GREMLIN Database
WCAC - Putative colanic acid biosynthesis glycosyl transferase WcaC
UniProt: P71237 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13571
Length: 405 (341)
Sequences: 50841 (43031)
Seq/√Len: 2330.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
245_A307_M4.7741.00
273_E289_V3.7901.00
193_Q215_R3.3561.00
310_L326_A3.2321.00
243_K275_H3.0001.00
99_H402_Y2.9591.00
267_A362_V2.8151.00
241_K273_E2.7901.00
275_H291_H2.7151.00
246_V258_N2.7101.00
382_S386_R2.4111.00
263_R358_V2.4061.00
34_H95_P2.2921.00
384_R388_A2.2441.00
257_T260_Q2.2431.00
34_H93_A2.2211.00
242_P369_I2.2011.00
337_H342_R2.1671.00
269_G287_N2.1131.00
345_L350_G2.1101.00
364_L367_P2.1031.00
277_F303_A2.0981.00
275_H289_V2.0711.00
243_K306_Q2.0601.00
243_K273_E2.0311.00
267_A359_L2.0061.00
371_Q374_F2.0031.00
265_M274_L1.9981.00
31_L399_V1.9931.00
244_I309_A1.9761.00
4_L95_P1.9751.00
99_H132_T1.9711.00
367_P374_F1.9661.00
250_D253_Y1.9321.00
242_P308_D1.8851.00
393_Q397_E1.8651.00
375_G379_A1.8431.00
351_K364_L1.8371.00
354_S360_Q1.8321.00
367_P371_Q1.8161.00
337_H354_S1.7971.00
220_G391_G1.7741.00
29_Q396_E1.7711.00
199_Q202_A1.7581.00
193_Q401_F1.7421.00
202_A216_I1.7411.00
261_L274_L1.7301.00
310_L331_V1.7081.00
294_E299_K1.7061.00
247_V300_L1.6911.00
196_S214_C1.6881.00
346_Q349_G1.6851.00
257_T315_R1.6731.00
199_Q343_E1.6561.00
366_K370_A1.6421.00
25_R392_Q1.6121.00
383_Q387_A1.6081.00
265_M272_I1.6051.00
382_S385_S1.5941.00
20_L24_Q1.5891.00
261_L311_V1.5861.00
357_E360_Q1.5791.00
351_K367_P1.5791.00
268_L366_K1.5781.00
25_R395_L1.5721.00
296_D299_K1.5691.00
202_A214_C1.5681.00
25_R28_Q1.5661.00
4_L36_V1.5521.00
330_G382_S1.5501.00
279_K283_F1.5461.00
360_Q364_L1.5351.00
299_K302_S1.5341.00
199_Q216_I1.5211.00
374_F377_T1.5181.00
255_G316_V1.5061.00
29_Q399_V1.5051.00
277_F291_H1.4511.00
335_A341_A1.4481.00
294_E303_A1.4351.00
307_M331_V1.4231.00
260_Q358_V1.4151.00
251_L276_T1.4031.00
275_H303_A1.3911.00
243_K308_D1.3861.00
264_E361_L1.3771.00
353_V364_L1.3751.00
244_I365_S1.3681.00
383_Q386_R1.3641.00
385_S388_A1.3621.00
131_W187_M1.3601.00
277_F294_E1.3581.00
358_V362_V1.3541.00
196_S202_A1.3481.00
244_I311_V1.3431.00
301_M329_I1.3421.00
100_F129_L1.3411.00
267_A358_V1.3411.00
291_H294_E1.3401.00
245_A277_F1.3371.00
246_V261_L1.3361.00
5_Q26_A1.3351.00
195_I398_Y1.3321.00
258_N276_T1.3191.00
5_Q101_H1.2971.00
393_Q396_E1.2961.00
397_E400_N1.2961.00
275_H307_M1.2811.00
199_Q203_D1.2371.00
195_I401_F1.2291.00
319_Y324_C1.2291.00
242_P309_A1.2241.00
85_L88_T1.2191.00
360_Q363_Q1.2161.00
226_E329_I1.2151.00
18_V321_L1.2141.00
323_L341_A1.2101.00
83_N87_R1.2041.00
55_V59_T1.1961.00
134_H321_L1.1961.00
312_F323_L1.1841.00
376_T380_E1.1771.00
349_G384_R1.1691.00
339_D342_R1.1561.00
25_R29_Q1.1541.00
242_P272_I1.1531.00
305_N329_I1.1501.00
362_V366_K1.1501.00
225_T301_M1.1451.00
372_A375_G1.1411.00
381_F384_R1.1391.00
390_S393_Q1.1301.00
260_Q315_R1.1271.00
260_Q336_T1.1201.00
300_L304_L1.1201.00
27_L30_G1.1141.00
312_F322_I1.1121.00
336_T353_V1.1121.00
197_P201_V1.1111.00
374_F378_L1.1081.00
335_A352_T1.1081.00
313_S361_L1.1061.00
260_Q356_E1.1041.00
259_Q263_R1.1021.00
197_P219_N1.1011.00
346_Q384_R1.1001.00
196_S205_F1.0991.00
368_E378_L1.0961.00
347_K364_L1.0941.00
260_Q263_R1.0921.00
394_M397_E1.0901.00
353_V361_L1.0871.00
242_P271_K1.0841.00
351_K378_L1.0831.00
241_K271_K1.0821.00
243_K307_M1.0791.00
253_Y281_S1.0771.00
297_K300_L1.0771.00
330_G380_E1.0761.00
280_F283_F1.0761.00
391_G394_M1.0751.00
275_H306_Q1.0731.00
304_L329_I1.0691.00
21_D24_Q1.0631.00
101_H134_H1.0621.00
331_V379_A1.0601.00
5_Q23_H1.0591.00
100_F131_W1.0491.00
327_L333_V1.0481.00
21_D391_G1.0471.00
310_L322_I1.0441.00
247_V277_F1.0431.00
314_S317_D1.0421.00
245_A303_A1.0421.00
291_H303_A1.0401.00
315_R356_E1.0371.00
210_G213_R1.0331.00
244_I265_M1.0331.00
247_V304_L1.0331.00
301_M305_N1.0321.00
250_D255_G1.0301.00
394_M398_Y1.0221.00
363_Q367_P1.0201.00
340_A343_E1.0171.00
197_P318_N1.0131.00
335_A345_L0.9971.00
268_L272_I0.9941.00
260_Q361_L0.9931.00
351_K368_E0.9921.00
268_L365_S0.9901.00
379_A382_S0.9861.00
320_P341_A0.9851.00
219_N321_L0.9791.00
334_I353_V0.9771.00
265_M287_N0.9731.00
220_G394_M0.9731.00
196_S201_V0.9731.00
261_L313_S0.9681.00
23_H35_F0.9661.00
246_V276_T0.9631.00
226_E301_M0.9611.00
18_V134_H0.9581.00
13_G16_A0.9551.00
279_K293_F0.9531.00
3_I31_L0.9521.00
326_A331_V0.9491.00
273_E287_N0.9481.00
266_M269_G0.9481.00
17_G21_D0.9461.00
317_D320_P0.9461.00
223_M390_S0.9451.00
272_I369_I0.9421.00
351_K374_F0.9381.00
268_L369_I0.9381.00
267_A270_D0.9321.00
396_E400_N0.9311.00
327_L349_G0.9271.00
130_V195_I0.9171.00
323_L344_V0.9161.00
372_A376_T0.9151.00
309_A368_E0.9091.00
19_A101_H0.9081.00
354_S357_E0.8991.00
23_H27_L0.8951.00
246_V313_S0.8941.00
264_E362_V0.8941.00
222_D225_T0.8911.00
266_M270_D0.8871.00
323_L333_V0.8851.00
268_L362_V0.8841.00
323_L335_A0.8801.00
114_V117_C0.8791.00
384_R387_A0.8771.00
376_T379_A0.8721.00
334_I364_L0.8711.00
345_L352_T0.8701.00
311_V365_S0.8691.00
381_F385_S0.8681.00
312_F341_A0.8671.00
115_R118_E0.8671.00
338_S341_A0.8661.00
17_G297_K0.8641.00
256_K317_D0.8641.00
245_A304_L0.8621.00
18_V132_T0.8561.00
215_R401_F0.8551.00
263_R267_A0.8551.00
128_T192_C0.8531.00
332_P379_A0.8501.00
195_I217_I0.8471.00
86_Y89_I0.8471.00
304_L331_V0.8461.00
218_N343_E0.8421.00
380_E383_Q0.8421.00
113_V117_C0.8421.00
256_K322_I0.8411.00
248_A258_N0.8371.00
264_E358_V0.8341.00
29_Q392_Q0.8341.00
34_H38_G0.8331.00
215_R397_E0.8321.00
309_A365_S0.8321.00
256_K314_S0.8301.00
222_D226_E0.8301.00
21_D222_D0.8251.00
332_P368_E0.8221.00
337_H352_T0.8211.00
178_A181_R0.8211.00
200_H203_D0.8131.00
303_A306_Q0.8131.00
390_S394_M0.8121.00
84_E88_T0.8111.00
217_I401_F0.8101.00
182_Q186_E0.8071.00
392_Q396_E0.8071.00
114_V118_E0.8061.00
246_V310_L0.8031.00
302_S305_N0.8021.00
18_V219_N0.8011.00
135_D255_G0.7981.00
97_V402_Y0.7971.00
218_N397_E0.7961.00
239_Q242_P0.7951.00
21_D25_R0.7951.00
302_S306_Q0.7911.00
359_L363_Q0.7901.00
396_E399_V0.7871.00
263_R266_M0.7871.00
134_H197_P0.7851.00
13_G250_D0.7781.00
197_P321_L0.7771.00
246_V274_L0.7761.00
130_V193_Q0.7731.00
200_H204_A0.7691.00
363_Q366_K0.7691.00
69_A73_L0.7681.00
308_D375_G0.7671.00
101_H132_T0.7651.00
320_P323_L0.7621.00
398_Y402_Y0.7611.00
7_N15_A0.7571.00
52_Y55_V0.7571.00
180_K184_F0.7561.00
391_G395_L0.7551.00
7_N19_A0.7531.00
181_R185_R0.7531.00
17_G20_L0.7471.00
367_P370_A0.7471.00
247_V310_L0.7471.00
29_Q395_L0.7461.00
5_Q33_S0.7381.00
345_L349_G0.7341.00
312_F320_P0.7311.00
244_I272_I0.7271.00
34_H56_I0.7271.00
27_L33_S0.7241.00
22_L398_Y0.7241.00
336_T355_E0.7211.00
259_Q315_R0.7211.00
297_K301_M0.7211.00
130_V402_Y0.7201.00
68_I72_R0.7171.00
342_R352_T0.7151.00
334_I368_E0.7111.00
229_L305_N0.7101.00
217_I398_Y0.7081.00
18_V398_Y0.7071.00
368_E375_G0.6991.00
347_K351_K0.6981.00
254_D259_Q0.6981.00
324_C389_Y0.6981.00
373_I377_T0.6971.00
218_N389_Y0.6971.00
319_Y389_Y0.6931.00
271_K287_N0.6931.00
203_D206_N0.6911.00
97_V130_V0.6911.00
23_H33_S0.6891.00
129_L187_M0.6891.00
294_E300_L0.6891.00
257_T313_S0.6881.00
67_N71_F0.6871.00
336_T361_L0.6871.00
251_L283_F0.6871.00
327_L385_S0.6851.00
244_I369_I0.6851.00
134_H219_N0.6811.00
242_P372_A0.6811.00
349_G381_F0.6811.00
359_L362_V0.6771.00
206_N209_Y0.6771.00
132_T398_Y0.6771.00
215_R218_N0.6761.00
55_V58_H0.6751.00
371_Q375_G0.6721.00
125_P128_T0.6721.00
349_G385_S0.6711.00
200_H342_R0.6701.00
5_Q99_H0.6701.00
348_S367_P0.6671.00
270_D366_K0.6661.00
99_H398_Y0.6651.00
9_R16_A0.6651.00
377_T380_E0.6641.00
262_V288_V0.6631.00
264_E365_S0.6621.00
28_Q392_Q0.6621.00
170_I173_A0.6611.00
51_N55_V0.6611.00
248_A256_K0.6591.00
311_V361_L0.6531.00
217_I397_E0.6521.00
303_A307_M0.6501.00
395_L399_V0.6491.00
337_H355_E0.6481.00
174_H177_V0.6471.00
353_V360_Q0.6451.00
274_L288_V0.6451.00
66_A69_A0.6441.00
223_M328_S0.6411.00
15_A102_V0.6401.00
30_G399_V0.6401.00
198_S201_V0.6391.00
178_A182_Q0.6391.00
49_H52_Y0.6381.00
265_M268_L0.6371.00
327_L379_A0.6361.00
98_L127_V0.6351.00
310_L333_V0.6341.00
174_H178_A0.6311.00
196_S216_I0.6291.00
242_P245_A0.6281.00
254_D315_R0.6261.00
384_R389_Y0.6251.00
27_L31_L0.6241.00
309_A334_I0.6241.00
251_L258_N0.6241.00
304_L322_I0.6221.00
67_N70_L0.6201.00
242_P375_G0.6191.00
245_A310_L0.6171.00
264_E268_L0.6171.00
5_Q402_Y0.6161.00
308_D372_A0.6131.00
21_D321_L0.6111.00
25_R391_G0.6091.00
327_L381_F0.6091.00
91_R125_P0.6071.00
170_I174_H0.6051.00
177_V181_R0.6031.00
334_I365_S0.6021.00
129_L192_C0.6011.00
56_I59_T0.6001.00
85_L89_I0.5991.00
224_A227_A0.5991.00
388_A393_Q0.5981.00
375_G378_L0.5971.00
24_Q28_Q0.5961.00
113_V116_F0.5961.00
95_P127_V0.5951.00
243_K303_A0.5941.00
257_T356_E0.5941.00
4_L34_H0.5911.00
18_V22_L0.5911.00
338_S355_E0.5901.00
132_T195_I0.5901.00
313_S336_T0.5881.00
135_D138_S0.5851.00
24_Q27_L0.5851.00
324_C344_V0.5841.00
124_K127_V0.5841.00
136_H139_V0.5831.00
309_A369_I0.5831.00
304_L310_L0.5821.00
83_N86_Y0.5811.00
373_I376_T0.5811.00
182_Q185_R0.5801.00
326_A333_V0.5791.00
225_T297_K0.5781.00
53_P56_I0.5781.00
199_Q218_N0.5781.00
322_I326_A0.5771.00
245_A275_H0.5771.00
227_A230_A0.5751.00
97_V128_T0.5721.00
227_A305_N0.5721.00
4_L93_A0.5681.00
260_Q264_E0.5681.00
250_D256_K0.5671.00
257_T336_T0.5671.00
378_L381_F0.5671.00
218_N319_Y0.5671.00
261_L265_M0.5651.00
10_L20_L0.5651.00
179_G182_Q0.5631.00
177_V180_K0.5621.00
388_A397_E0.5561.00
18_V101_H0.5551.00
222_D391_G0.5551.00
338_S342_R0.5511.00
240_G271_K0.5501.00
300_L303_A0.5501.00
254_D282_P0.5491.00
320_P324_C0.5491.00
187_M192_C0.5481.00
245_A331_V0.5471.00
136_H201_V0.5461.00
180_K183_L0.5451.00
277_F300_L0.5441.00
247_V322_I0.5441.00
201_V204_A0.5431.00
193_Q197_P0.5431.00
377_T381_F0.5421.00
226_E328_S0.5421.00
330_G379_A0.5401.00
381_F386_R0.5401.00
22_L25_R0.5391.00
132_T402_Y0.5381.00
68_I71_F0.5361.00
133_L201_V0.5351.00
65_M70_L0.5341.00
278_G292_G0.5321.00
223_M386_R0.5311.00
21_D220_G0.5301.00
304_L326_A0.5301.00
314_S318_N0.5281.00
94_G127_V0.5261.00
314_S320_P0.5261.00
88_T92_T0.5261.00
175_Q178_A0.5261.00
264_E311_V0.5241.00
95_P98_L0.5241.00
251_L290_N0.5221.00
385_S389_Y0.5221.00
368_E374_F0.5221.00
332_P375_G0.5201.00
269_G272_I0.5181.00
30_G33_S0.5151.00
279_K292_G0.5121.00
7_N10_L0.5121.00
19_A35_F0.5091.00
53_P59_T0.5071.00
12_E293_F0.5071.00
314_S322_I0.5061.00
294_E302_S0.5051.00
200_H343_E0.5041.00
366_K369_I0.5041.00
133_L136_H0.5041.00
4_L98_L0.5031.00
24_Q222_D0.5021.00
204_A207_S0.5011.00
277_F307_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n9wA 1 0.8247 100 0.197 Contact Map
1rzuA 1 0.9358 100 0.208 Contact Map
3froA 3 0.916 100 0.212 Contact Map
2r60A 1 0.9185 100 0.218 Contact Map
2qzsA 1 0.9333 100 0.222 Contact Map
3c48A 2 0.8815 100 0.224 Contact Map
2x6qA 1 0.8444 100 0.235 Contact Map
2x0dA 2 0.8296 100 0.245 Contact Map
3okpA 1 0.8469 100 0.25 Contact Map
3oy2A 2 0.8469 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0119 seconds.