GREMLIN Database
WCAJ - UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
UniProt: P71241 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13575
Length: 464 (435)
Sequences: 4358 (3500)
Seq/√Len: 167.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
296_I361_L5.5641.00
299_A352_V5.4181.00
329_S356_L5.1861.00
275_R279_I4.9941.00
286_L368_I4.5001.00
303_S351_K4.4971.00
313_T321_P4.3261.00
313_T323_K4.0871.00
370_V408_I4.0071.00
311_R323_K3.7461.00
429_K432_E3.6511.00
277_E281_L3.5151.00
296_I356_L3.5001.00
377_I450_V3.3861.00
355_F359_T3.3161.00
295_C299_A2.9061.00
100_A109_L2.8501.00
89_T116_Y2.7321.00
307_P332_V2.5891.00
146_M172_E2.5401.00
411_W415_N2.5001.00
301_K308_V2.4961.00
283_T371_L2.4501.00
367_F377_I2.4231.00
333_M337_K2.3951.00
300_V303_S2.3831.00
281_L377_I2.3701.00
315_Y321_P2.3251.00
282_A286_L2.2931.00
285_I289_I2.2791.00
311_R325_W2.2561.00
309_I325_W2.2481.00
297_A308_V2.2351.00
367_F408_I2.0931.00
333_M336_D2.0801.00
352_V356_L2.0651.00
282_A371_L2.0581.00
448_K452_L2.0301.00
301_K306_G2.0251.00
207_N235_L2.0161.00
177_Y199_D1.9971.00
436_E440_E1.9801.00
337_K340_T1.9761.00
345_N354_N1.9391.00
383_H387_H1.9281.00
384_A387_H1.9121.00
289_I293_L1.9111.00
293_L309_I1.9021.00
290_S294_C1.8491.00
391_Y427_M1.8481.00
146_M206_H1.8441.00
331_K337_K1.8411.00
277_E443_V1.8321.00
279_I282_A1.8281.00
325_W372_T1.8111.00
24_S126_C1.7921.00
199_D203_G1.7761.00
356_L361_L1.7731.00
315_Y388_N1.7731.00
103_N109_L1.7691.00
368_I372_T1.7681.00
198_E202_A1.7421.00
383_H391_Y1.7271.00
148_A177_Y1.7251.00
378_V409_T1.7211.00
32_G122_G1.7171.00
298_L302_L1.7171.00
286_L290_S1.7151.00
294_C298_L1.7091.00
144_K172_E1.7051.00
296_I327_F1.6821.00
32_G36_V1.6671.00
147_V171_F1.6441.00
356_L359_T1.6361.00
285_I377_I1.6301.00
387_H391_Y1.6301.00
349_V354_N1.6191.00
358_R460_N1.6031.00
293_L327_F1.5991.00
149_V160_M1.5931.00
341_Q387_H1.5921.00
160_M176_V1.5781.00
281_L285_I1.5661.00
175_G191_G1.5511.00
285_I367_F1.5351.00
40_S109_L1.5241.00
192_N195_Q1.5231.00
103_N108_Q1.5161.00
331_K347_P1.5091.00
40_S110_K1.5061.00
63_G68_F1.4931.00
283_T287_L1.4901.00
289_I292_V1.4871.00
411_W436_E1.4611.00
383_H427_M1.4591.00
383_H388_N1.4591.00
342_A387_H1.4541.00
278_D376_S1.4541.00
385_V389_E1.4441.00
279_I283_T1.4431.00
195_Q198_E1.4421.00
149_V156_G1.4101.00
291_P294_C1.4091.00
153_L156_G1.4031.00
310_F335_N1.3841.00
80_E131_R1.3801.00
316_G406_P1.3671.00
412_A419_G1.3641.00
252_E255_G1.3601.00
36_V40_S1.3581.00
364_L367_F1.3551.00
383_H430_R1.3341.00
325_W369_N1.3311.00
404_V438_I1.3221.00
411_W440_E1.3081.00
360_S418_R1.2981.00
420_E426_K1.2871.00
427_M430_R1.2791.00
367_F450_V1.2781.00
384_A427_M1.2751.00
419_G430_R1.2671.00
290_S293_L1.2661.00
342_A412_A1.2531.00
138_R141_G1.2531.00
452_L456_K1.2441.00
29_M119_T1.2381.00
275_R282_A1.2351.00
156_G176_V1.2301.00
152_D178_H1.2261.00
392_R399_M1.2261.00
455_F459_V1.2201.00
368_I374_G1.2041.00
296_I299_A1.2031.00
141_G170_G1.1961.00
443_V447_I1.1941.00
309_I368_I1.1911.00
28_I122_G1.1881.00
398_Y412_A1.1881.00
342_A419_G1.1851.00
200_A232_C1.1851.00
28_I126_C1.1841.00
114_A118_L1.1781.00
85_L120_S1.1711.00
59_F63_G1.1691.00
32_G118_L1.1631.00
149_V176_V1.1611.00
201_K230_T1.1601.00
447_I451_F1.1561.00
30_F56_L1.1431.00
303_S350_T1.1401.00
299_A302_L1.1391.00
383_H398_Y1.1361.00
428_E432_E1.1231.00
402_H419_G1.1231.00
331_K334_E1.1171.00
319_G402_H1.1161.00
384_A391_Y1.1161.00
457_G460_N1.1071.00
387_H427_M1.1021.00
197_V226_Q1.0991.00
421_T426_K1.0971.00
378_V450_V1.0951.00
386_A390_Q1.0851.00
277_E447_I1.0831.00
384_A388_N1.0801.00
338_V384_A1.0771.00
383_H412_A1.0681.00
292_V296_I1.0671.00
355_F361_L1.0650.99
421_T430_R1.0620.99
81_F124_V1.0590.99
360_S441_W1.0590.99
295_C298_L1.0590.99
92_V116_Y1.0580.99
341_Q383_H1.0540.99
398_Y430_R1.0540.99
296_I300_V1.0510.99
335_N339_V1.0490.99
335_N338_V1.0470.99
148_A175_G1.0430.99
119_T123_L1.0420.99
28_I32_G1.0380.99
110_K114_A1.0330.99
337_K412_A1.0320.99
174_V205_I1.0320.99
277_E450_V1.0290.99
416_G421_T1.0250.99
88_W120_S1.0230.99
279_I371_L1.0190.99
377_I408_I1.0170.99
287_L290_S1.0120.99
279_I367_F1.0120.99
310_F384_A1.0110.99
426_K430_R1.0100.99
208_V227_L1.0060.99
398_Y402_H1.0060.99
383_H401_R1.0060.99
292_V364_L1.0050.99
152_D156_G1.0050.99
273_L277_E1.0020.99
341_Q391_Y0.9940.99
160_M173_V0.9900.99
400_L439_R0.9880.99
200_A227_L0.9850.99
272_L276_A0.9820.99
341_Q427_M0.9770.99
300_V304_S0.9730.99
383_H386_A0.9710.99
411_W433_F0.9700.99
338_V386_A0.9700.99
383_H431_V0.9640.99
276_A279_I0.9630.99
419_G427_M0.9620.99
199_D205_I0.9620.99
339_V386_A0.9610.99
383_H419_G0.9580.99
216_D219_R0.9570.99
160_M187_N0.9570.99
63_G87_N0.9540.99
138_R143_N0.9490.99
418_R441_W0.9490.99
421_T433_F0.9460.99
342_A383_H0.9430.99
303_S352_V0.9400.99
342_A421_T0.9370.99
411_W445_F0.9350.99
313_T386_A0.9320.99
26_I56_L0.9320.99
62_L66_T0.9310.99
293_L364_L0.9310.99
289_I367_F0.9300.99
312_Q384_A0.9250.99
301_K305_P0.9230.99
24_S28_I0.9220.99
369_N374_G0.9200.99
25_D127_R0.9190.99
301_K304_S0.9160.98
455_F461_K0.9140.98
386_A391_Y0.9140.98
450_V457_G0.9140.98
342_A427_M0.9140.98
281_L450_V0.9130.98
399_M402_H0.9110.98
82_A86_Q0.9060.98
190_A199_D0.9010.98
37_C41_G0.9010.98
274_K278_D0.9010.98
36_V114_A0.9010.98
300_V352_V0.9000.98
398_Y427_M0.8980.98
343_T412_A0.8970.98
387_H419_G0.8960.98
293_L368_I0.8940.98
398_Y419_G0.8940.98
277_E377_I0.8910.98
149_V211_A0.8910.98
412_A430_R0.8890.98
387_H433_F0.8890.98
421_T427_M0.8890.98
384_A430_R0.8870.98
73_R138_R0.8860.98
148_A205_I0.8850.98
167_P170_G0.8850.98
191_G195_Q0.8840.98
88_W119_T0.8810.98
35_L39_V0.8790.98
420_E461_K0.8760.98
341_Q384_A0.8750.98
315_Y384_A0.8750.98
59_F91_S0.8690.98
415_N433_F0.8630.98
321_P385_V0.8560.98
427_M431_V0.8550.98
322_I375_M0.8550.98
342_A347_P0.8550.98
179_D219_R0.8530.98
77_A128_S0.8530.98
298_L301_K0.8510.98
416_G441_W0.8500.98
56_L60_Q0.8480.97
385_V388_N0.8450.97
388_N391_Y0.8430.97
341_Q420_E0.8410.97
274_K376_S0.8390.97
151_G211_A0.8360.97
110_K113_L0.8350.97
221_K225_H0.8340.97
398_Y431_V0.8310.97
387_H412_A0.8280.97
185_V188_D0.8240.97
200_A208_V0.8240.97
330_M342_A0.8240.97
123_L126_C0.8240.97
418_R430_R0.8230.97
451_F455_F0.8230.97
299_A303_S0.8220.97
426_K429_K0.8190.97
175_G190_A0.8180.97
79_T82_A0.8170.97
351_K354_N0.8160.97
280_V284_L0.8120.97
315_Y387_H0.8110.97
309_I323_K0.8100.97
146_M204_K0.8090.97
50_L53_L0.8080.97
340_T347_P0.8050.97
412_A427_M0.8050.97
388_N402_H0.8050.97
401_R430_R0.8010.96
62_L87_N0.7990.96
338_V387_H0.7980.96
100_A108_Q0.7970.96
152_D179_D0.7960.96
360_S416_G0.7960.96
360_S430_R0.7940.96
387_H402_H0.7920.96
35_L38_E0.7920.96
58_V91_S0.7910.96
415_N452_L0.7880.96
333_M338_V0.7860.96
37_C40_S0.7840.96
134_A143_N0.7790.96
391_Y401_R0.7790.96
126_C130_I0.7770.96
315_Y385_V0.7760.96
277_E280_V0.7760.96
339_V387_H0.7750.96
352_V355_F0.7750.96
123_L127_R0.7720.96
146_M174_V0.7710.96
28_I123_L0.7700.96
415_N419_G0.7690.96
294_C297_A0.7680.95
134_A138_R0.7680.95
73_R143_N0.7640.95
48_H52_A0.7630.95
270_N441_W0.7610.95
133_G137_L0.7600.95
384_A398_Y0.7580.95
335_N384_A0.7550.95
338_V342_A0.7540.95
338_V383_H0.7530.95
148_A199_D0.7520.95
401_R427_M0.7520.95
337_K387_H0.7510.95
411_W419_G0.7490.95
227_L234_V0.7470.95
66_T87_N0.7460.95
154_A292_V0.7460.95
77_A81_F0.7410.95
383_H402_H0.7400.95
100_A103_N0.7390.94
338_V412_A0.7380.94
304_S352_V0.7380.94
338_V391_Y0.7380.94
80_E127_R0.7370.94
83_L86_Q0.7330.94
341_Q385_V0.7320.94
291_P295_C0.7310.94
117_A121_I0.7300.94
384_A421_T0.7300.94
444_W447_I0.7300.94
100_A110_K0.7280.94
340_T343_T0.7280.94
281_L367_F0.7280.94
222_K226_Q0.7270.94
338_V427_M0.7230.94
197_V200_A0.7230.94
96_A100_A0.7220.94
147_V209_Y0.7220.94
341_Q412_A0.7210.94
186_S189_W0.7210.94
93_I97_G0.7210.94
333_M347_P0.7210.94
335_N341_Q0.7200.94
337_K384_A0.7200.94
196_L200_A0.7200.94
331_K349_V0.7200.94
384_A419_G0.7190.94
156_G211_A0.7170.94
343_T383_H0.7160.93
315_Y383_H0.7150.93
410_G430_R0.7140.93
122_G126_C0.7120.93
198_E201_K0.7120.93
322_I388_N0.7110.93
180_P184_G0.7110.93
121_I124_V0.7110.93
89_T93_I0.7100.93
306_G332_V0.7090.93
293_L367_F0.7070.93
138_R170_G0.7060.93
157_Q161_E0.7060.93
384_A412_A0.7030.93
412_A462_A0.7030.93
159_L209_Y0.7030.93
341_Q419_G0.7020.93
387_H421_T0.7020.93
402_H412_A0.7020.93
285_I450_V0.7010.93
312_Q324_V0.7010.93
289_I296_I0.7000.93
273_L276_A0.7000.93
179_D191_G0.6990.93
219_R222_K0.6980.93
410_G431_V0.6980.93
173_V187_N0.6970.93
312_Q401_R0.6960.93
456_K459_V0.6960.93
391_Y431_V0.6960.93
67_D70_R0.6930.92
334_E342_A0.6930.92
120_S124_V0.6930.92
48_H108_Q0.6930.92
158_M162_S0.6920.92
86_Q90_L0.6910.92
342_A384_A0.6900.92
40_S100_A0.6890.92
29_M123_L0.6890.92
196_L259_V0.6890.92
137_L142_Y0.6890.92
48_H109_L0.6860.92
412_A421_T0.6840.92
48_H107_T0.6840.92
400_L403_K0.6810.92
325_W374_G0.6800.92
337_K342_A0.6780.92
39_V118_L0.6780.92
324_V329_S0.6770.91
388_N401_R0.6760.91
330_M349_V0.6750.91
334_E338_V0.6740.91
87_N91_S0.6730.91
360_S456_K0.6710.91
176_V189_W0.6710.91
300_V308_V0.6700.91
35_L118_L0.6700.91
457_G462_A0.6700.91
338_V341_Q0.6700.91
228_A262_Y0.6690.91
22_R64_G0.6690.91
89_T120_S0.6660.91
300_V361_L0.6660.91
412_A433_F0.6660.91
342_A398_Y0.6620.91
145_R207_N0.6620.91
311_R324_V0.6610.90
343_T419_G0.6610.90
152_D189_W0.6600.90
411_W449_I0.6580.90
402_H430_R0.6540.90
143_N170_G0.6530.90
334_E340_T0.6520.90
148_A190_A0.6510.90
302_L305_P0.6500.90
156_G178_H0.6480.90
334_E341_Q0.6470.90
429_K433_F0.6470.90
301_K307_P0.6470.90
191_G199_D0.6460.89
312_Q335_N0.6450.89
282_A377_I0.6450.89
153_L180_P0.6450.89
387_H398_Y0.6440.89
257_P439_R0.6440.89
35_L122_G0.6430.89
436_E445_F0.6410.89
156_G179_D0.6410.89
324_V388_N0.6410.89
370_V450_V0.6400.89
276_A280_V0.6330.88
342_A462_A0.6320.88
299_A355_F0.6300.88
30_F34_W0.6270.88
401_R412_A0.6270.88
180_P219_R0.6260.88
286_L293_L0.6250.88
400_L435_L0.6240.88
159_L163_F0.6230.88
388_N427_M0.6210.88
119_T122_G0.6200.87
296_I352_V0.6190.87
315_Y322_I0.6180.87
456_K460_N0.6170.87
34_W38_E0.6150.87
339_V384_A0.6140.87
378_V414_I0.6100.87
346_D349_V0.6090.87
209_Y258_V0.6060.86
412_A415_N0.6060.86
130_I133_G0.6050.86
293_L296_I0.6050.86
390_Q393_Q0.6050.86
291_P367_F0.6020.86
284_L288_L0.6020.86
391_Y402_H0.6010.86
113_L117_A0.6000.86
303_S356_L0.6000.86
197_V201_K0.6000.86
342_A388_N0.5980.86
213_Q216_D0.5970.85
32_G40_S0.5960.85
235_L260_P0.5950.85
40_S103_N0.5950.85
350_T354_N0.5930.85
282_A287_L0.5930.85
288_L291_P0.5930.85
418_R427_M0.5920.85
293_L297_A0.5890.85
178_H219_R0.5890.85
147_V207_N0.5880.85
52_A56_L0.5870.84
84_L123_L0.5870.84
388_N420_E0.5870.84
162_S255_G0.5860.84
313_T385_V0.5840.84
295_C303_S0.5840.84
360_S427_M0.5840.84
418_R421_T0.5840.84
391_Y421_T0.5830.84
325_W368_I0.5830.84
95_S99_V0.5830.84
312_Q383_H0.5820.84
134_A141_G0.5820.84
305_P331_K0.5790.84
402_H421_T0.5780.84
39_V112_W0.5780.84
108_Q112_W0.5770.83
193_L197_V0.5750.83
402_H427_M0.5740.83
280_V283_T0.5740.83
218_A222_K0.5730.83
338_V398_Y0.5730.83
410_G413_Q0.5720.83
289_I327_F0.5720.83
322_I325_W0.5710.83
442_S445_F0.5710.83
210_I220_V0.5700.83
344_Q347_P0.5700.83
342_A420_E0.5690.83
388_N426_K0.5680.83
103_N107_T0.5670.82
293_L300_V0.5660.82
101_F113_L0.5660.82
26_I30_F0.5650.82
427_M433_F0.5640.82
171_F207_N0.5630.82
292_V295_C0.5630.82
36_V122_G0.5630.82
334_E384_A0.5620.82
341_Q421_T0.5610.82
419_G433_F0.5610.82
334_E347_P0.5600.82
92_V288_L0.5600.82
430_R441_W0.5600.82
101_F183_G0.5590.82
125_V198_E0.5570.81
297_A300_V0.5560.81
383_H421_T0.5560.81
312_Q427_M0.5540.81
383_H411_W0.5540.81
388_N430_R0.5530.81
179_D193_L0.5530.81
420_E427_M0.5530.81
450_V454_V0.5520.81
342_A401_R0.5510.81
310_F385_V0.5510.81
274_K441_W0.5510.81
386_A427_M0.5500.80
209_Y301_K0.5500.80
60_Q69_Y0.5500.80
200_A205_I0.5480.80
275_R405_K0.5450.80
335_N342_A0.5440.80
116_Y119_T0.5430.80
315_Y420_E0.5420.80
304_S350_T0.5400.79
227_L231_T0.5400.79
233_S260_P0.5400.79
343_T384_A0.5390.79
323_K374_G0.5390.79
34_W37_C0.5390.79
435_L439_R0.5390.79
380_P430_R0.5390.79
97_G101_F0.5390.79
341_Q388_N0.5360.79
301_K332_V0.5340.79
317_M405_K0.5340.79
32_G35_L0.5340.79
31_A35_L0.5340.79
176_V187_N0.5320.78
360_S457_G0.5320.78
207_N233_S0.5320.78
344_Q420_E0.5320.78
301_K309_I0.5320.78
236_L261_L0.5310.78
128_S132_I0.5310.78
367_F456_K0.5310.78
387_H390_Q0.5300.78
334_E339_V0.5290.78
343_T420_E0.5290.78
63_G123_L0.5290.78
73_R141_G0.5280.78
127_R131_R0.5280.78
100_A107_T0.5280.78
383_H406_P0.5270.78
456_K462_A0.5270.78
152_D176_V0.5270.78
341_Q392_R0.5260.77
387_H401_R0.5260.77
275_R278_D0.5250.77
45_L121_I0.5250.77
65_I405_K0.5240.77
279_I286_L0.5220.77
401_R410_G0.5220.77
324_V383_H0.5210.77
281_L284_L0.5210.77
286_L371_L0.5210.77
384_A402_H0.5200.77
46_Y161_E0.5190.77
179_D192_N0.5190.77
386_A431_V0.5180.76
385_V401_R0.5180.76
383_H426_K0.5170.76
337_K419_G0.5150.76
157_Q185_V0.5140.76
36_V111_I0.5140.76
303_S329_S0.5120.76
351_K355_F0.5110.75
318_D403_K0.5110.75
109_L113_L0.5110.75
302_L351_K0.5110.75
129_C133_G0.5110.75
62_L65_I0.5100.75
251_E260_P0.5070.75
306_G350_T0.5070.75
403_K439_R0.5070.75
310_F387_H0.5060.75
383_H390_Q0.5050.75
221_K234_V0.5040.74
344_Q391_Y0.5040.74
385_V427_M0.5040.74
88_W123_L0.5040.74
308_V327_F0.5030.74
309_I374_G0.5030.74
40_S108_Q0.5030.74
33_L52_A0.5030.74
25_D32_G0.5030.74
121_I125_V0.5020.74
398_Y421_T0.5020.74
312_Q373_G0.5010.74
29_M59_F0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nklA 2 0.2392 99.2 0.905 Contact Map
3keoA 2 0.4246 98 0.934 Contact Map
3wg9A 2 0.4353 97.8 0.938 Contact Map
2dt5A 3 0.4289 97.6 0.94 Contact Map
2vt3A 2 0.431 97.5 0.942 Contact Map
2py6A 4 0.6185 97.3 0.944 Contact Map
4m98A 3 0.4397 96.8 0.948 Contact Map
4rv9A 1 0.5237 95.3 0.954 Contact Map
4ea9A 3 0.4159 92.6 0.959 Contact Map
3ff4A 1 0.2414 89.9 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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