GREMLIN Database
YAHO - Uncharacterized protein YahO
UniProt: P75694 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13599
Length: 91 (87)
Sequences: 104 (70)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_M30_F3.9890.97
60_K64_E3.9750.97
67_A87_I3.9490.96
15_A47_N2.1270.60
25_M71_V2.0700.58
30_F37_Y1.9130.51
25_M73_T1.9130.51
14_L18_N1.7300.44
54_A81_I1.7200.44
29_E50_S1.6420.41
30_F68_D1.6040.39
59_I70_L1.5720.38
18_N25_M1.5530.37
28_A31_E1.5470.37
39_K88_Y1.5330.37
23_E81_I1.5000.35
33_V37_Y1.4250.33
76_Q79_N1.3610.31
23_E43_I1.3380.30
30_F33_V1.3360.30
37_Y71_V1.3210.29
9_V28_A1.3130.29
27_K80_K1.2460.27
39_K42_D1.2450.27
59_I87_I1.2450.27
23_E56_E1.2300.26
69_V87_I1.2200.26
61_K65_K1.2190.26
26_T77_T1.2160.26
56_E60_K1.2130.26
45_T80_K1.2070.26
48_E80_K1.2040.26
21_A40_I1.1910.25
20_Y24_L1.1440.24
29_E32_K1.1150.23
27_K71_V1.1120.23
74_S81_I1.1030.23
5_S13_A1.0870.22
61_K82_H1.0820.22
37_Y48_E1.0560.21
18_N56_E1.0480.21
14_L17_T1.0450.21
70_L87_I1.0340.21
69_V72_L1.0340.21
44_S86_N1.0090.20
27_K57_D1.0070.20
39_K86_N1.0050.20
49_M55_K1.0020.20
27_K45_T0.9750.19
6_K43_I0.9580.19
79_N83_G0.9530.19
56_E81_I0.9460.19
62_A89_K0.9260.18
32_K43_I0.9230.18
32_K50_S0.9220.18
59_I67_A0.9200.18
24_L46_S0.9060.18
50_S75_G0.9020.18
54_A74_S0.8980.17
48_E55_K0.8970.17
73_T84_T0.8770.17
19_V47_N0.8710.17
27_K67_A0.8690.17
15_A43_I0.8630.17
59_I63_D0.8600.17
36_Q78_D0.8410.16
65_K82_H0.8360.16
18_N72_L0.8350.16
7_M12_L0.8350.16
45_T83_G0.8250.16
45_T54_A0.8230.16
26_T29_E0.8070.15
3_I49_M0.8040.15
26_T75_G0.7990.15
31_E88_Y0.7980.15
32_K37_Y0.7860.15
4_I7_M0.7850.15
36_Q79_N0.7820.15
25_M37_Y0.7760.15
8_L72_L0.7620.15
11_A72_L0.7600.15
74_S84_T0.7550.14
49_M65_K0.7340.14
38_E84_T0.7290.14
70_L75_G0.7270.14
13_A26_T0.7070.13
4_I12_L0.6950.13
6_K61_K0.6880.13
33_V68_D0.6860.13
32_K54_A0.6810.13
20_Y52_A0.6750.13
67_A70_L0.6610.13
43_I58_L0.6540.13
37_Y79_N0.6500.12
41_G61_K0.6490.12
29_E38_E0.6450.12
39_K75_G0.6440.12
61_K84_T0.6430.12
54_A82_H0.6430.12
57_D64_E0.6410.12
12_L45_T0.6320.12
9_V31_E0.6290.12
28_A44_S0.6240.12
12_L16_V0.6240.12
46_S82_H0.6150.12
48_E84_T0.6010.12
47_N78_D0.6000.12
5_S9_V0.5980.12
33_V36_Q0.5940.12
81_I84_T0.5930.12
32_K48_E0.5840.11
14_L42_D0.5830.11
12_L80_K0.5790.11
41_G58_L0.5730.11
36_Q56_E0.5730.11
8_L83_G0.5700.11
11_A23_E0.5680.11
14_L55_K0.5650.11
43_I76_Q0.5610.11
45_T57_D0.5500.11
33_V54_A0.5490.11
8_L60_K0.5430.11
26_T52_A0.5280.11
11_A40_I0.5270.10
32_K36_Q0.5230.10
10_G71_V0.5190.10
29_E65_K0.5110.10
4_I13_A0.5050.10
57_D61_K0.5020.10
30_F69_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nocA 1 1 100 0.267 Contact Map
2jnaA 2 0.978 99.9 0.333 Contact Map
2ma4A 1 0.7692 99.9 0.434 Contact Map
2m2jA 1 0.7363 99.8 0.464 Contact Map
4evuA 2 0.7143 99.7 0.535 Contact Map
3layA 5 0.6374 37.5 0.911 Contact Map
3sg0A 1 0.6264 36.4 0.912 Contact Map
4wcwA 2 0.5055 32.9 0.914 Contact Map
2id1A 1 0.4725 29.4 0.916 Contact Map
2o5aA 2 0.4505 28.8 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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