GREMLIN Database
RZPD - Putative Rz endopeptidase from lambdoid prophage DLP12
UniProt: P75719 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13636
Length: 153 (143)
Sequences: 432 (271)
Seq/√Len: 22.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_D143_G4.5741.00
137_M141_L3.7991.00
109_S143_G3.6081.00
118_R124_E2.9150.99
137_M140_Q2.4900.98
44_L47_A2.4720.98
138_Q141_L2.3730.97
122_T133_R2.2860.97
125_R133_R2.1280.95
121_D133_R2.1100.95
109_S112_D2.0370.94
53_D57_R1.9740.93
127_Y130_L1.9470.92
30_A33_Y1.8330.90
78_E83_R1.8310.90
146_K150_E1.8210.89
131_R134_L1.8090.89
85_D91_R1.7790.88
14_C17_V1.7080.86
65_D69_T1.7050.86
124_E127_Y1.6730.85
12_I15_I1.6590.84
141_L148_I1.6420.84
77_A81_A1.5450.80
87_A91_R1.5440.80
86_V128_F1.5050.78
16_I19_L1.4970.78
129_T133_R1.4940.78
64_L68_Y1.4930.77
85_D92_R1.4780.77
118_R133_R1.4510.75
86_V89_G1.4180.74
130_L140_Q1.4170.74
137_M142_E1.3820.72
137_M143_G1.3630.71
121_D125_R1.3090.67
15_I20_S1.2990.67
85_D90_R1.2810.66
117_P127_Y1.2690.65
37_R41_A1.2470.64
20_S24_N1.2450.63
124_E133_R1.2210.62
117_P130_L1.2190.62
80_D91_R1.2090.61
127_Y140_Q1.2080.61
29_N33_Y1.2070.61
40_N43_E1.2050.61
33_Y36_Q1.2030.61
130_L141_L1.1920.60
140_Q143_G1.1880.60
129_T140_Q1.1800.59
118_R121_D1.1690.58
138_Q142_E1.1630.58
124_E140_Q1.1600.58
9_S19_L1.1440.57
44_L48_N1.1330.56
71_E89_G1.1200.55
136_T143_G1.1150.55
12_I16_I1.1130.55
70_K74_D1.1040.54
113_N120_A1.1020.54
39_K43_E1.1020.54
117_P137_M1.0960.53
30_A34_K1.0910.53
10_A14_C1.0860.53
133_R137_M1.0770.52
26_Y30_A1.0720.52
134_L137_M1.0530.51
20_S23_V1.0520.50
27_R31_I1.0430.50
33_Y37_R1.0380.49
134_L144_T1.0290.49
10_A21_W1.0130.48
112_D141_L1.0010.47
78_E81_A0.9930.46
74_D108_A0.9920.46
51_I54_M0.9900.46
14_C18_S0.9810.46
120_A134_L0.9780.45
57_R151_Q0.9760.45
43_E47_A0.9730.45
124_E137_M0.9700.45
9_S12_I0.9690.45
9_S13_I0.9610.44
133_R143_G0.9580.44
88_A98_V0.9520.44
9_S18_S0.9350.42
21_W25_H0.9330.42
79_N92_R0.9250.42
110_G123_A0.9080.41
21_W24_N0.9040.40
30_A36_Q0.8990.40
67_K71_E0.8990.40
17_V21_W0.8980.40
39_K42_R0.8940.40
130_L133_R0.8910.40
19_L23_V0.8890.39
112_D135_I0.8860.39
15_I18_S0.8790.39
36_Q41_A0.8740.38
81_A84_D0.8670.38
124_E130_L0.8650.38
86_V93_L0.8480.37
37_R40_N0.8390.36
17_V20_S0.8360.36
9_S14_C0.8360.36
126_D133_R0.8330.36
17_V25_H0.8280.35
13_I21_W0.8250.35
35_V39_K0.8240.35
47_A59_R0.8200.35
54_M58_Q0.8160.35
34_K38_D0.8160.35
117_P140_Q0.8150.35
128_F135_I0.8070.34
42_R45_K0.7980.34
86_V129_T0.7980.34
127_Y137_M0.7970.34
54_M68_Y0.7840.33
16_I28_D0.7820.33
117_P124_E0.7810.33
23_V26_Y0.7800.32
135_I143_G0.7720.32
17_V22_A0.7700.32
133_R141_L0.7700.32
79_N91_R0.7640.32
135_I140_Q0.7630.31
84_D87_A0.7510.31
14_C21_W0.7450.30
101_S104_E0.7450.30
113_N134_L0.7370.30
44_L55_Q0.7360.30
110_G143_G0.7210.29
23_V31_I0.7200.29
47_A57_R0.7130.29
83_R92_R0.7120.29
92_R97_A0.7040.28
32_A40_N0.7010.28
118_R127_Y0.7000.28
16_I23_V0.6990.28
79_N83_R0.6980.28
122_T125_R0.6970.28
134_L142_E0.6960.28
118_R130_L0.6920.27
63_A67_K0.6910.27
53_D60_D0.6880.27
137_M144_T0.6780.27
119_L123_A0.6770.27
121_D129_T0.6760.27
22_A27_R0.6740.26
130_L136_T0.6700.26
20_S25_H0.6630.26
11_L19_L0.6600.26
32_A35_V0.6550.25
130_L137_M0.6500.25
120_A135_I0.6470.25
122_T134_L0.6450.25
65_D73_A0.6410.25
81_A87_A0.6380.25
90_R93_L0.6360.24
112_D137_M0.6340.24
94_H128_F0.6330.24
27_R32_A0.6210.24
136_T141_L0.6170.23
124_E128_F0.6130.23
130_L138_Q0.6130.23
120_A137_M0.6110.23
86_V90_R0.6040.23
135_I138_Q0.6030.23
31_I40_N0.6030.23
10_A17_V0.6010.23
117_P120_A0.6000.23
31_I34_K0.5990.23
133_R136_T0.5970.23
29_N34_K0.5960.22
16_I22_A0.5950.22
127_Y143_G0.5910.22
9_S15_I0.5900.22
91_R94_H0.5890.22
119_L129_T0.5890.22
47_A55_Q0.5880.22
13_I24_N0.5860.22
109_S141_L0.5840.22
67_K73_A0.5810.22
68_Y139_K0.5710.21
15_I23_V0.5710.21
10_A13_I0.5670.21
131_R145_Q0.5670.21
134_L141_L0.5660.21
38_D41_A0.5610.21
75_A79_N0.5600.21
139_K148_I0.5580.21
50_A53_D0.5570.21
72_L75_A0.5540.20
35_V42_R0.5510.20
36_Q39_K0.5490.20
79_N85_D0.5430.20
25_H29_N0.5420.20
66_A70_K0.5410.20
19_L22_A0.5400.20
16_I39_K0.5400.20
70_K81_A0.5390.20
9_S22_A0.5350.20
92_R117_P0.5300.19
139_K142_E0.5270.19
23_V28_D0.5220.19
58_Q61_V0.5190.19
146_K151_Q0.5160.19
59_R62_A0.5140.19
69_T72_L0.5060.18
70_K77_A0.5050.18
134_L143_G0.5020.18
42_R107_T0.5000.18
105_A111_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4gX 1 0 90.8 0.898 Contact Map
4cgkA 3 0.6732 88.7 0.902 Contact Map
3layA 5 0.5033 44.5 0.931 Contact Map
3q0xA 2 0.5229 34.1 0.936 Contact Map
4nqiA 2 0.7908 24.8 0.94 Contact Map
4rsiA 1 0.4183 24.2 0.94 Contact Map
4rh7A 1 0.915 20.9 0.942 Contact Map
3oa8A 1 0.4837 20.7 0.942 Contact Map
5al7A 2 0.5033 20.7 0.942 Contact Map
2akhX 1 0.1699 17.6 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0064 seconds.