GREMLIN Database
WCAE - Putative colanic acid biosynthesis glycosyl transferase WcaE
UniProt: P71239 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13573
Length: 248 (201)
Sequences: 41465 (34730)
Seq/√Len: 2449.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_V158_K3.2381.00
12_N91_S2.9261.00
13_L46_G2.6791.00
173_A177_K2.4131.00
102_F190_G2.4041.00
76_K80_M2.2331.00
4_S83_G2.2241.00
9_A47_T2.1911.00
27_A101_N2.1331.00
79_A161_R2.0441.00
35_E61_R2.0161.00
48_R52_E1.9941.00
40_D64_S1.9831.00
96_H194_E1.9711.00
17_V21_A1.9521.00
39_V77_G1.9341.00
18_K196_S1.8931.00
112_N186_K1.8881.00
6_I77_G1.8681.00
7_T36_W1.8551.00
68_N72_D1.8151.00
11_R44_N1.7761.00
95_F99_A1.7431.00
4_S35_E1.7421.00
156_G183_Y1.7381.00
46_G49_E1.7341.00
48_R64_S1.7231.00
74_M90_N1.7151.00
103_V151_F1.6811.00
106_L188_L1.6731.00
63_V80_M1.6731.00
18_K94_I1.6591.00
72_D164_L1.6511.00
17_V54_L1.6341.00
3_L104_R1.6301.00
13_L50_Y1.6071.00
40_D43_S1.6021.00
87_L151_F1.5971.00
61_R80_M1.5891.00
70_I74_M1.5641.00
98_N102_F1.5401.00
99_A103_V1.5361.00
85_F151_F1.5281.00
106_L186_K1.5231.00
120_L194_E1.5191.00
17_V53_N1.5151.00
113_V153_P1.5141.00
7_T19_T1.5061.00
52_E64_S1.4861.00
38_V51_L1.4801.00
31_D104_R1.4751.00
76_K79_A1.4581.00
17_V50_Y1.4491.00
21_A54_L1.4441.00
48_R62_F1.4341.00
85_F107_K1.4331.00
21_A25_H1.4241.00
35_E83_G1.4131.00
159_K181_A1.4101.00
94_I194_E1.4031.00
71_Y170_S1.3991.00
89_L95_F1.3711.00
113_V183_Y1.3651.00
63_V76_K1.3611.00
9_A38_V1.3571.00
101_N105_K1.3481.00
114_M185_F1.3361.00
10_F67_D1.3361.00
87_L99_A1.3231.00
3_L100_A1.3171.00
155_S159_K1.3171.00
22_S95_F1.3151.00
102_F105_K1.3141.00
87_L100_A1.3141.00
163_D173_A1.3101.00
78_I157_L1.2731.00
106_L109_Q1.2701.00
65_E68_N1.2541.00
4_S81_A1.2451.00
9_A12_N1.2421.00
11_R43_S1.2411.00
86_A154_V1.2201.00
52_E55_N1.2091.00
159_K183_Y1.1861.00
31_D34_F1.1811.00
41_G67_D1.1681.00
65_E76_K1.1651.00
74_M88_F1.1591.00
150_I175_A1.1481.00
81_A154_V1.1461.00
9_A91_S1.1381.00
156_G178_M1.1321.00
12_N15_G1.1281.00
84_K153_P1.1171.00
20_H36_W1.1011.00
94_I196_S1.0981.00
155_S158_K1.0971.00
118_D187_K1.0891.00
98_N101_N1.0801.00
70_I170_S1.0681.00
87_L95_F1.0671.00
39_V73_A1.0651.00
103_V117_G1.0611.00
40_D48_R1.0571.00
111_D184_A1.0531.00
78_I88_F1.0471.00
35_E82_Q1.0451.00
50_Y54_L1.0401.00
19_T89_L1.0261.00
3_L151_F1.0231.00
122_D194_E1.0211.00
27_A31_D1.0151.00
123_F127_H1.0041.00
49_E52_E0.9851.00
22_S94_I0.9771.00
94_I122_D0.9691.00
25_H97_Q0.9671.00
78_I86_A0.9651.00
114_M178_M0.9611.00
153_P156_G0.9571.00
8_V73_A0.9561.00
198_G201_S0.9551.00
27_A98_N0.9541.00
4_S37_I0.9451.00
122_D126_G0.9341.00
49_E53_N0.9311.00
50_Y53_N0.9311.00
53_N57_I0.9291.00
51_L62_F0.9241.00
46_G50_Y0.9231.00
74_M170_S0.9221.00
109_Q112_N0.9191.00
103_V115_I0.9191.00
21_A24_A0.9141.00
102_F188_L0.8991.00
119_A148_Q0.8981.00
61_R82_Q0.8971.00
24_A54_L0.8971.00
157_L174_L0.8961.00
106_L115_I0.8931.00
23_L89_L0.8891.00
20_H54_L0.8891.00
36_W60_L0.8881.00
65_E72_D0.8841.00
120_L191_L0.8801.00
55_N60_L0.8791.00
85_F104_R0.8641.00
99_A117_G0.8611.00
113_V184_A0.8561.00
41_G73_A0.8501.00
5_I23_L0.8481.00
107_K110_K0.8381.00
24_A60_L0.8271.00
41_G69_G0.8161.00
70_I147_H0.8111.00
70_I202_T0.8111.00
96_H120_L0.8091.00
71_Y75_N0.8021.00
72_D76_K0.7981.00
27_A32_I0.7971.00
34_F100_A0.7961.00
23_L36_W0.7951.00
105_K108_M0.7911.00
53_N56_G0.7901.00
68_N73_A0.7861.00
70_I90_N0.7861.00
24_A57_I0.7811.00
160_W178_M0.7761.00
102_F106_L0.7721.00
15_G196_S0.7681.00
160_W181_A0.7601.00
5_I87_L0.7591.00
78_I81_A0.7581.00
19_T22_S0.7541.00
156_G160_W0.7521.00
99_A192_V0.7511.00
9_A51_L0.7481.00
39_V76_K0.7401.00
9_A16_I0.7351.00
42_G65_E0.7341.00
147_H162_Y0.7331.00
41_G68_N0.7311.00
18_K21_A0.7281.00
122_D196_S0.7261.00
107_K151_F0.7191.00
37_I77_G0.7171.00
24_A59_N0.7131.00
208_L211_D0.7111.00
113_V156_G0.7111.00
34_F59_N0.7071.00
123_F126_G0.7071.00
27_A97_Q0.7061.00
75_N161_R0.7041.00
117_G192_V0.7001.00
174_L178_M0.6981.00
23_L95_F0.6971.00
7_T23_L0.6971.00
20_H38_V0.6951.00
147_H150_I0.6931.00
88_F162_Y0.6901.00
73_A76_K0.6891.00
55_N62_F0.6881.00
51_L55_N0.6881.00
96_H99_A0.6851.00
70_I73_A0.6801.00
20_H24_A0.6781.00
75_N164_L0.6771.00
152_F175_A0.6751.00
84_K155_S0.6711.00
75_N162_Y0.6691.00
54_L57_I0.6681.00
12_N198_G0.6641.00
52_E62_F0.6611.00
157_L161_R0.6581.00
105_K109_Q0.6571.00
64_S76_K0.6551.00
93_D195_F0.6541.00
107_K112_N0.6531.00
148_Q193_S0.6521.00
96_H192_V0.6501.00
37_I80_M0.6501.00
21_A57_I0.6501.00
117_G149_A0.6451.00
78_I161_R0.6441.00
16_I50_Y0.6421.00
13_L17_V0.6401.00
106_L112_N0.6381.00
31_D101_N0.6371.00
81_A86_A0.6371.00
10_F41_G0.6351.00
8_V91_S0.6311.00
116_T187_K0.6311.00
5_I100_A0.6291.00
121_L197_M0.6281.00
201_S204_N0.6271.00
104_R151_F0.6261.00
161_R174_L0.6251.00
42_G67_D0.6231.00
107_K115_I0.6221.00
156_G159_K0.6211.00
138_Y141_H0.6191.00
152_F174_L0.6181.00
5_I34_F0.6171.00
27_A34_F0.6151.00
68_N76_K0.6151.00
48_R51_L0.6141.00
118_D189_N0.6131.00
141_H184_A0.6131.00
8_V41_G0.6131.00
3_L87_L0.6101.00
19_T23_L0.6101.00
178_M183_Y0.6101.00
37_I81_A0.6081.00
16_I91_S0.6051.00
208_L212_A0.5981.00
4_S82_Q0.5931.00
109_Q184_A0.5911.00
188_L191_L0.5871.00
52_E56_G0.5861.00
163_D177_K0.5851.00
15_G198_G0.5841.00
85_F153_P0.5841.00
37_I61_R0.5821.00
104_R107_K0.5811.00
99_A149_A0.5791.00
16_I51_L0.5721.00
75_N79_A0.5691.00
8_V74_M0.5661.00
13_L16_I0.5641.00
26_L101_N0.5571.00
107_K153_P0.5561.00
152_F157_L0.5531.00
158_K161_R0.5521.00
116_T145_A0.5511.00
17_V57_I0.5511.00
87_L149_A0.5491.00
106_L110_K0.5481.00
129_I136_G0.5441.00
13_L45_D0.5431.00
95_F100_A0.5401.00
31_D100_A0.5371.00
13_L49_E0.5361.00
110_K186_K0.5341.00
139_I142_S0.5301.00
89_L93_D0.5241.00
145_A175_A0.5231.00
113_V182_G0.5231.00
169_S172_Y0.5221.00
156_G182_G0.5221.00
19_T92_G0.5191.00
209_C212_A0.5131.00
113_V155_S0.5131.00
6_I39_V0.5121.00
73_A90_N0.5111.00
34_F83_G0.5051.00
26_L100_A0.5031.00
112_N153_P0.5031.00
191_L194_E0.5031.00
24_A36_W0.5011.00
148_Q195_F0.5011.00
149_A193_S0.5001.00
8_V70_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.6895 100 0.255 Contact Map
3l7iA 4 0 100 0.257 Contact Map
1qg8A 1 0.871 100 0.295 Contact Map
2z86A 2 0.9758 100 0.301 Contact Map
2d7iA 1 0.9879 100 0.302 Contact Map
1xhbA 1 0.9556 100 0.302 Contact Map
5ajoA 1 0.9798 100 0.318 Contact Map
4fixA 3 0.9839 100 0.351 Contact Map
4p02A 1 0.9597 100 0.375 Contact Map
3ckjA 2 0.9234 100 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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