WCAC - ECOLI - GREMLIN Contacts

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WCAC - Putative colanic acid biosynthesis glycosyl transferase WcaC

UniProt:	P71237	Sequences: MNILQFNVRLAEGGAAGVALDLHQRALQQGLASHFVYGYGKGGKESVSHQNYPQVIKHTPRMTAMANIALFRLFNRDLFGNFNELYRTITRTAGPVVLHFHVLHSYWLNLKSVVRFCEKVKNHKPDVTLVWTLHDHWSVTGRCAFTDGCEGWKTGCQKCPTLNNYPPVKIDRAHQLVAGKRQLFREMLALGCQFISPSQHVADAFNSLYGPGRCRIINNGIDMATEAILADLPPVRETQGKPKIAVVAHDLRYDGKTNQQLVREMMALGDKIELHTFGKFSPFTAGNVVNHGFETDKRKLMSALNQMDALVFSSRVDNYPLILCEALSIGVPVIATHSDAAREVLQKSGGKTVSEEEVLQLVQLSKPEIAQAIFGTTLAEFSQRSRAAYSGQQMLEEYVNFYQNL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13571
Length:	405 (341)
Sequences:	50841 (43031)
Seq/√Len:	2330.2

ECOLI - WCAC GLGA WCAL RFAG RFAB WCAI WBBK
BACSU - YPJH TUAC GLGA YTCC YQGM EPSF EPSD COTSA TUAH YKVP CGEB TAGE
HALSA - Q9HQQ0 Q9HSW1 Q9HS45 Q9HRP8 Q9HSV4 Q9HQT2 Q9HSV2 Q9HRP9
SULSO - Q97UM0 Q97V61 Q97XT7 Q97XT8 Q980C8 Q97VL4 Q97V80 Q97UU3 Q97ZD3 Q7LXF8 Q7LXI2 Q7LXM9 Q97XU2 Q97XT5 Q97XT9 Q97XF6 Q97XT1 Q97XT6 Q7LXF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
245_A	307_M	4.774	1.00
273_E	289_V	3.790	1.00
193_Q	215_R	3.356	1.00
310_L	326_A	3.232	1.00
243_K	275_H	3.000	1.00
99_H	402_Y	2.959	1.00
267_A	362_V	2.815	1.00
241_K	273_E	2.790	1.00
275_H	291_H	2.715	1.00
246_V	258_N	2.710	1.00
382_S	386_R	2.411	1.00
263_R	358_V	2.406	1.00
34_H	95_P	2.292	1.00
384_R	388_A	2.244	1.00
257_T	260_Q	2.243	1.00
34_H	93_A	2.221	1.00
242_P	369_I	2.201	1.00
337_H	342_R	2.167	1.00
269_G	287_N	2.113	1.00
345_L	350_G	2.110	1.00
364_L	367_P	2.103	1.00
277_F	303_A	2.098	1.00
275_H	289_V	2.071	1.00
243_K	306_Q	2.060	1.00
243_K	273_E	2.031	1.00
267_A	359_L	2.006	1.00
371_Q	374_F	2.003	1.00
265_M	274_L	1.998	1.00
31_L	399_V	1.993	1.00
244_I	309_A	1.976	1.00
4_L	95_P	1.975	1.00
99_H	132_T	1.971	1.00
367_P	374_F	1.966	1.00
250_D	253_Y	1.932	1.00
242_P	308_D	1.885	1.00
393_Q	397_E	1.865	1.00
375_G	379_A	1.843	1.00
351_K	364_L	1.837	1.00
354_S	360_Q	1.832	1.00
367_P	371_Q	1.816	1.00
337_H	354_S	1.797	1.00
220_G	391_G	1.774	1.00
29_Q	396_E	1.771	1.00
199_Q	202_A	1.758	1.00
193_Q	401_F	1.742	1.00
202_A	216_I	1.741	1.00
261_L	274_L	1.730	1.00
310_L	331_V	1.708	1.00
294_E	299_K	1.706	1.00
247_V	300_L	1.691	1.00
196_S	214_C	1.688	1.00
346_Q	349_G	1.685	1.00
257_T	315_R	1.673	1.00
199_Q	343_E	1.656	1.00
366_K	370_A	1.642	1.00
25_R	392_Q	1.612	1.00
383_Q	387_A	1.608	1.00
265_M	272_I	1.605	1.00
382_S	385_S	1.594	1.00
20_L	24_Q	1.589	1.00
261_L	311_V	1.586	1.00
357_E	360_Q	1.579	1.00
351_K	367_P	1.579	1.00
268_L	366_K	1.578	1.00
25_R	395_L	1.572	1.00
296_D	299_K	1.569	1.00
202_A	214_C	1.568	1.00
25_R	28_Q	1.566	1.00
4_L	36_V	1.552	1.00
330_G	382_S	1.550	1.00
279_K	283_F	1.546	1.00
360_Q	364_L	1.535	1.00
299_K	302_S	1.534	1.00
199_Q	216_I	1.521	1.00
374_F	377_T	1.518	1.00
255_G	316_V	1.506	1.00
29_Q	399_V	1.505	1.00
277_F	291_H	1.451	1.00
335_A	341_A	1.448	1.00
294_E	303_A	1.435	1.00
307_M	331_V	1.423	1.00
260_Q	358_V	1.415	1.00
251_L	276_T	1.403	1.00
275_H	303_A	1.391	1.00
243_K	308_D	1.386	1.00
264_E	361_L	1.377	1.00
353_V	364_L	1.375	1.00
244_I	365_S	1.368	1.00
383_Q	386_R	1.364	1.00
385_S	388_A	1.362	1.00
131_W	187_M	1.360	1.00
277_F	294_E	1.358	1.00
358_V	362_V	1.354	1.00
196_S	202_A	1.348	1.00
244_I	311_V	1.343	1.00
301_M	329_I	1.342	1.00
100_F	129_L	1.341	1.00
267_A	358_V	1.341	1.00
291_H	294_E	1.340	1.00
245_A	277_F	1.337	1.00
246_V	261_L	1.336	1.00
5_Q	26_A	1.335	1.00
195_I	398_Y	1.332	1.00
258_N	276_T	1.319	1.00
5_Q	101_H	1.297	1.00
393_Q	396_E	1.296	1.00
397_E	400_N	1.296	1.00
275_H	307_M	1.281	1.00
199_Q	203_D	1.237	1.00
195_I	401_F	1.229	1.00
319_Y	324_C	1.229	1.00
242_P	309_A	1.224	1.00
85_L	88_T	1.219	1.00
360_Q	363_Q	1.216	1.00
226_E	329_I	1.215	1.00
18_V	321_L	1.214	1.00
323_L	341_A	1.210	1.00
83_N	87_R	1.204	1.00
55_V	59_T	1.196	1.00
134_H	321_L	1.196	1.00
312_F	323_L	1.184	1.00
376_T	380_E	1.177	1.00
349_G	384_R	1.169	1.00
339_D	342_R	1.156	1.00
25_R	29_Q	1.154	1.00
242_P	272_I	1.153	1.00
305_N	329_I	1.150	1.00
362_V	366_K	1.150	1.00
225_T	301_M	1.145	1.00
372_A	375_G	1.141	1.00
381_F	384_R	1.139	1.00
390_S	393_Q	1.130	1.00
260_Q	315_R	1.127	1.00
260_Q	336_T	1.120	1.00
300_L	304_L	1.120	1.00
27_L	30_G	1.114	1.00
312_F	322_I	1.112	1.00
336_T	353_V	1.112	1.00
197_P	201_V	1.111	1.00
374_F	378_L	1.108	1.00
335_A	352_T	1.108	1.00
313_S	361_L	1.106	1.00
260_Q	356_E	1.104	1.00
259_Q	263_R	1.102	1.00
197_P	219_N	1.101	1.00
346_Q	384_R	1.100	1.00
196_S	205_F	1.099	1.00
368_E	378_L	1.096	1.00
347_K	364_L	1.094	1.00
260_Q	263_R	1.092	1.00
394_M	397_E	1.090	1.00
353_V	361_L	1.087	1.00
242_P	271_K	1.084	1.00
351_K	378_L	1.083	1.00
241_K	271_K	1.082	1.00
243_K	307_M	1.079	1.00
253_Y	281_S	1.077	1.00
297_K	300_L	1.077	1.00
330_G	380_E	1.076	1.00
280_F	283_F	1.076	1.00
391_G	394_M	1.075	1.00
275_H	306_Q	1.073	1.00
304_L	329_I	1.069	1.00
21_D	24_Q	1.063	1.00
101_H	134_H	1.062	1.00
331_V	379_A	1.060	1.00
5_Q	23_H	1.059	1.00
100_F	131_W	1.049	1.00
327_L	333_V	1.048	1.00
21_D	391_G	1.047	1.00
310_L	322_I	1.044	1.00
247_V	277_F	1.043	1.00
314_S	317_D	1.042	1.00
245_A	303_A	1.042	1.00
291_H	303_A	1.040	1.00
315_R	356_E	1.037	1.00
210_G	213_R	1.033	1.00
244_I	265_M	1.033	1.00
247_V	304_L	1.033	1.00
301_M	305_N	1.032	1.00
250_D	255_G	1.030	1.00
394_M	398_Y	1.022	1.00
363_Q	367_P	1.020	1.00
340_A	343_E	1.017	1.00
197_P	318_N	1.013	1.00
335_A	345_L	0.997	1.00
268_L	272_I	0.994	1.00
260_Q	361_L	0.993	1.00
351_K	368_E	0.992	1.00
268_L	365_S	0.990	1.00
379_A	382_S	0.986	1.00
320_P	341_A	0.985	1.00
219_N	321_L	0.979	1.00
334_I	353_V	0.977	1.00
265_M	287_N	0.973	1.00
220_G	394_M	0.973	1.00
196_S	201_V	0.973	1.00
261_L	313_S	0.968	1.00
23_H	35_F	0.966	1.00
246_V	276_T	0.963	1.00
226_E	301_M	0.961	1.00
18_V	134_H	0.958	1.00
13_G	16_A	0.955	1.00
279_K	293_F	0.953	1.00
3_I	31_L	0.952	1.00
326_A	331_V	0.949	1.00
273_E	287_N	0.948	1.00
266_M	269_G	0.948	1.00
17_G	21_D	0.946	1.00
317_D	320_P	0.946	1.00
223_M	390_S	0.945	1.00
272_I	369_I	0.942	1.00
351_K	374_F	0.938	1.00
268_L	369_I	0.938	1.00
267_A	270_D	0.932	1.00
396_E	400_N	0.931	1.00
327_L	349_G	0.927	1.00
130_V	195_I	0.917	1.00
323_L	344_V	0.916	1.00
372_A	376_T	0.915	1.00
309_A	368_E	0.909	1.00
19_A	101_H	0.908	1.00
354_S	357_E	0.899	1.00
23_H	27_L	0.895	1.00
246_V	313_S	0.894	1.00
264_E	362_V	0.894	1.00
222_D	225_T	0.891	1.00
266_M	270_D	0.887	1.00
323_L	333_V	0.885	1.00
268_L	362_V	0.884	1.00
323_L	335_A	0.880	1.00
114_V	117_C	0.879	1.00
384_R	387_A	0.877	1.00
376_T	379_A	0.872	1.00
334_I	364_L	0.871	1.00
345_L	352_T	0.870	1.00
311_V	365_S	0.869	1.00
381_F	385_S	0.868	1.00
312_F	341_A	0.867	1.00
115_R	118_E	0.867	1.00
338_S	341_A	0.866	1.00
17_G	297_K	0.864	1.00
256_K	317_D	0.864	1.00
245_A	304_L	0.862	1.00
18_V	132_T	0.856	1.00
215_R	401_F	0.855	1.00
263_R	267_A	0.855	1.00
128_T	192_C	0.853	1.00
332_P	379_A	0.850	1.00
195_I	217_I	0.847	1.00
86_Y	89_I	0.847	1.00
304_L	331_V	0.846	1.00
218_N	343_E	0.842	1.00
380_E	383_Q	0.842	1.00
113_V	117_C	0.842	1.00
256_K	322_I	0.841	1.00
248_A	258_N	0.837	1.00
264_E	358_V	0.834	1.00
29_Q	392_Q	0.834	1.00
34_H	38_G	0.833	1.00
215_R	397_E	0.832	1.00
309_A	365_S	0.832	1.00
256_K	314_S	0.830	1.00
222_D	226_E	0.830	1.00
21_D	222_D	0.825	1.00
332_P	368_E	0.822	1.00
337_H	352_T	0.821	1.00
178_A	181_R	0.821	1.00
200_H	203_D	0.813	1.00
303_A	306_Q	0.813	1.00
390_S	394_M	0.812	1.00
84_E	88_T	0.811	1.00
217_I	401_F	0.810	1.00
182_Q	186_E	0.807	1.00
392_Q	396_E	0.807	1.00
114_V	118_E	0.806	1.00
246_V	310_L	0.803	1.00
302_S	305_N	0.802	1.00
18_V	219_N	0.801	1.00
135_D	255_G	0.798	1.00
97_V	402_Y	0.797	1.00
218_N	397_E	0.796	1.00
239_Q	242_P	0.795	1.00
21_D	25_R	0.795	1.00
302_S	306_Q	0.791	1.00
359_L	363_Q	0.790	1.00
396_E	399_V	0.787	1.00
263_R	266_M	0.787	1.00
134_H	197_P	0.785	1.00
13_G	250_D	0.778	1.00
197_P	321_L	0.777	1.00
246_V	274_L	0.776	1.00
130_V	193_Q	0.773	1.00
200_H	204_A	0.769	1.00
363_Q	366_K	0.769	1.00
69_A	73_L	0.768	1.00
308_D	375_G	0.767	1.00
101_H	132_T	0.765	1.00
320_P	323_L	0.762	1.00
398_Y	402_Y	0.761	1.00
7_N	15_A	0.757	1.00
52_Y	55_V	0.757	1.00
180_K	184_F	0.756	1.00
391_G	395_L	0.755	1.00
7_N	19_A	0.753	1.00
181_R	185_R	0.753	1.00
17_G	20_L	0.747	1.00
367_P	370_A	0.747	1.00
247_V	310_L	0.747	1.00
29_Q	395_L	0.746	1.00
5_Q	33_S	0.738	1.00
345_L	349_G	0.734	1.00
312_F	320_P	0.731	1.00
244_I	272_I	0.727	1.00
34_H	56_I	0.727	1.00
27_L	33_S	0.724	1.00
22_L	398_Y	0.724	1.00
336_T	355_E	0.721	1.00
259_Q	315_R	0.721	1.00
297_K	301_M	0.721	1.00
130_V	402_Y	0.720	1.00
68_I	72_R	0.717	1.00
342_R	352_T	0.715	1.00
334_I	368_E	0.711	1.00
229_L	305_N	0.710	1.00
217_I	398_Y	0.708	1.00
18_V	398_Y	0.707	1.00
368_E	375_G	0.699	1.00
347_K	351_K	0.698	1.00
254_D	259_Q	0.698	1.00
324_C	389_Y	0.698	1.00
373_I	377_T	0.697	1.00
218_N	389_Y	0.697	1.00
319_Y	389_Y	0.693	1.00
271_K	287_N	0.693	1.00
203_D	206_N	0.691	1.00
97_V	130_V	0.691	1.00
23_H	33_S	0.689	1.00
129_L	187_M	0.689	1.00
294_E	300_L	0.689	1.00
257_T	313_S	0.688	1.00
67_N	71_F	0.687	1.00
336_T	361_L	0.687	1.00
251_L	283_F	0.687	1.00
327_L	385_S	0.685	1.00
244_I	369_I	0.685	1.00
134_H	219_N	0.681	1.00
242_P	372_A	0.681	1.00
349_G	381_F	0.681	1.00
359_L	362_V	0.677	1.00
206_N	209_Y	0.677	1.00
132_T	398_Y	0.677	1.00
215_R	218_N	0.676	1.00
55_V	58_H	0.675	1.00
371_Q	375_G	0.672	1.00
125_P	128_T	0.672	1.00
349_G	385_S	0.671	1.00
200_H	342_R	0.670	1.00
5_Q	99_H	0.670	1.00
348_S	367_P	0.667	1.00
270_D	366_K	0.666	1.00
99_H	398_Y	0.665	1.00
9_R	16_A	0.665	1.00
377_T	380_E	0.664	1.00
262_V	288_V	0.663	1.00
264_E	365_S	0.662	1.00
28_Q	392_Q	0.662	1.00
170_I	173_A	0.661	1.00
51_N	55_V	0.661	1.00
248_A	256_K	0.659	1.00
311_V	361_L	0.653	1.00
217_I	397_E	0.652	1.00
303_A	307_M	0.650	1.00
395_L	399_V	0.649	1.00
337_H	355_E	0.648	1.00
174_H	177_V	0.647	1.00
353_V	360_Q	0.645	1.00
274_L	288_V	0.645	1.00
66_A	69_A	0.644	1.00
223_M	328_S	0.641	1.00
15_A	102_V	0.640	1.00
30_G	399_V	0.640	1.00
198_S	201_V	0.639	1.00
178_A	182_Q	0.639	1.00
49_H	52_Y	0.638	1.00
265_M	268_L	0.637	1.00
327_L	379_A	0.636	1.00
98_L	127_V	0.635	1.00
310_L	333_V	0.634	1.00
174_H	178_A	0.631	1.00
196_S	216_I	0.629	1.00
242_P	245_A	0.628	1.00
254_D	315_R	0.626	1.00
384_R	389_Y	0.625	1.00
27_L	31_L	0.624	1.00
309_A	334_I	0.624	1.00
251_L	258_N	0.624	1.00
304_L	322_I	0.622	1.00
67_N	70_L	0.620	1.00
242_P	375_G	0.619	1.00
245_A	310_L	0.617	1.00
264_E	268_L	0.617	1.00
5_Q	402_Y	0.616	1.00
308_D	372_A	0.613	1.00
21_D	321_L	0.611	1.00
25_R	391_G	0.609	1.00
327_L	381_F	0.609	1.00
91_R	125_P	0.607	1.00
170_I	174_H	0.605	1.00
177_V	181_R	0.603	1.00
334_I	365_S	0.602	1.00
129_L	192_C	0.601	1.00
56_I	59_T	0.600	1.00
85_L	89_I	0.599	1.00
224_A	227_A	0.599	1.00
388_A	393_Q	0.598	1.00
375_G	378_L	0.597	1.00
24_Q	28_Q	0.596	1.00
113_V	116_F	0.596	1.00
95_P	127_V	0.595	1.00
243_K	303_A	0.594	1.00
257_T	356_E	0.594	1.00
4_L	34_H	0.591	1.00
18_V	22_L	0.591	1.00
338_S	355_E	0.590	1.00
132_T	195_I	0.590	1.00
313_S	336_T	0.588	1.00
135_D	138_S	0.585	1.00
24_Q	27_L	0.585	1.00
324_C	344_V	0.584	1.00
124_K	127_V	0.584	1.00
136_H	139_V	0.583	1.00
309_A	369_I	0.583	1.00
304_L	310_L	0.582	1.00
83_N	86_Y	0.581	1.00
373_I	376_T	0.581	1.00
182_Q	185_R	0.580	1.00
326_A	333_V	0.579	1.00
225_T	297_K	0.578	1.00
53_P	56_I	0.578	1.00
199_Q	218_N	0.578	1.00
322_I	326_A	0.577	1.00
245_A	275_H	0.577	1.00
227_A	230_A	0.575	1.00
97_V	128_T	0.572	1.00
227_A	305_N	0.572	1.00
4_L	93_A	0.568	1.00
260_Q	264_E	0.568	1.00
250_D	256_K	0.567	1.00
257_T	336_T	0.567	1.00
378_L	381_F	0.567	1.00
218_N	319_Y	0.567	1.00
261_L	265_M	0.565	1.00
10_L	20_L	0.565	1.00
179_G	182_Q	0.563	1.00
177_V	180_K	0.562	1.00
388_A	397_E	0.556	1.00
18_V	101_H	0.555	1.00
222_D	391_G	0.555	1.00
338_S	342_R	0.551	1.00
240_G	271_K	0.550	1.00
300_L	303_A	0.550	1.00
254_D	282_P	0.549	1.00
320_P	324_C	0.549	1.00
187_M	192_C	0.548	1.00
245_A	331_V	0.547	1.00
136_H	201_V	0.546	1.00
180_K	183_L	0.545	1.00
277_F	300_L	0.544	1.00
247_V	322_I	0.544	1.00
201_V	204_A	0.543	1.00
193_Q	197_P	0.543	1.00
377_T	381_F	0.542	1.00
226_E	328_S	0.542	1.00
330_G	379_A	0.540	1.00
381_F	386_R	0.540	1.00
22_L	25_R	0.539	1.00
132_T	402_Y	0.538	1.00
68_I	71_F	0.536	1.00
133_L	201_V	0.535	1.00
65_M	70_L	0.534	1.00
278_G	292_G	0.532	1.00
223_M	386_R	0.531	1.00
21_D	220_G	0.530	1.00
304_L	326_A	0.530	1.00
314_S	318_N	0.528	1.00
94_G	127_V	0.526	1.00
314_S	320_P	0.526	1.00
88_T	92_T	0.526	1.00
175_Q	178_A	0.526	1.00
264_E	311_V	0.524	1.00
95_P	98_L	0.524	1.00
251_L	290_N	0.522	1.00
385_S	389_Y	0.522	1.00
368_E	374_F	0.522	1.00
332_P	375_G	0.520	1.00
269_G	272_I	0.518	1.00
30_G	33_S	0.515	1.00
279_K	292_G	0.512	1.00
7_N	10_L	0.512	1.00
19_A	35_F	0.509	1.00
53_P	59_T	0.507	1.00
12_E	293_F	0.507	1.00
314_S	322_I	0.506	1.00
294_E	302_S	0.505	1.00
200_H	343_E	0.504	1.00
366_K	369_I	0.504	1.00
133_L	136_H	0.504	1.00
4_L	98_L	0.503	1.00
24_Q	222_D	0.502	1.00
204_A	207_S	0.501	1.00
277_F	307_M	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4n9wA	1	0.8247	100	0.197	Contact Map
1rzuA	1	0.9358	100	0.208	Contact Map
3froA	3	0.916	100	0.212	Contact Map
2r60A	1	0.9185	100	0.218	Contact Map
2qzsA	1	0.9333	100	0.222	Contact Map
3c48A	2	0.8815	100	0.224	Contact Map
2x6qA	1	0.8444	100	0.235	Contact Map
2x0dA	2	0.8296	100	0.245	Contact Map
3okpA	1	0.8469	100	0.25	Contact Map
3oy2A	2	0.8469	100	0.256	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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