GREMLIN Database
YAHK - Aldehyde reductase YahK
UniProt: P75691 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13595
Length: 349 (303)
Sequences: 52636 (36113)
Seq/√Len: 2074.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_A150_L3.0801.00
33_E69_V3.0031.00
35_A67_R2.9051.00
323_Q326_E2.7771.00
177_K200_H2.6851.00
31_K69_V2.5401.00
79_A82_D2.4971.00
83_L143_I2.4281.00
82_D142_R2.4031.00
183_I203_A2.3531.00
30_V140_V2.3311.00
22_R132_Q2.3281.00
319_I330_R2.3201.00
195_H220_D2.2601.00
317_E330_R2.2441.00
318_M343_D2.2261.00
33_E132_Q2.2151.00
7_G18_M2.2081.00
33_E67_R2.1851.00
178_V194_A2.1791.00
151_A318_M2.1511.00
149_Q152_A2.1431.00
27_P73_D2.0771.00
64_I86_V2.0651.00
26_G29_D2.0571.00
211_R215_K2.0531.00
27_P74_Q2.0341.00
173_G176_K2.0301.00
77_K137_E1.9971.00
146_P308_A1.9931.00
31_K134_V1.9851.00
320_R323_Q1.9671.00
200_H221_E1.9661.00
64_I128_G1.9551.00
69_V132_Q1.9481.00
48_R332_L1.9441.00
191_I219_A1.9031.00
28_N74_Q1.9001.00
83_L150_L1.8671.00
196_A311_G1.8621.00
305_D309_E1.8611.00
329_E333_R1.8551.00
65_V150_L1.8281.00
160_G189_M1.8111.00
263_T288_A1.7781.00
212_E216_A1.7611.00
179_G204_F1.7501.00
211_R222_V1.7431.00
330_R335_D1.7371.00
239_D259_K1.7341.00
212_E215_K1.7261.00
263_T290_A1.6951.00
179_G238_F1.6931.00
213_A216_A1.6811.00
202_V238_F1.6781.00
143_I150_L1.6721.00
326_E329_E1.6341.00
326_E330_R1.6251.00
205_T211_R1.5931.00
31_K132_Q1.5831.00
319_I327_A1.5761.00
24_E70_A1.5741.00
151_A343_D1.5701.00
200_H220_D1.5691.00
6_V324_I1.5661.00
67_R83_L1.5611.00
258_L264_M1.5431.00
4_K19_D1.5361.00
70_A80_P1.5321.00
208_E224_N1.5131.00
181_V254_F1.5121.00
208_E212_E1.5041.00
71_V80_P1.4951.00
170_W240_F1.4841.00
31_K70_A1.4721.00
241_I258_L1.4611.00
72_G75_V1.4531.00
325_N329_E1.4521.00
258_L287_R1.4491.00
78_Y142_R1.4471.00
78_Y82_D1.4461.00
28_N136_H1.4421.00
29_D136_H1.4401.00
129_Y328_Y1.4341.00
29_D134_V1.4341.00
34_I64_I1.4341.00
258_L262_G1.4121.00
83_L145_H1.3991.00
5_A20_I1.3961.00
176_K263_T1.3881.00
208_E227_N1.3741.00
224_N227_N1.3691.00
196_A306_F1.3581.00
241_I254_F1.3451.00
177_K202_V1.3421.00
25_P134_V1.3391.00
4_K322_D1.3261.00
143_I153_V1.3221.00
36_Y343_D1.3181.00
67_R150_L1.3141.00
206_T225_S1.3141.00
305_D308_A1.3141.00
25_P31_K1.3061.00
208_E211_R1.3061.00
30_V78_Y1.2981.00
229_D232_A1.2871.00
190_G242_L1.2781.00
6_V17_P1.2771.00
181_V204_F1.2741.00
68_V78_Y1.2651.00
47_V328_Y1.2601.00
35_A83_L1.2581.00
191_I203_A1.2481.00
36_Y151_A1.2421.00
34_I133_I1.2321.00
168_R299_E1.2281.00
228_A233_A1.2261.00
4_K131_Q1.2101.00
22_R31_K1.1881.00
11_A14_P1.1761.00
177_K239_D1.1731.00
211_R224_N1.1601.00
306_F311_G1.1591.00
28_N137_E1.1521.00
229_D233_A1.1491.00
78_Y140_V1.1491.00
192_K313_V1.1331.00
215_K222_V1.1241.00
213_A337_K1.1241.00
256_T281_N1.1161.00
297_I301_Q1.1151.00
320_R343_D1.1061.00
176_K239_D1.0971.00
168_R302_E1.0811.00
172_A199_A1.0781.00
165_S299_E1.0771.00
324_I342_I1.0721.00
7_G20_I1.0721.00
202_V221_E1.0711.00
302_E305_D1.0611.00
135_V140_V1.0511.00
231_M235_L1.0511.00
163_T190_G1.0501.00
194_A199_A1.0501.00
170_W265_T1.0471.00
206_T226_R1.0461.00
10_S16_E1.0431.00
36_Y150_L1.0351.00
32_I84_V1.0311.00
215_K221_E1.0301.00
172_A176_K1.0241.00
17_P322_D1.0211.00
152_A313_V1.0171.00
47_V332_L1.0111.00
232_A235_L1.0101.00
329_E332_L1.0061.00
37_C129_Y1.0011.00
10_S14_P1.0001.00
169_H288_A0.9981.00
75_V137_E0.9971.00
39_V327_A0.9971.00
69_V80_P0.9951.00
230_E233_A0.9911.00
253_D256_T0.9891.00
32_I66_G0.9851.00
330_R340_F0.9831.00
166_P267_V0.9691.00
203_A214_A0.9681.00
11_A56_Y0.9641.00
164_Y302_E0.9641.00
319_I323_Q0.9621.00
160_G303_M0.9621.00
245_V250_N0.9601.00
25_P29_D0.9601.00
302_E306_F0.9581.00
6_V321_A0.9541.00
301_Q305_D0.9541.00
230_E235_L0.9451.00
230_E234_H0.9431.00
166_P242_L0.9391.00
183_I205_T0.9341.00
163_T193_L0.9321.00
4_K17_P0.9151.00
76_E137_E0.9131.00
281_N285_K0.9121.00
85_G304_L0.9121.00
183_I191_I0.9111.00
176_K240_F0.9101.00
203_A219_A0.9101.00
169_H290_A0.9091.00
191_I201_V0.9081.00
261_D286_R0.9041.00
183_I214_A0.9021.00
129_Y324_I0.9021.00
188_H213_A0.9011.00
252_D256_T0.8971.00
207_S210_K0.8961.00
44_L331_M0.8931.00
36_Y341_V0.8901.00
58_C126_L0.8891.00
204_F225_S0.8881.00
152_A315_D0.8821.00
71_V79_A0.8821.00
210_K337_K0.8821.00
209_A212_E0.8811.00
35_A65_V0.8811.00
202_V223_V0.8781.00
37_C128_G0.8741.00
231_M256_T0.8631.00
40_C63_E0.8611.00
179_G257_L0.8591.00
71_V75_V0.8521.00
6_V15_L0.8501.00
7_G59_V0.8461.00
33_E131_Q0.8451.00
243_N246_A0.8451.00
205_T222_V0.8431.00
5_A59_V0.8431.00
298_P302_E0.8421.00
336_V340_F0.8391.00
156_L307_C0.8391.00
181_V241_I0.8351.00
22_R70_A0.8351.00
161_I299_E0.8351.00
180_V194_A0.8271.00
181_V250_N0.8221.00
141_L301_Q0.8181.00
273_P276_S0.8161.00
22_R69_V0.8101.00
171_Q263_T0.8091.00
306_F309_E0.8041.00
214_A219_A0.8021.00
194_A201_V0.8011.00
64_I133_I0.7941.00
282_L289_I0.7941.00
147_Q153_V0.7931.00
20_I126_L0.7921.00
30_V137_E0.7911.00
180_V190_G0.7911.00
40_C62_H0.7911.00
128_G133_I0.7881.00
241_I264_M0.7871.00
254_F264_M0.7841.00
193_L303_M0.7801.00
178_V199_A0.7791.00
10_S13_Q0.7791.00
177_K238_F0.7781.00
38_G63_E0.7771.00
20_I59_V0.7761.00
86_V135_V0.7741.00
167_L194_A0.7731.00
39_V331_M0.7691.00
79_A142_R0.7671.00
177_K236_K0.7671.00
298_P301_Q0.7651.00
317_E326_E0.7621.00
26_G134_V0.7591.00
144_R308_A0.7591.00
24_E31_K0.7591.00
244_T267_V0.7561.00
197_M302_E0.7551.00
163_T189_M0.7551.00
234_H238_F0.7501.00
206_T211_R0.7481.00
319_I340_F0.7441.00
231_M253_D0.7441.00
171_Q288_A0.7421.00
216_A313_V0.7391.00
227_N233_A0.7391.00
145_H308_A0.7391.00
193_L306_F0.7341.00
129_Y342_I0.7291.00
330_R333_R0.7281.00
28_N73_D0.7271.00
201_V220_D0.7251.00
17_P321_A0.7251.00
40_C43_D0.7241.00
42_S62_H0.7161.00
166_P190_G0.7151.00
230_E253_D0.7131.00
304_L308_A0.7111.00
172_A240_F0.7061.00
84_V140_V0.7051.00
85_G143_I0.7021.00
6_V325_N0.7021.00
282_L287_R0.7001.00
44_L332_L0.6981.00
278_E281_N0.6951.00
317_E340_F0.6941.00
202_V234_H0.6941.00
171_Q290_A0.6901.00
141_L300_T0.6881.00
205_T214_A0.6871.00
164_Y306_F0.6861.00
25_P70_A0.6851.00
213_A315_D0.6841.00
164_Y303_M0.6811.00
155_P341_V0.6791.00
180_V203_A0.6781.00
199_A240_F0.6781.00
147_Q307_C0.6771.00
34_I37_C0.6741.00
331_M340_F0.6741.00
282_L291_G0.6731.00
319_I342_I0.6701.00
188_H315_D0.6691.00
252_D281_N0.6671.00
28_N138_R0.6671.00
54_T58_C0.6651.00
266_L289_I0.6641.00
207_S224_N0.6591.00
36_Y65_V0.6591.00
243_N264_M0.6581.00
28_N72_G0.6581.00
240_F265_T0.6571.00
85_G157_L0.6571.00
260_R285_K0.6551.00
30_V68_V0.6551.00
213_A217_L0.6541.00
23_R134_V0.6521.00
165_S286_R0.6501.00
192_K217_L0.6491.00
229_D253_D0.6481.00
63_E158_C0.6481.00
163_T186_L0.6471.00
236_K259_K0.6451.00
251_L264_M0.6431.00
45_H50_E0.6431.00
247_A250_N0.6421.00
306_F310_H0.6411.00
162_T186_L0.6381.00
248_P252_D0.6381.00
281_N284_M0.6371.00
238_F241_I0.6371.00
35_A343_D0.6361.00
82_D145_H0.6331.00
65_V143_I0.6321.00
168_R197_M0.6311.00
65_V83_L0.6281.00
159_A189_M0.6271.00
164_Y299_E0.6271.00
40_C158_C0.6271.00
36_Y318_M0.6251.00
221_E233_A0.6241.00
330_R336_V0.6231.00
195_H201_V0.6191.00
273_P278_E0.6171.00
193_L197_M0.6171.00
77_K297_I0.6171.00
55_V58_C0.6151.00
40_C159_A0.6141.00
25_P72_G0.6121.00
240_F263_T0.6091.00
174_P198_G0.6081.00
191_I217_L0.6081.00
32_I86_V0.6061.00
163_T167_L0.6051.00
62_H158_C0.6041.00
87_G141_L0.6021.00
286_R296_G0.6011.00
141_L304_L0.6011.00
83_L146_P0.6001.00
42_S46_Q0.6001.00
219_A222_V0.5991.00
44_L48_R0.5971.00
205_T225_S0.5961.00
300_T304_L0.5961.00
231_M257_L0.5951.00
57_P61_G0.5951.00
238_F257_L0.5921.00
86_V140_V0.5921.00
211_R214_A0.5871.00
32_I140_V0.5851.00
166_P265_T0.5851.00
39_V129_Y0.5771.00
141_L297_I0.5761.00
252_D276_S0.5751.00
205_T210_K0.5711.00
159_A185_G0.5701.00
299_E302_E0.5691.00
328_Y332_L0.5691.00
61_G129_Y0.5681.00
77_K80_P0.5681.00
37_C342_I0.5671.00
190_G267_V0.5671.00
177_K237_S0.5661.00
307_C314_A0.5631.00
280_F283_I0.5631.00
39_V342_I0.5611.00
178_V240_F0.5611.00
13_Q48_R0.5591.00
170_W263_T0.5591.00
177_K221_E0.5591.00
231_M234_H0.5581.00
78_Y137_E0.5571.00
46_Q51_W0.5571.00
136_H139_Y0.5561.00
158_C162_T0.5551.00
71_V82_D0.5551.00
23_R29_D0.5551.00
41_H45_H0.5541.00
15_L328_Y0.5531.00
21_T24_E0.5521.00
167_L193_L0.5511.00
179_G241_I0.5501.00
8_A47_V0.5481.00
76_E79_A0.5471.00
327_A342_I0.5441.00
216_A315_D0.5431.00
281_N287_R0.5421.00
174_P197_M0.5401.00
180_V191_I0.5401.00
191_I214_A0.5391.00
155_P314_A0.5381.00
166_P292_S0.5381.00
152_A318_M0.5381.00
189_M193_L0.5371.00
214_A222_V0.5361.00
317_E323_Q0.5351.00
168_R171_Q0.5331.00
23_R132_Q0.5321.00
40_C339_R0.5291.00
241_I257_L0.5281.00
42_S45_H0.5271.00
188_H217_L0.5271.00
59_V127_G0.5261.00
204_F223_V0.5261.00
301_Q304_L0.5251.00
29_D125_T0.5221.00
10_S18_M0.5211.00
319_I326_E0.5201.00
237_S259_K0.5191.00
86_V128_G0.5191.00
171_Q197_M0.5191.00
165_S169_H0.5171.00
164_Y193_L0.5171.00
143_I154_A0.5171.00
234_H257_L0.5171.00
189_M312_I0.5161.00
161_I294_I0.5161.00
34_I86_V0.5151.00
210_K335_D0.5141.00
65_V154_A0.5121.00
250_N254_F0.5121.00
167_L190_G0.5101.00
168_R298_P0.5091.00
195_H219_A0.5071.00
251_L266_L0.5061.00
63_E339_R0.5061.00
14_P329_E0.5041.00
310_H313_V0.5041.00
71_V78_Y0.5031.00
162_T267_V0.5031.00
292_S295_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uufA 2 0.9685 100 0.15 Contact Map
3twoA 2 0.9799 100 0.16 Contact Map
4oaqA 2 0.9971 100 0.164 Contact Map
1f8fA 4 0.9742 100 0.167 Contact Map
1rjwA 4 0.957 100 0.168 Contact Map
1yqdA 2 0.9914 100 0.169 Contact Map
1h2bA 4 0.9427 100 0.171 Contact Map
2cf5A 1 0.9914 100 0.173 Contact Map
3ukoA 4 0.9799 100 0.174 Contact Map
1piwA 2 0.9885 100 0.174 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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