SFMH - ECOLI - GREMLIN Contacts

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SFMH - Uncharacterized fimbrial-like protein SfmH

UniProt:	P75715	Sequences: MAMACLCLANISWATVCANSTGVAEDEHYDLSNIFNSTNNQPGQIVVLPEKSGWVGVSAICPPGTLVNYTYRSYVTNFIVQETIDNYKYMQLHDYLLGAMSLVDSVMDIQFPPQNYIRMGTDPNVSQNLPFGVMDSRLIFRLKVIRPFINMVEIPRQVMFTVYVTSTPYDPLVTPVYTISFGGRVEVPQNCELNAGQIVEFDFGDIGASLFSAAGPGNRPAGVMPQTKSIAVKCTNVAAQAYLTMRLEASAVSGQAMVSDNQDLGFIVADQNDTPITPNDLNSVIPFRLDAAAAANVTLRAWPISITGQKPTEGPFSALGYLRVDYQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13884
Length:	327 (313)
Sequences:	225 (183)
Seq/√Len:	10.3

ECOLI - SFMH ELFG YRAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
269_A	302_W	4.839	1.00
164_V	176_V	4.054	0.99
206_I	316_F	3.768	0.98
307_T	311_P	3.616	0.98
249_A	257_M	3.551	0.98
246_R	325_D	3.497	0.97
81_Q	97_L	2.971	0.93
261_N	311_P	2.803	0.91
201_F	228_K	2.736	0.90
147_P	183_G	2.730	0.89
86_N	96_L	2.676	0.88
142_L	185_V	2.653	0.88
96_L	144_V	2.615	0.87
97_L	145_I	2.514	0.85
148_F	185_V	2.485	0.84
270_D	274_T	2.432	0.83
102_L	162_V	2.358	0.81
119_M	135_D	2.291	0.79
72_R	162_V	2.254	0.78
155_P	183_G	2.223	0.77
276_I	283_S	2.193	0.76
74_Y	162_V	2.167	0.75
59_A	150_N	2.123	0.73
264_L	313_E	2.055	0.71
71_Y	92_L	2.006	0.69
266_F	306_I	1.989	0.68
188_P	206_I	1.960	0.67
148_F	189_Q	1.951	0.66
55_V	135_D	1.945	0.66
258_V	266_F	1.905	0.65
89_Y	176_V	1.846	0.62
135_D	138_L	1.841	0.62
104_D	119_M	1.816	0.61
243_L	325_D	1.816	0.61
119_M	134_M	1.792	0.60
112_P	131_F	1.791	0.60
217_G	261_N	1.780	0.59
201_F	318_A	1.778	0.59
105_S	109_I	1.758	0.58
17_C	148_F	1.717	0.56
305_S	311_P	1.703	0.56
78_F	93_H	1.697	0.55
40_N	61_C	1.681	0.55
189_Q	305_S	1.670	0.54
261_N	307_T	1.664	0.54
203_F	316_F	1.651	0.53
138_L	179_I	1.651	0.53
91_Q	145_I	1.648	0.53
188_P	316_F	1.633	0.52
19_N	106_V	1.624	0.52
88_K	99_A	1.611	0.51
148_F	165_T	1.610	0.51
192_E	197_Q	1.599	0.51
196_G	199_V	1.597	0.51
259_S	318_A	1.581	0.50
101_S	139_I	1.574	0.50
104_D	114_Q	1.566	0.49
149_I	192_E	1.564	0.49
150_N	264_L	1.519	0.47
199_V	295_A	1.518	0.47
12_S	17_C	1.507	0.46
194_N	199_V	1.506	0.46
256_A	266_F	1.470	0.45
51_K	177_Y	1.464	0.44
189_Q	261_N	1.463	0.44
19_N	176_V	1.460	0.44
19_N	22_G	1.446	0.44
31_L	47_V	1.444	0.44
108_D	111_F	1.436	0.43
191_C	234_C	1.420	0.42
246_R	285_I	1.416	0.42
242_Y	313_E	1.406	0.42
142_L	236_N	1.405	0.42
184_R	190_N	1.402	0.42
280_D	302_W	1.397	0.41
29_Y	159_M	1.370	0.40
88_K	97_L	1.369	0.40
255_Q	267_I	1.358	0.40
159_M	264_L	1.357	0.40
13_W	16_V	1.353	0.39
100_M	181_F	1.340	0.39
154_I	263_D	1.336	0.39
268_V	274_T	1.326	0.38
76_T	79_I	1.323	0.38
290_D	325_D	1.320	0.38
111_F	182_G	1.308	0.37
229_S	299_L	1.302	0.37
258_V	306_I	1.301	0.37
102_L	142_L	1.299	0.37
99_A	261_N	1.298	0.37
90_M	143_K	1.297	0.37
323_R	326_Y	1.293	0.37
135_D	177_Y	1.276	0.36
188_P	197_Q	1.276	0.36
107_M	185_V	1.272	0.36
88_K	325_D	1.272	0.36
71_Y	318_A	1.264	0.36
223_V	260_D	1.260	0.35
191_C	303_P	1.256	0.35
187_V	263_D	1.254	0.35
79_I	159_M	1.253	0.35
176_V	198_I	1.249	0.35
165_T	311_P	1.245	0.35
257_M	305_S	1.245	0.35
79_I	169_Y	1.241	0.35
104_D	107_M	1.224	0.34
223_V	295_A	1.220	0.34
161_T	178_T	1.220	0.34
295_A	321_Y	1.218	0.34
163_Y	176_V	1.201	0.33
189_Q	308_G	1.195	0.33
197_Q	318_A	1.185	0.32
50_E	138_L	1.185	0.32
31_L	157_Q	1.181	0.32
211_F	305_S	1.170	0.32
267_I	322_L	1.168	0.32
217_G	278_P	1.162	0.31
59_A	155_P	1.155	0.31
266_F	321_Y	1.139	0.30
100_M	239_A	1.135	0.30
232_V	318_A	1.135	0.30
230_I	264_L	1.134	0.30
64_G	117_I	1.126	0.30
252_V	306_I	1.126	0.30
93_H	175_P	1.110	0.29
164_V	203_F	1.106	0.29
247_L	301_A	1.104	0.29
135_D	162_V	1.100	0.29
187_V	285_I	1.096	0.29
223_V	305_S	1.094	0.29
93_H	148_F	1.089	0.28
22_G	203_F	1.081	0.28
111_F	160_F	1.073	0.28
276_I	302_W	1.070	0.28
89_Y	153_E	1.069	0.28
234_C	303_P	1.068	0.28
182_G	245_M	1.065	0.28
179_I	240_Q	1.064	0.27
75_V	203_F	1.063	0.27
19_N	112_P	1.060	0.27
119_M	138_L	1.058	0.27
187_V	243_L	1.057	0.27
173_V	205_D	1.051	0.27
213_A	305_S	1.049	0.27
150_N	311_P	1.047	0.27
112_P	116_Y	1.044	0.27
151_M	326_Y	1.043	0.27
217_G	307_T	1.039	0.27
267_I	299_L	1.038	0.27
178_T	218_N	1.031	0.26
184_R	260_D	1.022	0.26
225_P	249_A	1.019	0.26
209_S	230_I	1.019	0.26
81_Q	88_K	1.018	0.26
100_M	160_F	1.017	0.26
265_G	304_I	1.013	0.26
298_T	320_G	1.009	0.26
150_N	157_Q	1.008	0.25
243_L	321_Y	1.006	0.25
203_F	237_V	1.002	0.25
114_Q	138_L	0.998	0.25
245_M	324_V	0.992	0.25
207_G	210_L	0.991	0.25
217_G	270_D	0.984	0.25
231_A	299_L	0.982	0.25
9_A	301_A	0.975	0.24
36_N	146_R	0.967	0.24
136_S	273_D	0.964	0.24
192_E	233_K	0.958	0.24
92_L	230_I	0.958	0.24
110_Q	120_G	0.956	0.24
261_N	308_G	0.956	0.24
165_T	261_N	0.954	0.24
228_K	299_L	0.953	0.24
319_L	322_L	0.950	0.23
262_Q	286_P	0.950	0.23
295_A	302_W	0.949	0.23
120_G	159_M	0.945	0.23
189_Q	311_P	0.940	0.23
9_A	12_S	0.939	0.23
10_N	203_F	0.933	0.23
38_T	202_D	0.932	0.23
201_F	310_K	0.931	0.23
92_L	199_V	0.929	0.23
48_L	94_D	0.923	0.23
205_D	291_A	0.922	0.23
13_W	201_F	0.921	0.23
142_L	162_V	0.921	0.23
185_V	270_D	0.921	0.23
36_N	39_N	0.920	0.22
287_F	321_Y	0.919	0.22
62_P	259_S	0.915	0.22
43_G	264_L	0.915	0.22
148_F	155_P	0.911	0.22
29_Y	181_F	0.903	0.22
91_Q	94_D	0.900	0.22
91_Q	301_A	0.895	0.22
61_C	142_L	0.889	0.21
23_V	174_T	0.888	0.21
278_P	313_E	0.884	0.21
15_T	247_L	0.883	0.21
277_T	283_S	0.882	0.21
123_P	129_L	0.881	0.21
160_F	177_Y	0.881	0.21
91_Q	247_L	0.879	0.21
256_A	264_L	0.879	0.21
90_M	119_M	0.872	0.21
237_V	293_A	0.872	0.21
225_P	267_I	0.871	0.21
219_R	225_P	0.870	0.21
90_M	135_D	0.870	0.21
245_M	287_F	0.863	0.21
255_Q	275_P	0.863	0.21
144_V	154_I	0.862	0.21
189_Q	307_T	0.856	0.20
10_N	23_V	0.855	0.20
95_Y	308_G	0.854	0.20
135_D	266_F	0.853	0.20
19_N	55_V	0.852	0.20
220_P	304_I	0.850	0.20
21_T	304_I	0.847	0.20
253_S	291_A	0.846	0.20
223_V	266_F	0.845	0.20
223_V	283_S	0.842	0.20
71_Y	163_Y	0.841	0.20
92_L	97_L	0.839	0.20
305_S	308_G	0.836	0.20
248_E	302_W	0.835	0.20
96_L	148_F	0.835	0.20
153_E	184_R	0.833	0.20
146_R	265_G	0.833	0.20
57_V	176_V	0.832	0.20
257_M	295_A	0.828	0.20
191_C	314_G	0.827	0.20
241_A	297_V	0.827	0.20
13_W	238_A	0.824	0.20
113_P	303_P	0.824	0.20
136_S	263_D	0.822	0.19
148_F	183_G	0.820	0.19
155_P	208_A	0.819	0.19
43_G	93_H	0.818	0.19
17_C	150_N	0.817	0.19
283_S	322_L	0.816	0.19
55_V	308_G	0.811	0.19
238_A	326_Y	0.811	0.19
136_S	179_I	0.808	0.19
196_G	263_D	0.808	0.19
22_G	316_F	0.808	0.19
201_F	204_G	0.808	0.19
119_M	164_V	0.807	0.19
98_G	143_K	0.807	0.19
27_E	80_V	0.804	0.19
104_D	168_P	0.801	0.19
149_I	266_F	0.799	0.19
306_I	311_P	0.797	0.19
17_C	256_A	0.797	0.19
285_I	293_A	0.795	0.19
193_L	258_V	0.794	0.19
163_Y	206_I	0.794	0.19
27_E	55_V	0.792	0.19
276_I	295_A	0.787	0.18
147_P	247_L	0.786	0.18
276_I	305_S	0.785	0.18
157_Q	183_G	0.784	0.18
247_L	320_G	0.783	0.18
141_R	160_F	0.778	0.18
312_T	317_S	0.777	0.18
246_R	326_Y	0.776	0.18
19_N	135_D	0.775	0.18
10_N	168_P	0.773	0.18
147_P	232_V	0.773	0.18
189_Q	211_F	0.771	0.18
10_N	19_N	0.771	0.18
81_Q	91_Q	0.767	0.18
259_S	266_F	0.762	0.18
42_P	147_P	0.762	0.18
210_L	326_Y	0.761	0.18
295_A	305_S	0.760	0.18
201_F	226_Q	0.759	0.18
249_A	270_D	0.758	0.18
244_T	298_T	0.755	0.18
241_A	326_Y	0.754	0.18
125_V	131_F	0.753	0.18
249_A	305_S	0.752	0.17
214_A	223_V	0.749	0.17
74_Y	135_D	0.749	0.17
150_N	235_T	0.747	0.17
168_P	324_V	0.744	0.17
262_Q	324_V	0.743	0.17
88_K	295_A	0.741	0.17
266_F	311_P	0.741	0.17
218_N	301_A	0.737	0.17
55_V	72_R	0.736	0.17
279_N	305_S	0.734	0.17
111_F	188_P	0.725	0.17
132_G	185_V	0.722	0.17
196_G	265_G	0.720	0.17
58_S	163_Y	0.717	0.17
98_G	179_I	0.716	0.17
116_Y	134_M	0.715	0.17
97_L	185_V	0.714	0.16
154_I	183_G	0.713	0.16
189_Q	236_N	0.712	0.16
43_G	320_G	0.712	0.16
254_G	274_T	0.710	0.16
110_Q	185_V	0.707	0.16
23_V	113_P	0.706	0.16
188_P	193_L	0.705	0.16
144_V	159_M	0.704	0.16
295_A	316_F	0.704	0.16
90_M	98_G	0.702	0.16
71_Y	118_R	0.697	0.16
198_I	298_T	0.696	0.16
12_S	308_G	0.696	0.16
92_L	136_S	0.695	0.16
293_A	318_A	0.693	0.16
87_Y	101_S	0.691	0.16
276_I	279_N	0.690	0.16
12_S	149_I	0.689	0.16
263_D	308_G	0.688	0.16
203_F	299_L	0.686	0.16
104_D	112_P	0.676	0.16
119_M	177_Y	0.673	0.15
56_G	180_S	0.673	0.15
146_R	297_V	0.672	0.15
191_C	265_G	0.669	0.15
90_M	102_L	0.666	0.15
297_V	301_A	0.665	0.15
299_L	322_L	0.664	0.15
211_F	297_V	0.664	0.15
42_P	66_L	0.660	0.15
26_D	178_T	0.659	0.15
246_R	295_A	0.656	0.15
290_D	293_A	0.655	0.15
98_G	160_F	0.653	0.15
30_D	94_D	0.652	0.15
21_T	262_Q	0.651	0.15
230_I	269_A	0.649	0.15
92_L	181_F	0.649	0.15
274_T	291_A	0.646	0.15
91_Q	161_T	0.645	0.15
17_C	61_C	0.644	0.15
63_P	96_L	0.642	0.15
221_A	264_L	0.641	0.15
147_P	204_G	0.641	0.15
169_Y	274_T	0.641	0.15
23_V	128_N	0.640	0.15
249_A	255_Q	0.640	0.15
223_V	276_I	0.639	0.15
159_M	243_L	0.638	0.15
79_I	211_F	0.637	0.15
149_I	195_A	0.634	0.15
89_Y	143_K	0.634	0.15
262_Q	276_I	0.633	0.15
115_N	197_Q	0.633	0.15
219_R	224_M	0.632	0.14
14_A	60_I	0.631	0.14
27_E	166_S	0.631	0.14
297_V	324_V	0.629	0.14
38_T	144_V	0.629	0.14
192_E	211_F	0.628	0.14
100_M	166_S	0.628	0.14
158_V	180_S	0.624	0.14
136_S	203_F	0.624	0.14
296_N	320_G	0.623	0.14
15_T	138_L	0.622	0.14
227_T	324_V	0.622	0.14
174_T	273_D	0.621	0.14
161_T	197_Q	0.621	0.14
96_L	183_G	0.620	0.14
234_C	314_G	0.619	0.14
198_I	322_L	0.618	0.14
126_S	129_L	0.617	0.14
153_E	174_T	0.615	0.14
220_P	316_F	0.614	0.14
112_P	288_R	0.613	0.14
147_P	285_I	0.611	0.14
60_I	264_L	0.611	0.14
158_V	161_T	0.608	0.14
183_G	217_G	0.608	0.14
210_L	222_G	0.606	0.14
70_T	94_D	0.600	0.14
144_V	202_D	0.599	0.14
68_N	126_S	0.598	0.14
142_L	181_F	0.598	0.14
118_R	134_M	0.597	0.14
116_Y	161_T	0.596	0.14
30_D	44_Q	0.595	0.14
257_M	265_G	0.595	0.14
142_L	301_A	0.593	0.14
17_C	211_F	0.588	0.14
53_G	188_P	0.586	0.13
27_E	177_Y	0.586	0.13
242_Y	321_Y	0.585	0.13
154_I	220_P	0.585	0.13
54_W	63_P	0.582	0.13
144_V	247_L	0.581	0.13
233_K	301_A	0.579	0.13
95_Y	186_E	0.578	0.13
246_R	311_P	0.577	0.13
317_S	322_L	0.576	0.13
189_Q	263_D	0.576	0.13
150_N	306_I	0.575	0.13
194_N	226_Q	0.573	0.13
203_F	228_K	0.572	0.13
67_V	245_M	0.570	0.13
15_T	60_I	0.566	0.13
29_Y	90_M	0.566	0.13
134_M	177_Y	0.564	0.13
306_I	319_L	0.564	0.13
247_L	297_V	0.561	0.13
106_V	112_P	0.560	0.13
18_A	272_N	0.558	0.13
74_Y	78_F	0.558	0.13
142_L	302_W	0.557	0.13
141_R	243_L	0.557	0.13
318_A	326_Y	0.557	0.13
30_D	52_S	0.556	0.13
104_D	135_D	0.556	0.13
242_Y	306_I	0.556	0.13
128_N	315_P	0.555	0.13
99_A	152_V	0.553	0.13
114_Q	134_M	0.553	0.13
108_D	117_I	0.552	0.13
104_D	240_Q	0.551	0.13
287_F	295_A	0.551	0.13
103_V	136_S	0.550	0.13
95_Y	278_P	0.550	0.13
32_S	41_Q	0.550	0.13
183_G	189_Q	0.546	0.13
37_S	150_N	0.545	0.13
223_V	287_F	0.544	0.13
181_F	301_A	0.542	0.13
108_D	112_P	0.542	0.13
112_P	118_R	0.542	0.13
43_G	261_N	0.538	0.12
96_L	319_L	0.538	0.12
266_F	295_A	0.538	0.12
95_Y	232_V	0.536	0.12
12_S	61_C	0.532	0.12
173_V	318_A	0.531	0.12
285_I	321_Y	0.530	0.12
256_A	267_I	0.529	0.12
27_E	135_D	0.528	0.12
264_L	308_G	0.528	0.12
252_V	274_T	0.526	0.12
107_M	181_F	0.526	0.12
41_Q	71_Y	0.525	0.12
47_V	304_I	0.524	0.12
55_V	177_Y	0.520	0.12
264_L	323_R	0.519	0.12
72_R	131_F	0.518	0.12
140_F	317_S	0.515	0.12
59_A	264_L	0.513	0.12
131_F	181_F	0.513	0.12
227_T	322_L	0.512	0.12
79_I	103_V	0.512	0.12
32_S	67_V	0.512	0.12
29_Y	296_N	0.511	0.12
35_F	162_V	0.508	0.12
194_N	201_F	0.507	0.12
204_G	316_F	0.506	0.12
300_R	315_P	0.506	0.12
144_V	305_S	0.505	0.12
201_F	232_V	0.505	0.12
172_L	176_V	0.504	0.12
45_I	114_Q	0.504	0.12
146_R	185_V	0.501	0.12
263_D	312_T	0.501	0.12
95_Y	243_L	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5afoA	1	0.948	100	0.487	Contact Map
1n12A	1	0.3853	99.8	0.788	Contact Map
2w07B	1	0.3547	99.8	0.804	Contact Map
3jwnH	1	0.8165	99.7	0.808	Contact Map
1pdkB	1	0.4159	99.7	0.815	Contact Map
2xg5B	1	0.4159	99.7	0.816	Contact Map
2jtyA	1	0.4526	99.7	0.817	Contact Map
2jmrA	1	0.4434	99.7	0.82	Contact Map
3bfqG	1	0.3914	99.6	0.825	Contact Map
2uy6B	2	0.4343	99.6	0.827	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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