GREMLIN Database
YAGE - Probable 2-keto-3-deoxy-galactonate aldolase YagE
UniProt: P75682 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13344
Length: 302 (286)
Sequences: 10365 (6783)
Seq/√Len: 401.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_D237_K3.7891.00
19_T23_Q3.2511.00
34_D71_H3.2471.00
121_I155_T3.1261.00
268_L293_K2.9391.00
30_A71_H2.8681.00
26_K63_A2.7511.00
26_K67_F2.6591.00
30_A67_F2.6471.00
62_K96_H2.5741.00
82_T94_S2.5241.00
229_A237_K2.5161.00
98_Q132_T2.4961.00
203_T208_G2.3491.00
94_S105_I2.2621.00
237_K240_G2.1251.00
125_E160_R2.0681.00
229_A234_D2.0301.00
224_V228_K2.0161.00
34_D75_R1.9931.00
11_I43_G1.9911.00
228_K232_D1.9881.00
35_D39_A1.9871.00
117_E149_T1.9761.00
129_D160_R1.9751.00
154_K182_T1.9331.00
204_L230_W1.9321.00
293_K297_Q1.9171.00
25_D28_G1.8931.00
117_E152_L1.8881.00
63_A66_R1.8781.00
42_D228_K1.8641.00
87_A123_Y1.8631.00
118_A122_R1.8511.00
264_E289_K1.8491.00
118_A155_T1.8471.00
125_E129_D1.8471.00
58_A89_E1.8411.00
34_D38_K1.8311.00
147_D175_H1.7941.00
39_A221_Q1.7891.00
121_I125_E1.7841.00
222_V244_T1.7781.00
30_A70_D1.7781.00
33_I68_A1.7751.00
63_A67_F1.7141.00
66_R70_D1.7061.00
29_T68_A1.6871.00
12_P216_G1.6641.00
136_M165_G1.6641.00
69_I78_V1.6571.00
128_A160_R1.6181.00
153_V166_I1.6051.00
107_V127_V1.6011.00
28_G31_A1.5981.00
122_R125_E1.5921.00
67_F71_H1.5781.00
46_F68_A1.5621.00
149_T152_L1.5581.00
290_A293_K1.5561.00
94_S131_V1.5141.00
240_G244_T1.5131.00
60_E278_L1.5101.00
65_A80_I1.4971.00
37_I76_V1.4561.00
29_T64_I1.4481.00
90_T127_V1.4181.00
17_I29_T1.3991.00
225_N229_A1.3821.00
98_Q131_V1.3791.00
98_Q133_L1.3771.00
122_R126_Q1.3751.00
286_E290_A1.3601.00
96_H99_Q1.3471.00
286_E289_K1.3431.00
67_F70_D1.3301.00
11_I45_F1.3281.00
225_N237_K1.3211.00
42_D224_V1.3161.00
254_L291_Q1.3151.00
290_A294_T1.3111.00
267_V274_S1.3061.00
15_S266_I1.3061.00
91_I126_Q1.3011.00
264_E268_L1.2991.00
178_S182_T1.2981.00
267_V272_P1.2911.00
86_N89_E1.2811.00
58_A92_E1.2761.00
221_Q225_N1.2741.00
285_D288_R1.2711.00
35_D271_R1.2661.00
8_T231_R1.2641.00
84_G90_T1.2621.00
294_T298_Q1.2611.00
62_K92_E1.2581.00
180_I192_V1.2471.00
79_L104_G1.2401.00
136_M212_I1.2391.00
58_A96_H1.2361.00
230_W235_V1.2301.00
62_K66_R1.2241.00
10_I41_V1.2041.00
126_Q130_S1.2001.00
59_E63_A1.2001.00
126_Q279_P1.1881.00
37_I75_R1.1851.00
105_I131_V1.1841.00
33_I72_V1.1721.00
201_F238_A1.1611.00
72_V78_V1.1501.00
191_T209_D1.1441.00
235_V239_A1.1441.00
20_A276_H1.1441.00
52_E263_K1.1421.00
227_L231_R1.1401.00
128_A162_N1.1401.00
65_A97_A1.1391.00
264_E267_V1.1211.00
66_R96_H1.1171.00
23_Q88_R1.1111.00
47_L64_I1.1041.00
95_Q99_Q1.1031.00
66_R100_A1.0991.00
95_Q130_S1.0961.00
151_A182_T1.0931.00
69_I103_D1.0911.00
225_N228_K1.0851.00
62_K99_Q1.0831.00
236_A239_A1.0831.00
265_A296_L1.0821.00
26_K30_A1.0801.00
18_F56_L1.0791.00
294_T297_Q1.0721.00
27_P30_A1.0651.00
155_T158_D1.0641.00
28_G273_V1.0571.00
205_L235_V1.0511.00
105_I133_L1.0441.00
96_H100_A1.0421.00
178_S250_Q1.0401.00
19_T25_D1.0331.00
80_I102_A1.0301.00
79_L136_M1.0271.00
91_I95_Q1.0261.00
264_E293_K1.0201.00
118_A121_I1.0101.00
118_A285_D1.0091.00
156_L163_I1.0081.00
33_I71_H1.0071.00
126_Q129_D0.9991.00
10_I224_V0.9961.00
176_L203_T0.9941.00
288_R291_Q0.9911.00
82_T97_A0.9911.00
289_K293_K0.9831.00
8_T209_D0.9811.00
284_L292_L0.9801.00
284_L288_R0.9801.00
291_Q294_T0.9771.00
105_I135_V0.9741.00
237_K241_Y0.9711.00
12_P41_V0.9701.00
58_A93_L0.9701.00
12_P36_L0.9601.00
92_E96_H0.9571.00
157_A190_F0.9571.00
30_A34_D0.9551.00
251_M295_L0.9531.00
91_I130_S0.9481.00
128_A135_V0.9461.00
239_A243_Q0.9421.00
154_K183_V0.9401.00
215_S249_P0.9371.00
14_V36_L0.9351.00
268_L297_Q0.9321.00
229_A241_Y0.9301.00
84_G89_E0.9301.00
121_I152_L0.9281.00
205_L239_A0.9251.00
59_E92_E0.9221.00
32_L266_I0.9201.00
37_I72_V0.9181.00
69_I102_A0.9181.00
137_L153_V0.9171.00
117_E155_T0.9151.00
267_V289_K0.9101.00
122_R282_S0.9071.00
82_T105_I0.9041.00
120_L146_Q0.9031.00
109_N146_Q0.8991.00
247_Q298_Q0.8981.00
22_G88_R0.8981.00
83_G108_I0.8971.00
154_K158_D0.8951.00
45_F106_V0.8941.00
69_I100_A0.8891.00
204_L227_L0.8871.00
78_V102_A0.8851.00
287_P290_A0.8821.00
42_D227_L0.8821.00
28_G272_P0.8811.00
61_R93_L0.8811.00
150_P182_T0.8711.00
139_N147_D0.8701.00
18_F278_L0.8671.00
92_E95_Q0.8631.00
33_I67_F0.8601.00
128_A163_I0.8581.00
205_L230_W0.8571.00
295_L298_Q0.8521.00
233_G236_A0.8461.00
236_A240_G0.8451.00
160_R163_I0.8391.00
25_D272_P0.8341.00
200_L211_A0.8341.00
226_L241_Y0.8341.00
87_A91_I0.8311.00
10_I227_L0.8301.00
95_Q98_Q0.8291.00
193_L210_G0.8281.00
194_C203_T0.8261.00
41_V220_P0.8231.00
107_V135_V0.8231.00
14_V44_L0.8231.00
213_S216_G0.8221.00
46_F64_I0.8221.00
287_P291_Q0.8181.00
219_A248_I0.8151.00
242_H246_L0.8151.00
22_G279_P0.8121.00
31_A271_R0.8061.00
27_P31_A0.7991.00
10_I211_A0.7971.00
59_E62_K0.7971.00
97_A102_A0.7861.00
65_A102_A0.7851.00
121_I160_R0.7831.00
56_L64_I0.7821.00
246_L250_Q0.7781.00
268_L289_K0.7781.00
150_P154_K0.7751.00
47_L80_I0.7751.00
65_A100_A0.7701.00
39_A220_P0.7631.00
183_V187_H0.7631.00
225_N241_Y0.7601.00
14_V29_T0.7511.00
88_R92_E0.7511.00
10_I216_G0.7501.00
219_A222_V0.7491.00
72_V75_R0.7411.00
122_R279_P0.7391.00
19_T22_G0.7361.00
90_T107_V0.7361.00
174_A198_D0.7351.00
183_V209_D0.7351.00
109_N148_L0.7351.00
150_P178_S0.7351.00
153_V179_M0.7331.00
202_N205_L0.7321.00
178_S181_H0.7301.00
277_V281_A0.7261.00
254_L288_R0.7251.00
150_P175_H0.7231.00
117_E151_A0.7231.00
44_L72_V0.7201.00
232_D237_K0.7191.00
29_T33_I0.7171.00
24_L29_T0.7161.00
138_Y167_K0.7161.00
267_V273_V0.7121.00
276_H283_P0.7121.00
43_G79_L0.7101.00
77_P103_D0.7071.00
101_G133_L0.7061.00
201_F230_W0.7031.00
49_S112_Y0.7031.00
202_N206_L0.6991.00
177_R181_H0.6981.00
20_A273_V0.6971.00
222_V225_N0.6971.00
219_A245_L0.6961.00
158_D189_H0.6941.00
33_I44_L0.6921.00
176_L180_I0.6891.00
62_K93_L0.6861.00
140_F144_T0.6841.00
274_S277_V0.6790.99
37_I71_H0.6790.99
132_T162_N0.6750.99
147_D172_S0.6740.99
82_T107_V0.6740.99
226_L230_W0.6740.99
87_A126_Q0.6730.99
24_L64_I0.6730.99
176_L192_V0.6720.99
137_L148_L0.6690.99
62_K100_A0.6690.99
58_A62_K0.6660.99
47_L56_L0.6650.99
201_F235_V0.6630.99
19_T27_P0.6570.99
291_Q295_L0.6550.99
181_H243_Q0.6550.99
34_D37_I0.6530.99
290_A297_Q0.6500.99
72_V76_V0.6490.99
125_E155_T0.6470.99
139_N168_D0.6440.99
119_N282_S0.6430.99
266_I269_C0.6410.99
273_V276_H0.6400.99
36_L41_V0.6390.99
256_T260_N0.6390.99
19_T276_H0.6380.99
177_R206_L0.6370.99
62_K97_A0.6370.99
148_L153_V0.6350.99
7_F104_G0.6340.99
32_L36_L0.6340.99
221_Q269_C0.6310.99
11_I79_L0.6300.99
65_A69_I0.6260.99
66_R99_Q0.6250.99
53_F81_G0.6220.99
200_L226_L0.6220.99
266_I271_R0.6200.99
89_E92_E0.6200.99
57_G88_R0.6180.99
229_A232_D0.6180.99
36_L39_A0.6150.99
151_A154_K0.6140.99
35_D269_C0.6130.99
187_H190_F0.6120.99
14_V68_A0.6120.99
151_A178_S0.6120.99
152_L155_T0.6040.99
284_L289_K0.6030.99
18_F60_E0.6020.99
175_H179_M0.6010.99
54_S113_W0.6010.99
177_R202_N0.5970.99
202_N242_H0.5970.99
277_V282_S0.5950.99
26_K71_H0.5950.99
268_L296_L0.5940.99
24_L67_F0.5920.99
136_M164_I0.5920.99
164_I191_T0.5890.99
116_S119_N0.5860.98
20_A274_S0.5860.98
201_F242_H0.5840.98
22_G276_H0.5830.98
218_F265_A0.5820.98
8_T42_D0.5820.98
74_R103_D0.5810.98
40_G224_V0.5800.98
148_L152_L0.5780.98
228_K231_R0.5770.98
179_M192_V0.5770.98
177_R242_H0.5760.98
240_G243_Q0.5760.98
201_F205_L0.5720.98
264_E277_V0.5710.98
47_L61_R0.5710.98
102_A133_L0.5700.98
248_I252_Y0.5700.98
45_F79_L0.5660.98
173_V199_H0.5660.98
157_A183_V0.5640.98
118_A282_S0.5640.98
183_V189_H0.5630.98
168_D176_L0.5620.98
158_D187_H0.5580.98
109_N124_F0.5580.98
165_G191_T0.5560.98
123_Y126_Q0.5520.98
274_S289_K0.5520.98
241_Y244_T0.5490.98
218_F262_I0.5490.98
172_S175_H0.5490.98
200_L223_S0.5480.98
180_I209_D0.5480.98
183_V188_P0.5460.98
136_M191_T0.5460.98
46_F78_V0.5440.98
15_S262_I0.5440.98
251_M291_Q0.5430.97
80_I97_A0.5420.97
180_I183_V0.5410.97
59_E96_H0.5400.97
107_V124_F0.5380.97
181_H247_Q0.5320.97
260_N277_V0.5310.97
91_I127_V0.5310.97
79_L106_V0.5280.97
218_F266_I0.5250.97
286_E293_K0.5250.97
41_V224_V0.5240.97
215_S219_A0.5220.97
265_A292_L0.5220.97
47_L65_A0.5210.97
93_L97_A0.5200.97
261_V284_L0.5200.97
70_D73_D0.5190.97
230_W238_A0.5190.97
9_G231_R0.5190.97
98_Q130_S0.5180.97
68_A72_V0.5170.97
204_L231_R0.5170.97
150_P179_M0.5160.97
179_M183_V0.5150.97
44_L76_V0.5140.97
165_G190_F0.5140.97
49_S138_Y0.5140.97
32_L271_R0.5140.97
55_Q87_A0.5120.96
129_D162_N0.5120.96
114_K142_A0.5110.96
252_Y262_I0.5110.96
13_P214_A0.5090.96
14_V33_I0.5090.96
265_A268_L0.5090.96
215_S223_S0.5080.96
32_L35_D0.5070.96
214_A262_I0.5060.96
88_R126_Q0.5040.96
156_L160_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oe7A 3 0.9868 100 0.038 Contact Map
3qzeA 2 0.9603 100 0.046 Contact Map
3si9A 3 0.9702 100 0.046 Contact Map
4i7wA 3 0.9603 100 0.047 Contact Map
3na8A 3 0.9603 100 0.048 Contact Map
3eb2A 3 0.9636 100 0.049 Contact Map
2ojpA 2 0.9603 100 0.05 Contact Map
1o5kA 3 0.9735 100 0.052 Contact Map
3cprA 3 0.9702 100 0.053 Contact Map
3fluA 3 0.9735 100 0.053 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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