GREMLIN Database
ALLP - Putative allantoin permease
UniProt: P75712 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13618
Length: 484 (428)
Sequences: 4820 (3100)
Seq/√Len: 149.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
393_A462_F6.9491.00
393_A466_A5.9241.00
404_N407_E5.6791.00
84_G248_S4.2341.00
432_V464_A4.1651.00
429_V464_A3.5931.00
433_A461_A3.3661.00
63_M277_V3.3231.00
429_V433_A3.3091.00
200_I204_S3.1871.00
68_L233_I3.0261.00
397_V462_F3.0191.00
229_F233_I2.9551.00
86_K257_F2.8771.00
389_G393_A2.8281.00
429_V468_L2.8201.00
433_A464_A2.7851.00
424_L428_S2.6671.00
52_F232_V2.6521.00
394_H399_M2.6511.00
21_T24_Q2.6441.00
407_E410_T2.5581.00
436_L460_V2.5011.00
65_A229_F2.4611.00
58_S61_S2.4511.00
390_V430_T2.3151.00
397_V466_A2.2871.00
296_N299_D2.2571.00
207_G210_P2.2171.00
72_F237_V2.2151.00
325_N329_N2.1791.00
427_F431_L2.1691.00
199_A274_L2.1561.00
25_R88_G2.1131.00
389_G458_V2.1111.00
255_H259_E2.0751.00
196_G200_I2.0741.00
346_T349_N2.0651.00
81_G251_T2.0431.00
256_S259_E2.0261.00
433_A460_V1.9981.00
120_F358_S1.9511.00
15_E24_Q1.9291.00
460_V464_A1.9281.00
106_F427_F1.9241.00
166_W359_L1.8741.00
466_A470_K1.8601.00
437_S457_G1.8501.00
124_C169_N1.8321.00
362_C365_K1.8301.00
470_K473_T1.8251.00
59_T63_M1.8161.00
53_F283_I1.8151.00
120_F325_N1.8131.00
127_G165_F1.8121.00
160_I164_I1.7911.00
98_S394_H1.7861.00
258_R262_L1.7821.00
345_L353_I1.7791.00
62_I280_V1.7761.00
102_R105_L1.7721.00
428_S468_L1.7721.00
464_A468_L1.7701.00
182_K185_A1.7681.00
15_E18_L1.7671.00
389_G461_A1.7661.00
119_W122_L1.7591.00
39_S327_T1.7581.00
455_F459_I1.7561.00
170_V355_S1.7471.00
463_A467_L1.7381.00
167_L171_G1.7381.00
61_S225_G1.7191.00
29_T259_E1.7171.00
351_V355_S1.6891.00
83_A94_I1.6691.00
344_K349_N1.6661.00
97_A403_I1.6481.00
390_V429_V1.6461.00
53_F62_I1.6341.00
175_G179_V1.6291.00
432_V460_V1.6121.00
163_L167_L1.5901.00
104_A339_A1.5831.00
459_I462_F1.5791.00
169_N325_N1.5621.00
459_I463_A1.5611.00
118_M376_F1.5581.00
193_I197_G1.5581.00
462_F466_A1.5401.00
64_L229_F1.5361.00
435_I439_G1.5361.00
60_F64_L1.5351.00
106_F422_F1.5031.00
52_F62_I1.5031.00
94_I248_S1.4701.00
345_L350_G1.4651.00
121_G358_S1.4391.00
99_Y426_A1.4331.00
78_V265_T1.4301.00
66_I280_V1.4281.00
390_V426_A1.3891.00
422_F427_F1.3891.00
452_V456_V1.3861.00
345_L349_N1.3811.00
132_L161_T1.3791.00
467_L470_K1.3731.00
31_N185_A1.3711.00
68_L229_F1.3631.00
199_A278_A1.3551.00
354_A358_S1.3441.00
82_A86_K1.3441.00
262_L266_L1.3431.00
65_A232_V1.3371.00
457_G461_A1.3291.00
389_G462_F1.3281.00
129_L296_N1.3211.00
426_A429_V1.3141.00
426_A465_Y1.3111.00
211_I214_Y1.3101.00
431_L435_I1.2961.00
28_K31_N1.2831.00
82_A257_F1.2821.00
84_G251_T1.2591.00
13_Y18_L1.2561.00
172_I183_F1.2461.00
128_S161_T1.2451.00
259_E263_G1.2441.00
394_H398_V1.2441.00
390_V433_A1.2431.00
123_Q329_N1.2401.00
65_A233_I1.2321.00
361_I365_K1.2131.00
15_E20_K1.2081.00
116_A246_S1.2031.00
57_L65_A1.2011.00
75_A79_L1.2011.00
253_N335_Y1.1951.00
159_L163_L1.1871.00
443_I446_M1.1791.00
110_L384_L1.1741.00
358_S361_I1.1721.00
98_S391_M1.1721.00
69_S236_V1.1721.00
333_A354_A1.1701.00
66_I276_A1.1671.00
96_R104_A1.1661.00
15_E21_T1.1611.00
197_G200_I1.1581.00
392_M396_F1.1571.00
250_F332_P1.1531.00
118_M377_L1.1491.00
386_P457_G1.1491.00
64_L68_L1.1481.00
342_P345_L1.1391.00
346_T350_G1.1371.00
102_R421_G1.1361.00
269_V273_I1.1351.00
123_Q325_N1.1351.00
398_V466_A1.1321.00
248_S251_T1.1311.00
199_A282_I1.1150.99
37_M271_A1.1150.99
125_Y128_S1.1140.99
352_L356_I1.1050.99
425_T428_S1.1050.99
338_A350_G1.1040.99
79_L396_F1.1030.99
226_G230_L1.1020.99
407_E415_Y1.1010.99
274_L278_A1.1010.99
72_F233_I1.0980.99
74_A78_V1.0980.99
351_V358_S1.0910.99
443_I447_E1.0910.99
465_Y469_K1.0850.99
99_Y103_G1.0830.99
354_A361_I1.0820.99
70_A276_A1.0780.99
388_I392_M1.0780.99
241_A385_G1.0780.99
410_T413_G1.0760.99
229_F236_V1.0750.99
80_N391_M1.0740.99
294_T299_D1.0740.99
66_I70_A1.0700.99
120_F355_S1.0680.99
467_L471_R1.0660.99
63_M67_I1.0590.99
425_T468_L1.0570.99
429_V465_Y1.0570.99
229_F232_V1.0530.99
93_M96_R1.0500.99
278_A282_I1.0490.99
320_T324_T1.0440.99
440_G456_V1.0360.99
209_G212_F1.0360.99
355_S358_S1.0350.99
405_L409_Y1.0310.99
273_I277_V1.0290.99
349_N352_L1.0220.99
407_E414_D1.0190.99
425_T469_K1.0180.99
410_T414_D0.9970.99
347_Y350_G0.9970.99
134_L314_V0.9950.99
81_G84_G0.9910.99
347_Y351_V0.9890.99
268_L272_Y0.9870.99
67_I273_I0.9870.99
404_N414_D0.9860.99
444_H447_E0.9840.99
43_V321_T0.9840.99
73_I240_W0.9790.99
244_A388_I0.9760.99
65_A69_S0.9730.98
420_N424_L0.9640.98
76_V244_A0.9630.98
109_L340_I0.9630.98
451_R456_V0.9630.98
363_P366_L0.9590.98
382_G441_K0.9570.98
69_S233_I0.9550.98
365_K368_E0.9540.98
460_V463_A0.9510.98
425_T429_V0.9480.98
120_F330_I0.9430.98
198_M304_W0.9420.98
91_F248_S0.9410.98
230_L234_N0.9410.98
189_P192_Y0.9410.98
83_A87_Y0.9370.98
456_V459_I0.9350.98
182_K186_I0.9350.98
463_A466_A0.9340.98
445_F448_P0.9330.98
428_S432_V0.9300.98
82_A401_G0.9290.98
134_L311_F0.9290.98
50_G126_A0.9170.98
99_Y107_P0.9150.98
412_P415_Y0.9120.98
449_L456_V0.9080.98
197_G309_A0.9060.98
233_I237_V0.8990.97
332_P336_Q0.8980.97
21_T25_R0.8980.97
36_W92_A0.8950.97
41_H191_I0.8940.97
404_N415_Y0.8890.97
299_D303_R0.8880.97
425_T472_T0.8880.97
436_L439_G0.8860.97
99_Y430_T0.8860.97
214_Y284_A0.8850.97
184_T323_S0.8830.97
397_V400_R0.8790.97
246_S250_F0.8780.97
119_W377_L0.8770.97
178_K182_K0.8760.97
393_A398_V0.8760.97
32_Y251_T0.8720.97
222_A225_G0.8720.97
283_I286_A0.8690.97
51_G54_I0.8650.97
173_G351_V0.8620.97
61_S64_L0.8600.97
196_G432_V0.8600.97
124_C166_W0.8580.97
254_A257_F0.8580.97
83_A391_M0.8550.97
464_A467_L0.8550.97
393_A397_V0.8530.97
81_G260_Q0.8510.97
234_N455_F0.8510.97
123_Q321_T0.8510.97
33_F37_M0.8480.96
462_F465_Y0.8480.96
436_L456_V0.8440.96
70_A239_V0.8400.96
429_V461_A0.8380.96
127_G321_T0.8380.96
74_A269_V0.8380.96
173_G355_S0.8370.96
74_A321_T0.8350.96
103_G427_F0.8340.96
128_S132_L0.8340.96
132_L157_P0.8300.96
87_Y403_I0.8300.96
202_A282_I0.8290.96
191_I324_T0.8260.96
432_V439_G0.8260.96
192_Y196_G0.8260.96
110_L380_I0.8250.96
443_I448_P0.8240.96
320_T323_S0.8230.96
17_L93_M0.8230.96
197_G201_W0.8210.96
202_A206_V0.8210.96
351_V354_A0.8210.96
82_A396_F0.8180.96
106_F431_L0.8170.96
300_I304_W0.8140.95
203_I281_C0.8140.95
469_K472_T0.8120.95
300_I303_R0.8090.95
434_V438_L0.8050.95
353_I357_I0.8050.95
159_L363_P0.8030.95
67_I277_V0.7990.95
346_T351_V0.7970.95
41_H324_T0.7950.95
112_G337_I0.7950.95
434_V439_G0.7940.95
49_V279_G0.7940.95
96_R339_A0.7940.95
71_F269_V0.7920.95
225_G231_V0.7920.95
85_S260_Q0.7910.95
434_V437_S0.7880.95
120_F123_Q0.7860.95
423_N469_K0.7850.95
172_I322_I0.7830.94
45_N48_M0.7820.94
39_S243_P0.7810.94
33_F266_L0.7810.94
411_A415_Y0.7800.94
70_A272_Y0.7790.94
362_C366_L0.7770.94
160_I163_L0.7750.94
124_C325_N0.7730.94
341_A344_K0.7720.94
209_G213_D0.7700.94
39_S321_T0.7700.94
372_S376_F0.7680.94
259_E262_L0.7660.94
267_G271_A0.7660.94
92_A336_Q0.7630.94
221_K224_N0.7630.94
360_L364_W0.7630.94
184_T326_A0.7630.94
331_I335_Y0.7620.94
80_N392_M0.7600.94
43_V46_Y0.7570.93
66_I273_I0.7550.93
30_F34_T0.7540.93
44_P128_S0.7540.93
431_L434_V0.7500.93
91_F332_P0.7480.93
97_A408_L0.7470.93
202_A278_A0.7460.93
317_I321_T0.7430.93
127_G172_I0.7420.93
394_H469_K0.7410.93
265_T269_V0.7400.93
442_F447_E0.7340.92
423_N426_A0.7330.92
134_L315_L0.7330.92
80_N247_A0.7330.92
424_L427_F0.7310.92
77_M242_A0.7250.92
77_M80_N0.7230.92
106_F160_I0.7220.92
307_L311_F0.7190.92
271_A275_F0.7160.91
78_V81_G0.7130.91
390_V461_A0.7120.91
326_A330_I0.7090.91
121_G361_I0.7090.91
102_R420_N0.7080.91
96_R101_V0.7060.91
134_L318_L0.7060.91
277_V281_C0.7050.91
89_V94_I0.7050.91
299_D302_Q0.7030.91
240_W244_A0.7030.91
424_L472_T0.7030.91
105_L340_I0.7000.90
189_P193_I0.6990.90
13_Y331_I0.6990.90
242_A384_L0.6980.90
403_I408_L0.6970.90
85_S254_A0.6960.90
432_V435_I0.6960.90
45_N279_G0.6960.90
224_N228_L0.6960.90
17_L96_R0.6950.90
235_A374_Y0.6940.90
96_R394_H0.6920.90
236_V239_V0.6910.90
429_V462_F0.6890.90
170_V174_F0.6890.90
115_A242_A0.6850.89
135_I138_I0.6840.89
361_I366_L0.6830.89
301_V304_W0.6830.89
11_R23_S0.6820.89
108_G336_Q0.6800.89
44_P321_T0.6790.89
135_I161_T0.6770.89
398_V469_K0.6770.89
433_A457_G0.6770.89
438_L442_F0.6770.89
282_I300_I0.6760.89
46_Y282_I0.6730.89
186_I189_P0.6720.89
120_F170_V0.6720.89
210_P213_D0.6710.88
266_L270_V0.6710.88
225_G229_F0.6660.88
287_S293_D0.6660.88
428_S431_L0.6650.88
253_N293_D0.6630.88
191_I320_T0.6630.88
431_L464_A0.6590.88
164_I171_G0.6590.88
131_C161_T0.6570.87
28_K255_H0.6560.87
281_C285_G0.6560.87
400_R420_N0.6540.87
95_L104_A0.6530.87
39_S240_W0.6530.87
305_D308_F0.6520.87
95_L387_V0.6520.87
252_Q331_I0.6510.87
330_I355_S0.6510.87
319_M323_S0.6500.87
111_R332_P0.6490.87
80_N83_A0.6480.87
225_G230_L0.6460.87
47_V50_G0.6460.87
133_I299_D0.6460.87
322_I327_T0.6430.86
69_S73_I0.6420.86
79_L397_V0.6420.86
116_A329_N0.6420.86
262_L265_T0.6410.86
314_V323_S0.6400.86
433_A436_L0.6370.86
95_L98_S0.6370.86
40_V92_A0.6360.86
128_S158_G0.6360.86
89_V409_Y0.6360.86
157_P160_I0.6350.86
40_V272_Y0.6350.86
266_L428_S0.6340.86
395_Y398_V0.6340.86
123_Q323_S0.6330.85
397_V401_G0.6330.85
111_R246_S0.6330.85
282_I286_A0.6330.85
295_W304_W0.6310.85
211_I281_C0.6300.85
42_N45_N0.6290.85
240_W268_L0.6290.85
60_F63_M0.6290.85
40_V271_A0.6290.85
72_F294_T0.6280.85
31_N181_N0.6280.85
184_T327_T0.6270.85
121_G125_Y0.6270.85
18_L21_T0.6270.85
61_S229_F0.6260.85
29_T263_G0.6260.85
106_F430_T0.6250.85
89_V93_M0.6250.85
433_A462_F0.6240.85
237_V241_A0.6240.85
50_G283_I0.6220.84
169_N172_I0.6220.84
351_V365_K0.6200.84
51_G374_Y0.6200.84
91_F111_R0.6190.84
202_A285_G0.6190.84
177_G253_N0.6190.84
13_Y16_D0.6190.84
116_A333_A0.6160.84
437_S441_K0.6160.84
159_L432_V0.6140.84
26_T178_K0.6140.84
190_C316_V0.6140.84
300_I383_M0.6130.84
116_A332_P0.6130.84
163_L359_L0.6110.83
213_D466_A0.6090.83
12_G16_D0.6090.83
320_T327_T0.6080.83
118_M380_I0.6080.83
198_M240_W0.6080.83
62_I66_I0.6070.83
321_T324_T0.6060.83
246_S249_D0.6050.83
108_G339_A0.6040.83
172_I326_A0.6040.83
47_V126_A0.6030.83
403_I409_Y0.6020.82
115_A377_L0.6010.82
343_T346_T0.6010.82
333_A336_Q0.5980.82
101_V411_A0.5980.82
183_F323_S0.5960.82
334_G339_A0.5930.82
85_S257_F0.5900.81
334_G350_G0.5890.81
67_I164_I0.5880.81
20_K88_G0.5870.81
377_L399_M0.5860.81
110_L387_V0.5840.81
386_P433_A0.5840.81
45_N239_V0.5820.80
21_T253_N0.5810.80
130_A298_L0.5810.80
18_L24_Q0.5800.80
348_K351_V0.5800.80
176_G331_I0.5800.80
410_T470_K0.5790.80
433_A437_S0.5790.80
342_P364_W0.5780.80
282_I301_V0.5780.80
119_W243_P0.5770.80
130_A134_L0.5770.80
240_W243_P0.5770.80
404_N413_G0.5770.80
73_I77_M0.5750.80
103_G422_F0.5740.79
128_S162_F0.5740.79
356_I360_L0.5730.79
438_L441_K0.5730.79
36_W43_V0.5720.79
194_V316_V0.5720.79
191_I323_S0.5710.79
297_V301_V0.5690.79
237_V458_V0.5680.79
243_P373_I0.5680.79
59_T284_A0.5670.79
397_V471_R0.5660.78
411_A414_D0.5650.78
180_L326_A0.5630.78
193_I200_I0.5630.78
102_R422_F0.5630.78
232_V236_V0.5620.78
32_Y81_G0.5600.78
344_K347_Y0.5600.78
50_G84_G0.5600.78
59_T212_F0.5600.78
98_S390_V0.5600.78
390_V465_Y0.5570.77
48_M454_W0.5570.77
19_P87_Y0.5560.77
129_L299_D0.5550.77
246_S332_P0.5540.77
173_G330_I0.5540.77
108_G340_I0.5530.77
125_Y392_M0.5520.77
432_V468_L0.5520.77
43_V123_Q0.5520.77
44_P122_L0.5510.77
45_N123_Q0.5510.77
319_M361_I0.5500.76
71_F273_I0.5480.76
184_T324_T0.5480.76
126_A321_T0.5480.76
342_P349_N0.5470.76
242_A454_W0.5470.76
406_D447_E0.5470.76
453_S457_G0.5460.76
460_V469_K0.5460.76
32_Y254_A0.5440.76
192_Y278_A0.5430.76
125_Y129_L0.5420.75
169_N322_I0.5420.75
112_G243_P0.5400.75
171_G436_L0.5400.75
203_I210_P0.5390.75
48_M374_Y0.5390.75
42_N46_Y0.5380.75
24_Q322_I0.5380.75
195_F320_T0.5370.75
120_F169_N0.5370.75
382_G438_L0.5370.75
196_G337_I0.5360.75
393_A465_Y0.5350.75
360_L424_L0.5340.74
77_M244_A0.5340.74
372_S375_L0.5340.74
126_A367_M0.5340.74
80_N396_F0.5330.74
240_W272_Y0.5320.74
459_I467_L0.5310.74
345_L411_A0.5310.74
396_F401_G0.5300.74
342_P350_G0.5300.74
57_L61_S0.5290.74
117_I380_I0.5290.74
294_T300_I0.5280.74
270_V279_G0.5280.74
202_A314_V0.5270.73
23_S295_W0.5250.73
201_W205_L0.5240.73
120_F243_P0.5240.73
406_D409_Y0.5240.73
79_L392_M0.5240.73
364_W370_Q0.5240.73
233_I236_V0.5230.73
167_L432_V0.5210.73
117_I338_A0.5200.72
74_A268_L0.5200.72
55_L228_L0.5190.72
77_M247_A0.5190.72
135_I352_L0.5180.72
165_F322_I0.5180.72
127_G180_L0.5180.72
205_L208_I0.5180.72
11_R411_A0.5170.72
208_I301_V0.5160.72
106_F381_G0.5160.72
73_I245_V0.5150.72
168_V171_G0.5120.71
78_V261_A0.5120.71
67_I258_R0.5100.71
160_I311_F0.5090.71
41_H323_S0.5080.71
42_N239_V0.5080.71
272_Y317_I0.5070.71
385_G389_G0.5070.71
263_G267_G0.5070.71
52_F236_V0.5070.71
298_L303_R0.5060.70
38_G188_N0.5060.70
439_G446_M0.5060.70
231_V451_R0.5060.70
118_M267_G0.5050.70
297_V304_W0.5050.70
368_E372_S0.5040.70
126_A380_I0.5030.70
223_E270_V0.5020.70
194_V313_A0.5020.70
130_A321_T0.5020.70
345_L352_L0.5020.70
70_A115_A0.5010.70
383_M434_V0.5000.70
406_D410_T0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.8988 100 0.213 Contact Map
4djkA 2 0.8409 99.6 0.842 Contact Map
3l1lA 2 0.8306 99.4 0.856 Contact Map
3giaA 1 0.8512 99.3 0.862 Contact Map
3dh4A 3 0.8409 99.3 0.865 Contact Map
2xq2A 2 0.8409 99.2 0.868 Contact Map
4wgvA 2 0.7479 98.4 0.902 Contact Map
4us3A 1 0.8368 98.1 0.912 Contact Map
2a65A 2 0.9112 97.6 0.92 Contact Map
4xp4A 1 0.9236 95.7 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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