GREMLIN Database
ALLE - (S)-ureidoglycine aminohydrolase
UniProt: P75713 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13622
Length: 261 (246)
Sequences: 439 (235)
Seq/√Len: 15.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
208_S244_G5.9151.00
112_P146_L5.0371.00
84_F108_Y4.7891.00
51_S227_Y4.3631.00
82_E110_Y3.5800.99
94_A148_S3.5360.99
107_G150_N3.5310.99
15_L195_I3.0720.98
61_D227_Y3.0540.98
113_P144_P3.0270.98
92_I127_S2.9810.98
92_I107_G2.9150.97
45_C64_V2.5770.95
186_F190_A2.5410.94
104_S107_G2.5050.94
84_F171_L2.3460.91
84_F181_M2.2290.89
195_I214_N2.1960.88
15_L214_N2.1810.88
108_Y171_L2.1500.87
47_A64_V2.1300.86
157_I182_H2.1090.86
145_W176_G2.1030.86
144_P176_G2.0450.84
45_C66_L2.0030.83
49_I259_V1.9730.82
43_E259_V1.9120.80
74_Q140_E1.9090.80
30_T77_G1.8900.79
60_V259_V1.8740.78
41_G139_V1.8360.77
89_S125_E1.8350.77
105_E150_N1.8320.77
165_V190_A1.8150.76
154_L157_I1.8130.76
89_S128_Q1.8110.76
41_G77_G1.8020.75
171_L177_F1.8000.75
82_E113_P1.7900.75
146_L182_H1.7850.75
17_N195_I1.7820.75
206_I247_F1.7660.74
19_A30_T1.7620.74
214_N217_N1.7510.73
92_I119_F1.7490.73
26_F218_N1.7150.72
101_F148_S1.7110.71
150_N154_L1.7080.71
238_G247_F1.7000.71
108_Y183_I1.6910.71
29_L35_V1.6520.69
13_D223_K1.6250.67
31_P63_L1.6240.67
206_I228_I1.6130.67
74_Q139_V1.5830.65
108_Y181_M1.5730.65
150_N153_E1.5570.64
94_A109_L1.5520.64
17_N214_N1.5000.61
24_G231_G1.4710.59
63_L88_I1.4380.58
104_S150_N1.4190.57
73_Q120_V1.3980.55
156_R168_L1.3930.55
151_A154_L1.3850.55
150_N182_H1.3700.54
80_G135_R1.3690.54
47_A66_L1.3570.53
51_S190_A1.3490.53
78_G81_I1.3390.52
41_G110_Y1.3220.51
91_N104_S1.3040.50
139_V142_Y1.2700.48
21_V57_A1.2560.47
57_A258_D1.2550.47
20_I217_N1.2540.47
47_A259_V1.2480.47
93_T100_T1.2440.47
85_L119_F1.2310.46
96_A111_C1.2210.45
96_A146_L1.2210.45
114_G118_T1.2190.45
107_G152_S1.2040.45
26_F220_I1.1900.44
86_Y233_Y1.1900.44
27_A57_A1.1820.43
94_A101_F1.1640.42
84_F147_V1.1580.42
85_L109_L1.1540.42
93_T102_A1.1460.41
18_R195_I1.1410.41
210_Q239_Y1.1400.41
91_N124_A1.1120.40
212_V241_V1.1070.39
64_V214_N1.0980.39
155_E158_H1.0760.38
123_Q127_S1.0710.37
91_N102_A1.0610.37
82_E179_M1.0540.36
63_L239_Y1.0540.36
27_A258_D1.0520.36
11_R134_R1.0520.36
149_G171_L1.0480.36
113_P143_A1.0400.36
85_L113_P1.0350.35
149_G153_E1.0320.35
206_I235_L1.0310.35
210_Q243_R1.0300.35
180_N255_C1.0270.35
210_Q241_V1.0180.35
18_R136_Y1.0160.34
110_Y186_F1.0110.34
76_F83_T1.0040.34
79_E123_Q1.0010.34
103_L172_P1.0010.34
82_E134_R0.9960.33
136_Y171_L0.9950.33
160_E194_Y0.9910.33
93_T120_V0.9740.32
12_E211_G0.9730.32
80_G150_N0.9550.31
214_N241_V0.9450.31
88_I211_G0.9400.31
101_F109_L0.9320.30
81_I258_D0.9280.30
158_H161_G0.9220.30
84_F149_G0.8990.29
27_A54_K0.8960.29
134_R137_V0.8920.29
132_Y182_H0.8900.28
41_G74_Q0.8850.28
147_V182_H0.8830.28
49_I60_V0.8830.28
67_H126_D0.8810.28
142_Y175_L0.8600.27
54_K57_A0.8570.27
27_A81_I0.8570.27
66_L129_I0.8540.27
192_H237_A0.8450.26
84_F170_F0.8430.26
13_D195_I0.8410.26
77_G83_T0.8390.26
32_D211_G0.8390.26
21_V27_A0.8360.26
80_G114_G0.8310.26
85_L94_A0.8290.26
23_H227_Y0.8280.26
18_R84_F0.8270.26
21_V258_D0.8230.25
22_K217_N0.8150.25
18_R223_K0.8140.25
165_V175_L0.8140.25
93_T122_A0.8090.25
249_Y253_K0.8060.25
206_I238_G0.8050.25
64_V129_I0.8050.25
44_N114_G0.8050.25
99_K122_A0.8020.25
81_I176_G0.8000.24
14_L241_V0.7990.24
85_L135_R0.7970.24
91_N256_N0.7780.24
190_A227_Y0.7770.24
102_A148_S0.7750.23
91_N127_S0.7750.23
49_I181_M0.7730.23
79_E114_G0.7710.23
100_T122_A0.7680.23
147_V171_L0.7660.23
73_Q122_A0.7650.23
49_I244_G0.7650.23
93_T97_E0.7640.23
35_V254_D0.7630.23
21_V81_I0.7620.23
109_L148_S0.7550.23
66_L110_Y0.7520.23
182_H191_S0.7510.23
55_L259_V0.7500.22
172_P175_L0.7500.22
184_L251_Y0.7480.22
54_K81_I0.7480.22
28_L218_N0.7470.22
104_S153_E0.7460.22
49_I84_F0.7430.22
37_N255_C0.7420.22
53_P59_F0.7390.22
108_Y177_F0.7370.22
159_Y251_Y0.7360.22
14_L191_S0.7350.22
38_I173_K0.7300.22
102_A152_S0.7270.22
108_Y148_S0.7270.22
169_D184_L0.7230.21
120_V125_E0.7200.21
156_R182_H0.7170.21
100_T104_S0.7170.21
52_T166_I0.7140.21
89_S100_T0.7140.21
51_S229_F0.7090.21
44_N138_P0.7090.21
74_Q158_H0.7040.21
50_L63_L0.7030.21
149_G154_L0.7030.21
182_H200_Q0.6990.21
46_D194_Y0.6970.20
118_T124_A0.6960.20
42_F72_N0.6960.20
97_E100_T0.6940.20
75_G225_G0.6920.20
80_G138_P0.6910.20
36_K48_T0.6900.20
103_L124_A0.6890.20
108_Y128_Q0.6880.20
160_E193_G0.6870.20
57_A176_G0.6870.20
212_V239_Y0.6810.20
18_R171_L0.6800.20
91_N224_K0.6770.20
41_G140_E0.6750.20
235_L240_G0.6750.20
63_L191_S0.6730.20
220_I238_G0.6720.20
200_Q252_S0.6710.20
33_G248_S0.6710.20
100_T152_S0.6690.19
239_Y243_R0.6690.19
132_Y199_V0.6680.19
99_K150_N0.6670.19
11_R30_T0.6660.19
31_P128_Q0.6640.19
151_A248_S0.6610.19
228_I247_F0.6610.19
211_G244_G0.6590.19
212_V221_P0.6580.19
49_I217_N0.6560.19
32_D233_Y0.6560.19
47_A77_G0.6550.19
60_V77_G0.6550.19
99_K127_S0.6530.19
158_H163_D0.6490.19
184_L192_H0.6490.19
128_Q135_R0.6470.19
67_H113_P0.6390.18
30_T182_H0.6380.18
173_K234_S0.6380.18
61_D229_F0.6370.18
80_G152_S0.6350.18
102_A122_A0.6340.18
93_T104_S0.6320.18
195_I217_N0.6270.18
204_A252_S0.6250.18
223_K259_V0.6250.18
28_L129_I0.6240.18
136_Y256_N0.6240.18
191_S239_Y0.6210.18
63_L183_I0.6170.18
57_A81_I0.6170.18
61_D163_D0.6170.18
31_P50_L0.6120.18
21_V176_G0.6120.18
80_G136_Y0.6090.17
99_K104_S0.6090.17
79_E110_Y0.6090.17
34_L225_G0.6070.17
17_N20_I0.6060.17
42_F66_L0.6060.17
207_L235_L0.6040.17
33_G197_T0.6010.17
138_P143_A0.6000.17
23_H61_D0.6000.17
191_S210_Q0.5990.17
176_G258_D0.5990.17
50_L54_K0.5990.17
88_I130_F0.5980.17
43_E102_A0.5980.17
89_S135_R0.5950.17
62_Y72_N0.5930.17
113_P172_P0.5890.17
95_K98_G0.5880.17
21_V62_Y0.5880.17
210_Q231_G0.5880.17
133_K169_D0.5850.17
22_K218_N0.5850.17
240_G250_I0.5850.17
110_Y172_P0.5850.17
190_A214_N0.5820.17
89_S140_E0.5780.16
88_I128_Q0.5770.16
15_L239_Y0.5760.16
27_A176_G0.5750.16
210_Q223_K0.5720.16
21_V54_K0.5700.16
102_A120_V0.5700.16
206_I250_I0.5670.16
92_I102_A0.5650.16
180_N200_Q0.5640.16
125_E155_E0.5640.16
50_L88_I0.5630.16
64_V110_Y0.5630.16
97_E155_E0.5620.16
44_N89_S0.5620.16
104_S217_N0.5610.16
47_A137_V0.5610.16
72_N75_G0.5610.16
169_D192_H0.5600.16
27_A55_L0.5580.16
122_A142_Y0.5580.16
133_K184_L0.5580.16
97_E173_K0.5570.16
97_E105_E0.5570.16
119_F173_K0.5560.16
20_I28_L0.5540.16
88_I158_H0.5500.16
134_R193_G0.5480.16
138_P259_V0.5480.16
66_L92_I0.5480.16
40_P219_W0.5460.16
242_G253_K0.5450.15
242_G249_Y0.5450.15
99_K125_E0.5440.15
142_Y176_G0.5430.15
80_G107_G0.5420.15
92_I123_Q0.5410.15
60_V210_Q0.5410.15
102_A135_R0.5400.15
67_H135_R0.5390.15
96_A100_T0.5370.15
60_V130_F0.5370.15
43_E135_R0.5360.15
134_R232_A0.5350.15
66_L85_L0.5340.15
115_S146_L0.5330.15
15_L241_V0.5330.15
38_I153_E0.5320.15
160_E232_A0.5300.15
48_T192_H0.5290.15
26_F228_I0.5290.15
16_A241_V0.5270.15
29_L259_V0.5270.15
18_R210_Q0.5250.15
20_I100_T0.5250.15
128_Q231_G0.5240.15
21_V86_Y0.5230.15
63_L210_Q0.5220.15
134_R194_Y0.5210.15
86_Y222_V0.5190.15
134_R156_R0.5170.15
189_G247_F0.5170.15
57_A170_F0.5170.15
76_F131_L0.5160.15
12_E244_G0.5150.15
186_F205_Y0.5150.15
217_N223_K0.5130.15
74_Q77_G0.5130.15
96_A148_S0.5130.15
77_G89_S0.5130.15
61_D130_F0.5130.15
61_D211_G0.5120.15
57_A229_F0.5090.14
98_G187_A0.5090.14
41_G66_L0.5080.14
225_G230_M0.5060.14
143_A152_S0.5060.14
211_G228_I0.5050.14
136_Y177_F0.5040.14
48_T200_Q0.5040.14
16_A243_R0.5040.14
69_N153_E0.5020.14
165_V227_Y0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sefA 5 0.954 100 0.609 Contact Map
1rc6A 4 0.9272 100 0.616 Contact Map
1sq4A 5 0.9847 100 0.618 Contact Map
1sfnA 5 0.9272 100 0.674 Contact Map
4e2qA 6 0.9502 100 0.707 Contact Map
3bu7A 3 0.9617 99.9 0.801 Contact Map
2d40A 3 0.8621 99.9 0.811 Contact Map
3nw4A 3 0.954 99.9 0.82 Contact Map
2vqaA 3 0.9157 99.8 0.836 Contact Map
1juhA 3 0.9272 99.7 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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