GREMLIN Database
YAIS - Uncharacterized deacetylase YaiS
UniProt: P71311 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13302
Length: 185 (162)
Sequences: 4492 (3053)
Seq/√Len: 239.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_A168_V2.9021.00
52_M134_V2.8601.00
42_Q175_V2.8431.00
18_G46_Y2.8431.00
86_F101_A2.8191.00
48_A109_Q2.6351.00
71_N74_K2.5981.00
42_Q172_Y2.5951.00
39_R43_K2.5141.00
21_A37_L2.4161.00
40_L45_I2.4161.00
133_A136_Q2.3011.00
75_I182_K2.2321.00
39_R172_Y2.2191.00
48_A82_I2.1941.00
22_I138_S2.1911.00
19_I40_L2.1481.00
54_T66_H2.0181.00
82_I108_N1.9371.00
38_A175_V1.9101.00
50_V105_I1.8831.00
67_E71_N1.7881.00
178_A181_K1.7371.00
71_N182_K1.6771.00
51_V69_S1.6081.00
21_A29_I1.6021.00
82_I105_I1.5871.00
98_M137_A1.5591.00
20_L50_V1.5501.00
22_I50_V1.5321.00
75_I178_A1.5181.00
20_L106_I1.5101.00
101_A104_D1.4941.00
18_G48_A1.4921.00
37_L41_A1.4811.00
177_L181_K1.4801.00
30_E72_A1.4751.00
46_Y79_H1.4711.00
99_I140_V1.4631.00
66_H70_R1.4561.00
41_A47_I1.3961.00
33_C120_Y1.3861.00
54_T85_N1.3791.00
66_H85_N1.3571.00
75_I175_V1.3361.00
48_A80_Q1.3281.00
37_L47_I1.3181.00
132_L136_Q1.3061.00
103_E107_K1.2981.00
175_V178_A1.2561.00
41_A79_H1.2431.00
38_A42_Q1.2351.00
82_I109_Q1.2341.00
39_R166_E1.2281.00
38_A76_L1.2231.00
105_I109_Q1.2131.00
36_S40_L1.2071.00
71_N184_K1.2061.00
42_Q171_E1.1721.00
18_G112_S1.1541.00
40_L120_Y1.1501.00
70_R74_K1.1481.00
97_D101_A1.1471.00
66_H83_H1.1431.00
35_A176_K1.1351.00
38_A179_A1.1291.00
105_I108_N1.1161.00
84_L101_A1.1161.00
39_R171_E1.1021.00
92_H95_L1.0981.00
50_V102_L1.0931.00
23_G29_I1.0921.00
96_N100_S1.0891.00
67_E70_R1.0661.00
34_G76_L1.0651.00
172_Y175_V1.0601.00
37_L76_L1.0471.00
121_T126_D1.0441.00
134_V138_S1.0221.00
103_E144_T1.0191.00
173_F177_L1.0171.00
51_V81_T1.0121.00
154_P157_W1.0121.00
38_A172_Y0.9961.00
55_G88_D0.9861.00
174_T178_A0.9811.00
69_S83_H0.9801.00
76_L179_A0.9731.00
153_T156_T0.9681.00
120_Y126_D0.9681.00
151_Y155_S0.9651.00
24_A122_M0.9571.00
72_A179_A0.9511.00
107_K145_I0.9501.00
57_S87_A0.9481.00
167_S172_Y0.9381.00
53_T91_A0.9351.00
26_P55_G0.9351.00
121_T138_S0.9311.00
133_A137_A0.9201.00
22_I102_L0.9191.00
149_L153_T0.9191.00
35_A167_S0.9171.00
70_R81_T0.9111.00
71_N75_I0.9111.00
135_Y139_M0.9061.00
41_A77_G0.9061.00
102_L137_A0.9011.00
152_E155_S0.8991.00
17_K112_S0.8991.00
29_I49_A0.8800.99
34_G179_A0.8700.99
87_A90_R0.8690.99
151_Y154_P0.8680.99
20_L109_Q0.8660.99
119_V126_D0.8630.99
119_V142_C0.8600.99
49_A73_L0.8590.99
169_K172_Y0.8430.99
37_L49_A0.8390.99
119_V138_S0.8370.99
58_G88_D0.8230.99
51_V83_H0.8220.99
86_F98_M0.8170.99
148_I153_T0.8160.99
73_L78_C0.8080.99
56_N87_A0.8020.99
19_I45_I0.8000.99
17_K48_A0.7990.99
32_G151_Y0.7970.99
22_I52_M0.7920.99
70_R83_H0.7910.99
103_E141_A0.7750.99
20_L105_I0.7740.99
104_D108_N0.7740.99
148_I151_Y0.7710.99
95_L136_Q0.7710.99
45_I120_Y0.7680.99
36_S166_E0.7660.99
73_L81_T0.7630.98
17_K45_I0.7560.98
57_S90_R0.7540.98
140_V143_R0.7500.98
147_Q150_G0.7500.98
124_D135_Y0.7490.98
168_V173_F0.7480.98
147_Q152_E0.7430.98
52_M84_L0.7380.98
50_V84_L0.7360.98
38_A41_A0.7330.98
20_L111_P0.7240.98
147_Q151_Y0.7220.98
151_Y156_T0.7100.98
65_R88_D0.7100.98
153_T157_W0.7080.98
91_A133_A0.7010.97
124_D127_R0.6930.97
99_I103_E0.6920.97
54_T83_H0.6910.97
168_V172_Y0.6880.97
69_S183_H0.6880.97
95_L98_M0.6860.97
150_G153_T0.6820.97
55_G89_T0.6740.97
18_G45_I0.6660.96
23_G120_Y0.6620.96
86_F91_A0.6620.96
99_I141_A0.6600.96
100_S144_T0.6560.96
151_Y157_W0.6560.96
91_A98_M0.6530.96
30_E69_S0.6530.96
50_V109_Q0.6480.96
149_L152_E0.6470.96
80_Q109_Q0.6440.96
148_I155_S0.6360.95
148_I152_E0.6340.95
100_S104_D0.6330.95
59_T62_I0.6310.95
30_E183_H0.6310.95
152_E156_T0.6280.95
69_S73_L0.6250.95
27_D128_H0.6250.95
174_T177_L0.6180.95
19_I114_V0.6170.95
178_A182_K0.6140.94
49_A78_C0.6130.94
57_S89_T0.6130.94
148_I154_P0.6120.94
91_A134_V0.6100.94
23_G126_D0.6070.94
138_S142_C0.5990.94
35_A172_Y0.5970.94
48_A79_H0.5970.94
96_N144_T0.5920.93
147_Q156_T0.5900.93
102_L141_A0.5900.93
23_G33_C0.5860.93
58_G89_T0.5840.93
28_D131_H0.5830.93
96_N99_I0.5820.93
52_M91_A0.5800.93
68_E128_H0.5770.92
149_L154_P0.5730.92
46_Y80_Q0.5710.92
97_D100_S0.5680.92
55_G58_G0.5680.92
27_D65_R0.5640.92
88_D130_D0.5620.91
95_L99_I0.5560.91
98_M133_A0.5540.91
22_I134_V0.5500.91
149_L164_V0.5490.90
159_S162_P0.5480.90
121_T135_Y0.5480.90
36_S176_K0.5480.90
101_A105_I0.5470.90
168_V176_K0.5400.90
150_G155_S0.5390.90
21_A33_C0.5390.90
106_I142_C0.5370.89
136_Q140_V0.5360.89
126_D176_K0.5350.89
72_A182_K0.5310.89
158_L161_M0.5300.89
45_I112_S0.5290.89
18_G109_Q0.5280.89
52_M102_L0.5260.88
52_M98_M0.5240.88
55_G65_R0.5230.88
27_D131_H0.5210.88
150_G154_P0.5200.88
93_L99_I0.5190.88
30_E34_G0.5180.88
149_L157_W0.5130.87
106_I141_A0.5120.87
152_E157_W0.5090.87
102_L138_S0.5090.87
31_L34_G0.5040.86
65_R68_E0.5020.86
37_L78_C0.5010.86
40_L114_V0.5000.86
75_I179_A0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ixdA 5 0.8703 100 0.247 Contact Map
4xlzA 5 0.973 100 0.252 Contact Map
1uanA 5 0.8649 100 0.26 Contact Map
1q74A 1 0.8919 100 0.276 Contact Map
5bmoA 3 0.9459 100 0.277 Contact Map
3dffA 1 0.8811 100 0.294 Contact Map
3dfiA 1 0.8432 100 0.295 Contact Map
4nesA 2 0.7946 90.6 0.897 Contact Map
2x0dA 2 0.8432 88.5 0.901 Contact Map
2r60A 1 0.8216 86.2 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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