GREMLIN Database
YAFS - Uncharacterized protein YafS
UniProt: P75672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13331
Length: 240 (212)
Sequences: 1163 (887)
Seq/√Len: 60.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_F91_V4.1821.00
94_C113_A4.0261.00
96_L113_A3.3961.00
45_L93_V3.3401.00
112_E115_R3.2781.00
46_L94_C3.2481.00
84_L116_V3.0571.00
113_A123_L2.8751.00
48_I84_L2.7531.00
161_D165_L2.6941.00
175_R197_G2.6301.00
68_V79_A2.5951.00
114_D168_F2.5331.00
33_L126_S2.4911.00
127_G200_Q2.4311.00
163_L204_A2.4051.00
122_W203_V2.3241.00
169_E207_R2.2681.00
44_H64_H2.1931.00
122_W205_R2.1831.00
101_P151_S2.1051.00
117_L121_G2.0901.00
178_V189_L1.9951.00
186_G189_L1.9921.00
68_V86_F1.9831.00
107_H165_L1.9371.00
46_L91_V1.9261.00
181_W185_G1.9241.00
82_L108_R1.8371.00
215_P219_S1.8031.00
77_V86_F1.7840.99
158_R161_D1.7620.99
87_A90_S1.7520.99
134_M198_C1.7490.99
162_W166_L1.6810.99
107_H162_W1.6680.99
32_Q35_P1.6490.99
111_R165_L1.6470.99
16_W132_S1.5970.99
137_R141_P1.5620.99
161_D166_L1.5230.98
120_D207_R1.5130.98
89_K119_D1.5100.98
126_S201_L1.4710.98
130_P158_R1.4700.98
171_L205_R1.4670.98
163_L202_I1.4670.98
81_P109_L1.4540.98
19_L22_G1.4440.98
111_R166_L1.4230.97
132_S135_G1.3890.97
149_Y153_M1.3800.97
217_K221_N1.3560.97
173_A202_I1.3520.97
120_D205_R1.3300.96
211_L214_N1.3130.96
39_K43_F1.2990.96
158_R165_L1.2910.95
112_E132_S1.2900.95
117_L206_K1.2800.95
148_P151_S1.2760.95
189_L193_I1.2690.95
180_P189_L1.2620.95
102_W151_S1.2540.95
220_K223_P1.2400.94
178_V186_G1.2400.94
162_W165_L1.2310.94
47_K53_A1.2260.94
156_L173_A1.2250.94
112_E116_V1.2100.94
182_N185_G1.2090.94
111_R162_W1.2010.93
91_V94_C1.1990.93
46_L116_V1.1960.93
163_L168_F1.1870.93
106_P162_W1.1810.93
96_L123_L1.1710.92
95_L126_S1.1590.92
47_K51_L1.1580.92
32_Q174_S1.1570.92
124_V201_L1.1530.92
209_I213_L1.1490.92
46_L86_F1.1350.91
107_H161_D1.1310.91
118_I197_G1.1240.91
29_L98_H1.1060.90
48_I81_P1.1030.90
122_W171_L1.1020.90
96_L99_T1.0970.90
66_V91_V1.0950.90
21_W134_M1.0900.89
46_L68_V1.0890.89
67_N70_A1.0860.89
25_Y199_L1.0840.89
209_I212_T1.0790.89
107_H111_R1.0740.89
111_R161_D1.0650.88
32_Q201_L1.0540.88
47_K97_A1.0500.88
156_L202_I1.0440.87
106_P110_L1.0410.87
101_P127_G1.0400.87
16_W128_F1.0330.87
158_R162_W1.0260.86
91_V116_V1.0240.86
107_H110_L1.0020.85
32_Q176_F1.0020.85
96_L100_L0.9960.85
108_R166_L0.9820.84
101_P129_N0.9580.82
35_P38_T0.9490.82
58_E69_S0.9410.81
214_N218_Q0.9410.81
107_H166_L0.9350.81
171_L203_V0.9340.81
54_E57_C0.9320.81
13_P51_L0.9200.80
79_A85_P0.9190.80
167_N211_L0.9180.80
41_Y44_H0.9140.79
219_S223_P0.9120.79
107_H158_R0.9120.79
89_K213_L0.9110.79
215_P218_Q0.9050.79
88_D115_R0.9030.78
33_L94_C0.9030.78
125_I171_L0.8950.78
45_L62_V0.8940.78
49_G154_F0.8940.78
127_G130_P0.8930.78
183_K222_K0.8920.78
141_P155_T0.8840.77
39_K61_A0.8780.76
212_T217_K0.8740.76
49_G101_P0.8650.75
41_Y165_L0.8650.75
49_G97_A0.8620.75
24_L86_F0.8620.75
13_P17_G0.8590.75
77_V119_D0.8570.75
18_D123_L0.8560.75
68_V77_V0.8510.74
44_H63_S0.8470.74
117_L123_L0.8380.73
94_C116_V0.8370.73
41_Y111_R0.8360.73
46_L84_L0.8280.72
48_I168_F0.8250.72
114_D167_N0.8220.72
55_I155_T0.8200.71
130_P162_W0.8140.71
98_H128_F0.8130.71
43_F118_I0.8130.71
47_K50_N0.8040.70
106_P154_F0.7990.69
30_E34_N0.7940.69
151_S203_V0.7890.68
141_P177_H0.7890.68
111_R158_R0.7800.68
21_W33_L0.7790.67
92_D118_I0.7750.67
36_W105_D0.7720.67
167_N202_I0.7680.66
28_A32_Q0.7680.66
218_Q221_N0.7680.66
138_K153_M0.7670.66
13_P19_L0.7650.66
178_V192_H0.7650.66
169_E205_R0.7640.66
215_P220_K0.7640.66
214_N219_S0.7630.66
138_K149_Y0.7620.66
20_P217_K0.7600.66
37_F203_V0.7570.65
50_N53_A0.7510.65
130_P200_Q0.7490.64
98_H101_P0.7460.64
54_E97_A0.7370.63
180_P186_G0.7340.63
33_L95_L0.7340.63
25_Y29_L0.7320.63
31_R34_N0.7250.62
48_I113_A0.7250.62
17_G176_F0.7240.62
20_P123_L0.7220.62
41_Y62_V0.7210.61
43_F61_A0.7210.61
188_L221_N0.7200.61
120_D169_E0.7180.61
170_V202_I0.7140.61
89_K206_K0.7110.60
210_P214_N0.7090.60
36_W201_L0.7040.60
173_A192_H0.7010.59
42_G204_A0.7000.59
218_Q222_K0.6990.59
33_L124_V0.6880.58
125_I189_L0.6780.57
93_V98_H0.6770.57
36_W126_S0.6730.56
161_D169_E0.6720.56
217_K222_K0.6690.56
167_N207_R0.6680.56
37_F93_V0.6650.55
98_H133_F0.6630.55
121_G206_K0.6500.54
128_F154_F0.6500.54
188_L193_I0.6480.53
97_A126_S0.6470.53
176_F201_L0.6460.53
28_A176_F0.6460.53
168_F202_I0.6440.53
104_T172_H0.6430.53
89_K150_N0.6420.53
132_S149_Y0.6410.53
71_Q78_Q0.6410.53
14_D155_T0.6410.53
26_R31_R0.6370.52
82_L95_L0.6360.52
17_G210_P0.6350.52
129_N196_L0.6340.52
105_D108_R0.6320.52
212_T215_P0.6310.51
102_W128_F0.6300.51
17_G89_K0.6300.51
68_V84_L0.6270.51
185_G222_K0.6220.50
52_S68_V0.6190.50
139_L197_G0.6180.50
216_M219_S0.6170.50
216_M222_K0.6080.49
34_N61_A0.6080.49
101_P134_M0.6050.48
51_L120_D0.6040.48
66_V152_R0.6020.48
37_F40_M0.6000.48
94_C117_L0.5980.48
159_Q197_G0.5980.48
219_S222_K0.5970.48
98_H132_S0.5960.47
32_Q38_T0.5940.47
191_A195_A0.5940.47
98_H168_F0.5930.47
48_I78_Q0.5930.47
126_S151_S0.5900.47
40_M203_V0.5890.47
37_F45_L0.5850.46
37_F95_L0.5840.46
16_W102_W0.5840.46
57_C60_C0.5830.46
218_Q223_P0.5820.46
120_D210_P0.5810.46
87_A222_K0.5800.46
105_D210_P0.5790.46
11_V15_C0.5790.46
217_K220_K0.5780.45
175_R191_A0.5780.45
172_H201_L0.5750.45
34_N41_Y0.5730.45
136_L140_V0.5720.45
178_V190_N0.5710.45
79_A212_T0.5710.45
82_L103_C0.5690.44
10_V63_S0.5660.44
123_L204_A0.5650.44
110_L113_A0.5630.44
29_L126_S0.5620.44
77_V90_S0.5620.44
111_R163_L0.5610.44
109_L125_I0.5570.43
26_R29_L0.5540.43
80_D152_R0.5540.43
55_I64_H0.5530.43
56_N59_A0.5520.43
98_H127_G0.5500.42
98_H158_R0.5490.42
50_N54_E0.5480.42
38_T181_W0.5460.42
135_G149_Y0.5460.42
28_A34_N0.5410.41
61_A192_H0.5380.41
75_V222_K0.5360.41
63_S197_G0.5360.41
46_L95_L0.5340.41
216_M223_P0.5320.40
207_R210_P0.5280.40
41_Y214_N0.5270.40
166_L170_V0.5260.40
213_L220_K0.5250.40
82_L216_M0.5240.39
29_L97_A0.5230.39
44_H170_V0.5220.39
106_P152_R0.5210.39
50_N70_A0.5210.39
46_L104_T0.5190.39
154_F159_Q0.5190.39
177_H198_C0.5170.39
75_V80_D0.5140.38
134_M153_M0.5140.38
95_L195_A0.5130.38
31_R35_P0.5130.38
132_S153_M0.5110.38
188_L196_L0.5110.38
26_R56_N0.5110.38
22_G100_L0.5100.38
181_W184_H0.5100.38
80_D109_L0.5090.38
96_L125_I0.5090.38
17_G198_C0.5080.38
127_G159_Q0.5080.38
139_L157_M0.5050.37
41_Y118_I0.5040.37
128_F149_Y0.5040.37
197_G212_T0.5020.37
29_L199_L0.5010.37
134_M180_P0.5000.37
80_D104_T0.5000.37
17_G29_L0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gs9A 2 0.8167 100 0.528 Contact Map
4htfA 2 0.8458 99.9 0.589 Contact Map
2p7iA 6 0.7875 99.9 0.593 Contact Map
4kdcA 1 0.7917 99.9 0.602 Contact Map
1vlmA 1 0.8208 99.9 0.606 Contact Map
2avnA 3 0.8458 99.9 0.606 Contact Map
4kdrA 1 0.7708 99.9 0.62 Contact Map
3cc8A 2 0.7542 99.9 0.625 Contact Map
3l8dA 2 0.7792 99.9 0.628 Contact Map
4pneA 2 0.8542 99.9 0.63 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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