GREMLIN Database
INSO1 - Putative transposase InsO for insertion sequence element IS911A
UniProt: P75680 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40121
Length: 141 (136)
Sequences: 4373 (3077)
Seq/√Len: 263.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_R75_L3.5351.00
29_R67_L2.8151.00
35_Q59_R2.7191.00
111_N114_W2.6891.00
109_E112_Q2.6791.00
36_V52_I2.5661.00
101_L113_V2.5231.00
11_H14_S2.4401.00
107_V113_V2.4271.00
120_Y127_G2.4011.00
33_R74_E2.3531.00
39_L55_M2.3331.00
53_A57_T2.3261.00
64_G67_L2.2841.00
39_L52_I2.2351.00
49_A65_R2.1361.00
35_Q38_E2.1141.00
115_C136_R2.0801.00
49_A69_G2.0741.00
33_R71_L1.9611.00
32_L63_M1.9411.00
35_Q61_Y1.9381.00
122_V127_G1.9261.00
123_P126_Q1.9251.00
47_A51_S1.8621.00
121_S130_G1.8321.00
55_M58_Q1.7431.00
108_T112_Q1.7041.00
40_H77_L1.6591.00
17_Y21_R1.5831.00
63_M68_A1.5561.00
29_R70_R1.5431.00
116_G131_C1.5101.00
71_L75_L1.4871.00
55_M59_R1.4741.00
67_L70_R1.4461.00
104_Q113_V1.4311.00
37_L41_G1.4241.00
41_G45_G1.4161.00
37_L75_L1.4051.00
23_E30_A1.3791.00
57_T62_Q1.3711.00
50_R69_G1.3061.00
53_A68_A1.2821.00
113_V136_R1.2641.00
40_H45_G1.2611.00
31_V61_Y1.2601.00
107_V112_Q1.2361.00
47_A55_M1.2111.00
114_W133_N1.2091.00
101_L136_R1.2061.00
65_R69_G1.2011.00
110_P137_V1.1831.00
43_S46_S1.1551.00
26_D29_R1.1351.00
91_G94_H1.0991.00
89_R92_H1.0981.00
38_E42_I1.0631.00
36_V71_L1.0601.00
123_P128_G1.0581.00
35_Q39_L1.0491.00
53_A65_R1.0351.00
14_S18_W1.0281.00
31_V35_Q1.0251.00
4_L7_V1.0141.00
134_E139_L1.0141.00
66_W69_G1.0021.00
39_L42_I0.9811.00
37_L77_L0.9751.00
25_P28_R0.9661.00
69_G73_K0.9651.00
67_L71_L0.9611.00
40_H52_I0.9551.00
71_L74_E0.9351.00
10_V14_S0.9271.00
51_S55_M0.9051.00
131_C138_C0.8991.00
40_H79_S0.8971.00
39_L43_S0.8891.00
33_R37_L0.8761.00
52_I72_M0.8701.00
42_I59_R0.8691.00
53_A64_G0.8641.00
13_S16_K0.8581.00
43_S47_A0.8471.00
118_V130_G0.8471.00
78_V81_Q0.8320.99
43_S55_M0.8290.99
15_Y19_K0.8270.99
40_H78_V0.8260.99
109_E137_V0.8230.99
88_K92_H0.8190.99
18_W21_R0.8140.99
121_S127_G0.8050.99
85_H88_K0.8010.99
54_T57_T0.7890.99
92_H96_A0.7830.99
36_V75_L0.7780.99
4_L8_F0.7660.99
46_S51_S0.7550.99
101_L115_C0.7530.99
34_S38_E0.7320.99
49_A72_M0.7300.99
30_A34_S0.7260.98
39_L59_R0.7200.98
29_R71_L0.7170.98
29_R74_E0.7160.98
14_S17_Y0.7150.98
56_A61_Y0.7150.98
36_V72_M0.7060.98
125_V128_G0.7020.98
111_N138_C0.7000.98
108_T137_V0.7000.98
104_Q107_V0.6980.98
79_S136_R0.6960.98
13_S17_Y0.6960.98
99_N102_E0.6950.98
38_E59_R0.6940.98
6_H9_G0.6930.98
85_H89_R0.6890.98
22_P25_P0.6870.98
94_H97_I0.6850.98
50_R65_R0.6830.98
10_V18_W0.6810.98
4_L10_V0.6800.98
99_N103_R0.6780.98
132_L137_V0.6740.98
70_R74_E0.6730.97
111_N140_E0.6710.97
32_L61_Y0.6680.97
45_G77_L0.6660.97
136_R139_L0.6650.97
56_A68_A0.6590.97
114_W140_E0.6570.97
107_V136_R0.6550.97
66_W70_R0.6410.97
21_R25_P0.6390.97
115_C132_L0.6350.96
90_G95_V0.6290.96
17_Y78_V0.6240.96
73_K78_V0.6210.96
90_G94_H0.6190.96
39_L47_A0.6180.96
90_G96_A0.6170.96
21_R24_K0.6170.96
87_Y90_G0.6120.96
92_H95_V0.6100.96
12_R16_K0.6070.95
24_K28_R0.6070.95
80_C84_T0.6040.95
47_A52_I0.6040.95
116_G133_N0.6020.95
35_Q56_A0.5990.95
26_D33_R0.5960.95
115_C134_E0.5940.95
5_C10_V0.5910.95
34_S37_L0.5900.95
107_V110_P0.5850.94
43_S52_I0.5790.94
105_F113_V0.5730.94
118_V131_C0.5700.94
134_E140_E0.5670.93
18_W22_P0.5670.93
5_C12_R0.5670.93
39_L44_H0.5640.93
28_R31_V0.5610.93
5_C14_S0.5580.93
41_G62_Q0.5540.93
88_K91_G0.5530.93
36_V70_R0.5450.92
54_T58_Q0.5430.92
29_R63_M0.5430.92
39_L56_A0.5420.92
128_G137_V0.5400.92
106_A136_R0.5370.92
4_L99_N0.5360.91
8_F64_G0.5350.91
32_L56_A0.5340.91
36_V68_A0.5330.91
107_V137_V0.5290.91
52_I68_A0.5270.91
20_N23_E0.5270.91
111_N137_V0.5210.90
97_I100_H0.5210.90
76_G126_Q0.5190.90
106_A139_L0.5180.90
49_A68_A0.5180.90
21_R30_A0.5170.90
31_V34_S0.5150.90
120_Y129_H0.5150.90
56_A63_M0.5150.90
112_Q137_V0.5140.90
22_P26_D0.5130.90
123_P127_G0.5130.90
20_N24_K0.5090.89
56_A59_R0.5080.89
49_A53_A0.5080.89
98_P102_E0.5060.89
118_V129_H0.5050.89
101_L105_F0.5040.89
4_L9_G0.5040.89
26_D31_V0.5030.89
132_L138_C0.5020.89
72_M77_L0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7bA 2 0.9574 99.7 0.605 Contact Map
4fcyA 4 0.9007 99.6 0.648 Contact Map
3oymA 3 0.9149 98.6 0.77 Contact Map
1k78A 1 0.5248 98.4 0.785 Contact Map
1pdnC 1 0.5035 98.3 0.789 Contact Map
2k27A 1 0.695 98.2 0.8 Contact Map
2ahqA 1 0.461 97.8 0.815 Contact Map
4cf8A 2 0.1986 97.6 0.824 Contact Map
1u78A 1 0.5035 97.2 0.835 Contact Map
4fw2A 2 0.2624 96.2 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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