40
267_T296_L0.5320.40
32_A84_A0.5310.40
98_E408_A0.5300.40
320_Q352_N0.5290.40
13_L21_M0.5280.39
153_Q291_A0.5270.39
214_K284_N0.5260.39
168_P199_K0.5240.39
99_M130_G0.5240.39
247_I322_G0.5230.39
273_G276_D0.5220.39
43_G87_F0.5210.39
82_Y185_A0.5200.39
103_G132_S0.5200.39
310_L368_W0.5190.39
23_G29_E0.5180.38
249_Q278_V0.5180.38
201_P311_E0.5170.38
209_F434_Y0.5170.38
141_K145_V0.5160.38
210_Y324_F0.5160.38
50_R458_K0.5150.38
384_D387_P0.5150.38
414_V428_K0.5140.38
15_I19_T0.5120.38
274_T289_G0.5120.38
279_D284_N0.5120.38
15_I27_M0.5110.38
191_S223_S0.5110.38
42_T421_R0.5100.38
103_G129_S0.5090.37
185_A252_A0.5090.37
220_Y236_L0.5080.37
431_F456_D0.5080.37
16_A20_A0.5080.37
153_Q454_E0.5080.37
32_A35_F0.5080.37
346_R434_Y0.5070.37
149_A172_Q0.5070.37
319_G351_A0.5070.37
246_Y287_Y0.5060.37
344_D375_I0.5050.37
245_G278_V0.5050.37
370_L373_F0.5040.37
50_R111_I0.5020.37
276_D286_L0.5020.37
15_I20_A0.5020.37
99_M132_S0.5010.37
142_Y178_A0.5010.37
156_G241_G0.5000.37
417_I421_R0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sybA 2 0.8483 100 0.228 Contact Map
2y0lA 1 0.7628 100 0.256 Contact Map
3sy7A 1 0.8056 100 0.257 Contact Map
4frxA 1 0.8034 100 0.259 Contact Map
4fsoA 1 0.7436 100 0.259 Contact Map
3szdB 1 0.7863 100 0.26 Contact Map
4frtA 1 0.7863 100 0.261 Contact Map
3t24A 3 0.7842 100 0.261 Contact Map
4fspA 1 0.7628 100 0.262 Contact Map
4ft6A 1 0.8226 100 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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