GREMLIN Database
YAAW - UPF0174 protein YaaW
UniProt: P75617 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14340
Length: 237 (220)
Sequences: 164 (129)
Seq/√Len: 8.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_G80_N7.4541.00
21_Q231_M4.0980.98
98_K104_A3.2570.93
76_D211_S2.8280.87
97_S117_L2.6220.82
19_E60_R2.5050.79
215_Y219_I2.3900.75
91_A95_D2.3500.74
120_Q124_N2.3140.73
22_L66_I2.2920.72
93_L117_L2.2770.71
43_L66_I2.2480.70
168_L195_G2.1450.67
29_L66_I2.1120.65
128_K180_H2.0960.65
214_A220_P2.0820.64
138_L194_A2.0430.63
41_S44_M1.9950.61
28_L221_A1.9770.60
186_L189_G1.9730.60
175_R195_G1.9400.59
13_F38_R1.8890.56
59_H62_N1.8810.56
189_G193_G1.8010.53
17_C228_L1.7930.52
202_A208_K1.7380.50
22_L43_L1.7360.50
199_P216_R1.7100.49
216_R220_P1.7010.48
38_R97_S1.6850.48
89_Y114_E1.6460.46
75_G83_R1.6370.46
199_P220_P1.6300.45
13_F93_L1.6270.45
25_F69_E1.6210.45
57_E62_N1.6170.45
30_T35_G1.6110.45
10_D66_I1.5920.44
75_G217_V1.5810.43
13_F17_C1.5560.42
95_D218_T1.5530.42
178_R189_G1.5340.41
177_L180_H1.5240.41
63_W67_A1.4980.40
96_V222_V1.4670.39
192_R195_G1.4610.38
22_L118_L1.4530.38
12_D34_K1.4380.37
38_R93_L1.4260.37
32_N38_R1.4230.37
81_K136_E1.4160.37
72_H80_N1.4090.36
74_G92_I1.4020.36
94_L113_I1.3930.36
49_F76_D1.3900.36
131_E181_A1.3740.35
185_V224_Q1.3710.35
90_R204_L1.3650.35
83_R95_D1.3580.34
163_K196_L1.3510.34
210_V215_Y1.3320.33
42_V213_S1.3310.33
56_P59_H1.3290.33
90_R200_V1.3020.32
168_L171_S1.2980.32
19_E58_Q1.2930.32
198_G201_G1.2860.32
38_R117_L1.2680.31
132_E200_V1.2340.30
87_K91_A1.2330.30
217_V220_P1.2270.29
36_K39_L1.2250.29
179_T195_G1.2210.29
168_L179_T1.2180.29
167_H190_L1.2180.29
32_N63_W1.1970.28
26_A30_T1.1950.28
171_S190_L1.1930.28
77_S232_V1.1780.28
73_F216_R1.1780.28
63_W68_G1.1760.28
79_A83_R1.1740.28
203_A206_G1.1590.27
115_Q230_R1.1490.27
212_G221_A1.1460.27
121_F166_S1.1430.27
118_L226_A1.1420.27
158_D162_A1.1350.26
76_D105_D1.1290.26
171_S175_R1.1200.26
182_A186_L1.1140.26
28_L92_I1.1100.25
163_K170_S1.1040.25
26_A57_E1.1000.25
62_N228_L1.1000.25
100_L225_I1.0980.25
20_E133_H1.0870.25
118_L196_L1.0870.25
127_K180_H1.0850.25
154_L166_S1.0740.24
80_N86_G1.0730.24
121_F176_I1.0670.24
199_P214_A1.0660.24
50_K62_N1.0660.24
162_A169_L1.0650.24
49_F62_N1.0640.24
158_D203_A1.0530.24
97_S102_L1.0510.24
171_S179_T1.0470.23
66_I228_L1.0450.23
108_M200_V1.0300.23
66_I102_L1.0300.23
222_V229_R1.0260.23
92_I203_A1.0210.23
86_G218_T1.0200.23
105_D108_M1.0160.23
31_H36_K1.0150.23
31_H47_E1.0120.22
174_T177_L1.0030.22
83_R86_G0.9950.22
178_R223_L0.9950.22
65_L70_L0.9890.22
19_E117_L0.9860.22
75_G95_D0.9750.21
143_A225_I0.9750.21
17_C117_L0.9680.21
139_H207_V0.9670.21
78_I181_A0.9630.21
159_K174_T0.9600.21
11_L14_L0.9510.21
15_Q136_E0.9500.21
42_V72_H0.9490.21
128_K219_I0.9470.21
114_E229_R0.9440.20
138_L182_A0.9410.20
37_T99_R0.9410.20
170_S204_L0.9400.20
80_N217_V0.9400.20
23_A77_S0.9390.20
205_N209_A0.9340.20
227_C231_M0.9340.20
70_L225_I0.9330.20
186_L213_S0.9310.20
24_N228_L0.9300.20
13_F31_H0.9280.20
20_E210_V0.9260.20
10_D97_S0.9190.20
80_N85_H0.9100.20
225_I228_L0.9070.19
63_W71_Q0.9050.19
18_S143_A0.8830.19
61_R173_L0.8790.19
129_M167_H0.8770.19
175_R192_R0.8710.19
105_D135_Q0.8690.18
11_L63_W0.8660.18
189_G192_R0.8630.18
171_S183_M0.8590.18
29_L215_Y0.8560.18
125_T162_A0.8550.18
159_K163_K0.8530.18
71_Q93_L0.8500.18
34_K38_R0.8420.18
13_F71_Q0.8420.18
77_S223_L0.8370.18
49_F118_L0.8230.17
135_Q140_A0.8170.17
104_A133_H0.8030.17
83_R87_K0.8010.17
157_K166_S0.8000.17
111_F208_K0.7970.17
82_L113_I0.7950.17
77_S138_L0.7920.17
80_N83_R0.7910.17
56_P99_R0.7900.17
188_H192_R0.7880.16
66_I97_S0.7880.16
79_A101_K0.7850.16
110_T146_N0.7820.16
34_K42_V0.7800.16
77_S217_V0.7760.16
100_L178_R0.7760.16
19_E228_L0.7730.16
84_G96_V0.7730.16
66_I118_L0.7720.16
187_G190_L0.7630.16
25_F35_G0.7580.16
122_L128_K0.7560.16
30_T224_Q0.7530.16
47_E50_K0.7430.15
103_K215_Y0.7390.15
79_A183_M0.7340.15
44_M49_F0.7330.15
114_E226_A0.7320.15
195_G219_I0.7300.15
71_Q217_V0.7300.15
43_L118_L0.7270.15
92_I140_A0.7270.15
108_M143_A0.7200.15
174_T187_G0.7180.15
41_S62_N0.7070.15
78_I209_A0.7060.15
221_A228_L0.7030.15
83_R91_A0.6980.14
83_R218_T0.6950.14
90_R166_S0.6950.14
200_V205_N0.6930.14
163_K197_G0.6900.14
82_L124_N0.6890.14
32_N71_Q0.6880.14
92_I206_G0.6860.14
116_Q207_V0.6860.14
73_F217_V0.6860.14
15_Q129_M0.6850.14
108_M113_I0.6840.14
177_L228_L0.6720.14
38_R71_Q0.6720.14
137_F164_G0.6720.14
10_D93_L0.6710.14
205_N230_R0.6690.14
85_H226_A0.6670.14
158_D178_R0.6670.14
107_E139_H0.6670.14
182_A197_G0.6630.14
30_T73_F0.6610.14
27_R31_H0.6600.14
166_S170_S0.6590.14
43_L102_L0.6580.14
68_G93_L0.6580.14
76_D198_G0.6570.14
167_H209_A0.6560.14
72_H75_G0.6550.14
21_Q122_L0.6540.14
16_H131_E0.6530.14
103_K112_E0.6510.14
70_L178_R0.6510.14
24_N28_L0.6500.13
195_G223_L0.6490.13
13_F85_H0.6480.13
179_T190_L0.6480.13
76_D208_K0.6460.13
129_M177_L0.6430.13
98_K118_L0.6370.13
60_R65_L0.6360.13
33_E36_K0.6360.13
167_H183_M0.6360.13
153_P184_S0.6350.13
100_L137_F0.6350.13
154_L158_D0.6320.13
13_F36_K0.6290.13
101_K174_T0.6290.13
150_E157_K0.6270.13
73_F220_P0.6250.13
103_K122_L0.6220.13
101_K130_D0.6200.13
60_R174_T0.6190.13
101_K175_R0.6170.13
27_R68_G0.6160.13
163_K174_T0.6150.13
212_G220_P0.6140.13
21_Q25_F0.6120.13
199_P208_K0.6100.13
99_R219_I0.6070.13
41_S49_F0.6060.13
58_Q230_R0.6060.13
87_K95_D0.6050.13
112_E165_V0.6050.13
90_R113_I0.6040.13
26_A62_N0.6040.13
121_F147_E0.6020.13
75_G86_G0.6020.13
10_D228_L0.5970.12
109_S192_R0.5960.12
130_D163_K0.5960.12
92_I96_V0.5930.12
175_R183_M0.5910.12
129_M168_L0.5900.12
76_D126_W0.5880.12
194_A215_Y0.5870.12
100_L131_E0.5830.12
199_P209_A0.5810.12
165_V183_M0.5800.12
92_I164_G0.5800.12
44_M143_A0.5720.12
47_E51_S0.5700.12
43_L49_F0.5650.12
55_H117_L0.5630.12
83_R214_A0.5620.12
103_K212_G0.5600.12
26_A59_H0.5590.12
79_A169_L0.5590.12
13_F55_H0.5570.12
209_A222_V0.5500.12
14_L67_A0.5490.12
26_A41_S0.5460.12
198_G204_L0.5450.12
169_L186_L0.5410.11
71_Q87_K0.5400.11
150_E204_L0.5390.11
16_H228_L0.5330.11
40_S102_L0.5330.11
125_T222_V0.5320.11
19_E225_I0.5320.11
206_G222_V0.5300.11
23_A59_H0.5290.11
168_L183_M0.5280.11
57_E92_I0.5270.11
106_K146_N0.5260.11
22_L59_H0.5230.11
125_T224_Q0.5230.11
189_G201_G0.5230.11
26_A230_R0.5180.11
48_L51_S0.5170.11
37_T51_S0.5170.11
157_K207_V0.5140.11
127_K204_L0.5120.11
194_A221_A0.5120.11
81_K231_M0.5110.11
78_I90_R0.5100.11
103_K152_L0.5080.11
93_L221_A0.5080.11
13_F228_L0.5060.11
89_Y229_R0.5060.11
159_K225_I0.5050.11
168_L181_A0.5050.11
56_P181_A0.5040.11
214_A221_A0.5020.11
19_E122_L0.5010.11
103_K116_Q0.5010.11
152_L206_G0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rh1A 1 0.8861 49 0.958 Contact Map
2q1zA 1 0.6709 34 0.961 Contact Map
3qwgA 2 0.3291 27 0.963 Contact Map
3op9A 4 0.4388 24.8 0.964 Contact Map
1a87A 1 0.8354 22.9 0.965 Contact Map
4ls9A 2 0.384 20.5 0.965 Contact Map
2hh6A 2 0.4346 18.1 0.966 Contact Map
1b0nA 2 0.4177 17.1 0.967 Contact Map
1colA 1 0.7679 16.1 0.967 Contact Map
3r1fA 2 0.4684 15.4 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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