GREMLIN Database
YAFX - Uncharacterized protein YafX
UniProt: P75676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13336
Length: 152 (133)
Sequences: 306 (178)
Seq/√Len: 15.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_F104_E6.9401.00
101_M109_A6.9341.00
116_S120_C3.9211.00
54_M106_A3.2850.99
71_L75_G3.0370.98
54_M110_V2.3990.93
111_C115_Y2.3360.92
69_Y79_S2.0370.85
57_F110_V2.0300.85
33_W51_F1.9210.81
132_Y135_R1.8700.79
105_A143_E1.8620.79
90_L106_A1.8440.78
97_N146_A1.8420.78
80_P107_G1.7410.74
68_F75_G1.7300.74
19_L73_N1.7220.73
106_A110_V1.7140.73
79_S88_W1.6660.71
131_Y135_R1.6650.71
107_G111_C1.6330.69
47_E51_F1.6300.69
91_F98_D1.5730.66
19_L72_S1.5170.63
37_F46_L1.5090.63
54_M90_L1.4980.62
105_A141_H1.4540.60
112_L135_R1.4450.59
112_L151_I1.4420.59
55_D68_F1.4020.57
21_V106_A1.3980.57
109_A150_I1.3720.55
94_L97_N1.3460.54
61_Y112_L1.2950.51
135_R139_M1.2750.50
69_Y110_V1.2680.49
59_E68_F1.2660.49
88_W101_M1.2520.48
46_L111_C1.2490.48
79_S131_Y1.2330.47
113_I150_I1.2000.46
74_G90_L1.1890.45
127_M130_H1.1660.44
95_N138_A1.1530.43
138_A148_L1.1350.42
82_P88_W1.1260.41
77_F137_Y1.1150.41
36_Y76_A1.1070.40
116_S128_T1.1050.40
75_G133_R1.0980.40
99_A150_I1.0650.38
92_N113_I1.0640.38
144_A148_L1.0540.37
126_A130_H1.0530.37
113_I151_I1.0370.37
68_F109_A1.0350.36
101_M108_I1.0340.36
115_Y128_T1.0270.36
28_Q70_T1.0170.35
51_F121_R1.0070.35
53_W56_R1.0060.35
21_V69_Y1.0030.35
26_D131_Y0.9950.34
26_D53_W0.9870.34
124_C149_R0.9840.34
86_E89_R0.9790.34
116_S119_A0.9760.33
25_P28_Q0.9720.33
64_G81_E0.9670.33
97_N150_I0.9640.33
90_L110_V0.9620.33
111_C150_I0.9590.33
34_P51_F0.9510.32
79_S104_E0.9360.31
34_P47_E0.9220.31
60_G98_D0.9210.31
88_W103_A0.9160.30
88_W117_H0.9150.30
53_W120_C0.9080.30
49_H118_H0.9060.30
104_E116_S0.8920.29
92_N117_H0.8920.29
95_N152_D0.8780.29
75_G141_H0.8740.28
68_F103_A0.8710.28
64_G95_N0.8610.28
52_A114_A0.8600.28
92_N95_N0.8590.28
68_F93_C0.8550.28
118_H150_I0.8530.27
87_T100_Q0.8450.27
98_D138_A0.8440.27
33_W78_M0.8420.27
33_W115_Y0.8380.27
36_Y122_T0.7990.25
130_H133_R0.7970.25
82_P87_T0.7950.25
136_E151_I0.7860.25
42_Q118_H0.7780.24
21_V53_W0.7750.24
67_S149_R0.7680.24
56_R103_A0.7640.24
57_F113_I0.7610.23
50_I114_A0.7600.23
89_R145_H0.7590.23
104_E141_H0.7580.23
19_L71_L0.7460.23
56_R124_C0.7400.23
29_R38_G0.7360.22
63_G66_W0.7300.22
31_D67_S0.7270.22
36_Y119_A0.7270.22
25_P144_A0.7240.22
93_C114_A0.7180.22
95_N136_E0.7110.21
54_M78_M0.7100.21
72_S92_N0.7050.21
24_V38_G0.6990.21
57_F109_A0.6970.21
46_L49_H0.6970.21
27_E148_L0.6960.21
98_D142_P0.6950.21
54_M82_P0.6920.21
54_M151_I0.6910.21
24_V39_A0.6910.21
102_S109_A0.6900.21
87_T103_A0.6890.21
85_D114_A0.6870.21
61_Y147_I0.6840.20
16_E129_A0.6750.20
112_L136_E0.6750.20
106_A126_A0.6670.20
92_N120_C0.6630.20
91_F132_Y0.6630.20
116_S124_C0.6590.20
103_A107_G0.6560.19
86_E91_F0.6530.19
73_N76_A0.6500.19
26_D31_D0.6400.19
80_P111_C0.6330.19
105_A151_I0.6300.19
36_Y130_H0.6270.18
115_Y137_Y0.6240.18
56_R65_I0.6230.18
65_I86_E0.6160.18
59_E86_E0.6160.18
33_W111_C0.6110.18
71_L92_N0.6100.18
29_R64_G0.6090.18
23_P67_S0.6080.18
111_C139_M0.6040.18
38_G51_F0.6020.18
45_L121_R0.6010.18
28_Q85_D0.5950.17
57_F92_N0.5860.17
22_T131_Y0.5820.17
23_P136_E0.5820.17
113_I132_Y0.5790.17
71_L74_G0.5790.17
48_P55_D0.5750.17
56_R74_G0.5740.17
76_A116_S0.5730.17
24_V31_D0.5690.17
76_A110_V0.5690.17
102_S143_E0.5670.16
49_H65_I0.5660.16
94_L113_I0.5640.16
36_Y73_N0.5580.16
81_E85_D0.5570.16
118_H141_H0.5550.16
52_A137_Y0.5550.16
46_L118_H0.5510.16
97_N132_Y0.5500.16
54_M111_C0.5500.16
20_T72_S0.5500.16
32_F60_G0.5490.16
73_N151_I0.5480.16
81_E87_T0.5480.16
39_A93_C0.5470.16
60_G125_D0.5440.16
51_F76_A0.5440.16
110_V149_R0.5380.16
19_L50_I0.5380.16
90_L135_R0.5350.15
94_L110_V0.5310.15
79_S103_A0.5300.15
35_Q43_W0.5280.15
20_T23_P0.5270.15
38_G47_E0.5230.15
33_W47_E0.5220.15
32_F68_F0.5220.15
119_A122_T0.5190.15
67_S81_E0.5190.15
77_F124_C0.5160.15
43_W76_A0.5150.15
21_V89_R0.5150.15
78_M94_L0.5100.15
32_F111_C0.5070.15
26_D140_Q0.5040.15
119_A130_H0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wj9A 2 0.9342 100 0.117 Contact Map
2kmgA 1 0.9079 100 0.141 Contact Map
1vw1A 5 0.9276 17.5 0.952 Contact Map
4gr2A 2 0.3487 8.6 0.958 Contact Map
5bs1A 2 0.3947 8.4 0.958 Contact Map
5rubA 2 0.6645 8.1 0.958 Contact Map
1rwhA 1 0.4737 7.7 0.959 Contact Map
3cxbA 1 0.2961 6.8 0.96 Contact Map
3r8wA 2 0.9803 6.7 0.96 Contact Map
2qzbA 1 0.3224 5.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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