GREMLIN Database
YAIX - Putative uncharacterized acetyltransferase YaiX
UniProt: P75697 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14236
Length: 230 (186)
Sequences: 1954 (1381)
Seq/√Len: 101.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_C108_V2.7791.00
69_G88_A2.6751.00
107_G124_E2.6601.00
183_R201_N2.6531.00
67_V85_V2.5611.00
124_E141_Q2.5341.00
182_Q200_P2.4561.00
106_N123_A2.3401.00
39_K43_K2.3371.00
205_G221_L2.3351.00
68_I72_T2.2481.00
200_P216_T2.2161.00
63_A82_G2.1961.00
88_A106_N2.1901.00
132_F136_S2.1871.00
207_R223_Q2.1801.00
164_T182_Q2.1751.00
77_G95_Y2.1521.00
71_N89_N2.1231.00
85_V103_I2.0691.00
56_Q77_G2.0651.00
78_A92_I2.0001.00
165_P183_R1.9821.00
89_N107_G1.9621.00
38_L42_L1.9351.00
127_I131_C1.9191.00
179_Y197_I1.9161.00
83_P101_G1.8961.00
63_A66_V1.8761.00
72_T90_C1.8451.00
68_I74_I1.7761.00
65_E83_P1.7311.00
132_F137_V1.6861.00
181_G200_P1.6571.00
199_S216_T1.6271.00
132_F135_D1.6241.00
70_A88_A1.6181.00
153_H157_E1.5911.00
135_D157_E1.5591.00
101_G118_N1.5281.00
95_Y113_A1.5181.00
201_N217_G1.5071.00
116_I119_A1.5011.00
149_R152_N1.4901.00
96_A110_I1.4871.00
204_L210_V1.4751.00
105_S123_A1.4421.00
149_R153_H1.4321.00
197_I213_N1.4261.00
186_L190_V1.4151.00
39_K42_L1.4131.00
81_Q100_P1.4021.00
193_L196_R1.4011.00
186_L192_I1.3710.99
38_L43_K1.3570.99
215_P218_T1.3510.99
90_C104_I1.3370.99
189_Q207_R1.3180.99
130_Q147_Q1.3080.99
90_C123_A1.3010.99
190_V204_L1.3000.99
80_I84_V1.2940.99
69_G72_T1.2810.99
161_S179_Y1.2540.99
121_I125_A1.2530.99
171_T189_Q1.2480.99
153_H156_D1.2220.99
178_C194_P1.2180.99
38_L41_Y1.2110.99
87_G106_N1.2100.99
186_L204_L1.2050.99
54_A76_H1.2030.99
121_I127_I1.1990.99
90_C106_N1.1940.99
108_V123_A1.1890.98
166_E184_S1.1850.98
214_L220_S1.1570.98
65_E82_G1.1480.98
152_N155_L1.1480.98
201_N216_T1.1330.98
152_N156_D1.1260.98
108_V125_A1.1090.98
166_E182_Q1.1070.98
103_I120_V1.0820.97
102_T116_I1.0730.97
55_D58_I1.0720.97
40_N43_K1.0660.97
184_S200_P1.0630.97
98_I110_I1.0520.97
204_L208_V1.0510.97
199_S215_P1.0400.96
203_Q219_Y1.0370.96
141_Q183_R1.0310.96
199_S202_T1.0280.96
104_I116_I1.0120.96
78_A96_A1.0080.96
54_A58_I0.9990.96
133_I136_S0.9740.95
192_I198_I0.9730.95
137_V177_G0.9690.95
71_N88_A0.9600.95
74_I78_A0.9570.94
152_N157_E0.9560.94
184_S202_T0.9450.94
149_R156_D0.9410.94
191_I206_P0.9340.94
54_A57_V0.9310.94
150_T180_I0.9290.93
222_R225_L0.9140.93
104_I108_V0.9070.93
202_T216_T0.9050.93
159_P170_A0.9050.93
99_R112_F0.9010.92
122_E140_N0.8940.92
92_I98_I0.8920.92
69_G87_G0.8900.92
149_R155_L0.8850.92
173_C191_I0.8820.92
84_V102_T0.8790.91
89_N106_N0.8780.91
86_I98_I0.8750.91
134_A137_V0.8690.91
160_V174_D0.8640.91
149_R154_R0.8590.91
56_Q59_I0.8580.90
41_Y44_L0.8530.90
154_R157_E0.8470.90
169_I187_G0.8450.90
202_T214_L0.8450.90
58_I79_V0.8400.90
59_I66_V0.8380.89
137_V179_Y0.8320.89
112_F115_E0.8310.89
136_S150_T0.8270.89
94_N97_F0.8270.89
143_Y146_A0.8190.88
114_T131_C0.8190.88
55_D59_I0.8190.88
196_R213_N0.8060.88
66_V81_Q0.8050.87
96_A114_T0.8010.87
103_I106_N0.7960.87
178_C198_I0.7860.86
93_G96_A0.7800.86
58_I77_G0.7780.86
146_A149_R0.7690.85
168_I172_G0.7670.85
122_E137_V0.7670.85
175_K193_L0.7570.84
127_I133_I0.7460.83
111_G126_T0.7460.83
120_V137_V0.7460.83
111_G115_E0.7430.83
52_Q73_R0.7420.83
140_N182_Q0.7410.83
123_A140_N0.7400.83
72_T88_A0.7390.83
215_P220_S0.7380.83
166_E180_I0.7370.82
40_N44_L0.7370.82
180_I184_S0.7360.82
184_S216_T0.7330.82
142_A184_S0.7280.82
180_I186_L0.7240.81
73_R91_L0.7230.81
99_R111_G0.7190.81
47_K50_N0.7180.81
110_I114_T0.7150.80
64_G82_G0.7100.80
102_T119_A0.7080.80
143_Y152_N0.7040.79
98_I102_T0.7000.79
75_C94_N0.6990.79
193_L206_P0.6980.79
93_G97_F0.6970.79
93_G99_R0.6960.79
111_G129_P0.6950.79
92_I96_A0.6940.78
177_G195_G0.6930.78
72_T106_N0.6860.78
80_I86_I0.6840.77
173_C189_Q0.6830.77
113_A129_P0.6770.77
187_G203_Q0.6710.76
86_I90_C0.6700.76
38_L44_L0.6690.76
189_Q209_I0.6680.76
69_G106_N0.6670.76
39_K44_L0.6660.76
171_T209_I0.6660.76
66_V80_I0.6640.75
93_G100_P0.6600.75
216_T220_S0.6590.75
104_I110_I0.6570.75
53_I74_I0.6540.74
178_C192_I0.6490.74
172_G186_L0.6450.73
168_I186_L0.6440.73
75_C78_A0.6430.73
84_V99_R0.6410.73
76_H94_N0.6380.72
211_E223_Q0.6350.72
113_A130_Q0.6350.72
163_R168_I0.6330.72
138_V144_L0.6330.72
198_I202_T0.6310.72
112_F129_P0.6300.72
140_N143_Y0.6230.71
188_V206_P0.6190.70
202_T218_T0.6160.70
162_V166_E0.6150.70
59_I80_I0.6100.69
110_I116_I0.6100.69
53_I57_V0.6100.69
74_I80_I0.6090.69
116_I121_I0.6070.69
84_V98_I0.6060.69
220_S225_L0.6060.69
79_V94_N0.6060.69
54_A79_V0.6030.68
134_A145_G0.6030.68
134_A146_A0.6020.68
93_G109_K0.6020.68
175_K192_I0.6010.68
119_A135_D0.6000.68
142_A146_A0.5970.67
98_I104_I0.5940.67
85_V88_A0.5910.67
77_G113_A0.5890.66
199_S217_G0.5890.66
68_I86_I0.5870.66
66_V82_G0.5870.66
191_I209_I0.5840.66
69_G90_C0.5820.65
160_V178_C0.5810.65
92_I104_I0.5770.65
99_R117_K0.5770.65
212_R225_L0.5770.65
67_V88_A0.5760.65
108_V121_I0.5750.65
193_L209_I0.5750.65
165_P201_N0.5750.65
119_A136_S0.5740.64
109_K126_T0.5720.64
54_A73_R0.5680.64
166_E200_P0.5630.63
178_C193_L0.5630.63
51_I56_Q0.5620.63
187_G207_R0.5620.63
190_V208_V0.5610.63
97_F112_F0.5570.62
171_T207_R0.5530.62
88_A107_G0.5520.61
58_I76_H0.5520.61
131_C148_V0.5490.61
66_V84_V0.5480.61
205_G220_S0.5470.61
44_L48_E0.5410.60
199_S218_T0.5410.60
45_N49_K0.5390.60
128_G132_F0.5370.59
220_S226_I0.5300.58
211_E226_I0.5290.58
167_G185_R0.5280.58
42_L46_V0.5270.58
67_V70_A0.5240.57
96_A113_A0.5220.57
121_I133_I0.5210.57
221_L225_L0.5200.57
115_E130_Q0.5180.57
78_A113_A0.5160.56
170_A178_C0.5130.56
48_E51_I0.5100.55
64_G80_I0.5090.55
117_K135_D0.5070.55
82_G100_P0.5070.55
67_V89_N0.5060.55
212_R221_L0.5060.55
50_N73_R0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iu8A 3 0.9826 100 0.355 Contact Map
4g3qA 3 0.9739 100 0.371 Contact Map
1hm9A 3 0.9739 100 0.388 Contact Map
4e79A 3 0.9739 100 0.389 Contact Map
2v0hA 3 0.9783 100 0.389 Contact Map
3pmoA 3 0.9783 100 0.395 Contact Map
2ggoA 3 0.9348 100 0.395 Contact Map
4ihfA 4 0.9826 100 0.403 Contact Map
3t57A 3 0.7652 100 0.405 Contact Map
3fs8A 3 0.7957 100 0.406 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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