GREMLIN Database
UBIF - 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
UniProt: P75728 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13658
Length: 391 (340)
Sequences: 27128 (20758)
Seq/√Len: 1125.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_T131_R4.1671.00
36_H135_S3.5291.00
16_V304_G3.4491.00
9_A158_A3.4241.00
7_E30_A3.2931.00
7_E159_K3.2051.00
335_Q339_M3.0071.00
138_A174_M2.7491.00
135_S151_K2.7401.00
27_H316_V2.6791.00
6_T32_T2.6611.00
34_I156_I2.6181.00
147_E155_V2.6051.00
121_A124_A2.5981.00
20_L162_I2.5201.00
23_G312_I2.4101.00
134_G152_G2.3971.00
9_A34_I2.3571.00
147_E157_R2.3421.00
140_H147_E2.3421.00
116_Q120_Q2.3061.00
71_A120_Q2.2961.00
241_N244_Q2.2461.00
138_A149_E2.2141.00
149_E155_V2.1911.00
137_I151_K2.1301.00
16_V286_V2.0951.00
145_L157_R2.0931.00
19_A305_Y2.0831.00
9_A148_L2.0571.00
131_R134_G2.0461.00
163_G171_V2.0391.00
64_K69_W2.0351.00
38_E133_P1.9201.00
134_G150_L1.9161.00
314_V337_R1.9051.00
140_H149_E1.8751.00
8_I29_F1.8721.00
71_A121_A1.8471.00
30_A129_T1.8451.00
7_E32_T1.8121.00
121_A125_H1.8001.00
8_I24_L1.7981.00
142_H147_E1.7831.00
22_L121_A1.7821.00
163_G285_L1.7811.00
62_L309_D1.7561.00
59_S302_N1.7481.00
308_V312_I1.7451.00
242_M246_Q1.7361.00
34_I150_L1.7291.00
314_V333_R1.7231.00
29_F316_V1.7121.00
136_L148_L1.7011.00
339_M343_F1.6901.00
164_A286_V1.6801.00
279_V332_K1.6701.00
150_L156_I1.6561.00
91_A94_V1.6401.00
277_Q280_Q1.6271.00
71_A74_A1.6211.00
141_R280_Q1.6121.00
65_G309_D1.6011.00
25_A128_V1.6001.00
243_A247_A1.5991.00
165_D169_S1.5961.00
244_Q247_A1.5861.00
119_W132_V1.5811.00
279_V284_A1.5721.00
70_D74_A1.5651.00
142_H157_R1.5621.00
71_A124_A1.5581.00
247_A251_K1.5361.00
22_L26_Q1.5341.00
142_H145_L1.5331.00
170_Q174_M1.5271.00
9_A156_I1.5161.00
310_A314_V1.5091.00
247_A250_A1.5071.00
122_L128_V1.4961.00
139_L161_V1.4901.00
21_A33_V1.4861.00
20_L308_V1.4771.00
119_W123_E1.4711.00
32_T156_I1.4661.00
260_V263_L1.4421.00
26_Q125_H1.4371.00
69_W73_Q1.4311.00
310_A337_R1.4311.00
175_A283_L1.4131.00
277_Q335_Q1.4121.00
284_A311_L1.3991.00
278_Y342_N1.3981.00
23_G66_L1.3921.00
11_V136_L1.3831.00
160_L331_L1.3711.00
15_M301_V1.3691.00
278_Y335_Q1.3401.00
75_M113_V1.3401.00
307_D338_R1.3311.00
25_A125_H1.3271.00
59_S305_Y1.3211.00
162_I286_V1.3121.00
306_R341_D1.3011.00
11_V165_D1.2931.00
314_V330_V1.2931.00
131_R156_I1.2901.00
246_Q250_A1.2871.00
313_D337_R1.2711.00
6_T9_A1.2691.00
170_Q173_Q1.2551.00
120_Q123_E1.2511.00
140_H155_V1.2451.00
22_L122_L1.2401.00
70_D73_Q1.2381.00
291_H307_D1.2361.00
40_A132_V1.2351.00
22_L125_H1.2301.00
10_I20_L1.2221.00
148_L158_A1.2201.00
134_G154_E1.2171.00
136_L171_V1.2161.00
32_T129_T1.2141.00
257_L260_V1.2091.00
20_L24_L1.2061.00
272_R350_D1.2041.00
137_I149_E1.2021.00
279_V335_Q1.1921.00
136_L139_L1.1841.00
259_Y262_P1.1681.00
9_A32_T1.1541.00
243_A246_Q1.1541.00
75_M116_Q1.1511.00
314_V317_N1.1481.00
113_V116_Q1.1481.00
19_A66_L1.1341.00
162_I284_A1.1261.00
285_L289_A1.1191.00
11_V171_V1.1181.00
141_R282_G1.1111.00
92_H95_F1.1091.00
167_A292_T1.1061.00
110_E113_V1.1051.00
139_L174_M1.1051.00
194_Q261_T1.0881.00
34_I131_R1.0851.00
178_G276_L1.0841.00
180_H276_L1.0801.00
33_V130_L1.0781.00
240_M244_Q1.0771.00
53_S301_V1.0751.00
326_A329_P1.0741.00
71_A117_A1.0661.00
254_P257_L1.0661.00
10_I21_A1.0601.00
6_T30_A1.0591.00
26_Q121_A1.0571.00
146_Q282_G1.0501.00
293_I303_L1.0471.00
158_A161_V1.0421.00
141_R146_Q1.0411.00
60_V69_W1.0381.00
20_L286_V1.0281.00
194_Q222_W1.0221.00
13_G18_G1.0191.00
6_T129_T1.0161.00
7_E29_F1.0151.00
25_A127_K1.0131.00
84_E92_H1.0101.00
248_E252_H1.0091.00
279_V328_Y1.0091.00
214_A226_V1.0071.00
21_A31_V1.0051.00
19_A23_G1.0041.00
343_F347_S1.0041.00
120_Q124_A0.9981.00
65_G313_D0.9981.00
18_G122_L0.9941.00
31_V128_V0.9901.00
39_P132_V0.9881.00
136_L170_Q0.9881.00
119_W130_L0.9861.00
68_V121_A0.9831.00
71_A75_M0.9821.00
273_R292_T0.9811.00
332_K336_M0.9751.00
270_L273_R0.9741.00
286_V334_Y0.9721.00
257_L261_T0.9661.00
233_R236_Q0.9591.00
146_Q150_L0.9571.00
10_I31_V0.9551.00
255_S258_G0.9511.00
139_L175_A0.9511.00
34_I134_G0.9501.00
82_R202_S0.9471.00
310_A313_D0.9461.00
248_E251_K0.9331.00
40_A119_W0.9331.00
293_I346_Q0.9241.00
163_G283_L0.9191.00
284_A334_Y0.9181.00
350_D354_A0.9161.00
317_N333_R0.9111.00
117_A120_Q0.9071.00
11_V161_V0.9051.00
333_R336_M0.9051.00
254_P258_G0.9041.00
75_M117_A0.9031.00
24_L29_F0.9011.00
15_M305_Y0.9001.00
275_A285_L0.8971.00
194_Q221_N0.8931.00
53_S111_N0.8921.00
32_T158_A0.8921.00
146_Q161_V0.8911.00
261_T264_A0.8881.00
191_I225_L0.8871.00
265_A268_F0.8861.00
280_Q283_L0.8861.00
117_A121_A0.8821.00
28_G31_V0.8811.00
224_S228_Y0.8811.00
25_A122_L0.8791.00
125_H128_V0.8771.00
136_L174_M0.8751.00
22_L66_L0.8741.00
29_F319_R0.8701.00
61_S64_K0.8701.00
23_G27_H0.8671.00
328_Y332_K0.8651.00
72_V114_L0.8651.00
18_G119_W0.8601.00
72_V117_A0.8581.00
244_Q248_E0.8561.00
237_L241_N0.8531.00
68_V117_A0.8531.00
188_C192_S0.8501.00
58_A306_R0.8491.00
94_V98_A0.8461.00
58_A299_Q0.8451.00
148_L161_V0.8441.00
259_Y263_L0.8431.00
123_E129_T0.8411.00
246_Q261_T0.8341.00
58_A61_S0.8311.00
77_C107_Y0.8301.00
60_V107_Y0.8281.00
18_G115_Q0.8231.00
25_A31_V0.8171.00
51_R111_N0.8151.00
34_I158_A0.8151.00
188_C191_I0.8131.00
7_E158_A0.8071.00
24_L312_I0.8061.00
309_D313_D0.8041.00
141_R281_P0.8031.00
269_P272_R0.8021.00
81_R201_D0.8021.00
171_V283_L0.8001.00
259_Y264_A0.7961.00
13_G35_E0.7951.00
177_I275_A0.7941.00
139_L171_V0.7931.00
195_C198_D0.7931.00
25_A123_E0.7931.00
54_A106_G0.7921.00
312_I316_V0.7911.00
203_T206_Q0.7901.00
297_A349_M0.7901.00
258_G262_P0.7851.00
93_V97_A0.7821.00
258_G261_T0.7821.00
327_S330_V0.7801.00
285_L290_A0.7791.00
23_G26_Q0.7781.00
35_E132_V0.7751.00
269_P273_R0.7741.00
94_V97_A0.7741.00
245_L253_F0.7721.00
279_V331_L0.7681.00
50_V53_S0.7651.00
249_I253_F0.7651.00
249_I252_H0.7641.00
162_I311_L0.7641.00
64_K73_Q0.7631.00
278_Y290_A0.7621.00
63_L305_Y0.7591.00
160_L284_A0.7591.00
122_L127_K0.7551.00
111_N115_Q0.7551.00
318_A333_R0.7541.00
21_A122_L0.7491.00
24_L315_L0.7471.00
54_A108_M0.7471.00
123_E127_K0.7451.00
139_L283_L0.7441.00
327_S331_L0.7421.00
221_N224_S0.7411.00
333_R337_R0.7411.00
274_H343_F0.7411.00
189_M192_S0.7381.00
34_I148_L0.7351.00
122_L125_H0.7291.00
109_V114_L0.7291.00
245_L249_I0.7281.00
253_F256_R0.7281.00
84_E202_S0.7271.00
21_A128_V0.7251.00
115_Q119_W0.7241.00
293_I297_A0.7221.00
7_E156_I0.7211.00
195_C223_A0.7201.00
278_Y339_M0.7191.00
27_H312_I0.7191.00
23_G62_L0.7141.00
292_T307_D0.7131.00
184_Y350_D0.7131.00
63_L68_V0.7111.00
60_V64_K0.7091.00
79_P105_L0.7091.00
169_S172_R0.7081.00
19_A118_L0.7071.00
260_V264_A0.7041.00
8_I160_L0.7011.00
110_E219_F0.7001.00
202_S205_Q0.6991.00
176_G179_V0.6981.00
337_R340_A0.6921.00
268_F271_T0.6921.00
275_A278_Y0.6871.00
242_M265_A0.6861.00
230_S233_R0.6851.00
37_A47_Q0.6791.00
204_W207_F0.6781.00
303_L342_N0.6781.00
194_Q197_N0.6751.00
225_L228_Y0.6741.00
92_H96_D0.6721.00
62_L66_L0.6721.00
86_W204_W0.6701.00
122_L130_L0.6701.00
177_I280_Q0.6691.00
342_N346_Q0.6691.00
163_G169_S0.6671.00
316_V320_S0.6671.00
31_V127_K0.6651.00
340_A344_I0.6641.00
195_C199_P0.6581.00
23_G309_D0.6571.00
59_S62_L0.6571.00
113_V219_F0.6541.00
241_N245_L0.6541.00
135_S170_Q0.6521.00
20_L312_I0.6511.00
8_I20_L0.6511.00
237_L240_M0.6491.00
250_A254_P0.6491.00
270_L294_H0.6481.00
281_P328_Y0.6461.00
299_Q303_L0.6461.00
257_L264_A0.6451.00
13_G33_V0.6421.00
58_A341_D0.6381.00
171_V174_M0.6381.00
332_K335_Q0.6381.00
25_A129_T0.6371.00
301_V304_G0.6361.00
31_V122_L0.6351.00
96_D99_E0.6331.00
301_V305_Y0.6311.00
262_P265_A0.6311.00
175_A280_Q0.6311.00
225_L229_D0.6301.00
75_M109_V0.6291.00
172_R285_L0.6271.00
329_P333_R0.6271.00
90_T93_V0.6251.00
18_G33_V0.6231.00
150_L154_E0.6211.00
203_T207_F0.6211.00
22_L25_A0.6201.00
344_I347_S0.6191.00
145_L159_K0.6181.00
56_S302_N0.6171.00
286_V308_V0.6161.00
110_E222_W0.6151.00
150_L153_G0.6151.00
64_K70_D0.6151.00
84_E87_E0.6091.00
95_F98_A0.6091.00
303_L345_M0.6071.00
187_S231_P0.6031.00
326_A330_V0.6031.00
296_L353_Y0.6031.00
293_I349_M0.6021.00
256_R263_L0.6011.00
22_L128_V0.5981.00
163_G170_Q0.5971.00
274_H278_Y0.5951.00
299_Q302_N0.5951.00
196_E221_N0.5951.00
254_P259_Y0.5941.00
160_L315_L0.5941.00
246_Q252_H0.5881.00
139_L146_Q0.5871.00
256_R264_A0.5861.00
255_S259_Y0.5841.00
250_A257_L0.5841.00
160_L319_R0.5831.00
318_A329_P0.5821.00
294_H297_A0.5811.00
179_V273_R0.5811.00
161_V283_L0.5801.00
131_R154_E0.5801.00
134_G151_K0.5751.00
186_Q190_L0.5721.00
64_K104_L0.5721.00
40_A115_Q0.5701.00
38_E132_V0.5701.00
352_F355_G0.5701.00
351_L354_A0.5691.00
274_H339_M0.5691.00
318_A330_V0.5681.00
69_W72_V0.5661.00
19_A63_L0.5641.00
18_G130_L0.5631.00
187_S191_I0.5631.00
80_Y108_M0.5621.00
318_A326_A0.5601.00
63_L114_L0.5601.00
350_D353_Y0.5591.00
249_I260_V0.5581.00
163_G175_A0.5571.00
183_Q271_T0.5551.00
165_D285_L0.5551.00
159_K319_R0.5531.00
6_T156_I0.5531.00
16_V162_I0.5521.00
284_A331_L0.5511.00
313_D317_N0.5501.00
306_R310_A0.5491.00
62_L65_G0.5491.00
145_L148_L0.5471.00
242_M245_L0.5471.00
77_C80_Y0.5461.00
183_Q187_S0.5441.00
184_Y190_L0.5421.00
173_Q178_G0.5421.00
160_L327_S0.5421.00
30_A159_K0.5401.00
239_N242_M0.5391.00
23_G308_V0.5391.00
136_L150_L0.5391.00
268_F273_R0.5381.00
84_E94_V0.5371.00
140_H143_D0.5371.00
20_L315_L0.5361.00
201_D206_Q0.5361.00
159_K282_G0.5331.00
221_N225_L0.5321.00
91_A96_D0.5301.00
334_Y338_R0.5301.00
187_S190_L0.5271.00
57_A61_S0.5261.00
291_H338_R0.5261.00
72_V107_Y0.5261.00
61_S65_G0.5251.00
256_R260_V0.5241.00
186_Q296_L0.5241.00
194_Q198_D0.5241.00
55_I59_S0.5231.00
240_M248_E0.5221.00
186_Q189_M0.5211.00
177_I181_A0.5211.00
73_Q79_P0.5201.00
183_Q189_M0.5191.00
29_F320_S0.5181.00
238_Q241_N0.5171.00
229_D233_R0.5161.00
93_V96_D0.5161.00
85_T88_W0.5141.00
161_V171_V0.5141.00
201_D204_W0.5141.00
13_G40_A0.5131.00
39_P47_Q0.5131.00
257_L262_P0.5121.00
329_P332_K0.5121.00
238_Q242_M0.5121.00
36_H168_N0.5111.00
288_D304_G0.5111.00
212_P216_L0.5101.00
240_M243_A0.5091.00
177_I180_H0.5091.00
148_L156_I0.5091.00
202_S206_Q0.5091.00
20_L164_A0.5081.00
123_E132_V0.5081.00
63_L72_V0.5071.00
344_I348_G0.5071.00
181_A273_R0.5061.00
40_A116_Q0.5061.00
250_A261_T0.5041.00
27_H313_D0.5041.00
192_S222_W0.5041.00
224_S229_D0.5031.00
213_R217_P0.5021.00
20_L23_G0.5011.00
168_N173_Q0.5011.00
310_A334_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n9xA 5 0.9258 100 0.246 Contact Map
2qa1A 2 0.9361 100 0.262 Contact Map
2qa2A 2 0.9437 100 0.266 Contact Map
4k5sA 2 0.9463 100 0.272 Contact Map
4k2xA 2 0.9335 100 0.299 Contact Map
2x3nA 1 0.9003 100 0.305 Contact Map
4k22A 4 0.9028 100 0.305 Contact Map
1pn0A 3 0.954 100 0.305 Contact Map
1k0iA 2 0.9591 100 0.312 Contact Map
2dkhA 2 0.9003 100 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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