GREMLIN Database
RCLC - Inner membrane protein RclC
UniProt: P75685 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13579
Length: 197 (182)
Sequences: 132 (81)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_H72_E3.4190.86
22_S168_A3.2890.84
75_P79_A2.8800.75
24_A105_L2.7960.72
55_F93_L2.6870.69
44_T57_Y2.6490.68
68_T77_A2.5880.66
24_A28_M2.4930.63
142_A148_H2.4440.61
118_G173_I2.4320.61
26_V165_L2.2850.56
52_L126_L2.0690.48
89_F93_L2.0170.46
56_F89_F1.9880.45
139_W161_L1.9070.43
26_V68_T1.8810.42
4_Y102_L1.8580.41
60_P66_Y1.8550.41
26_V41_D1.8500.41
42_S124_T1.7930.39
96_V161_L1.7750.38
97_E124_T1.7440.37
81_Q111_R1.7230.36
73_Y78_R1.6490.34
10_R175_A1.6490.34
104_V111_R1.6210.33
19_I169_G1.6050.33
96_V166_M1.5950.32
107_N174_M1.5820.32
26_V77_A1.5650.31
138_A155_G1.5350.30
18_L164_T1.5090.30
61_E65_Q1.4960.29
45_P48_A1.4950.29
58_E85_N1.4840.29
72_E139_W1.4710.29
179_R183_K1.4660.28
65_Q126_L1.4490.28
53_M56_F1.4340.28
106_A111_R1.4080.27
118_G174_M1.3980.27
56_F93_L1.3840.26
104_V177_S1.3740.26
147_H152_Y1.3620.26
88_G95_V1.3510.25
14_I17_T1.3500.25
48_A61_E1.3450.25
48_A60_P1.3430.25
27_F121_A1.3370.25
56_F92_G1.3340.25
85_N88_G1.3050.24
42_S97_E1.3030.24
9_S66_Y1.2920.24
26_V166_M1.2880.24
72_E79_A1.2580.23
27_F125_P1.2550.23
125_P165_L1.2530.23
19_I22_S1.2450.23
46_F49_N1.2310.22
75_P130_S1.2150.22
61_E66_Y1.2130.22
53_M89_F1.2020.21
89_F92_G1.1990.21
28_M105_L1.1860.21
74_K119_L1.1810.21
27_F35_F1.1790.21
109_V121_A1.1780.21
83_A99_I1.1750.21
177_S180_E1.1740.21
23_I27_F1.1730.21
92_G122_F1.1720.21
69_H79_A1.1660.21
76_E79_A1.1630.21
25_I56_F1.1620.21
35_F133_I1.1610.20
15_G27_F1.1590.20
78_R123_T1.1460.20
27_F85_N1.1420.20
133_I152_Y1.1360.20
91_N133_I1.1260.20
19_I65_Q1.1240.20
48_A64_K1.1240.20
26_V74_K1.1180.20
23_I104_V1.1130.19
104_V169_G1.1090.19
99_I103_L1.1050.19
74_K77_A1.1050.19
81_Q124_T1.1030.19
110_N167_L1.0950.19
138_A161_L1.0930.19
4_Y184_Q1.0920.19
37_P41_D1.0850.19
5_L113_L1.0780.19
66_Y73_Y1.0780.19
142_A147_H1.0600.18
99_I102_L1.0590.18
127_V166_M1.0480.18
85_N125_P1.0350.18
52_L133_I1.0310.18
48_A59_H1.0240.18
35_F95_V1.0150.17
19_I173_I1.0110.17
118_G171_V1.0100.17
113_L142_A1.0080.17
138_A179_R1.0070.17
4_Y99_I1.0060.17
68_T81_Q1.0050.17
104_V183_K1.0020.17
11_G99_I0.9970.17
97_E125_P0.9880.17
68_T74_K0.9880.17
19_I172_M0.9880.17
170_A174_M0.9770.17
49_N160_V0.9750.17
114_G181_I0.9750.17
105_L114_G0.9750.17
89_F96_V0.9720.16
97_E101_A0.9700.16
58_E61_E0.9630.16
25_I103_L0.9520.16
119_L174_M0.9500.16
8_L118_G0.9480.16
10_R179_R0.9450.16
37_P78_R0.9450.16
148_H173_I0.9440.16
12_D16_L0.9420.16
138_A156_A0.9340.16
61_E64_K0.9300.16
41_D74_K0.9270.16
126_L142_A0.9090.15
73_Y139_W0.9020.15
139_W145_D0.9020.15
105_L168_A0.8990.15
62_D172_M0.8980.15
19_I168_A0.8830.15
55_F89_F0.8740.15
35_F166_M0.8720.15
32_L101_A0.8600.14
13_K148_H0.8510.14
64_K79_A0.8450.14
62_D76_E0.8420.14
106_A124_T0.8410.14
138_A145_D0.8340.14
20_R28_M0.8260.14
41_D68_T0.8220.14
42_S125_P0.8160.14
62_D116_L0.8110.14
68_T165_L0.8000.13
83_A147_H0.7950.13
93_L96_V0.7930.13
77_A111_R0.7890.13
67_L107_N0.7830.13
4_Y179_R0.7810.13
71_G149_G0.7710.13
27_F165_L0.7710.13
106_A110_N0.7650.13
77_A81_Q0.7630.13
106_A113_L0.7520.13
21_L126_L0.7500.13
167_L177_S0.7460.13
99_I130_S0.7340.12
23_I168_A0.7290.12
52_L99_I0.7280.12
100_I104_V0.7220.12
56_F164_T0.7220.12
44_T61_E0.7200.12
37_P73_Y0.7200.12
105_L123_T0.7180.12
66_Y76_E0.7140.12
46_F160_V0.7110.12
25_I104_V0.7110.12
182_L185_R0.7100.12
76_E108_P0.7080.12
14_I18_L0.7060.12
133_I166_M0.7000.12
44_T68_T0.6980.12
105_L181_I0.6960.12
22_S25_I0.6930.12
90_S121_A0.6900.12
59_H62_D0.6880.12
44_T175_A0.6850.12
110_N148_H0.6810.12
6_H10_R0.6810.12
59_H126_L0.6790.12
67_L97_E0.6780.12
102_L106_A0.6690.11
83_A109_V0.6670.11
35_F91_N0.6640.11
103_L161_L0.6640.11
25_I126_L0.6630.11
59_H76_E0.6620.11
53_M93_L0.6620.11
138_A146_A0.6610.11
32_L125_P0.6610.11
9_S12_D0.6590.11
22_S169_G0.6580.11
21_L182_L0.6570.11
133_I181_I0.6540.11
98_V106_A0.6530.11
108_P174_M0.6510.11
110_N161_L0.6500.11
64_K147_H0.6500.11
12_D107_N0.6460.11
143_L148_H0.6450.11
100_I114_G0.6450.11
88_G175_A0.6420.11
125_P166_M0.6380.11
24_A164_T0.6360.11
72_E109_V0.6320.11
35_F78_R0.6310.11
68_T111_R0.6300.11
35_F93_L0.6300.11
5_L114_G0.6300.11
69_H161_L0.6280.11
15_G21_L0.6280.11
48_A179_R0.6250.11
95_V175_A0.6250.11
119_L138_A0.6220.11
16_L172_M0.6190.11
47_V53_M0.6170.11
32_L124_T0.6140.11
55_F92_G0.6100.11
5_L168_A0.6070.11
116_L169_G0.6060.11
83_A106_A0.6000.10
145_D174_M0.5990.10
169_G172_M0.5990.10
73_Y146_A0.5970.10
44_T62_D0.5910.10
46_F156_A0.5910.10
74_K141_P0.5890.10
11_G116_L0.5840.10
11_G111_R0.5760.10
145_D152_Y0.5740.10
13_K161_L0.5740.10
52_L119_L0.5730.10
92_G179_R0.5730.10
100_I123_T0.5730.10
42_S69_H0.5670.10
133_I146_A0.5660.10
25_I110_N0.5620.10
123_T171_V0.5610.10
4_Y106_A0.5590.10
32_L106_A0.5570.10
125_P171_V0.5570.10
89_F134_T0.5560.10
45_P156_A0.5540.10
60_P126_L0.5540.10
59_H64_K0.5500.10
73_Y145_D0.5490.10
130_S182_L0.5490.10
152_Y166_M0.5480.10
5_L115_L0.5460.10
61_E122_F0.5430.10
96_V125_P0.5380.10
75_P99_I0.5300.10
42_S81_Q0.5230.09
85_N123_T0.5210.09
37_P82_T0.5200.09
48_A126_L0.5180.09
23_I169_G0.5170.09
89_F100_I0.5150.09
155_G160_V0.5140.09
67_L124_T0.5130.09
7_L14_I0.5120.09
85_N166_M0.5100.09
28_M147_H0.5090.09
24_A168_A0.5080.09
37_P146_A0.5070.09
54_S58_E0.5040.09
75_P148_H0.5040.09
19_I183_K0.5040.09
82_T147_H0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.599 31.6 0.968 Contact Map
1zauA 1 0.3147 6.4 0.977 Contact Map
3jslA 2 0.3046 6.3 0.977 Contact Map
2xn6B 1 0.1523 5.8 0.977 Contact Map
2rivB 1 0.1421 4.8 0.978 Contact Map
4glwA 2 0.3096 4.2 0.979 Contact Map
1as4B 1 0.1472 4.1 0.979 Contact Map
2mxeA 1 0.198 3.8 0.979 Contact Map
4y3uB 1 0.1472 3.7 0.979 Contact Map
4kytB 2 0.1421 3.5 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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