GREMLIN Database
SUGE - Quaternary ammonium compound-resistance protein SugE
UniProt: P69937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11616
Length: 105 (102)
Sequences: 4242 (2931)
Seq/√Len: 290.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_S99_G2.8591.00
12_L41_V2.6471.00
48_W51_K2.5481.00
5_I48_W2.4391.00
75_I82_A2.3471.00
19_G34_I2.3321.00
15_V38_A2.1411.00
2_S52_S2.1411.00
71_A90_L1.9551.00
73_T77_L1.9311.00
10_G65_I1.9291.00
50_M58_A1.8081.00
92_L96_G1.8081.00
30_T34_I1.7361.00
53_L58_A1.7281.00
16_W38_A1.5771.00
91_A95_L1.5201.00
36_V40_I1.5191.00
15_V34_I1.4981.00
23_T32_S1.4891.00
92_L95_L1.4851.00
39_M43_M1.4731.00
44_A48_W1.4651.00
18_V22_Y1.4621.00
84_P88_A1.4211.00
28_R31_P1.4131.00
50_M55_V1.3701.00
26_F32_S1.3601.00
16_W39_M1.3341.00
23_T26_F1.3151.00
89_S103_S1.3121.00
93_I96_G1.3091.00
14_V69_G1.3041.00
12_L38_A1.3041.00
5_I45_L1.2831.00
18_V73_T1.2721.00
20_L35_T1.2621.00
83_N86_R1.2531.00
89_S96_G1.2441.00
22_Y78_L1.2341.00
29_L32_S1.2331.00
98_I102_L1.2051.00
87_L91_A1.1911.00
49_A58_A1.1741.00
90_L100_L1.1531.00
85_M103_S1.1481.00
67_A71_A1.1391.00
30_T33_V1.1331.00
3_W61_V1.1191.00
46_L58_A1.1101.00
81_S86_R1.1061.00
15_V19_G1.0961.00
89_S93_I1.0871.00
24_H28_R1.0831.00
29_L33_V1.0361.00
86_R100_L1.0301.00
82_A87_L1.0291.00
7_V65_I1.0221.00
40_I44_A0.9831.00
85_M88_A0.9811.00
4_I8_I0.9641.00
82_A86_R0.9501.00
57_T86_R0.9361.00
61_V65_I0.9191.00
93_I97_I0.9081.00
8_I45_L0.9041.00
95_L99_G0.8941.00
72_I76_V0.8921.00
2_S53_L0.8871.00
68_V90_L0.8801.00
68_V94_V0.8691.00
21_K25_G0.8661.00
19_G22_Y0.8471.00
84_P87_L0.8401.00
56_G60_A0.8391.00
55_V70_A0.8351.00
80_E86_R0.8311.00
73_T78_L0.8281.00
89_S92_L0.8261.00
27_S32_S0.8231.00
81_S84_P0.8191.00
74_G80_E0.8151.00
33_V37_T0.8111.00
7_V10_G0.8091.00
94_V98_I0.8081.00
17_A70_A0.8000.99
10_G42_S0.8000.99
74_G78_L0.7870.99
60_A63_T0.7770.99
27_S51_K0.7740.99
18_V78_L0.7710.99
14_V73_T0.7590.99
24_H27_S0.7430.99
64_G97_I0.7420.99
92_L99_G0.7300.99
67_A94_V0.7270.99
63_T74_G0.7180.99
99_G103_S0.7170.99
88_A92_L0.7120.99
19_G38_A0.6900.98
19_G35_T0.6860.98
71_A100_L0.6830.98
2_S5_I0.6810.98
33_V36_V0.6670.98
13_E42_S0.6660.98
54_P57_T0.6620.98
85_M89_S0.6590.98
27_S31_P0.6570.98
16_W35_T0.6520.98
65_I69_G0.6450.98
76_V79_G0.6430.98
55_V78_L0.6400.97
32_S35_T0.6350.97
74_G86_R0.6330.97
9_A45_L0.6300.97
39_M63_T0.6240.97
75_I81_S0.6190.97
37_T41_V0.6190.97
11_L69_G0.6190.97
10_G97_I0.6160.97
23_T27_S0.6100.97
75_I87_L0.6080.97
21_K24_H0.6060.96
57_T60_A0.6050.96
23_T28_R0.6010.96
19_G23_T0.5970.96
18_V55_V0.5960.96
18_V74_G0.5950.96
60_A90_L0.5920.96
26_F31_P0.5890.96
11_L15_V0.5800.96
43_M50_M0.5780.95
39_M55_V0.5710.95
20_L62_W0.5700.95
48_W52_S0.5680.95
9_A46_L0.5630.95
6_L58_A0.5550.94
88_A91_A0.5540.94
20_L42_S0.5460.94
80_E83_N0.5390.93
38_A42_S0.5350.93
35_T47_A0.5350.93
75_I80_E0.5330.93
19_G36_V0.5280.93
34_I38_A0.5260.93
62_W93_I0.5150.92
63_T101_K0.5120.92
32_S47_A0.5100.91
16_W63_T0.5050.91
5_I49_A0.5030.91
37_T40_I0.5030.91
43_M47_A0.5010.91
26_F35_T0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.9714 99.9 0.319 Contact Map
2i68A 2 0.7429 99.9 0.359 Contact Map
4pypA 1 1 6.2 0.931 Contact Map
1pw4A 1 1 3.7 0.938 Contact Map
4o9uB 2 0.6952 3.7 0.938 Contact Map
4gx0A 3 0.7524 2.7 0.942 Contact Map
3effK 4 0.7714 2.3 0.944 Contact Map
2gfpA 2 0.9905 2.3 0.944 Contact Map
2ls4A 1 0.2286 2.2 0.945 Contact Map
3rqwA 4 0.4762 2.2 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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