GREMLIN Database
CILA - Citrate lyase alpha chain
UniProt: P75726 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13541
Length: 510 (473)
Sequences: 369 (209)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
374_I438_L6.2551.00
494_V505_V4.5220.99
159_N199_K4.2420.99
217_S345_E3.9850.99
261_V437_I3.8160.98
154_Q349_N3.6730.97
86_A115_V3.6380.97
51_E84_V3.5970.97
55_R88_M3.5700.97
394_S398_C3.5270.97
167_V203_M3.5180.97
79_N106_P3.1970.94
278_T370_S3.1840.94
176_A203_M3.0770.93
489_R507_Q3.0700.93
300_A320_I2.9550.91
446_V460_A2.9030.91
303_A311_M2.8200.89
86_A113_Q2.7920.89
110_H113_Q2.7850.89
83_D110_H2.7740.88
51_E55_R2.7730.88
151_H495_R2.7410.88
112_R136_L2.7340.88
446_V464_V2.7270.88
426_L486_F2.6660.86
413_L474_A2.6490.86
86_A110_H2.6450.86
261_V446_V2.6010.85
316_E340_N2.5980.85
471_R475_R2.5940.85
286_T314_L2.5720.84
421_L438_L2.5620.84
120_Y144_H2.5180.83
487_T507_Q2.4970.82
51_E87_K2.4840.82
290_E317_K2.4790.82
444_I462_I2.4640.81
57_S162_V2.3750.79
196_D222_Q2.3430.78
261_V457_L2.3170.77
294_R317_K2.2580.75
404_S407_S2.2450.75
390_L505_V2.2160.74
304_L346_I2.1740.72
110_H115_V2.1630.72
54_I59_L2.1620.72
71_F166_G2.1310.71
331_S334_A2.1060.70
129_A410_V2.0660.68
446_V459_E2.0430.67
118_R139_E2.0420.67
454_A466_S1.9920.65
265_S406_L1.9430.63
257_S463_K1.9350.63
303_A323_L1.9190.62
372_L391_R1.9110.62
85_I90_F1.8970.61
165_L203_M1.8930.61
96_A158_L1.8410.59
316_E339_R1.8390.59
326_V348_A1.8270.58
95_L116_V1.8130.58
123_G393_A1.7960.57
185_C188_L1.7940.57
172_E363_R1.7800.56
52_E56_R1.7650.55
345_E415_R1.7620.55
107_L435_V1.7500.55
101_S393_A1.7280.54
109_E112_R1.7150.53
170_C226_I1.7050.53
100_L128_L1.6960.52
49_N52_E1.6950.52
335_Q339_R1.6860.52
490_V504_V1.6770.51
65_V85_I1.6640.51
54_I162_V1.6440.50
200_Q225_L1.6370.50
143_I383_L1.6320.49
57_S202_V1.6170.49
153_V160_I1.6160.49
322_K435_V1.6090.48
100_L121_T1.6060.48
372_L420_T1.5600.46
377_Q424_N1.5590.46
47_C50_L1.5580.46
65_V82_M1.5480.46
47_C56_R1.5290.45
445_A474_A1.5230.45
116_V492_A1.5220.45
414_V478_T1.5220.45
217_S415_R1.5130.44
299_R321_R1.5120.44
433_S449_A1.5000.44
370_S393_A1.4940.43
82_M116_V1.4770.43
51_E88_M1.4750.42
493_V501_V1.4700.42
350_Q360_S1.4560.42
412_P415_R1.4540.42
125_R393_A1.4490.41
243_T283_L1.4420.41
274_M492_A1.4410.41
270_E299_R1.4320.41
251_E370_S1.4280.40
106_P109_E1.4200.40
53_A58_G1.3890.39
240_A331_S1.3860.39
496_Y502_I1.3860.39
262_I366_V1.3780.38
332_H335_Q1.3740.38
145_S398_C1.3680.38
54_I57_S1.3670.38
475_R480_E1.3590.37
492_A505_V1.3480.37
123_G251_E1.3400.37
107_L129_A1.3390.37
143_I394_S1.3250.36
423_D471_R1.3230.36
482_Q485_E1.3160.36
125_R242_A1.3110.35
82_M107_L1.3080.35
79_N110_H1.2900.35
230_D321_R1.2860.34
367_V400_T1.2780.34
382_V397_H1.2750.34
454_A458_Q1.2700.34
168_P185_C1.2640.34
130_E134_R1.2620.33
451_P454_A1.2600.33
84_V87_K1.2490.33
78_V104_H1.2440.33
460_A464_V1.2430.33
50_L204_L1.2320.32
144_H415_R1.2300.32
165_L195_A1.2280.32
123_G242_A1.2230.32
242_A393_A1.2230.32
370_S429_I1.2220.32
99_S150_V1.2170.32
93_L285_V1.2100.31
312_V336_S1.2090.31
258_A419_P1.2080.31
386_S417_R1.2070.31
217_S411_A1.2060.31
80_M229_V1.2060.31
266_G456_R1.2050.31
173_F358_G1.2020.31
54_I58_G1.1910.31
129_A266_G1.1880.31
59_L65_V1.1800.30
105_A129_A1.1800.30
374_I411_A1.1790.30
101_S123_G1.1790.30
200_Q435_V1.1750.30
278_T393_A1.1740.30
173_F362_D1.1600.29
243_T326_V1.1570.29
263_V296_R1.1570.29
490_V506_H1.1570.29
230_D493_V1.1540.29
407_S434_S1.1520.29
48_A52_E1.1490.29
48_A488_D1.1470.29
129_A303_A1.1470.29
54_I85_I1.1430.29
53_A193_V1.1430.29
85_I202_V1.1400.29
144_H152_L1.1400.29
101_S278_T1.1370.29
128_L394_S1.1370.29
104_H107_L1.1360.29
453_L492_A1.1340.29
61_D92_N1.1310.28
298_I367_V1.1300.28
280_G400_T1.1290.28
101_S370_S1.1250.28
157_E500_S1.1170.28
140_P244_R1.1150.28
278_T429_I1.1150.28
383_L429_I1.1100.28
144_H412_P1.1090.28
270_E321_R1.1090.28
57_S200_Q1.1070.28
239_G331_S1.1050.27
54_I65_V1.1030.27
106_P110_H1.1020.27
80_M483_P1.1020.27
290_E294_R1.1010.27
145_S393_A1.0920.27
405_A492_A1.0900.27
280_G283_L1.0810.27
143_I492_A1.0810.27
250_R300_A1.0780.27
152_L495_R1.0740.26
108_V141_V1.0710.26
311_M315_H1.0710.26
95_L119_I1.0700.26
116_V119_I1.0690.26
122_S393_A1.0680.26
216_A219_E1.0650.26
50_L84_V1.0630.26
84_V88_M1.0610.26
294_R505_V1.0580.26
406_L457_L1.0580.26
446_V462_I1.0450.25
116_V274_M1.0400.25
80_M299_R1.0320.25
96_A319_L1.0310.25
390_L492_A1.0270.25
372_L385_G1.0220.25
116_V285_V1.0180.24
124_L248_N1.0130.24
417_R479_G1.0120.24
47_C53_A1.0090.24
407_S449_A1.0080.24
61_D481_P1.0040.24
242_A251_E1.0040.24
385_G391_R1.0040.24
101_S242_A0.9940.24
125_R251_E0.9930.24
211_Y220_Q0.9930.24
281_A411_A0.9930.24
151_H356_S0.9900.24
143_I251_E0.9880.23
215_P358_G0.9860.23
309_A333_A0.9840.23
46_L172_E0.9830.23
213_H372_L0.9810.23
391_R420_T0.9650.23
196_D347_S0.9650.23
240_A283_L0.9630.23
309_A332_H0.9620.23
361_V403_A0.9610.23
246_T359_A0.9590.23
203_M226_I0.9580.23
434_S496_Y0.9580.23
81_V202_V0.9570.22
129_A412_P0.9550.22
48_A55_R0.9550.22
349_N356_S0.9540.22
471_R481_P0.9510.22
125_R412_P0.9510.22
297_D314_L0.9500.22
104_H280_G0.9480.22
280_G390_L0.9470.22
92_N138_A0.9460.22
212_P358_G0.9420.22
76_L231_R0.9390.22
387_D391_R0.9390.22
99_S121_T0.9390.22
307_I323_L0.9370.22
366_V406_L0.9330.22
251_E393_A0.9320.22
58_G208_L0.9270.22
315_H501_V0.9260.22
217_S337_L0.9240.21
136_L162_V0.9200.21
242_A370_S0.9190.21
85_I93_L0.9180.21
446_V457_L0.9180.21
53_A57_S0.9160.21
251_E383_L0.9130.21
122_S125_R0.9110.21
444_I464_V0.9090.21
182_K231_R0.9030.21
122_S251_E0.9020.21
168_P210_P0.9010.21
152_L206_E0.9000.21
109_E116_V0.8990.21
47_C225_L0.8970.21
121_T393_A0.8960.21
131_E136_L0.8940.21
256_R260_D0.8940.21
154_Q362_D0.8930.21
210_P289_L0.8920.21
173_F225_L0.8900.20
230_D270_E0.8880.20
90_F202_V0.8870.20
71_F185_C0.8860.20
291_D295_S0.8830.20
349_N392_G0.8790.20
125_R372_L0.8760.20
123_G412_P0.8760.20
99_S393_A0.8730.20
52_E472_E0.8710.20
150_V348_A0.8700.20
469_W493_V0.8690.20
385_G392_G0.8690.20
346_I372_L0.8670.20
418_I486_F0.8660.20
281_A393_A0.8650.20
324_L360_S0.8640.20
41_A362_D0.8640.20
126_G129_A0.8640.20
322_K342_N0.8640.20
124_L128_L0.8620.20
54_I84_V0.8620.20
116_V453_L0.8600.20
166_G312_V0.8600.20
165_L341_P0.8570.20
263_V292_K0.8570.20
404_S500_S0.8570.20
61_D91_K0.8570.20
125_R392_G0.8550.19
73_G116_V0.8520.19
254_I422_V0.8520.19
237_K353_N0.8520.19
143_I393_A0.8500.19
123_G278_T0.8460.19
123_G370_S0.8400.19
309_A313_D0.8390.19
362_D495_R0.8390.19
44_R202_V0.8390.19
240_A326_V0.8330.19
54_I439_V0.8320.19
362_D403_A0.8300.19
301_D358_G0.8280.19
240_A243_T0.8270.19
288_F323_L0.8220.19
122_S242_A0.8220.19
79_N86_A0.8210.19
367_V409_I0.8200.18
501_V507_Q0.8170.18
103_C416_G0.8130.18
346_I367_V0.8130.18
465_V473_R0.8080.18
187_S326_V0.8060.18
170_C203_M0.8020.18
97_S414_V0.7990.18
267_Y418_I0.7950.18
143_I415_R0.7940.18
273_S302_F0.7940.18
127_P393_A0.7920.18
413_L473_R0.7910.18
76_L409_I0.7910.18
73_G102_D0.7910.18
232_V237_K0.7910.18
413_L445_A0.7890.18
210_P376_T0.7870.18
112_R464_V0.7850.18
243_T370_S0.7840.18
104_H222_Q0.7830.18
183_A228_K0.7800.17
98_S150_V0.7800.17
451_P469_W0.7790.17
358_G467_I0.7780.17
95_L492_A0.7750.17
370_S383_L0.7730.17
76_L80_M0.7730.17
73_G323_L0.7710.17
115_V340_N0.7710.17
243_T280_G0.7710.17
129_A274_M0.7710.17
112_R141_V0.7700.17
348_A390_L0.7690.17
250_R320_I0.7670.17
242_A383_L0.7660.17
398_C502_I0.7630.17
128_L300_A0.7630.17
129_A345_E0.7610.17
390_L491_V0.7590.17
302_F371_A0.7590.17
63_M415_R0.7580.17
268_F289_L0.7580.17
307_I312_V0.7580.17
50_L57_S0.7570.17
52_E55_R0.7570.17
56_R225_L0.7560.17
237_K486_F0.7560.17
128_L429_I0.7560.17
145_S267_Y0.7560.17
82_M85_I0.7550.17
101_S125_R0.7530.17
92_N188_L0.7520.17
393_A486_F0.7520.17
106_P113_Q0.7490.17
260_D461_G0.7480.17
129_A144_H0.7440.17
213_H387_D0.7440.17
219_E444_I0.7430.16
446_V494_V0.7410.16
323_L339_R0.7410.16
418_I492_A0.7400.16
348_A352_A0.7400.16
85_I204_L0.7390.16
71_F232_V0.7370.16
387_D420_T0.7360.16
247_T441_D0.7340.16
276_T286_T0.7340.16
112_R162_V0.7330.16
121_T392_G0.7310.16
390_L409_I0.7290.16
143_I390_L0.7280.16
53_A202_V0.7270.16
125_R370_S0.7270.16
144_H206_E0.7260.16
304_L367_V0.7260.16
400_T407_S0.7260.16
144_H167_V0.7240.16
304_L360_S0.7230.16
316_E389_V0.7210.16
125_R383_L0.7200.16
219_E350_Q0.7190.16
349_N495_R0.7180.16
187_S337_L0.7180.16
130_E362_D0.7170.16
60_Q404_S0.7160.16
446_V463_K0.7150.16
55_R87_K0.7150.16
274_M441_D0.7120.16
260_D292_K0.7120.16
71_F274_M0.7120.16
65_V98_S0.7080.16
258_A408_I0.7060.16
105_A316_E0.7060.16
427_T444_I0.7040.16
93_L304_L0.7040.16
103_C462_I0.7020.16
77_T204_L0.7020.16
177_N180_T0.7000.15
345_E412_P0.7000.15
412_P479_G0.6970.15
93_L262_I0.6960.15
242_A429_I0.6950.15
243_T348_A0.6940.15
183_A434_S0.6920.15
91_K159_N0.6920.15
248_N435_V0.6910.15
53_A108_V0.6900.15
230_D455_E0.6880.15
383_L398_C0.6880.15
397_H413_L0.6870.15
352_A415_R0.6860.15
201_V223_V0.6860.15
67_F392_G0.6850.15
137_L202_V0.6840.15
267_Y287_R0.6830.15
236_A490_V0.6820.15
393_A429_I0.6820.15
98_S316_E0.6790.15
221_D350_Q0.6790.15
215_P427_T0.6770.15
351_Y430_T0.6770.15
382_V413_L0.6760.15
182_K228_K0.6760.15
387_D418_I0.6750.15
347_S446_V0.6750.15
411_A420_T0.6750.15
65_V438_L0.6740.15
96_A220_Q0.6740.15
170_C176_A0.6720.15
455_E472_E0.6720.15
65_V93_L0.6720.15
422_V428_C0.6690.15
323_L353_N0.6680.15
293_M301_D0.6670.15
185_C309_A0.6670.15
165_L245_M0.6650.15
383_L393_A0.6650.15
208_L226_I0.6640.15
137_L285_V0.6640.15
240_A334_A0.6630.15
259_A462_I0.6630.15
144_H394_S0.6630.15
206_E495_R0.6610.15
185_C367_V0.6600.15
239_G370_S0.6590.15
55_R84_V0.6560.14
116_V374_I0.6550.14
210_P507_Q0.6530.14
167_V282_S0.6520.14
356_S495_R0.6520.14
109_E113_Q0.6520.14
70_A206_E0.6520.14
232_V331_S0.6520.14
137_L199_K0.6510.14
285_V364_L0.6510.14
370_S391_R0.6500.14
450_R454_A0.6490.14
48_A53_A0.6480.14
280_G285_V0.6480.14
283_L492_A0.6480.14
145_S383_L0.6470.14
178_G210_P0.6460.14
454_A464_V0.6460.14
46_L421_L0.6460.14
398_C496_Y0.6450.14
454_A461_G0.6440.14
290_E507_Q0.6420.14
121_T383_L0.6420.14
50_L90_F0.6410.14
119_I492_A0.6380.14
254_I410_V0.6380.14
80_M204_L0.6380.14
162_V496_Y0.6370.14
197_N314_L0.6370.14
88_M473_R0.6360.14
102_D127_P0.6350.14
258_A506_H0.6340.14
50_L196_D0.6330.14
60_Q488_D0.6320.14
285_V380_V0.6310.14
73_G184_C0.6310.14
125_R391_R0.6310.14
213_H320_I0.6300.14
63_M183_A0.6300.14
129_A466_S0.6290.14
220_Q495_R0.6290.14
252_L284_A0.6290.14
97_S398_C0.6290.14
201_V402_I0.6290.14
76_L356_S0.6280.14
283_L436_D0.6260.14
123_G128_L0.6260.14
268_F286_T0.6250.14
240_A505_V0.6250.14
357_K485_E0.6250.14
484_I502_I0.6250.14
173_F211_Y0.6230.14
50_L424_N0.6230.14
185_C353_N0.6220.14
69_H190_Y0.6220.14
337_L345_E0.6220.14
129_A158_L0.6220.14
204_L232_V0.6220.14
150_V189_G0.6210.14
414_V471_R0.6210.14
41_A208_L0.6210.14
270_E506_H0.6180.14
168_P203_M0.6170.14
42_R139_E0.6160.14
280_G325_D0.6160.14
144_H226_I0.6150.14
128_L412_P0.6150.14
88_M237_K0.6140.14
108_V155_S0.6130.14
81_V164_F0.6130.14
287_R389_V0.6120.13
77_T232_V0.6110.13
141_V334_A0.6110.13
315_H342_N0.6110.13
265_S268_F0.6110.13
276_T411_A0.6090.13
254_I441_D0.6090.13
185_C337_L0.6080.13
133_S387_D0.6070.13
191_A382_V0.6070.13
167_V176_A0.6060.13
129_A456_R0.6060.13
79_N104_H0.6060.13
349_N353_N0.6050.13
217_S220_Q0.6040.13
279_G439_V0.6030.13
185_C314_L0.6020.13
53_A59_L0.6010.13
126_G302_F0.5990.13
263_V368_V0.5980.13
141_V383_L0.5970.13
82_M414_V0.5960.13
254_I502_I0.5950.13
220_Q398_C0.5940.13
151_H453_L0.5940.13
229_V469_W0.5940.13
328_S383_L0.5930.13
120_Y412_P0.5930.13
53_A110_H0.5930.13
117_T200_Q0.5920.13
173_F302_F0.5910.13
119_I132_I0.5900.13
466_S469_W0.5890.13
85_I323_L0.5880.13
213_H367_V0.5880.13
237_K331_S0.5870.13
215_P435_V0.5860.13
46_L208_L0.5860.13
452_E462_I0.5860.13
324_L446_V0.5850.13
143_I244_R0.5840.13
160_I299_R0.5840.13
281_A436_D0.5830.13
288_F415_R0.5830.13
241_G394_S0.5820.13
172_E508_V0.5810.13
61_D77_T0.5800.13
59_L118_R0.5790.13
250_R268_F0.5790.13
445_A467_I0.5790.13
170_C421_L0.5780.13
466_S484_I0.5770.13
458_Q461_G0.5770.13
349_N452_E0.5750.13
151_H206_E0.5750.13
389_V404_S0.5740.13
213_H391_R0.5740.13
117_T139_E0.5740.13
60_Q84_V0.5730.13
134_R389_V0.5710.13
173_F314_L0.5690.13
144_H221_D0.5670.13
248_N251_E0.5660.13
409_I489_R0.5660.13
169_S317_K0.5660.13
227_V491_V0.5660.13
475_R481_P0.5650.13
77_T166_G0.5650.13
280_G361_V0.5640.13
169_S466_S0.5630.13
210_P321_R0.5620.12
96_A276_T0.5620.12
97_S347_S0.5600.12
251_E420_T0.5590.12
390_L444_I0.5590.12
151_H349_N0.5580.12
420_T426_L0.5580.12
220_Q394_S0.5580.12
248_N344_I0.5570.12
290_E359_A0.5560.12
298_I356_S0.5550.12
376_T471_R0.5550.12
73_G283_L0.5540.12
144_H345_E0.5540.12
321_R444_I0.5530.12
265_S291_D0.5530.12
264_N268_F0.5530.12
239_G423_D0.5520.12
173_F356_S0.5520.12
294_R500_S0.5510.12
445_A457_L0.5500.12
324_L350_Q0.5490.12
468_E474_A0.5480.12
480_E490_V0.5470.12
80_M335_Q0.5470.12
189_G291_D0.5470.12
187_S346_I0.5460.12
184_C208_L0.5460.12
56_R461_G0.5460.12
294_R319_L0.5450.12
143_I278_T0.5450.12
138_A269_K0.5440.12
124_L366_V0.5440.12
157_E355_G0.5430.12
84_V404_S0.5420.12
148_G343_H0.5420.12
314_L466_S0.5410.12
351_Y401_A0.5410.12
154_Q356_S0.5390.12
262_I268_F0.5390.12
121_T288_F0.5390.12
301_D421_L0.5390.12
88_M304_L0.5370.12
226_I291_D0.5360.12
459_E489_R0.5340.12
96_A99_S0.5330.12
73_G310_T0.5330.12
165_L204_L0.5320.12
45_K49_N0.5310.12
156_G201_V0.5310.12
280_G436_D0.5300.12
135_G276_T0.5290.12
259_A263_V0.5280.12
458_Q462_I0.5270.12
288_F383_L0.5260.12
351_Y497_R0.5250.12
401_A430_T0.5240.12
122_S429_I0.5230.12
297_D455_E0.5230.12
304_L345_E0.5230.12
77_T241_G0.5220.12
50_L332_H0.5220.12
187_S304_L0.5220.12
99_S397_H0.5220.12
125_R145_S0.5210.12
352_A430_T0.5210.12
121_T125_R0.5200.12
312_V334_A0.5200.12
78_V331_S0.5190.12
63_M479_G0.5180.12
96_A215_P0.5170.12
240_A370_S0.5160.12
117_T225_L0.5160.12
302_F439_V0.5150.12
58_G88_M0.5140.12
189_G265_S0.5130.12
244_R415_R0.5130.12
111_I140_P0.5130.12
80_M182_K0.5120.12
202_V402_I0.5110.12
71_F77_T0.5100.11
177_N370_S0.5090.11
150_V245_M0.5080.11
43_D52_E0.5080.11
377_Q468_E0.5080.11
207_E480_E0.5070.11
118_R269_K0.5070.11
125_R143_I0.5070.11
260_D344_I0.5060.11
168_P281_A0.5060.11
91_K269_K0.5050.11
240_A278_T0.5050.11
245_M442_H0.5050.11
437_I446_V0.5040.11
122_S372_L0.5040.11
459_E472_E0.5040.11
280_G348_A0.5030.11
270_E480_E0.5010.11
50_L202_V0.5010.11
56_R91_K0.5000.11
59_L244_R0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hj0A 2 0.9922 100 0.533 Contact Map
1xr4A 2 0.9824 100 0.545 Contact Map
3eh7A 2 0.7353 100 0.754 Contact Map
3d3uA 1 0.7137 100 0.765 Contact Map
2oasA 3 0.7784 100 0.767 Contact Map
2nvvA 2 0.8451 100 0.771 Contact Map
2g39A 2 0.8549 100 0.773 Contact Map
4eu9A 2 0.8471 100 0.774 Contact Map
3gk7A 2 0.8098 100 0.78 Contact Map
3qliA 2 0.7922 100 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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