GREMLIN Database
INSN1 - Transposase InsN for insertion sequence element IS911A
UniProt: P75679 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40014
Length: 134 (104)
Sequences: 413 (334)
Seq/√Len: 32.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_K90_E5.6311.00
78_E83_R4.5431.00
86_L89_I3.4221.00
78_E81_E3.3041.00
62_R66_T2.7501.00
26_S44_M2.6531.00
61_E65_K2.4260.99
27_A55_V2.3490.99
53_R57_Q2.3130.99
79_I83_R2.2660.99
29_L33_Q1.8700.97
79_I86_L1.8420.96
87_Q90_E1.8010.96
26_S51_M1.7560.95
58_L62_R1.7500.95
92_E96_L1.6770.94
88_R91_M1.6420.93
18_F22_F1.6350.93
31_V55_V1.5900.92
86_L93_N1.5750.91
22_F26_S1.5640.91
62_R65_K1.4980.89
100_T103_S1.4730.88
30_V40_A1.4670.88
101_V104_I1.4420.87
91_M94_E1.4040.86
106_Q112_K1.3770.85
92_E97_K1.3610.84
77_I80_R1.2790.80
47_G50_T1.2640.79
87_Q94_E1.2580.79
89_I93_N1.2520.79
87_Q91_M1.2400.78
77_I81_E1.1950.75
68_K71_P1.1890.75
80_R83_R1.1670.73
76_Q80_R1.1550.73
44_M51_M1.0930.68
105_G111_V1.0910.68
18_F23_K1.0850.68
93_N96_L1.0800.67
27_A31_V1.0740.67
102_D105_G1.0590.66
98_K101_V1.0530.65
94_E99_A1.0280.64
108_N114_W1.0220.63
22_F44_M1.0080.62
85_K88_R0.9550.58
95_I111_V0.9450.57
95_I99_A0.9410.57
103_S106_Q0.9350.56
23_K36_T0.9310.56
30_V55_V0.9300.56
21_E86_L0.9210.55
49_S52_T0.8990.53
19_S59_R0.8950.53
27_A40_A0.8900.53
56_K65_K0.8840.52
21_E25_E0.8750.51
22_F36_T0.8620.50
109_S113_T0.8580.50
55_V59_R0.8510.49
28_Q98_K0.8460.49
100_T104_I0.8430.49
42_S45_D0.8380.48
37_V52_T0.8220.47
29_L44_M0.8170.46
79_I85_K0.8120.46
14_K45_D0.8100.46
80_R88_R0.8100.46
35_Y40_A0.8090.46
17_N46_V0.8080.46
30_V41_A0.8060.46
81_E84_K0.8060.46
28_Q32_D0.8040.45
111_V114_W0.7960.45
105_G109_S0.7910.44
25_E34_N0.7900.44
37_V55_V0.7880.44
38_A42_S0.7850.44
34_N98_K0.7780.43
109_S112_K0.7590.42
76_Q79_I0.7460.41
27_A32_D0.7460.41
34_N51_M0.7410.40
54_W82_L0.7250.39
18_F36_T0.7200.39
107_R112_K0.7160.38
31_V52_T0.7120.38
106_Q109_S0.6990.37
88_R94_E0.6950.37
16_R48_L0.6950.37
47_G52_T0.6950.37
21_E51_M0.6840.36
101_V112_K0.6800.36
32_D40_A0.6750.35
40_A44_M0.6740.35
42_S113_T0.6680.35
37_V51_M0.6650.34
24_R27_A0.6640.34
79_I84_K0.6600.34
46_V102_D0.6550.34
35_Y88_R0.6490.33
82_L86_L0.6380.32
39_D72_I0.6330.32
27_A92_E0.6330.32
64_G67_P0.6310.32
12_I36_T0.6300.32
23_K70_S0.6270.32
84_K91_M0.6240.31
29_L43_A0.6240.31
91_M102_D0.6100.30
26_S40_A0.6100.30
76_Q86_L0.6080.30
80_R89_I0.6070.30
15_K50_T0.6040.30
11_V44_M0.6030.30
87_Q101_V0.6000.30
73_T76_Q0.5980.30
47_G57_Q0.5880.29
34_N101_V0.5710.28
37_V53_R0.5700.28
46_V60_D0.5690.28
77_I86_L0.5690.28
27_A58_L0.5660.27
106_Q110_Y0.5610.27
18_F50_T0.5600.27
58_L97_K0.5540.27
57_Q70_S0.5520.26
67_P75_E0.5510.26
15_K48_L0.5490.26
104_I107_R0.5470.26
36_T89_I0.5470.26
75_E79_I0.5450.26
27_A65_K0.5420.26
19_S50_T0.5400.26
25_E88_R0.5400.26
101_V105_G0.5380.26
109_S114_W0.5360.25
70_S73_T0.5350.25
39_D81_E0.5330.25
68_K73_T0.5300.25
48_L52_T0.5250.25
69_A74_P0.5240.25
12_I46_V0.5220.25
16_R27_A0.5200.24
68_K72_I0.5200.24
79_I90_E0.5150.24
27_A30_V0.5130.24
40_A94_E0.5110.24
102_D113_T0.5110.24
31_V85_K0.5110.24
52_T56_K0.5100.24
28_Q45_D0.5090.24
79_I82_L0.5080.24
110_Y114_W0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rn7A 1 0.7537 99.8 0.484 Contact Map
2jn6A 1 0.7164 99.7 0.547 Contact Map
1hlvA 1 0.8209 98.8 0.715 Contact Map
2oa4A 1 0.6269 98.8 0.721 Contact Map
2gloA 1 0.4179 98.6 0.731 Contact Map
2elhA 1 0.597 98.6 0.733 Contact Map
2jrtA 1 0.5896 98.3 0.756 Contact Map
2k27A 1 0.9478 98.2 0.764 Contact Map
1k78A 1 0.903 98.2 0.765 Contact Map
1u78A 1 0.7687 98.2 0.767 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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