GREMLIN Database
INTF - Putative prophage CP4-6 integrase
UniProt: P71298 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13554
Length: 466 (382)
Sequences: 7003 (5779)
Seq/√Len: 295.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_L208_Y4.2891.00
314_R362_G3.7791.00
74_Q81_T3.4801.00
100_E103_R3.2641.00
319_D322_W3.0291.00
304_G402_F3.0161.00
44_P50_T2.8921.00
185_Q189_S2.8201.00
313_L318_V2.7791.00
140_S144_E2.6461.00
41_F52_L2.6181.00
403_G420_M2.6181.00
315_W351_A2.5761.00
445_E449_T2.4961.00
107_L112_I2.4901.00
295_A350_L2.4611.00
70_A85_T2.3551.00
315_W364_V2.3301.00
411_V446_K2.2851.00
191_G219_N2.2711.00
305_A310_I2.2201.00
74_Q83_R2.1861.00
205_T208_Y2.1831.00
323_S341_P2.1811.00
348_N351_A2.1431.00
299_V343_V2.1391.00
402_F406_A2.1331.00
403_G416_V2.0711.00
400_R434_R2.0561.00
216_E227_A2.0071.00
295_A346_L1.9791.00
205_T249_P1.9711.00
323_S344_S1.9661.00
344_S348_N1.9421.00
341_P445_E1.9281.00
313_L364_V1.8641.00
54_D98_R1.8581.00
200_P203_E1.8571.00
335_R421_G1.8201.00
339_L343_V1.8181.00
180_S184_G1.8161.00
204_L235_I1.7851.00
70_A88_N1.7851.00
300_L395_L1.7851.00
313_L325_M1.7401.00
186_G190_A1.7311.00
76_V81_T1.7281.00
415_I443_W1.6831.00
295_A349_V1.6791.00
51_F63_R1.6751.00
326_R336_I1.6621.00
320_F344_S1.6281.00
324_S336_I1.6271.00
187_P230_L1.6191.00
411_V443_W1.6181.00
407_E416_V1.6121.00
209_I253_A1.6091.00
340_T448_E1.6081.00
302_L448_E1.5941.00
278_L401_S1.5841.00
93_K96_D1.5831.00
41_F62_C1.5701.00
192_P231_L1.5521.00
117_A120_V1.5501.00
320_F348_N1.5271.00
72_V85_T1.5251.00
195_S215_T1.5091.00
178_G182_K1.5041.00
403_G407_E1.4931.00
162_Y201_L1.4901.00
106_T110_T1.4851.00
73_F108_I1.4821.00
177_G180_S1.4751.00
99_A106_T1.4701.00
307_R396_H1.4661.00
394_S397_G1.4601.00
160_R164_T1.4591.00
38_L62_C1.4511.00
41_F50_T1.4471.00
53_W61_A1.4301.00
296_Y310_I1.4281.00
213_L228_Y1.4281.00
63_R83_R1.4211.00
73_F104_L1.4181.00
412_P415_I1.4091.00
235_I252_L1.4051.00
117_A121_K1.4011.00
236_K251_D1.3981.00
277_Q280_S1.3971.00
279_K283_S1.3951.00
341_P345_E1.3931.00
100_E104_L1.3851.00
294_S298_Q1.3831.00
407_E413_T1.3801.00
442_K446_K1.3801.00
299_V310_I1.3751.00
112_I117_A1.3731.00
184_G230_L1.3701.00
281_W285_V1.3651.00
333_G423_K1.3651.00
82_L113_D1.3641.00
315_W347_L1.3581.00
340_T343_V1.3561.00
296_Y377_P1.3551.00
51_F83_R1.3481.00
316_S362_G1.3361.00
73_F105_Q1.3351.00
183_R186_G1.3341.00
214_S245_Q1.3241.00
45_E50_T1.3221.00
61_A83_R1.3201.00
51_F61_A1.3151.00
342_Y452_L1.3121.00
62_C71_F1.3071.00
50_T64_A1.3071.00
286_R298_Q1.3001.00
107_L117_A1.2971.00
280_S284_A1.2951.00
191_G220_R1.2891.00
419_I444_H1.2731.00
176_R184_G1.2731.00
317_D328_K1.2641.00
189_S193_L1.2641.00
378_R382_N1.2551.00
77_Y82_L1.2511.00
115_R118_K1.2501.00
301_L398_L1.2391.00
291_P295_A1.2391.00
300_L310_I1.2351.00
37_R40_R1.2331.00
237_W245_Q1.2331.00
139_F143_W1.2331.00
164_T168_A1.2321.00
53_W74_Q1.2321.00
325_M329_D1.2301.00
402_F419_I1.2301.00
115_R119_A1.2251.00
307_R311_A1.2241.00
222_T226_H1.2211.00
159_K163_S1.2171.00
196_L212_W1.2171.00
99_A102_R1.2001.00
407_E433_R1.2001.00
188_T192_P1.1981.00
409_V446_K1.1871.00
103_R106_T1.1851.00
73_F101_A1.1831.00
96_D99_A1.1801.00
214_S217_R1.1801.00
82_L115_R1.1791.00
320_F323_S1.1781.00
163_S234_F1.1741.00
234_F238_S1.1681.00
331_I421_G1.1671.00
403_G417_A1.1661.00
274_Q277_Q1.1581.00
85_T88_N1.1581.00
43_L50_T1.1521.00
299_V303_T1.1521.00
162_Y238_S1.1471.00
302_L340_T1.1461.00
38_L41_F1.1451.00
239_N248_I1.1391.00
291_P294_S1.1371.00
61_A74_Q1.1251.00
403_G428_A1.1251.00
240_Y257_N1.1241.00
438_D441_R1.1181.00
319_D324_S1.1141.00
417_A428_A1.1071.00
404_T433_R1.1041.00
195_S211_A1.1041.00
403_G433_R1.0981.00
71_F89_I1.0951.00
158_T161_P1.0931.00
188_T193_L1.0901.00
165_R169_D1.0841.00
235_I239_N1.0831.00
308_E312_S1.0791.00
318_V347_L1.0781.00
314_R317_D1.0771.00
160_R198_N1.0741.00
238_S248_I1.0671.00
39_R89_I1.0581.00
64_A69_K1.0551.00
407_E414_G1.0551.00
116_I119_A1.0541.00
305_A325_M1.0461.00
72_V83_R1.0451.00
228_Y232_R1.0451.00
57_V60_L1.0371.00
314_R363_W1.0361.00
68_A88_N1.0351.00
273_L281_W1.0341.00
307_R395_L1.0301.00
160_R193_L1.0271.00
163_S188_T1.0241.00
201_L235_I1.0201.00
277_Q392_H1.0201.00
326_R334_E1.0161.00
138_T142_A1.0151.00
311_A374_I1.0141.00
318_V364_V1.0141.00
406_A411_V1.0131.00
377_P395_L1.0111.00
427_L431_H1.0061.00
96_D100_E1.0051.00
406_A416_V1.0031.00
305_A337_I1.0021.00
191_G195_S0.9911.00
77_Y108_I0.9901.00
228_Y253_A0.9881.00
232_R253_A0.9881.00
305_A313_L0.9861.00
282_F298_Q0.9811.00
235_I248_I0.9791.00
164_T193_L0.9771.00
96_D106_T0.9751.00
397_G400_R0.9741.00
61_A72_V0.9731.00
65_T68_A0.9711.00
401_S405_L0.9691.00
222_T225_A0.9691.00
86_I100_E0.9661.00
209_I231_L0.9641.00
51_F74_Q0.9501.00
342_Y345_E0.9501.00
84_M115_R0.9491.00
182_K186_G0.9481.00
116_I120_V0.9461.00
236_K254_Q0.9441.00
207_D246_G0.9411.00
415_I439_L0.9401.00
433_R437_L0.9391.00
206_P246_G0.9361.00
342_Y449_T0.9341.00
191_G194_A0.9341.00
216_E224_T0.9331.00
176_R180_S0.9311.00
220_R223_V0.9301.00
86_I92_W0.9301.00
113_D116_I0.9301.00
412_P439_L0.9291.00
199_L204_L0.9261.00
299_V347_L0.9261.00
319_D326_R0.9221.00
304_G406_A0.9221.00
318_V325_M0.9211.00
201_L238_S0.9191.00
62_C69_K0.9161.00
410_E439_L0.9131.00
37_R41_F0.9111.00
51_F81_T0.9101.00
325_M328_K0.9091.00
99_A103_R0.9051.00
424_P430_K0.9021.00
140_S143_W0.9021.00
192_P227_A0.9011.00
65_T70_A0.9001.00
339_L344_S0.8991.00
400_R431_H0.8991.00
424_P427_L0.8941.00
207_D211_A0.8921.00
37_R52_L0.8921.00
63_R72_V0.8891.00
208_Y211_A0.8881.00
164_T185_Q0.8881.00
199_L203_E0.8861.00
84_M104_L0.8831.00
205_T246_G0.8831.00
271_D397_G0.8791.00
239_N250_G0.8701.00
291_P349_V0.8681.00
342_Y445_E0.8671.00
382_N385_L0.8661.00
379_S383_R0.8651.00
95_D99_A0.8621.00
102_R106_T0.8541.00
269_A272_C0.8511.00
317_D325_M0.8501.00
345_E348_N0.8481.00
321_K348_N0.8441.00
167_I185_Q0.8441.00
236_K255_D0.8411.00
107_L110_T0.8371.00
181_K185_Q0.8371.00
427_L430_K0.8361.00
213_L224_T0.8361.00
342_Y448_E0.8361.00
159_K234_F0.8351.00
351_A354_P0.8351.00
381_H385_L0.8341.00
86_I104_L0.8321.00
162_Y165_R0.8301.00
403_G424_P0.8291.00
302_L343_V0.8291.00
106_T109_D0.8291.00
159_K231_L0.8241.00
439_L442_K0.8221.00
347_L364_V0.8221.00
320_F347_L0.8171.00
275_K405_L0.8171.00
350_L364_V0.8151.00
226_H229_R0.8131.00
183_R187_P0.8061.00
271_D277_Q0.8051.00
309_E335_R0.8041.00
114_P119_A0.8031.00
176_R181_K0.8021.00
281_W381_H0.8011.00
298_Q342_Y0.8001.00
210_A214_S0.8001.00
186_G189_S0.7950.99
285_V297_L0.7910.99
232_R236_K0.7850.99
92_W100_E0.7840.99
378_R381_H0.7800.99
424_P428_A0.7780.99
323_S326_R0.7770.99
57_V101_A0.7750.99
131_E134_K0.7750.99
180_S183_R0.7740.99
408_W435_R0.7730.99
144_E148_Q0.7700.99
85_T92_W0.7690.99
142_A146_Y0.7690.99
163_S167_I0.7680.99
173_L181_K0.7680.99
94_I97_A0.7660.99
179_E182_K0.7650.99
88_N91_D0.7640.99
185_Q193_L0.7640.99
166_Y170_H0.7630.99
103_R107_L0.7630.99
137_V141_V0.7620.99
414_G417_A0.7600.99
379_S382_N0.7590.99
188_T234_F0.7580.99
378_R395_L0.7540.99
349_V352_Q0.7540.99
407_E435_R0.7520.99
138_T141_V0.7520.99
312_S317_D0.7510.99
393_I401_S0.7490.99
186_G191_G0.7490.99
178_G181_K0.7480.99
96_D110_T0.7450.99
147_L185_Q0.7440.99
206_P255_D0.7430.99
71_F90_N0.7420.99
341_P449_T0.7400.99
138_T146_Y0.7380.99
147_L151_R0.7370.99
290_N293_A0.7340.99
206_P240_Y0.7330.99
92_W97_A0.7330.99
297_L398_L0.7330.99
441_R445_E0.7320.99
376_E380_A0.7280.99
167_I181_K0.7270.99
58_T105_Q0.7260.99
204_L209_I0.7260.99
94_I98_R0.7240.99
292_I350_L0.7240.99
411_V415_I0.7230.99
326_R329_D0.7230.99
417_A420_M0.7220.99
373_K376_E0.7210.99
445_E448_E0.7200.99
73_F86_I0.7190.99
235_I253_A0.7170.99
57_V102_R0.7160.99
75_S115_R0.7150.99
140_S198_N0.7130.99
376_E379_S0.7120.99
435_R439_L0.7110.99
325_M339_L0.7090.99
431_H434_R0.7070.99
75_S82_L0.7050.99
405_L447_I0.6990.99
319_D323_S0.6990.99
404_T435_R0.6980.99
428_A431_H0.6980.99
101_A105_Q0.6980.99
381_H395_L0.6950.99
272_C400_R0.6950.99
63_R74_Q0.6950.99
298_Q346_L0.6940.99
428_A433_R0.6940.99
195_S212_W0.6940.99
145_D149_E0.6930.99
181_K184_G0.6910.99
312_S371_S0.6890.99
309_E421_G0.6880.99
450_W453_N0.6880.99
84_M118_K0.6870.98
98_R101_A0.6870.98
104_L107_L0.6860.98
417_A430_K0.6860.98
216_E220_R0.6850.98
419_I443_W0.6850.98
57_V73_F0.6850.98
210_A245_Q0.6850.98
382_N386_V0.6850.98
305_A327_I0.6840.98
235_I251_D0.6810.98
179_E183_R0.6810.98
229_R233_A0.6810.98
232_R251_D0.6780.98
111_G114_P0.6770.98
438_D442_K0.6730.98
296_Y311_A0.6710.98
91_D105_Q0.6710.98
251_D254_Q0.6700.98
108_I111_G0.6690.98
272_C434_R0.6680.98
380_A383_R0.6680.98
305_A309_E0.6650.98
268_K272_C0.6620.98
43_L69_K0.6590.98
250_G255_D0.6550.98
168_A173_L0.6540.98
52_L62_C0.6540.98
372_G376_E0.6540.98
139_F142_A0.6530.98
113_D118_K0.6520.98
315_W354_P0.6520.98
413_T428_A0.6470.98
177_G332_E0.6460.98
340_T445_E0.6450.98
193_L197_L0.6440.98
144_E193_L0.6440.98
406_A447_I0.6440.98
192_P196_L0.6430.98
300_L377_P0.6430.98
63_R70_A0.6400.98
293_A376_E0.6380.98
191_G196_L0.6380.98
271_D391_P0.6360.98
234_F237_W0.6350.97
336_I436_P0.6340.97
282_F302_L0.6340.97
282_F342_Y0.6340.97
191_G216_E0.6330.97
306_R396_H0.6330.97
282_F286_R0.6330.97
346_L350_L0.6300.97
273_L277_Q0.6290.97
278_L301_L0.6280.97
144_E185_Q0.6270.97
148_Q151_R0.6260.97
141_V145_D0.6260.97
393_I397_G0.6260.97
240_Y255_D0.6240.97
270_D394_S0.6210.97
302_L451_I0.6200.97
303_T310_I0.6170.97
302_L342_Y0.6170.97
206_P210_A0.6160.97
343_V346_L0.6150.97
75_S113_D0.6150.97
273_L393_I0.6140.97
414_G418_Q0.6140.97
448_E452_L0.6080.97
419_I440_L0.6080.97
440_L444_H0.6070.97
270_D273_L0.6060.97
225_A266_A0.6060.97
214_S218_Q0.6020.97
187_P191_G0.6020.97
170_H176_R0.6020.97
375_I382_N0.6020.97
374_I378_R0.6010.97
303_T340_T0.6000.96
63_R66_S0.5990.96
304_G419_I0.5990.96
211_A215_T0.5980.96
54_D57_V0.5970.96
331_I423_K0.5940.96
201_L248_I0.5930.96
38_L71_F0.5930.96
412_P443_W0.5920.96
324_S441_R0.5910.96
406_A443_W0.5860.96
162_Y237_W0.5860.96
303_T343_V0.5840.96
114_P118_K0.5830.96
141_V144_E0.5830.96
143_W146_Y0.5820.96
75_S84_M0.5820.96
373_K377_P0.5780.96
416_V428_A0.5760.96
407_E428_A0.5740.95
407_E412_P0.5730.95
311_A371_S0.5730.95
372_G377_P0.5700.95
43_L67_G0.5690.95
275_K279_K0.5690.95
404_T434_R0.5690.95
348_N352_Q0.5680.95
384_A388_A0.5670.95
167_I170_H0.5670.95
139_F147_L0.5650.95
400_R404_T0.5650.95
415_I419_I0.5630.95
350_L354_P0.5630.95
42_T50_T0.5620.95
278_L451_I0.5620.95
67_G70_A0.5610.95
187_P227_A0.5610.95
37_R53_W0.5600.95
305_A335_R0.5580.95
295_A298_Q0.5540.95
132_S136_K0.5540.95
76_V79_G0.5530.95
293_A380_A0.5530.95
320_F364_V0.5520.94
42_T69_K0.5500.94
331_I334_E0.5490.94
415_I418_Q0.5490.94
413_T417_A0.5470.94
184_G187_P0.5460.94
192_P197_L0.5460.94
403_G435_R0.5460.94
191_G227_A0.5460.94
426_A430_K0.5460.94
405_L409_V0.5450.94
41_F64_A0.5450.94
422_H428_A0.5430.94
146_Y150_L0.5420.94
270_D397_G0.5420.94
102_R109_D0.5420.94
407_E437_L0.5410.94
413_T430_K0.5390.94
239_N251_D0.5380.94
113_D119_A0.5360.94
38_L89_I0.5350.93
92_W109_D0.5330.93
146_Y149_E0.5330.93
320_F325_M0.5330.93
212_W231_L0.5300.93
338_P419_I0.5270.93
222_T266_A0.5260.93
405_L408_W0.5230.93
217_R221_P0.5220.93
284_A390_L0.5220.93
53_W60_L0.5200.93
282_F301_L0.5190.92
413_T433_R0.5180.92
159_K204_L0.5170.92
60_L71_F0.5170.92
161_P164_T0.5150.92
212_W227_A0.5130.92
281_W393_I0.5120.92
270_D274_Q0.5120.92
140_S193_L0.5120.92
160_R197_L0.5110.92
420_M428_A0.5110.92
425_S428_A0.5090.92
413_T416_V0.5080.92
327_I337_I0.5070.92
276_E279_K0.5070.92
407_E424_P0.5070.92
144_E147_L0.5060.92
212_W215_T0.5050.91
418_Q424_P0.5050.91
183_R230_L0.5040.91
143_W147_L0.5030.91
322_W325_M0.5020.91
221_P265_S0.5020.91
187_P223_V0.5010.91
304_G444_H0.5000.91
166_Y233_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.7296 100 0.478 Contact Map
1a0pA 1 0.5601 100 0.512 Contact Map
1z19A 3 0.588 100 0.524 Contact Map
2a3vA 3 0.5901 100 0.524 Contact Map
4a8eA 2 0.5558 100 0.553 Contact Map
1xo0A 3 0.6009 100 0.555 Contact Map
3nkhA 2 0.4013 100 0.634 Contact Map
1ae9A 4 0.3412 100 0.681 Contact Map
1aihA 2 0.3584 100 0.695 Contact Map
3vcfA 1 0.3369 99.9 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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