GREMLIN Database
WCAK - Colanic acid biosynthesis protein WcaK
UniProt: P71242 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13577
Length: 426 (337)
Sequences: 2081 (1879)
Seq/√Len: 102.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_A328_C5.3821.00
235_K329_E4.6911.00
4_L118_Y3.7561.00
2_K35_E3.5891.00
188_F203_H3.5651.00
333_G338_S3.2111.00
234_Q275_Q2.9961.00
363_Q368_P2.9221.00
189_D193_R2.9021.00
185_S189_D2.8351.00
158_V187_S2.7111.00
37_D118_Y2.6681.00
123_Q128_F2.6631.00
336_L340_I2.6111.00
188_F192_K2.5871.00
351_A362_M2.5781.00
150_P178_D2.5341.00
20_L38_V2.5321.00
263_A302_H2.4971.00
236_T328_C2.4051.00
163_D166_F2.3861.00
267_N303_I2.2931.00
235_K274_Y2.2761.00
331_T342_S2.2621.00
238_A279_L2.2161.00
403_A406_R2.1541.00
25_D28_N2.1431.00
119_D149_K2.1171.00
124_V207_T2.0251.00
392_Q395_A2.0191.00
23_L154_I1.9291.00
361_I365_L1.9201.00
209_W361_I1.9031.00
211_V215_T1.9021.00
3_L34_A1.8791.00
184_E357_K1.8551.00
339_A351_A1.8421.00
236_T327_A1.8421.00
154_I207_T1.8381.00
217_D326_G1.8351.00
317_N320_E1.8331.00
396_L400_L1.8251.00
19_I207_T1.8181.00
343_M361_I1.8151.00
239_I266_V1.8121.00
128_F156_H1.8071.00
152_F179_A1.8061.00
388_D392_Q1.7691.00
328_C331_T1.7331.00
343_M365_L1.7271.00
267_N304_S1.7131.00
123_Q177_C1.6851.00
342_S349_A1.6821.00
8_N11_C1.6481.00
10_T17_S1.6471.00
154_I204_G1.6431.00
326_G345_F1.6341.00
336_L361_I1.6141.00
386_V390_L1.5891.00
191_M201_V1.5631.00
236_T275_Q1.5571.00
8_N16_D1.5571.00
115_L121_I1.5441.00
393_L397_N1.5421.00
240_T338_S1.5381.00
16_D125_G1.5381.00
382_L386_V1.5061.00
151_L177_C1.4921.00
397_N401_S1.4911.00
185_S203_H1.4811.00
14_R341_I1.4811.00
191_M196_I1.4741.00
151_L176_H1.4741.00
155_G207_T1.4691.00
33_H36_V1.4561.00
269_I330_L1.4461.00
398_A401_S1.4431.00
242_R334_T1.4431.00
267_N271_D1.4391.00
120_A152_F1.4351.00
153_M156_H1.4271.00
260_K302_H1.4251.00
323_K327_A1.4021.00
184_E335_R1.3941.00
24_L36_V1.3861.00
405_S409_Q1.3831.00
127_S357_K1.3741.00
236_T277_I1.3690.99
394_P397_N1.3500.99
182_L187_S1.3470.99
127_S355_E1.3450.99
26_A210_L1.3370.99
124_V127_S1.3360.99
400_L403_A1.3190.99
322_G341_I1.3130.99
339_A362_M1.3090.99
177_C180_L1.3080.99
238_A325_L1.3070.99
237_V330_L1.3040.99
174_F180_L1.3030.99
237_V274_Y1.3020.99
385_M388_D1.3010.99
22_G211_V1.3010.99
329_E393_L1.2990.99
386_V389_T1.2870.99
116_S121_I1.2860.99
275_Q310_H1.2850.99
145_F178_D1.2830.99
191_M195_N1.2820.99
184_E187_S1.2780.99
351_A358_S1.2620.99
186_V360_G1.2540.99
399_R402_E1.2510.99
184_E336_L1.2500.99
19_I22_G1.2400.99
189_D192_K1.2390.99
16_D334_T1.2390.99
299_L303_I1.2370.99
403_A407_E1.2210.99
123_Q156_H1.2090.99
126_G129_F1.2050.99
400_L404_V1.2010.99
120_A150_P1.1980.99
167_N194_S1.1910.99
259_E298_N1.1900.99
387_A391_G1.1880.99
161_F170_A1.1870.99
182_L188_F1.1740.98
265_V382_L1.1700.98
334_T358_S1.1670.98
236_T274_Y1.1570.98
333_G339_A1.1450.98
269_I272_E1.1410.98
340_I361_I1.1390.98
272_E387_A1.1390.98
242_R355_E1.1360.98
16_D126_G1.1330.98
330_L348_P1.1320.98
262_F299_L1.1280.98
127_S130_V1.1190.98
127_S336_L1.1090.98
264_G268_R1.1030.98
128_F157_S1.1000.98
383_Q386_V1.0920.97
238_A331_T1.0910.97
378_L381_S1.0900.97
185_S363_Q1.0790.97
167_N193_R1.0690.97
258_Y334_T1.0640.97
128_F207_T1.0600.97
124_V128_F1.0580.97
27_I34_A1.0550.97
9_H20_L1.0530.97
350_I389_T1.0520.97
23_L26_A1.0430.97
127_S242_R1.0380.97
26_A30_L1.0330.96
16_D20_L1.0330.96
384_A387_A1.0320.96
9_H16_D1.0300.96
179_A202_E1.0230.96
274_Y329_E1.0210.96
155_G181_I1.0120.96
171_N175_G1.0000.96
27_I122_I0.9960.96
16_D355_E0.9930.96
17_S335_R0.9860.95
153_M177_C0.9800.95
185_S188_F0.9800.95
125_G157_S0.9770.95
2_K117_G0.9760.95
268_R383_Q0.9750.95
18_A341_I0.9750.95
19_I336_L0.9730.95
325_L338_S0.9710.95
131_D160_P0.9700.95
329_E348_P0.9690.95
270_L308_R0.9670.95
340_I357_K0.9660.95
8_N334_T0.9610.95
353_N359_A0.9580.95
156_H180_L0.9580.95
242_R357_K0.9520.94
237_V332_V0.9520.94
182_L191_M0.9500.94
266_V276_V0.9460.94
5_I23_L0.9450.94
23_L122_I0.9450.94
16_D242_R0.9440.94
388_D391_G0.9440.94
157_S184_E0.9430.94
7_G10_T0.9400.94
16_D157_S0.9400.94
331_T347_T0.9360.94
8_N17_S0.9340.94
377_L382_L0.9330.94
263_A267_N0.9310.94
123_Q127_S0.9300.94
197_T200_K0.9290.94
332_V352_I0.9260.94
187_S190_L0.9210.93
181_I204_G0.9210.93
7_G19_I0.9190.93
127_S335_R0.9180.93
4_L115_L0.9140.93
37_D41_R0.9110.93
20_L157_S0.9080.93
393_L400_L0.9060.93
8_N156_H0.9040.93
31_N39_M0.9040.93
126_G130_V0.9020.93
127_S157_S0.8980.93
24_L28_N0.8950.92
322_G344_N0.8900.92
208_A344_N0.8870.92
360_G364_Q0.8840.92
264_G267_N0.8820.92
27_I30_L0.8800.92
259_E299_L0.8780.92
172_Y175_G0.8710.91
171_N194_S0.8700.91
362_M367_L0.8690.91
164_E167_N0.8670.91
18_A208_A0.8600.91
399_R403_A0.8550.91
273_G308_R0.8550.91
316_L324_I0.8550.91
401_S404_V0.8530.90
281_T322_G0.8530.90
382_L390_L0.8520.90
19_I125_G0.8510.90
331_T338_S0.8500.90
157_S281_T0.8410.90
297_L301_Q0.8360.90
336_L358_S0.8330.89
20_L24_L0.8270.89
16_D354_Y0.8260.89
240_T333_G0.8250.89
335_R357_K0.8230.89
320_E323_K0.8210.89
157_S351_A0.8210.89
296_A299_L0.8190.89
10_T40_S0.8190.89
10_T16_D0.8180.89
190_L193_R0.8160.88
332_V350_I0.8160.88
341_I344_N0.8150.88
130_V242_R0.8140.88
186_V356_H0.8130.88
107_G110_D0.8120.88
239_I262_F0.8090.88
238_A241_L0.8080.88
36_V40_S0.8070.88
270_L276_V0.8010.87
336_L341_I0.7970.87
216_E321_M0.7960.87
277_I324_I0.7920.87
4_L39_M0.7890.87
401_S405_S0.7870.87
187_S356_H0.7870.87
241_L244_L0.7840.86
19_I126_G0.7830.86
168_Q171_N0.7830.86
196_I199_A0.7830.86
181_I207_T0.7810.86
325_L341_I0.7760.86
243_E354_Y0.7700.85
130_V133_Y0.7680.85
187_S357_K0.7680.85
393_L396_L0.7670.85
16_D127_S0.7650.85
336_L355_E0.7610.85
29_I215_T0.7610.85
157_S336_L0.7570.84
231_A323_K0.7550.84
8_N127_S0.7520.84
8_N130_V0.7500.84
281_T341_I0.7460.83
23_L210_L0.7450.83
395_A399_R0.7440.83
18_A345_F0.7440.83
40_S46_S0.7420.83
268_R387_A0.7410.83
399_R409_Q0.7400.83
330_L350_I0.7390.83
266_V273_G0.7390.83
127_S184_E0.7380.83
322_G345_F0.7350.83
398_A402_E0.7350.83
16_D19_I0.7300.82
238_A324_I0.7290.82
9_H38_V0.7290.82
25_D29_I0.7290.82
127_S338_S0.7290.82
7_G20_L0.7260.82
237_V272_E0.7260.82
17_S40_S0.7230.82
158_V191_M0.7230.82
278_A309_Y0.7170.81
237_V269_I0.7170.81
8_N128_F0.7170.81
127_S354_Y0.7160.81
217_D345_F0.7150.81
188_F201_V0.7120.81
265_V352_I0.7090.80
33_H38_V0.7080.80
123_Q126_G0.7060.80
242_R354_Y0.7030.80
105_A114_L0.7030.80
16_D341_I0.7010.80
6_L123_Q0.7010.80
281_T354_Y0.7010.80
325_L347_T0.6990.79
404_V408_R0.6970.79
240_T341_I0.6960.79
125_G208_A0.6950.79
240_T335_R0.6950.79
114_L121_I0.6920.79
196_I200_K0.6910.79
349_A362_M0.6910.79
315_E321_M0.6900.78
8_N358_S0.6880.78
263_A299_L0.6860.78
131_D166_F0.6860.78
405_S408_R0.6850.78
263_A303_I0.6850.78
236_T329_E0.6840.78
266_V303_I0.6830.78
157_S358_S0.6810.78
10_T281_T0.6800.77
22_G208_A0.6800.77
390_L393_L0.6790.77
209_W340_I0.6790.77
184_E361_I0.6770.77
19_I127_S0.6770.77
158_V190_L0.6760.77
10_T20_L0.6760.77
10_T354_Y0.6750.77
3_L120_A0.6740.77
181_I205_V0.6740.77
17_S281_T0.6740.77
173_V372_I0.6730.77
145_F151_L0.6720.77
277_I328_C0.6700.76
17_S280_S0.6670.76
7_G157_S0.6650.76
397_N400_L0.6640.76
122_I181_I0.6630.76
227_W230_V0.6600.75
145_F149_K0.6590.75
184_E340_I0.6560.75
156_H207_T0.6560.75
395_A398_A0.6550.75
22_G338_S0.6550.75
239_I357_K0.6550.75
359_A373_D0.6550.75
392_Q396_L0.6530.75
180_L191_M0.6510.74
127_S281_T0.6490.74
386_V391_G0.6460.74
19_I321_M0.6460.74
340_I344_N0.6440.74
127_S341_I0.6440.74
237_V276_V0.6430.73
8_N134_G0.6420.73
230_V234_Q0.6420.73
158_V194_S0.6410.73
17_S318_D0.6390.73
145_F176_H0.6390.73
108_F112_V0.6380.73
31_N38_V0.6370.73
156_H160_P0.6360.73
11_C16_D0.6360.73
115_L149_K0.6350.72
234_Q329_E0.6340.72
184_E328_C0.6300.72
280_S333_G0.6260.71
131_D163_D0.6260.71
332_V386_V0.6230.71
300_R311_V0.6200.71
258_Y262_F0.6200.71
7_G17_S0.6200.71
398_A406_R0.6190.71
244_L354_Y0.6130.70
125_G128_F0.6120.70
354_Y358_S0.6110.70
121_I145_F0.6100.69
148_K218_F0.6100.69
330_L386_V0.6090.69
19_I124_V0.6090.69
161_F187_S0.6070.69
19_I23_L0.6050.69
241_L262_F0.6050.69
6_L128_F0.6010.68
376_H381_S0.6010.68
8_N281_T0.6000.68
124_V157_S0.5950.68
336_L362_M0.5940.67
137_Q140_H0.5930.67
208_A340_I0.5920.67
9_H40_S0.5910.67
244_L355_E0.5910.67
280_S296_A0.5910.67
129_F153_M0.5900.67
266_V332_V0.5900.67
334_T355_E0.5890.67
170_A174_F0.5870.67
232_A275_Q0.5860.66
24_L38_V0.5830.66
160_P190_L0.5800.66
259_E295_V0.5790.65
269_I350_I0.5780.65
245_A265_V0.5770.65
19_I155_G0.5760.65
395_A405_S0.5760.65
191_M318_D0.5710.64
401_S406_R0.5710.64
18_A22_G0.5700.64
353_N371_A0.5700.64
3_L7_G0.5680.64
23_L124_V0.5680.64
318_D322_G0.5680.64
323_K326_G0.5680.64
397_N402_E0.5670.64
343_M349_A0.5660.64
19_I156_H0.5660.64
321_M365_L0.5650.64
173_V177_C0.5640.63
123_Q187_S0.5640.63
19_I340_I0.5620.63
11_C17_S0.5610.63
158_V201_V0.5600.63
318_D341_I0.5600.63
213_H326_G0.5590.63
124_V130_V0.5560.62
123_Q341_I0.5560.62
391_G409_Q0.5560.62
336_L339_A0.5560.62
129_F336_L0.5530.62
281_T335_R0.5520.62
126_G240_T0.5510.62
343_M367_L0.5500.62
297_L311_V0.5500.62
8_N133_Y0.5490.61
354_Y357_K0.5490.61
341_I349_A0.5470.61
395_A401_S0.5470.61
280_S354_Y0.5460.61
16_D128_F0.5450.61
170_A389_T0.5430.61
382_L389_T0.5430.61
387_A392_Q0.5410.60
207_T336_L0.5410.60
175_G196_I0.5410.60
120_A149_K0.5410.60
164_E169_L0.5390.60
191_M194_S0.5390.60
160_P354_Y0.5370.60
112_V147_A0.5370.60
128_F358_S0.5360.60
46_S50_L0.5340.59
381_S384_A0.5330.59
353_N358_S0.5320.59
171_N196_I0.5310.59
233_Q400_L0.5310.59
18_A347_T0.5310.59
242_R335_R0.5280.58
102_I105_A0.5280.58
166_F169_L0.5280.58
197_T402_E0.5270.58
55_M264_G0.5270.58
7_G125_G0.5260.58
392_Q399_R0.5250.58
394_P398_A0.5250.58
156_H159_G0.5240.58
25_D212_D0.5220.58
19_I123_Q0.5210.57
123_Q153_M0.5200.57
16_D156_H0.5200.57
206_D336_L0.5200.57
316_L320_E0.5200.57
260_K264_G0.5180.57
218_F268_R0.5180.57
16_D153_M0.5180.57
122_I154_I0.5170.57
279_L328_C0.5170.57
256_Q406_R0.5160.57
243_E332_V0.5140.56
14_R318_D0.5130.56
341_I345_F0.5130.56
400_L406_R0.5130.56
14_R19_I0.5120.56
155_G204_G0.5120.56
389_T393_L0.5080.56
7_G208_A0.5070.55
112_V146_M0.5060.55
4_L37_D0.5060.55
136_P139_E0.5050.55
272_E276_V0.5050.55
12_G17_S0.5030.55
27_I313_M0.5020.55
7_G281_T0.5020.55
126_G155_G0.5010.55
262_F334_T0.5010.55
138_F143_C0.5000.54
124_V155_G0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tovA 1 0.784 99.6 0.789 Contact Map
2gt1A 1 0.7394 99.6 0.794 Contact Map
3ot5A 2 0.8427 99.5 0.806 Contact Map
1pswA 1 0.7277 99.4 0.81 Contact Map
3c48A 2 0.8521 99.4 0.815 Contact Map
1vgvA 2 0.8451 99.3 0.825 Contact Map
3oy2A 2 0.8239 99.2 0.828 Contact Map
4nesA 2 0.8357 99.2 0.828 Contact Map
3okpA 1 0.8263 99.2 0.828 Contact Map
3dzcA 2 0.8427 99.2 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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