ALLE - ECOLI - GREMLIN Contacts

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ALLE - (S)-ureidoglycine aminohydrolase

UniProt:	P75713	Sequences: MGYLNNVTGYREDLLANRAIVKHGNFALLTPDGLVKNIIPGFENCDATILSTPKLGASFVDYLVTLHQNGGNQQGFGGEGIETFLYVISGNITAKAEGKTFALSEGGYLYCPPGSLMTFVNAQAEDSQIFLYKRRYVPVEGYAPWLVSGNASELERIHYEGMDDVILLDFLPKELGFDMNMHILSFAPGASHGYIETHVQEHGAYILSGQGVYNLDNNWIPVKKGDYIFMGAYSLQAGYGVGRGEAFSYIYSKDCNRDVEI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13622
Length:	261 (246)
Sequences:	439 (235)
Seq/√Len:	15.0

ECOLI - ALLE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
208_S	244_G	5.915	1.00
112_P	146_L	5.037	1.00
84_F	108_Y	4.789	1.00
51_S	227_Y	4.363	1.00
82_E	110_Y	3.580	0.99
94_A	148_S	3.536	0.99
107_G	150_N	3.531	0.99
15_L	195_I	3.072	0.98
61_D	227_Y	3.054	0.98
113_P	144_P	3.027	0.98
92_I	127_S	2.981	0.98
92_I	107_G	2.915	0.97
45_C	64_V	2.577	0.95
186_F	190_A	2.541	0.94
104_S	107_G	2.505	0.94
84_F	171_L	2.346	0.91
84_F	181_M	2.229	0.89
195_I	214_N	2.196	0.88
15_L	214_N	2.181	0.88
108_Y	171_L	2.150	0.87
47_A	64_V	2.130	0.86
157_I	182_H	2.109	0.86
145_W	176_G	2.103	0.86
144_P	176_G	2.045	0.84
45_C	66_L	2.003	0.83
49_I	259_V	1.973	0.82
43_E	259_V	1.912	0.80
74_Q	140_E	1.909	0.80
30_T	77_G	1.890	0.79
60_V	259_V	1.874	0.78
41_G	139_V	1.836	0.77
89_S	125_E	1.835	0.77
105_E	150_N	1.832	0.77
165_V	190_A	1.815	0.76
154_L	157_I	1.813	0.76
89_S	128_Q	1.811	0.76
41_G	77_G	1.802	0.75
171_L	177_F	1.800	0.75
82_E	113_P	1.790	0.75
146_L	182_H	1.785	0.75
17_N	195_I	1.782	0.75
206_I	247_F	1.766	0.74
19_A	30_T	1.762	0.74
214_N	217_N	1.751	0.73
92_I	119_F	1.749	0.73
26_F	218_N	1.715	0.72
101_F	148_S	1.711	0.71
150_N	154_L	1.708	0.71
238_G	247_F	1.700	0.71
108_Y	183_I	1.691	0.71
29_L	35_V	1.652	0.69
13_D	223_K	1.625	0.67
31_P	63_L	1.624	0.67
206_I	228_I	1.613	0.67
74_Q	139_V	1.583	0.65
108_Y	181_M	1.573	0.65
150_N	153_E	1.557	0.64
94_A	109_L	1.552	0.64
17_N	214_N	1.500	0.61
24_G	231_G	1.471	0.59
63_L	88_I	1.438	0.58
104_S	150_N	1.419	0.57
73_Q	120_V	1.398	0.55
156_R	168_L	1.393	0.55
151_A	154_L	1.385	0.55
150_N	182_H	1.370	0.54
80_G	135_R	1.369	0.54
47_A	66_L	1.357	0.53
51_S	190_A	1.349	0.53
78_G	81_I	1.339	0.52
41_G	110_Y	1.322	0.51
91_N	104_S	1.304	0.50
139_V	142_Y	1.270	0.48
21_V	57_A	1.256	0.47
57_A	258_D	1.255	0.47
20_I	217_N	1.254	0.47
47_A	259_V	1.248	0.47
93_T	100_T	1.244	0.47
85_L	119_F	1.231	0.46
96_A	111_C	1.221	0.45
96_A	146_L	1.221	0.45
114_G	118_T	1.219	0.45
107_G	152_S	1.204	0.45
26_F	220_I	1.190	0.44
86_Y	233_Y	1.190	0.44
27_A	57_A	1.182	0.43
94_A	101_F	1.164	0.42
84_F	147_V	1.158	0.42
85_L	109_L	1.154	0.42
93_T	102_A	1.146	0.41
18_R	195_I	1.141	0.41
210_Q	239_Y	1.140	0.41
91_N	124_A	1.112	0.40
212_V	241_V	1.107	0.39
64_V	214_N	1.098	0.39
155_E	158_H	1.076	0.38
123_Q	127_S	1.071	0.37
91_N	102_A	1.061	0.37
82_E	179_M	1.054	0.36
63_L	239_Y	1.054	0.36
27_A	258_D	1.052	0.36
11_R	134_R	1.052	0.36
149_G	171_L	1.048	0.36
113_P	143_A	1.040	0.36
85_L	113_P	1.035	0.35
149_G	153_E	1.032	0.35
206_I	235_L	1.031	0.35
210_Q	243_R	1.030	0.35
180_N	255_C	1.027	0.35
210_Q	241_V	1.018	0.35
18_R	136_Y	1.016	0.34
110_Y	186_F	1.011	0.34
76_F	83_T	1.004	0.34
79_E	123_Q	1.001	0.34
103_L	172_P	1.001	0.34
82_E	134_R	0.996	0.33
136_Y	171_L	0.995	0.33
160_E	194_Y	0.991	0.33
93_T	120_V	0.974	0.32
12_E	211_G	0.973	0.32
80_G	150_N	0.955	0.31
214_N	241_V	0.945	0.31
88_I	211_G	0.940	0.31
101_F	109_L	0.932	0.30
81_I	258_D	0.928	0.30
158_H	161_G	0.922	0.30
84_F	149_G	0.899	0.29
27_A	54_K	0.896	0.29
134_R	137_V	0.892	0.29
132_Y	182_H	0.890	0.28
41_G	74_Q	0.885	0.28
147_V	182_H	0.883	0.28
49_I	60_V	0.883	0.28
67_H	126_D	0.881	0.28
142_Y	175_L	0.860	0.27
54_K	57_A	0.857	0.27
27_A	81_I	0.857	0.27
66_L	129_I	0.854	0.27
192_H	237_A	0.845	0.26
84_F	170_F	0.843	0.26
13_D	195_I	0.841	0.26
77_G	83_T	0.839	0.26
32_D	211_G	0.839	0.26
21_V	27_A	0.836	0.26
80_G	114_G	0.831	0.26
85_L	94_A	0.829	0.26
23_H	227_Y	0.828	0.26
18_R	84_F	0.827	0.26
21_V	258_D	0.823	0.25
22_K	217_N	0.815	0.25
18_R	223_K	0.814	0.25
165_V	175_L	0.814	0.25
93_T	122_A	0.809	0.25
249_Y	253_K	0.806	0.25
206_I	238_G	0.805	0.25
64_V	129_I	0.805	0.25
44_N	114_G	0.805	0.25
99_K	122_A	0.802	0.25
81_I	176_G	0.800	0.24
14_L	241_V	0.799	0.24
85_L	135_R	0.797	0.24
91_N	256_N	0.778	0.24
190_A	227_Y	0.777	0.24
102_A	148_S	0.775	0.23
91_N	127_S	0.775	0.23
49_I	181_M	0.773	0.23
79_E	114_G	0.771	0.23
100_T	122_A	0.768	0.23
147_V	171_L	0.766	0.23
73_Q	122_A	0.765	0.23
49_I	244_G	0.765	0.23
93_T	97_E	0.764	0.23
35_V	254_D	0.763	0.23
21_V	81_I	0.762	0.23
109_L	148_S	0.755	0.23
66_L	110_Y	0.752	0.23
182_H	191_S	0.751	0.23
55_L	259_V	0.750	0.22
172_P	175_L	0.750	0.22
184_L	251_Y	0.748	0.22
54_K	81_I	0.748	0.22
28_L	218_N	0.747	0.22
104_S	153_E	0.746	0.22
49_I	84_F	0.743	0.22
37_N	255_C	0.742	0.22
53_P	59_F	0.739	0.22
108_Y	177_F	0.737	0.22
159_Y	251_Y	0.736	0.22
14_L	191_S	0.735	0.22
38_I	173_K	0.730	0.22
102_A	152_S	0.727	0.22
108_Y	148_S	0.727	0.22
169_D	184_L	0.723	0.21
120_V	125_E	0.720	0.21
156_R	182_H	0.717	0.21
100_T	104_S	0.717	0.21
52_T	166_I	0.714	0.21
89_S	100_T	0.714	0.21
51_S	229_F	0.709	0.21
44_N	138_P	0.709	0.21
74_Q	158_H	0.704	0.21
50_L	63_L	0.703	0.21
149_G	154_L	0.703	0.21
182_H	200_Q	0.699	0.21
46_D	194_Y	0.697	0.20
118_T	124_A	0.696	0.20
42_F	72_N	0.696	0.20
97_E	100_T	0.694	0.20
75_G	225_G	0.692	0.20
80_G	138_P	0.691	0.20
36_K	48_T	0.690	0.20
103_L	124_A	0.689	0.20
108_Y	128_Q	0.688	0.20
160_E	193_G	0.687	0.20
57_A	176_G	0.687	0.20
212_V	239_Y	0.681	0.20
18_R	171_L	0.680	0.20
91_N	224_K	0.677	0.20
41_G	140_E	0.675	0.20
235_L	240_G	0.675	0.20
63_L	191_S	0.673	0.20
220_I	238_G	0.672	0.20
200_Q	252_S	0.671	0.20
33_G	248_S	0.671	0.20
100_T	152_S	0.669	0.19
239_Y	243_R	0.669	0.19
132_Y	199_V	0.668	0.19
99_K	150_N	0.667	0.19
11_R	30_T	0.666	0.19
31_P	128_Q	0.664	0.19
151_A	248_S	0.661	0.19
228_I	247_F	0.661	0.19
211_G	244_G	0.659	0.19
212_V	221_P	0.658	0.19
49_I	217_N	0.656	0.19
32_D	233_Y	0.656	0.19
47_A	77_G	0.655	0.19
60_V	77_G	0.655	0.19
99_K	127_S	0.653	0.19
158_H	163_D	0.649	0.19
184_L	192_H	0.649	0.19
128_Q	135_R	0.647	0.19
67_H	113_P	0.639	0.18
30_T	182_H	0.638	0.18
173_K	234_S	0.638	0.18
61_D	229_F	0.637	0.18
80_G	152_S	0.635	0.18
102_A	122_A	0.634	0.18
93_T	104_S	0.632	0.18
195_I	217_N	0.627	0.18
204_A	252_S	0.625	0.18
223_K	259_V	0.625	0.18
28_L	129_I	0.624	0.18
136_Y	256_N	0.624	0.18
191_S	239_Y	0.621	0.18
63_L	183_I	0.617	0.18
57_A	81_I	0.617	0.18
61_D	163_D	0.617	0.18
31_P	50_L	0.612	0.18
21_V	176_G	0.612	0.18
80_G	136_Y	0.609	0.17
99_K	104_S	0.609	0.17
79_E	110_Y	0.609	0.17
34_L	225_G	0.607	0.17
17_N	20_I	0.606	0.17
42_F	66_L	0.606	0.17
207_L	235_L	0.604	0.17
33_G	197_T	0.601	0.17
138_P	143_A	0.600	0.17
23_H	61_D	0.600	0.17
191_S	210_Q	0.599	0.17
176_G	258_D	0.599	0.17
50_L	54_K	0.599	0.17
88_I	130_F	0.598	0.17
43_E	102_A	0.598	0.17
89_S	135_R	0.595	0.17
62_Y	72_N	0.593	0.17
113_P	172_P	0.589	0.17
95_K	98_G	0.588	0.17
21_V	62_Y	0.588	0.17
210_Q	231_G	0.588	0.17
133_K	169_D	0.585	0.17
22_K	218_N	0.585	0.17
240_G	250_I	0.585	0.17
110_Y	172_P	0.585	0.17
190_A	214_N	0.582	0.17
89_S	140_E	0.578	0.16
88_I	128_Q	0.577	0.16
15_L	239_Y	0.576	0.16
27_A	176_G	0.575	0.16
210_Q	223_K	0.572	0.16
21_V	54_K	0.570	0.16
102_A	120_V	0.570	0.16
206_I	250_I	0.567	0.16
92_I	102_A	0.565	0.16
180_N	200_Q	0.564	0.16
125_E	155_E	0.564	0.16
50_L	88_I	0.563	0.16
64_V	110_Y	0.563	0.16
97_E	155_E	0.562	0.16
44_N	89_S	0.562	0.16
104_S	217_N	0.561	0.16
47_A	137_V	0.561	0.16
72_N	75_G	0.561	0.16
169_D	192_H	0.560	0.16
27_A	55_L	0.558	0.16
122_A	142_Y	0.558	0.16
133_K	184_L	0.558	0.16
97_E	173_K	0.557	0.16
97_E	105_E	0.557	0.16
119_F	173_K	0.556	0.16
20_I	28_L	0.554	0.16
88_I	158_H	0.550	0.16
134_R	193_G	0.548	0.16
138_P	259_V	0.548	0.16
66_L	92_I	0.548	0.16
40_P	219_W	0.546	0.16
242_G	253_K	0.545	0.15
242_G	249_Y	0.545	0.15
99_K	125_E	0.544	0.15
142_Y	176_G	0.543	0.15
80_G	107_G	0.542	0.15
92_I	123_Q	0.541	0.15
60_V	210_Q	0.541	0.15
102_A	135_R	0.540	0.15
67_H	135_R	0.539	0.15
96_A	100_T	0.537	0.15
60_V	130_F	0.537	0.15
43_E	135_R	0.536	0.15
134_R	232_A	0.535	0.15
66_L	85_L	0.534	0.15
115_S	146_L	0.533	0.15
15_L	241_V	0.533	0.15
38_I	153_E	0.532	0.15
160_E	232_A	0.530	0.15
48_T	192_H	0.529	0.15
26_F	228_I	0.529	0.15
16_A	241_V	0.527	0.15
29_L	259_V	0.527	0.15
18_R	210_Q	0.525	0.15
20_I	100_T	0.525	0.15
128_Q	231_G	0.524	0.15
21_V	86_Y	0.523	0.15
63_L	210_Q	0.522	0.15
134_R	194_Y	0.521	0.15
86_Y	222_V	0.519	0.15
134_R	156_R	0.517	0.15
189_G	247_F	0.517	0.15
57_A	170_F	0.517	0.15
76_F	131_L	0.516	0.15
12_E	244_G	0.515	0.15
186_F	205_Y	0.515	0.15
217_N	223_K	0.513	0.15
74_Q	77_G	0.513	0.15
96_A	148_S	0.513	0.15
77_G	89_S	0.513	0.15
61_D	130_F	0.513	0.15
61_D	211_G	0.512	0.15
57_A	229_F	0.509	0.14
98_G	187_A	0.509	0.14
41_G	66_L	0.508	0.14
225_G	230_M	0.506	0.14
143_A	152_S	0.506	0.14
211_G	228_I	0.505	0.14
136_Y	177_F	0.504	0.14
48_T	200_Q	0.504	0.14
16_A	243_R	0.504	0.14
69_N	153_E	0.502	0.14
165_V	227_Y	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sefA	5	0.954	100	0.609	Contact Map
1rc6A	4	0.9272	100	0.616	Contact Map
1sq4A	5	0.9847	100	0.618	Contact Map
1sfnA	5	0.9272	100	0.674	Contact Map
4e2qA	6	0.9502	100	0.707	Contact Map
3bu7A	3	0.9617	99.9	0.801	Contact Map
2d40A	3	0.8621	99.9	0.811	Contact Map
3nw4A	3	0.954	99.9	0.82	Contact Map
2vqaA	3	0.9157	99.8	0.836	Contact Map
1juhA	3	0.9272	99.7	0.848	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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