GREMLIN Database
RIR2 - Ribonucleoside-diphosphate reductase 1 subunit beta
UniProt: P69924 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10661
Length: 376 (311)
Sequences: 2134 (711)
Seq/√Len: 40.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_K286_D6.3281.00
289_D306_C4.9511.00
54_V122_S4.6081.00
314_N327_Q4.3531.00
285_K310_E4.1861.00
68_E71_K4.0971.00
148_Q152_E3.4231.00
72_H76_S3.3971.00
270_K323_D3.2831.00
278_V325_P3.2571.00
203_A277_F3.1831.00
196_L272_E3.1121.00
281_A326_F3.0991.00
274_Y325_P3.0171.00
198_L249_M2.7641.00
274_Y317_M2.7531.00
199_M273_C2.6191.00
285_K306_C2.5401.00
67_P70_E2.4721.00
250_L268_E2.4641.00
281_A313_T2.4611.00
274_Y323_D2.4221.00
274_Y322_L2.3991.00
271_Q275_D2.3191.00
88_Q158_Y2.1320.99
56_V125_H2.1150.99
205_E239_E2.0590.99
310_E328_T2.0500.99
278_V326_F2.0460.99
274_Y278_V2.0400.99
275_D279_Q1.9760.99
199_M320_V1.9750.99
116_E205_E1.9610.99
62_D65_A1.9360.99
116_E239_E1.8600.98
29_Y107_T1.8580.98
44_Q115_S1.8480.98
70_E224_L1.8440.98
85_D123_Y1.8430.98
51_P122_S1.8290.98
145_E149_K1.8270.98
45_L50_R1.8200.98
75_I131_V1.8150.98
156_S279_Q1.7950.98
60_R64_Q1.7590.97
160_E196_L1.7510.97
110_E113_A1.7380.97
282_Q286_D1.7310.97
36_I252_L1.7140.97
192_K272_E1.6810.97
44_Q112_W1.6540.96
34_Y102_I1.6470.96
273_C322_L1.6430.96
209_F239_E1.6400.96
250_L322_L1.6150.96
149_K279_Q1.6140.96
66_L225_M1.6080.96
63_Y75_I1.6070.96
303_D307_Q1.5800.95
213_F239_E1.5650.95
108_W245_G1.5510.95
318_Q324_L1.5480.95
111_T115_S1.5440.95
234_L237_R1.5420.95
306_C310_E1.5400.94
110_E117_T1.5360.94
267_E271_Q1.5310.94
239_E242_H1.5270.94
260_P263_A1.5160.94
209_F235_I1.4760.93
119_H242_H1.4710.93
193_K196_L1.4670.93
111_T114_F1.4560.93
73_I291_L1.4490.92
254_R263_A1.4410.92
230_K355_S1.4350.92
289_D302_K1.4310.92
259_D263_A1.4240.92
42_E52_E1.4160.92
270_K274_Y1.4000.91
296_S303_D1.3760.90
214_A335_W1.3440.89
254_R270_K1.3300.89
278_V282_Q1.3200.88
207_I277_F1.3190.88
214_A288_A1.3160.88
219_F225_M1.3020.88
213_F357_Y1.2990.88
213_F242_H1.2840.87
152_E156_S1.2640.86
63_Y71_K1.2610.86
34_Y252_L1.2590.86
205_E213_F1.2280.84
45_L51_P1.2170.84
69_H296_S1.2140.84
71_K75_I1.2120.84
60_R129_N1.2080.83
220_A229_A1.2050.83
281_A310_E1.1970.83
272_E275_D1.1950.83
195_Y250_L1.1940.83
51_P54_V1.1810.82
51_P125_H1.1740.82
93_N97_L1.1710.81
251_N254_R1.1700.81
152_E323_D1.1650.81
74_F228_N1.1640.81
119_H357_Y1.1630.81
89_G117_T1.1590.81
293_R301_N1.1490.80
116_E209_F1.1320.79
243_L315_I1.1280.79
308_Y336_I1.1260.79
42_E121_R1.1240.79
259_D262_M1.1220.79
347_V352_V1.1110.78
42_E50_R1.1070.78
126_I228_N1.1030.77
36_I39_K1.1000.77
270_K322_L1.0950.77
85_D228_N1.0950.77
307_Q328_T1.0890.76
267_E270_K1.0820.76
35_D39_K1.0820.76
275_D282_Q1.0780.76
288_A309_V1.0780.76
54_V237_R1.0670.75
36_I248_H1.0580.74
230_K234_L1.0550.74
217_F236_A1.0470.74
353_E359_V1.0440.73
348_A351_E1.0390.73
312_I316_R1.0330.73
270_K275_D1.0310.72
358_L363_D1.0230.72
139_D143_T1.0140.71
65_A224_L1.0000.70
69_H294_D0.9990.70
205_E209_F0.9970.70
99_L197_C0.9950.70
294_D298_I0.9950.70
106_E110_E0.9830.69
285_K289_D0.9820.69
149_K153_G0.9810.69
64_Q69_H0.9760.68
150_R287_W0.9740.68
119_H213_F0.9730.68
100_I194_L0.9710.68
54_V234_L0.9590.67
314_N328_T0.9580.67
81_Q212_S0.9550.66
221_E335_W0.9490.66
38_E121_R0.9480.66
233_R345_V0.9480.66
92_P112_W0.9460.66
314_N324_L0.9440.66
152_E325_P0.9420.65
282_Q285_K0.9380.65
107_T117_T0.9370.65
53_E353_E0.9370.65
192_K268_E0.9350.65
209_F213_F0.9330.65
48_F111_T0.9320.65
122_S231_I0.9140.63
344_N356_S0.9140.63
223_E355_S0.9130.63
282_Q289_D0.9080.62
61_I64_Q0.9050.62
317_M325_P0.9040.62
351_E354_V0.9030.62
252_L255_S0.9030.62
261_E266_A0.9000.62
247_Q319_A0.9000.62
333_I336_I0.8980.62
80_Y287_W0.8960.61
365_E368_T0.8910.61
45_L118_I0.8900.61
196_L268_E0.8850.60
64_Q132_N0.8810.60
51_P118_I0.8790.60
74_F225_M0.8790.60
85_D357_Y0.8780.60
286_D289_D0.8760.60
85_D238_D0.8760.60
95_A98_P0.8760.60
194_L198_L0.8690.59
269_C272_E0.8670.59
201_V246_T0.8660.59
53_E359_V0.8620.58
110_E272_E0.8610.58
220_A233_R0.8590.58
272_E276_L0.8500.57
26_V31_Q0.8480.57
100_I198_L0.8400.56
243_L316_R0.8350.56
203_A273_C0.8340.56
38_E42_E0.8330.56
211_V309_V0.8320.56
302_K306_C0.8310.56
156_S270_K0.8300.56
53_E336_I0.8240.55
68_E278_V0.8240.55
92_P120_S0.8220.55
245_G249_M0.8200.55
40_L106_E0.8170.54
304_I307_Q0.8140.54
364_S368_T0.8130.54
64_Q275_D0.8120.54
56_V231_I0.8040.53
192_K269_C0.7980.53
119_H239_E0.7940.52
296_S302_K0.7910.52
243_L311_Y0.7910.52
281_A285_K0.7910.52
119_H238_D0.7880.52
306_C309_V0.7870.52
301_N304_I0.7850.51
242_H357_Y0.7840.51
288_A306_C0.7820.51
292_F305_L0.7800.51
107_T110_E0.7790.51
207_I211_V0.7790.51
42_E46_S0.7750.51
68_E271_Q0.7710.50
81_Q88_Q0.7640.50
41_I121_R0.7640.50
62_D219_F0.7630.49
68_E273_C0.7590.49
196_L269_C0.7580.49
271_Q274_Y0.7560.49
94_V97_L0.7510.48
198_L254_R0.7500.48
124_T128_R0.7490.48
310_E326_F0.7460.48
79_K137_V0.7450.48
150_R283_Q0.7440.48
40_L244_T0.7430.48
245_G248_H0.7410.47
72_H77_N0.7390.47
144_N290_Y0.7390.47
239_E357_Y0.7380.47
258_D262_M0.7350.47
99_L161_L0.7330.47
154_I204_L0.7330.47
323_D327_Q0.7320.47
214_A303_D0.7320.47
40_L245_G0.7320.47
311_Y315_I0.7280.46
150_R348_A0.7280.46
199_M269_C0.7240.46
105_L249_M0.7240.46
37_F248_H0.7230.46
89_G113_A0.7230.46
112_W209_F0.7220.46
114_F118_I0.7210.46
158_Y210_Y0.7190.45
116_E123_Y0.7180.45
274_Y324_L0.7140.45
314_N317_M0.7110.45
127_I298_I0.7110.45
57_S60_R0.7100.45
145_E323_D0.7090.44
50_R118_I0.7070.44
37_F252_L0.7070.44
139_D271_Q0.7070.44
66_L297_M0.7040.44
216_S232_I0.7000.44
119_H209_F0.6990.44
254_R322_L0.6990.44
125_H128_R0.6960.43
61_I286_D0.6940.43
195_Y268_E0.6930.43
26_V30_D0.6930.43
246_T309_V0.6910.43
74_F81_Q0.6900.43
212_S235_I0.6900.43
235_I238_D0.6890.43
214_A305_L0.6860.42
81_Q348_A0.6830.42
73_I215_C0.6820.42
76_S309_V0.6790.42
135_S159_D0.6780.42
58_R62_D0.6760.41
102_I253_L0.6760.41
124_T359_V0.6760.41
269_C322_L0.6740.41
150_R284_E0.6730.41
138_F209_F0.6730.41
93_N214_A0.6720.41
224_L319_A0.6700.41
160_E367_D0.6700.41
193_K279_Q0.6670.41
93_N98_P0.6660.41
151_A308_Y0.6640.40
345_V356_S0.6630.40
206_A316_R0.6630.40
327_Q330_S0.6620.40
44_Q245_G0.6610.40
37_F105_L0.6590.40
146_Q290_Y0.6580.40
161_L193_K0.6570.40
65_A261_E0.6560.40
160_E214_A0.6560.40
255_S267_E0.6550.40
91_S112_W0.6530.39
48_F84_L0.6530.39
203_A276_L0.6520.39
347_V354_V0.6520.39
213_F238_D0.6510.39
349_P354_V0.6510.39
85_D235_I0.6490.39
68_E261_E0.6460.39
116_E213_F0.6450.39
56_V129_N0.6450.39
68_E303_D0.6430.39
109_V246_T0.6420.38
130_I344_N0.6410.38
35_D136_V0.6400.38
123_Y242_H0.6400.38
161_L196_L0.6400.38
251_N320_V0.6400.38
250_L269_C0.6380.38
220_A225_M0.6360.38
289_D293_R0.6340.38
143_T323_D0.6340.38
255_S275_D0.6300.37
97_L113_A0.6290.37
44_Q47_F0.6280.37
238_D242_H0.6280.37
194_L197_C0.6260.37
224_L278_V0.6240.37
255_S322_L0.6220.37
85_D242_H0.6210.37
345_V352_V0.6210.37
191_K261_E0.6210.37
308_Y349_P0.6200.37
213_F349_P0.6190.36
318_Q327_Q0.6180.36
223_E341_V0.6180.36
44_Q241_L0.6170.36
145_E274_Y0.6160.36
111_T117_T0.6160.36
56_V227_G0.6150.36
231_I283_Q0.6140.36
203_A280_A0.6130.36
191_K262_M0.6100.36
324_L327_Q0.6100.36
214_A309_V0.6090.36
293_R298_I0.6090.36
67_P303_D0.6080.36
68_E160_E0.6080.36
36_I253_L0.6070.35
201_V243_L0.6070.35
35_D64_Q0.6060.35
33_K103_P0.6050.35
322_L325_P0.6030.35
206_A281_A0.6020.35
134_P143_T0.6020.35
68_E334_P0.6000.35
39_K279_Q0.5970.35
237_R313_T0.5970.35
48_F118_I0.5960.35
255_S303_D0.5940.34
214_A219_F0.5940.34
122_S204_L0.5930.34
149_K155_S0.5900.34
85_D119_H0.5890.34
61_I303_D0.5870.34
29_Y280_A0.5860.34
55_D58_R0.5850.34
307_Q330_S0.5840.34
201_V211_V0.5840.34
279_Q283_Q0.5790.33
317_M324_L0.5790.33
236_A246_T0.5780.33
206_A243_L0.5780.33
145_E282_Q0.5770.33
87_I150_R0.5760.33
152_E326_F0.5750.33
160_E192_K0.5720.33
220_A235_I0.5710.33
82_T292_F0.5710.33
236_A340_L0.5700.32
67_P306_C0.5700.32
289_D303_D0.5680.32
85_D124_T0.5670.32
223_E354_V0.5670.32
267_E368_T0.5670.32
297_M353_E0.5650.32
279_Q282_Q0.5640.32
72_H267_E0.5630.32
96_L197_C0.5620.32
270_K273_C0.5620.32
26_V202_N0.5610.32
150_R209_F0.5590.32
267_E322_L0.5580.31
260_P266_A0.5570.31
260_P268_E0.5570.31
161_L197_C0.5560.31
310_E314_N0.5560.31
114_F117_T0.5550.31
250_L320_V0.5520.31
288_A335_W0.5520.31
204_L216_S0.5510.31
82_T127_I0.5460.31
247_Q251_N0.5460.31
112_W348_A0.5450.30
247_Q311_Y0.5450.30
209_F357_Y0.5440.30
247_Q320_V0.5420.30
78_L228_N0.5420.30
160_E191_K0.5410.30
71_K307_Q0.5410.30
33_K118_I0.5400.30
159_D291_L0.5400.30
150_R205_E0.5380.30
84_L88_Q0.5380.30
65_A136_V0.5370.30
153_G279_Q0.5360.30
84_L122_S0.5360.30
118_I291_L0.5360.30
49_W119_H0.5330.30
88_Q210_Y0.5330.30
152_E275_D0.5330.30
139_D253_L0.5330.30
78_L137_V0.5320.29
31_Q104_E0.5320.29
76_S291_L0.5280.29
58_R61_I0.5260.29
271_Q278_V0.5260.29
238_D357_Y0.5260.29
273_C355_S0.5250.29
332_P351_E0.5250.29
65_A323_D0.5230.29
281_A309_V0.5230.29
29_Y245_G0.5220.29
281_A327_Q0.5220.29
81_Q235_I0.5200.29
58_R352_V0.5180.28
45_L241_L0.5170.28
270_K325_P0.5160.28
335_W338_T0.5150.28
135_S326_F0.5150.28
136_V143_T0.5140.28
77_N349_P0.5130.28
73_I294_D0.5120.28
337_N341_V0.5110.28
277_F313_T0.5100.28
30_D88_Q0.5090.28
200_S276_L0.5080.28
263_A266_A0.5080.28
134_P271_Q0.5070.28
229_A233_R0.5060.27
81_Q216_S0.5060.27
150_R202_N0.5050.27
217_F340_L0.5050.27
53_E214_A0.5050.27
261_E267_E0.5030.27
44_Q111_T0.5020.27
157_Y272_E0.5020.27
35_D97_L0.5020.27
38_E41_I0.5020.27
195_Y269_C0.5010.27
66_L71_K0.5010.27
146_Q291_L0.5000.27
123_Y213_F0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mxrA 2 0.9016 100 0.116 Contact Map
2rccA 4 0.8218 100 0.173 Contact Map
1syyA 2 0.8298 100 0.216 Contact Map
1h0oA 2 0.758 100 0.227 Contact Map
1jk0A 1 0.7846 100 0.234 Contact Map
1jk0B 1 0.6968 100 0.236 Contact Map
2p1iA 2 0.6782 100 0.247 Contact Map
3n37A 2 0.742 100 0.253 Contact Map
4bmoA 2 0.766 100 0.259 Contact Map
3dhzA 2 0.7739 100 0.26 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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