GREMLIN Database
CSRA - Carbon storage regulator
UniProt: P69913 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11447
Length: 61 (57)
Sequences: 718 (423)
Seq/√Len: 56.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_T35_N3.4131.00
43_H51_I3.0131.00
45_E49_Q2.7961.00
22_V32_I2.6501.00
43_H47_I2.2891.00
19_T45_E2.1231.00
50_R53_A1.9461.00
13_M45_E1.9361.00
28_N50_R1.9161.00
48_Y51_I1.8861.00
14_I40_V1.6410.99
47_I51_I1.6400.99
54_E57_Q1.5240.98
53_A57_Q1.3650.96
49_Q52_Q1.3550.96
21_T35_N1.3230.95
21_T26_K1.3030.95
3_I26_K1.2280.93
23_L33_G1.1180.89
8_V14_I1.0910.87
52_Q55_K1.0840.87
50_R55_K1.0720.86
11_T22_V1.0610.86
7_R10_E1.0500.85
13_M19_T1.0480.85
49_Q53_A1.0470.85
3_I43_H1.0330.84
39_E42_V1.0270.84
5_T26_K1.0210.84
4_L29_Q1.0170.83
31_R55_K1.0140.83
14_I22_V1.0060.83
32_I54_E1.0040.83
3_I50_R0.9740.81
13_M31_R0.9200.77
29_Q33_G0.8870.74
7_R49_Q0.8700.73
4_L28_N0.8590.72
31_R36_A0.8300.69
3_I29_Q0.8200.68
25_V30_V0.7710.63
34_V42_V0.7670.63
14_I39_E0.7580.62
7_R18_V0.7350.59
41_S47_I0.7330.59
26_K31_R0.7300.59
3_I28_N0.7130.57
41_S52_Q0.7110.57
17_E39_E0.7040.56
12_L52_Q0.6990.56
28_N55_K0.6960.55
13_M17_E0.6890.55
7_R45_E0.6880.54
23_L28_N0.6820.54
8_V24_G0.6810.54
14_I36_A0.6810.54
13_M49_Q0.6710.53
25_V39_E0.6600.51
25_V57_Q0.6580.51
28_N36_A0.6450.50
11_T45_E0.6420.50
48_Y52_Q0.6410.49
1_M6_R0.6340.49
17_E23_L0.6280.48
24_G31_R0.6270.48
9_G12_L0.6240.48
43_H56_S0.6180.47
3_I15_G0.6090.46
48_Y57_Q0.5950.44
22_V53_A0.5840.43
2_L6_R0.5750.42
11_T26_K0.5630.41
9_G27_G0.5590.41
42_V56_S0.5540.40
35_N54_E0.5510.40
9_G50_R0.5420.39
11_T31_R0.5390.39
11_T20_V0.5290.38
21_T57_Q0.5250.37
10_E32_I0.5240.37
26_K50_R0.5180.36
22_V55_K0.5130.36
7_R51_I0.5130.36
21_T25_V0.5110.36
8_V15_G0.5100.36
5_T8_V0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2btiA 2 0.9344 99.9 0.135 Contact Map
1t3oA 1 1 99.9 0.144 Contact Map
2jppA 2 0.8689 99.9 0.151 Contact Map
1vpzA 2 0.9016 99.9 0.153 Contact Map
4krwA 2 0.7869 99.8 0.25 Contact Map
2vnuD 1 0.4754 58.9 0.859 Contact Map
4ifdJ 1 0.6066 56.5 0.861 Contact Map
1e3pA 3 0.2951 41.5 0.873 Contact Map
1go3E 1 0.8361 41 0.873 Contact Map
2id0A 1 0.5738 34.8 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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