GREMLIN Database
SFMH - Uncharacterized fimbrial-like protein SfmH
UniProt: P75715 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13884
Length: 327 (313)
Sequences: 225 (183)
Seq/√Len: 10.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_A302_W4.8391.00
164_V176_V4.0540.99
206_I316_F3.7680.98
307_T311_P3.6160.98
249_A257_M3.5510.98
246_R325_D3.4970.97
81_Q97_L2.9710.93
261_N311_P2.8030.91
201_F228_K2.7360.90
147_P183_G2.7300.89
86_N96_L2.6760.88
142_L185_V2.6530.88
96_L144_V2.6150.87
97_L145_I2.5140.85
148_F185_V2.4850.84
270_D274_T2.4320.83
102_L162_V2.3580.81
119_M135_D2.2910.79
72_R162_V2.2540.78
155_P183_G2.2230.77
276_I283_S2.1930.76
74_Y162_V2.1670.75
59_A150_N2.1230.73
264_L313_E2.0550.71
71_Y92_L2.0060.69
266_F306_I1.9890.68
188_P206_I1.9600.67
148_F189_Q1.9510.66
55_V135_D1.9450.66
258_V266_F1.9050.65
89_Y176_V1.8460.62
135_D138_L1.8410.62
104_D119_M1.8160.61
243_L325_D1.8160.61
119_M134_M1.7920.60
112_P131_F1.7910.60
217_G261_N1.7800.59
201_F318_A1.7780.59
105_S109_I1.7580.58
17_C148_F1.7170.56
305_S311_P1.7030.56
78_F93_H1.6970.55
40_N61_C1.6810.55
189_Q305_S1.6700.54
261_N307_T1.6640.54
203_F316_F1.6510.53
138_L179_I1.6510.53
91_Q145_I1.6480.53
188_P316_F1.6330.52
19_N106_V1.6240.52
88_K99_A1.6110.51
148_F165_T1.6100.51
192_E197_Q1.5990.51
196_G199_V1.5970.51
259_S318_A1.5810.50
101_S139_I1.5740.50
104_D114_Q1.5660.49
149_I192_E1.5640.49
150_N264_L1.5190.47
199_V295_A1.5180.47
12_S17_C1.5070.46
194_N199_V1.5060.46
256_A266_F1.4700.45
51_K177_Y1.4640.44
189_Q261_N1.4630.44
19_N176_V1.4600.44
19_N22_G1.4460.44
31_L47_V1.4440.44
108_D111_F1.4360.43
191_C234_C1.4200.42
246_R285_I1.4160.42
242_Y313_E1.4060.42
142_L236_N1.4050.42
184_R190_N1.4020.42
280_D302_W1.3970.41
29_Y159_M1.3700.40
88_K97_L1.3690.40
255_Q267_I1.3580.40
159_M264_L1.3570.40
13_W16_V1.3530.39
100_M181_F1.3400.39
154_I263_D1.3360.39
268_V274_T1.3260.38
76_T79_I1.3230.38
290_D325_D1.3200.38
111_F182_G1.3080.37
229_S299_L1.3020.37
258_V306_I1.3010.37
102_L142_L1.2990.37
99_A261_N1.2980.37
90_M143_K1.2970.37
323_R326_Y1.2930.37
135_D177_Y1.2760.36
188_P197_Q1.2760.36
107_M185_V1.2720.36
88_K325_D1.2720.36
71_Y318_A1.2640.36
223_V260_D1.2600.35
191_C303_P1.2560.35
187_V263_D1.2540.35
79_I159_M1.2530.35
176_V198_I1.2490.35
165_T311_P1.2450.35
257_M305_S1.2450.35
79_I169_Y1.2410.35
104_D107_M1.2240.34
223_V295_A1.2200.34
161_T178_T1.2200.34
295_A321_Y1.2180.34
163_Y176_V1.2010.33
189_Q308_G1.1950.33
197_Q318_A1.1850.32
50_E138_L1.1850.32
31_L157_Q1.1810.32
211_F305_S1.1700.32
267_I322_L1.1680.32
217_G278_P1.1620.31
59_A155_P1.1550.31
266_F321_Y1.1390.30
100_M239_A1.1350.30
232_V318_A1.1350.30
230_I264_L1.1340.30
64_G117_I1.1260.30
252_V306_I1.1260.30
93_H175_P1.1100.29
164_V203_F1.1060.29
247_L301_A1.1040.29
135_D162_V1.1000.29
187_V285_I1.0960.29
223_V305_S1.0940.29
93_H148_F1.0890.28
22_G203_F1.0810.28
111_F160_F1.0730.28
276_I302_W1.0700.28
89_Y153_E1.0690.28
234_C303_P1.0680.28
182_G245_M1.0650.28
179_I240_Q1.0640.27
75_V203_F1.0630.27
19_N112_P1.0600.27
119_M138_L1.0580.27
187_V243_L1.0570.27
173_V205_D1.0510.27
213_A305_S1.0490.27
150_N311_P1.0470.27
112_P116_Y1.0440.27
151_M326_Y1.0430.27
217_G307_T1.0390.27
267_I299_L1.0380.27
178_T218_N1.0310.26
184_R260_D1.0220.26
225_P249_A1.0190.26
209_S230_I1.0190.26
81_Q88_K1.0180.26
100_M160_F1.0170.26
265_G304_I1.0130.26
298_T320_G1.0090.26
150_N157_Q1.0080.25
243_L321_Y1.0060.25
203_F237_V1.0020.25
114_Q138_L0.9980.25
245_M324_V0.9920.25
207_G210_L0.9910.25
217_G270_D0.9840.25
231_A299_L0.9820.25
9_A301_A0.9750.24
36_N146_R0.9670.24
136_S273_D0.9640.24
192_E233_K0.9580.24
92_L230_I0.9580.24
110_Q120_G0.9560.24
261_N308_G0.9560.24
165_T261_N0.9540.24
228_K299_L0.9530.24
319_L322_L0.9500.23
262_Q286_P0.9500.23
295_A302_W0.9490.23
120_G159_M0.9450.23
189_Q311_P0.9400.23
9_A12_S0.9390.23
10_N203_F0.9330.23
38_T202_D0.9320.23
201_F310_K0.9310.23
92_L199_V0.9290.23
48_L94_D0.9230.23
205_D291_A0.9220.23
13_W201_F0.9210.23
142_L162_V0.9210.23
185_V270_D0.9210.23
36_N39_N0.9200.22
287_F321_Y0.9190.22
62_P259_S0.9150.22
43_G264_L0.9150.22
148_F155_P0.9110.22
29_Y181_F0.9030.22
91_Q94_D0.9000.22
91_Q301_A0.8950.22
61_C142_L0.8890.21
23_V174_T0.8880.21
278_P313_E0.8840.21
15_T247_L0.8830.21
277_T283_S0.8820.21
123_P129_L0.8810.21
160_F177_Y0.8810.21
91_Q247_L0.8790.21
256_A264_L0.8790.21
90_M119_M0.8720.21
237_V293_A0.8720.21
225_P267_I0.8710.21
219_R225_P0.8700.21
90_M135_D0.8700.21
245_M287_F0.8630.21
255_Q275_P0.8630.21
144_V154_I0.8620.21
189_Q307_T0.8560.20
10_N23_V0.8550.20
95_Y308_G0.8540.20
135_D266_F0.8530.20
19_N55_V0.8520.20
220_P304_I0.8500.20
21_T304_I0.8470.20
253_S291_A0.8460.20
223_V266_F0.8450.20
223_V283_S0.8420.20
71_Y163_Y0.8410.20
92_L97_L0.8390.20
305_S308_G0.8360.20
248_E302_W0.8350.20
96_L148_F0.8350.20
153_E184_R0.8330.20
146_R265_G0.8330.20
57_V176_V0.8320.20
257_M295_A0.8280.20
191_C314_G0.8270.20
241_A297_V0.8270.20
13_W238_A0.8240.20
113_P303_P0.8240.20
136_S263_D0.8220.19
148_F183_G0.8200.19
155_P208_A0.8190.19
43_G93_H0.8180.19
17_C150_N0.8170.19
283_S322_L0.8160.19
55_V308_G0.8110.19
238_A326_Y0.8110.19
136_S179_I0.8080.19
196_G263_D0.8080.19
22_G316_F0.8080.19
201_F204_G0.8080.19
119_M164_V0.8070.19
98_G143_K0.8070.19
27_E80_V0.8040.19
104_D168_P0.8010.19
149_I266_F0.7990.19
306_I311_P0.7970.19
17_C256_A0.7970.19
285_I293_A0.7950.19
193_L258_V0.7940.19
163_Y206_I0.7940.19
27_E55_V0.7920.19
276_I295_A0.7870.18
147_P247_L0.7860.18
276_I305_S0.7850.18
157_Q183_G0.7840.18
247_L320_G0.7830.18
141_R160_F0.7780.18
312_T317_S0.7770.18
246_R326_Y0.7760.18
19_N135_D0.7750.18
10_N168_P0.7730.18
147_P232_V0.7730.18
189_Q211_F0.7710.18
10_N19_N0.7710.18
81_Q91_Q0.7670.18
259_S266_F0.7620.18
42_P147_P0.7620.18
210_L326_Y0.7610.18
295_A305_S0.7600.18
201_F226_Q0.7590.18
249_A270_D0.7580.18
244_T298_T0.7550.18
241_A326_Y0.7540.18
125_V131_F0.7530.18
249_A305_S0.7520.17
214_A223_V0.7490.17
74_Y135_D0.7490.17
150_N235_T0.7470.17
168_P324_V0.7440.17
262_Q324_V0.7430.17
88_K295_A0.7410.17
266_F311_P0.7410.17
218_N301_A0.7370.17
55_V72_R0.7360.17
279_N305_S0.7340.17
111_F188_P0.7250.17
132_G185_V0.7220.17
196_G265_G0.7200.17
58_S163_Y0.7170.17
98_G179_I0.7160.17
116_Y134_M0.7150.17
97_L185_V0.7140.16
154_I183_G0.7130.16
189_Q236_N0.7120.16
43_G320_G0.7120.16
254_G274_T0.7100.16
110_Q185_V0.7070.16
23_V113_P0.7060.16
188_P193_L0.7050.16
144_V159_M0.7040.16
295_A316_F0.7040.16
90_M98_G0.7020.16
71_Y118_R0.6970.16
198_I298_T0.6960.16
12_S308_G0.6960.16
92_L136_S0.6950.16
293_A318_A0.6930.16
87_Y101_S0.6910.16
276_I279_N0.6900.16
12_S149_I0.6890.16
263_D308_G0.6880.16
203_F299_L0.6860.16
104_D112_P0.6760.16
119_M177_Y0.6730.15
56_G180_S0.6730.15
146_R297_V0.6720.15
191_C265_G0.6690.15
90_M102_L0.6660.15
297_V301_A0.6650.15
299_L322_L0.6640.15
211_F297_V0.6640.15
42_P66_L0.6600.15
26_D178_T0.6590.15
246_R295_A0.6560.15
290_D293_A0.6550.15
98_G160_F0.6530.15
30_D94_D0.6520.15
21_T262_Q0.6510.15
230_I269_A0.6490.15
92_L181_F0.6490.15
274_T291_A0.6460.15
91_Q161_T0.6450.15
17_C61_C0.6440.15
63_P96_L0.6420.15
221_A264_L0.6410.15
147_P204_G0.6410.15
169_Y274_T0.6410.15
23_V128_N0.6400.15
249_A255_Q0.6400.15
223_V276_I0.6390.15
159_M243_L0.6380.15
79_I211_F0.6370.15
149_I195_A0.6340.15
89_Y143_K0.6340.15
262_Q276_I0.6330.15
115_N197_Q0.6330.15
219_R224_M0.6320.14
14_A60_I0.6310.14
27_E166_S0.6310.14
297_V324_V0.6290.14
38_T144_V0.6290.14
192_E211_F0.6280.14
100_M166_S0.6280.14
158_V180_S0.6240.14
136_S203_F0.6240.14
296_N320_G0.6230.14
15_T138_L0.6220.14
227_T324_V0.6220.14
174_T273_D0.6210.14
161_T197_Q0.6210.14
96_L183_G0.6200.14
234_C314_G0.6190.14
198_I322_L0.6180.14
126_S129_L0.6170.14
153_E174_T0.6150.14
220_P316_F0.6140.14
112_P288_R0.6130.14
147_P285_I0.6110.14
60_I264_L0.6110.14
158_V161_T0.6080.14
183_G217_G0.6080.14
210_L222_G0.6060.14
70_T94_D0.6000.14
144_V202_D0.5990.14
68_N126_S0.5980.14
142_L181_F0.5980.14
118_R134_M0.5970.14
116_Y161_T0.5960.14
30_D44_Q0.5950.14
257_M265_G0.5950.14
142_L301_A0.5930.14
17_C211_F0.5880.14
53_G188_P0.5860.13
27_E177_Y0.5860.13
242_Y321_Y0.5850.13
154_I220_P0.5850.13
54_W63_P0.5820.13
144_V247_L0.5810.13
233_K301_A0.5790.13
95_Y186_E0.5780.13
246_R311_P0.5770.13
317_S322_L0.5760.13
189_Q263_D0.5760.13
150_N306_I0.5750.13
194_N226_Q0.5730.13
203_F228_K0.5720.13
67_V245_M0.5700.13
15_T60_I0.5660.13
29_Y90_M0.5660.13
134_M177_Y0.5640.13
306_I319_L0.5640.13
247_L297_V0.5610.13
106_V112_P0.5600.13
18_A272_N0.5580.13
74_Y78_F0.5580.13
142_L302_W0.5570.13
141_R243_L0.5570.13
318_A326_Y0.5570.13
30_D52_S0.5560.13
104_D135_D0.5560.13
242_Y306_I0.5560.13
128_N315_P0.5550.13
99_A152_V0.5530.13
114_Q134_M0.5530.13
108_D117_I0.5520.13
104_D240_Q0.5510.13
287_F295_A0.5510.13
103_V136_S0.5500.13
95_Y278_P0.5500.13
32_S41_Q0.5500.13
183_G189_Q0.5460.13
37_S150_N0.5450.13
223_V287_F0.5440.13
181_F301_A0.5420.13
108_D112_P0.5420.13
112_P118_R0.5420.13
43_G261_N0.5380.12
96_L319_L0.5380.12
266_F295_A0.5380.12
95_Y232_V0.5360.12
12_S61_C0.5320.12
173_V318_A0.5310.12
285_I321_Y0.5300.12
256_A267_I0.5290.12
27_E135_D0.5280.12
264_L308_G0.5280.12
252_V274_T0.5260.12
107_M181_F0.5260.12
41_Q71_Y0.5250.12
47_V304_I0.5240.12
55_V177_Y0.5200.12
264_L323_R0.5190.12
72_R131_F0.5180.12
140_F317_S0.5150.12
59_A264_L0.5130.12
131_F181_F0.5130.12
227_T322_L0.5120.12
79_I103_V0.5120.12
32_S67_V0.5120.12
29_Y296_N0.5110.12
35_F162_V0.5080.12
194_N201_F0.5070.12
204_G316_F0.5060.12
300_R315_P0.5060.12
144_V305_S0.5050.12
201_F232_V0.5050.12
172_L176_V0.5040.12
45_I114_Q0.5040.12
146_R185_V0.5010.12
263_D312_T0.5010.12
95_Y243_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5afoA 1 0.948 100 0.487 Contact Map
1n12A 1 0.3853 99.8 0.788 Contact Map
2w07B 1 0.3547 99.8 0.804 Contact Map
3jwnH 1 0.8165 99.7 0.808 Contact Map
1pdkB 1 0.4159 99.7 0.815 Contact Map
2xg5B 1 0.4159 99.7 0.816 Contact Map
2jtyA 1 0.4526 99.7 0.817 Contact Map
2jmrA 1 0.4434 99.7 0.82 Contact Map
3bfqG 1 0.3914 99.6 0.825 Contact Map
2uy6B 2 0.4343 99.6 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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