YAHK - ECOLI - GREMLIN Contacts

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YAHK - Aldehyde reductase YahK

UniProt:	P75691	Sequences: MKIKAVGAYSAKQPLEPMDITRREPGPNDVKIEIAYCGVCHSDLHQVRSEWAGTVYPCVPGHEIVGRVVAVGDQVEKYAPGDLVGVGCIVDSCKHCEECEDGLENYCDHMTGTYNSPTPDEPGHTLGGYSQQIVVHERYVLRIRHPQEQLAAVAPLLCAGITTYSPLRHWQAGPGKKVGVVGIGGLGHMGIKLAHAMGAHVVAFTTSEAKREAAKALGADEVVNSRNADEMAAHLKSFDFILNTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMKRRAIAGSMIGGIPETQEMLDFCAEHGIVADIEMIRADQINEAYERMLRGDVKYRFVIDNRTLTD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13595
Length:	349 (303)
Sequences:	52636 (36113)
Seq/√Len:	2074.7

ECOLI - YAHK YBDR AHR FRMA ADHP YGGP RSPB YPHC GATD YDJJ YDJL TDH YJJN IDND ACUI QOR1 YCJQ CURA
BACSU - ADHA ADHB YJMD YYCR YOGA DHSO TDH BDHA YHFP YFMJ
HALSA - Q9HP38 Q9HMB6 GLCDH Q9HQS8 Q9HR85
SULSO - Q7LXK1 Q97XR4 ADH Q97YT7 Q97ZV3 Q97VW0 Q97VV5 Q97YM2 Q97V32 GLCD3 GLCD1 Q97WA1 GLCD2 Q97TZ4 Q97W06 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_A	150_L	3.080	1.00
33_E	69_V	3.003	1.00
35_A	67_R	2.905	1.00
323_Q	326_E	2.777	1.00
177_K	200_H	2.685	1.00
31_K	69_V	2.540	1.00
79_A	82_D	2.497	1.00
83_L	143_I	2.428	1.00
82_D	142_R	2.403	1.00
183_I	203_A	2.353	1.00
30_V	140_V	2.331	1.00
22_R	132_Q	2.328	1.00
319_I	330_R	2.320	1.00
195_H	220_D	2.260	1.00
317_E	330_R	2.244	1.00
318_M	343_D	2.226	1.00
33_E	132_Q	2.215	1.00
7_G	18_M	2.208	1.00
33_E	67_R	2.185	1.00
178_V	194_A	2.179	1.00
151_A	318_M	2.151	1.00
149_Q	152_A	2.143	1.00
27_P	73_D	2.077	1.00
64_I	86_V	2.065	1.00
26_G	29_D	2.057	1.00
211_R	215_K	2.053	1.00
27_P	74_Q	2.034	1.00
173_G	176_K	2.030	1.00
77_K	137_E	1.997	1.00
146_P	308_A	1.993	1.00
31_K	134_V	1.985	1.00
320_R	323_Q	1.967	1.00
200_H	221_E	1.966	1.00
64_I	128_G	1.955	1.00
69_V	132_Q	1.948	1.00
48_R	332_L	1.944	1.00
191_I	219_A	1.903	1.00
28_N	74_Q	1.900	1.00
83_L	150_L	1.867	1.00
196_A	311_G	1.862	1.00
305_D	309_E	1.861	1.00
329_E	333_R	1.855	1.00
65_V	150_L	1.828	1.00
160_G	189_M	1.811	1.00
263_T	288_A	1.778	1.00
212_E	216_A	1.761	1.00
179_G	204_F	1.750	1.00
211_R	222_V	1.743	1.00
330_R	335_D	1.737	1.00
239_D	259_K	1.734	1.00
212_E	215_K	1.726	1.00
263_T	290_A	1.695	1.00
179_G	238_F	1.693	1.00
213_A	216_A	1.681	1.00
202_V	238_F	1.678	1.00
143_I	150_L	1.672	1.00
326_E	329_E	1.634	1.00
326_E	330_R	1.625	1.00
205_T	211_R	1.593	1.00
31_K	132_Q	1.583	1.00
319_I	327_A	1.576	1.00
24_E	70_A	1.574	1.00
151_A	343_D	1.570	1.00
200_H	220_D	1.569	1.00
6_V	324_I	1.566	1.00
67_R	83_L	1.561	1.00
258_L	264_M	1.543	1.00
4_K	19_D	1.536	1.00
70_A	80_P	1.532	1.00
208_E	224_N	1.513	1.00
181_V	254_F	1.512	1.00
208_E	212_E	1.504	1.00
71_V	80_P	1.495	1.00
170_W	240_F	1.484	1.00
31_K	70_A	1.472	1.00
241_I	258_L	1.461	1.00
72_G	75_V	1.453	1.00
325_N	329_E	1.452	1.00
258_L	287_R	1.449	1.00
78_Y	142_R	1.447	1.00
78_Y	82_D	1.446	1.00
28_N	136_H	1.442	1.00
29_D	136_H	1.440	1.00
129_Y	328_Y	1.434	1.00
29_D	134_V	1.434	1.00
34_I	64_I	1.434	1.00
258_L	262_G	1.412	1.00
83_L	145_H	1.399	1.00
5_A	20_I	1.396	1.00
176_K	263_T	1.388	1.00
208_E	227_N	1.374	1.00
224_N	227_N	1.369	1.00
196_A	306_F	1.358	1.00
241_I	254_F	1.345	1.00
177_K	202_V	1.342	1.00
25_P	134_V	1.339	1.00
4_K	322_D	1.326	1.00
143_I	153_V	1.322	1.00
36_Y	343_D	1.318	1.00
67_R	150_L	1.314	1.00
206_T	225_S	1.314	1.00
305_D	308_A	1.314	1.00
25_P	31_K	1.306	1.00
208_E	211_R	1.306	1.00
30_V	78_Y	1.298	1.00
229_D	232_A	1.287	1.00
190_G	242_L	1.278	1.00
6_V	17_P	1.277	1.00
181_V	204_F	1.274	1.00
68_V	78_Y	1.265	1.00
47_V	328_Y	1.260	1.00
35_A	83_L	1.258	1.00
191_I	203_A	1.248	1.00
36_Y	151_A	1.242	1.00
34_I	133_I	1.232	1.00
168_R	299_E	1.228	1.00
228_A	233_A	1.226	1.00
4_K	131_Q	1.210	1.00
22_R	31_K	1.188	1.00
11_A	14_P	1.176	1.00
177_K	239_D	1.173	1.00
211_R	224_N	1.160	1.00
306_F	311_G	1.159	1.00
28_N	137_E	1.152	1.00
229_D	233_A	1.149	1.00
78_Y	140_V	1.149	1.00
192_K	313_V	1.133	1.00
215_K	222_V	1.124	1.00
213_A	337_K	1.124	1.00
256_T	281_N	1.116	1.00
297_I	301_Q	1.115	1.00
320_R	343_D	1.106	1.00
176_K	239_D	1.097	1.00
168_R	302_E	1.081	1.00
172_A	199_A	1.078	1.00
165_S	299_E	1.077	1.00
324_I	342_I	1.072	1.00
7_G	20_I	1.072	1.00
202_V	221_E	1.071	1.00
302_E	305_D	1.061	1.00
135_V	140_V	1.051	1.00
231_M	235_L	1.051	1.00
163_T	190_G	1.050	1.00
194_A	199_A	1.050	1.00
170_W	265_T	1.047	1.00
206_T	226_R	1.046	1.00
10_S	16_E	1.043	1.00
36_Y	150_L	1.035	1.00
32_I	84_V	1.031	1.00
215_K	221_E	1.030	1.00
172_A	176_K	1.024	1.00
17_P	322_D	1.021	1.00
152_A	313_V	1.017	1.00
47_V	332_L	1.011	1.00
232_A	235_L	1.010	1.00
329_E	332_L	1.006	1.00
37_C	129_Y	1.001	1.00
10_S	14_P	1.000	1.00
169_H	288_A	0.998	1.00
75_V	137_E	0.997	1.00
39_V	327_A	0.997	1.00
69_V	80_P	0.995	1.00
230_E	233_A	0.991	1.00
253_D	256_T	0.989	1.00
32_I	66_G	0.985	1.00
330_R	340_F	0.983	1.00
166_P	267_V	0.969	1.00
203_A	214_A	0.968	1.00
11_A	56_Y	0.964	1.00
164_Y	302_E	0.964	1.00
319_I	323_Q	0.962	1.00
160_G	303_M	0.962	1.00
245_V	250_N	0.960	1.00
25_P	29_D	0.960	1.00
302_E	306_F	0.958	1.00
6_V	321_A	0.954	1.00
301_Q	305_D	0.954	1.00
230_E	235_L	0.945	1.00
230_E	234_H	0.943	1.00
166_P	242_L	0.939	1.00
183_I	205_T	0.934	1.00
163_T	193_L	0.932	1.00
4_K	17_P	0.915	1.00
76_E	137_E	0.913	1.00
281_N	285_K	0.912	1.00
85_G	304_L	0.912	1.00
183_I	191_I	0.911	1.00
176_K	240_F	0.910	1.00
203_A	219_A	0.910	1.00
169_H	290_A	0.909	1.00
191_I	201_V	0.908	1.00
261_D	286_R	0.904	1.00
183_I	214_A	0.902	1.00
129_Y	324_I	0.902	1.00
188_H	213_A	0.901	1.00
252_D	256_T	0.897	1.00
207_S	210_K	0.896	1.00
44_L	331_M	0.893	1.00
36_Y	341_V	0.890	1.00
58_C	126_L	0.889	1.00
204_F	225_S	0.888	1.00
152_A	315_D	0.882	1.00
71_V	79_A	0.882	1.00
210_K	337_K	0.882	1.00
209_A	212_E	0.881	1.00
35_A	65_V	0.881	1.00
202_V	223_V	0.878	1.00
37_C	128_G	0.874	1.00
231_M	256_T	0.863	1.00
40_C	63_E	0.861	1.00
179_G	257_L	0.859	1.00
71_V	75_V	0.852	1.00
6_V	15_L	0.850	1.00
7_G	59_V	0.846	1.00
33_E	131_Q	0.845	1.00
243_N	246_A	0.845	1.00
205_T	222_V	0.843	1.00
5_A	59_V	0.843	1.00
298_P	302_E	0.842	1.00
336_V	340_F	0.839	1.00
156_L	307_C	0.839	1.00
181_V	241_I	0.835	1.00
22_R	70_A	0.835	1.00
161_I	299_E	0.835	1.00
180_V	194_A	0.827	1.00
181_V	250_N	0.822	1.00
141_L	301_Q	0.818	1.00
273_P	276_S	0.816	1.00
22_R	69_V	0.810	1.00
171_Q	263_T	0.809	1.00
306_F	309_E	0.804	1.00
214_A	219_A	0.802	1.00
194_A	201_V	0.801	1.00
64_I	133_I	0.794	1.00
282_L	289_I	0.794	1.00
147_Q	153_V	0.793	1.00
20_I	126_L	0.792	1.00
30_V	137_E	0.791	1.00
180_V	190_G	0.791	1.00
40_C	62_H	0.791	1.00
128_G	133_I	0.788	1.00
241_I	264_M	0.787	1.00
254_F	264_M	0.784	1.00
193_L	303_M	0.780	1.00
178_V	199_A	0.779	1.00
10_S	13_Q	0.779	1.00
177_K	238_F	0.778	1.00
38_G	63_E	0.777	1.00
20_I	59_V	0.776	1.00
86_V	135_V	0.774	1.00
167_L	194_A	0.773	1.00
39_V	331_M	0.769	1.00
79_A	142_R	0.767	1.00
177_K	236_K	0.767	1.00
298_P	301_Q	0.765	1.00
317_E	326_E	0.762	1.00
26_G	134_V	0.759	1.00
144_R	308_A	0.759	1.00
24_E	31_K	0.759	1.00
244_T	267_V	0.756	1.00
197_M	302_E	0.755	1.00
163_T	189_M	0.755	1.00
234_H	238_F	0.750	1.00
206_T	211_R	0.748	1.00
319_I	340_F	0.744	1.00
231_M	253_D	0.744	1.00
171_Q	288_A	0.742	1.00
216_A	313_V	0.739	1.00
227_N	233_A	0.739	1.00
145_H	308_A	0.739	1.00
193_L	306_F	0.734	1.00
129_Y	342_I	0.729	1.00
330_R	333_R	0.728	1.00
28_N	73_D	0.727	1.00
201_V	220_D	0.725	1.00
17_P	321_A	0.725	1.00
40_C	43_D	0.724	1.00
42_S	62_H	0.716	1.00
166_P	190_G	0.715	1.00
230_E	253_D	0.713	1.00
304_L	308_A	0.711	1.00
172_A	240_F	0.706	1.00
84_V	140_V	0.705	1.00
85_G	143_I	0.702	1.00
6_V	325_N	0.702	1.00
282_L	287_R	0.700	1.00
44_L	332_L	0.698	1.00
278_E	281_N	0.695	1.00
317_E	340_F	0.694	1.00
202_V	234_H	0.694	1.00
171_Q	290_A	0.690	1.00
141_L	300_T	0.688	1.00
205_T	214_A	0.687	1.00
164_Y	306_F	0.686	1.00
25_P	70_A	0.685	1.00
213_A	315_D	0.684	1.00
164_Y	303_M	0.681	1.00
155_P	341_V	0.679	1.00
180_V	203_A	0.678	1.00
199_A	240_F	0.678	1.00
147_Q	307_C	0.677	1.00
34_I	37_C	0.674	1.00
331_M	340_F	0.674	1.00
282_L	291_G	0.673	1.00
319_I	342_I	0.670	1.00
188_H	315_D	0.669	1.00
252_D	281_N	0.667	1.00
28_N	138_R	0.667	1.00
54_T	58_C	0.665	1.00
266_L	289_I	0.664	1.00
207_S	224_N	0.659	1.00
36_Y	65_V	0.659	1.00
243_N	264_M	0.658	1.00
28_N	72_G	0.658	1.00
240_F	265_T	0.657	1.00
85_G	157_L	0.657	1.00
260_R	285_K	0.655	1.00
30_V	68_V	0.655	1.00
213_A	217_L	0.654	1.00
23_R	134_V	0.652	1.00
165_S	286_R	0.650	1.00
192_K	217_L	0.649	1.00
229_D	253_D	0.648	1.00
63_E	158_C	0.648	1.00
163_T	186_L	0.647	1.00
236_K	259_K	0.645	1.00
251_L	264_M	0.643	1.00
45_H	50_E	0.643	1.00
247_A	250_N	0.642	1.00
306_F	310_H	0.641	1.00
162_T	186_L	0.638	1.00
248_P	252_D	0.638	1.00
281_N	284_M	0.637	1.00
238_F	241_I	0.637	1.00
35_A	343_D	0.636	1.00
82_D	145_H	0.633	1.00
65_V	143_I	0.632	1.00
168_R	197_M	0.631	1.00
65_V	83_L	0.628	1.00
159_A	189_M	0.627	1.00
164_Y	299_E	0.627	1.00
40_C	158_C	0.627	1.00
36_Y	318_M	0.625	1.00
221_E	233_A	0.624	1.00
330_R	336_V	0.623	1.00
195_H	201_V	0.619	1.00
273_P	278_E	0.617	1.00
193_L	197_M	0.617	1.00
77_K	297_I	0.617	1.00
55_V	58_C	0.615	1.00
40_C	159_A	0.614	1.00
25_P	72_G	0.612	1.00
240_F	263_T	0.609	1.00
174_P	198_G	0.608	1.00
191_I	217_L	0.608	1.00
32_I	86_V	0.606	1.00
163_T	167_L	0.605	1.00
62_H	158_C	0.604	1.00
87_G	141_L	0.602	1.00
286_R	296_G	0.601	1.00
141_L	304_L	0.601	1.00
83_L	146_P	0.600	1.00
42_S	46_Q	0.600	1.00
219_A	222_V	0.599	1.00
44_L	48_R	0.597	1.00
205_T	225_S	0.596	1.00
300_T	304_L	0.596	1.00
231_M	257_L	0.595	1.00
57_P	61_G	0.595	1.00
238_F	257_L	0.592	1.00
86_V	140_V	0.592	1.00
211_R	214_A	0.587	1.00
32_I	140_V	0.585	1.00
166_P	265_T	0.585	1.00
39_V	129_Y	0.577	1.00
141_L	297_I	0.576	1.00
252_D	276_S	0.575	1.00
205_T	210_K	0.571	1.00
159_A	185_G	0.570	1.00
299_E	302_E	0.569	1.00
328_Y	332_L	0.569	1.00
61_G	129_Y	0.568	1.00
77_K	80_P	0.568	1.00
37_C	342_I	0.567	1.00
190_G	267_V	0.567	1.00
177_K	237_S	0.566	1.00
307_C	314_A	0.563	1.00
280_F	283_I	0.563	1.00
39_V	342_I	0.561	1.00
178_V	240_F	0.561	1.00
13_Q	48_R	0.559	1.00
170_W	263_T	0.559	1.00
177_K	221_E	0.559	1.00
231_M	234_H	0.558	1.00
78_Y	137_E	0.557	1.00
46_Q	51_W	0.557	1.00
136_H	139_Y	0.556	1.00
158_C	162_T	0.555	1.00
71_V	82_D	0.555	1.00
23_R	29_D	0.555	1.00
41_H	45_H	0.554	1.00
15_L	328_Y	0.553	1.00
21_T	24_E	0.552	1.00
167_L	193_L	0.551	1.00
179_G	241_I	0.550	1.00
8_A	47_V	0.548	1.00
76_E	79_A	0.547	1.00
327_A	342_I	0.544	1.00
216_A	315_D	0.543	1.00
281_N	287_R	0.542	1.00
174_P	197_M	0.540	1.00
180_V	191_I	0.540	1.00
191_I	214_A	0.539	1.00
155_P	314_A	0.538	1.00
166_P	292_S	0.538	1.00
152_A	318_M	0.538	1.00
189_M	193_L	0.537	1.00
214_A	222_V	0.536	1.00
317_E	323_Q	0.535	1.00
168_R	171_Q	0.533	1.00
23_R	132_Q	0.532	1.00
40_C	339_R	0.529	1.00
241_I	257_L	0.528	1.00
42_S	45_H	0.527	1.00
188_H	217_L	0.527	1.00
59_V	127_G	0.526	1.00
204_F	223_V	0.526	1.00
301_Q	304_L	0.525	1.00
29_D	125_T	0.522	1.00
10_S	18_M	0.521	1.00
319_I	326_E	0.520	1.00
237_S	259_K	0.519	1.00
86_V	128_G	0.519	1.00
171_Q	197_M	0.519	1.00
165_S	169_H	0.517	1.00
164_Y	193_L	0.517	1.00
143_I	154_A	0.517	1.00
234_H	257_L	0.517	1.00
189_M	312_I	0.516	1.00
161_I	294_I	0.516	1.00
34_I	86_V	0.515	1.00
210_K	335_D	0.514	1.00
65_V	154_A	0.512	1.00
250_N	254_F	0.512	1.00
167_L	190_G	0.510	1.00
168_R	298_P	0.509	1.00
195_H	219_A	0.507	1.00
251_L	266_L	0.506	1.00
63_E	339_R	0.506	1.00
14_P	329_E	0.504	1.00
310_H	313_V	0.504	1.00
71_V	78_Y	0.503	1.00
162_T	267_V	0.503	1.00
292_S	295_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1uufA	2	0.9685	100	0.15	Contact Map
3twoA	2	0.9799	100	0.16	Contact Map
4oaqA	2	0.9971	100	0.164	Contact Map
1f8fA	4	0.9742	100	0.167	Contact Map
1rjwA	4	0.957	100	0.168	Contact Map
1yqdA	2	0.9914	100	0.169	Contact Map
1h2bA	4	0.9427	100	0.171	Contact Map
2cf5A	1	0.9914	100	0.173	Contact Map
3ukoA	4	0.9799	100	0.174	Contact Map
1piwA	2	0.9885	100	0.174	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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