GREMLIN Database
DCEB - Glutamate decarboxylase beta
UniProt: P69910 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11490
Length: 466 (356)
Sequences: 8318 (5164)
Seq/√Len: 273.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_F222_P4.3401.00
195_I235_G4.1801.00
352_Y435_E4.0601.00
356_E438_L3.7981.00
352_Y431_M3.4561.00
205_V227_L3.4401.00
161_P181_P3.3611.00
209_F247_G3.1641.00
183_R188_F2.8791.00
183_R186_Q2.8381.00
193_R196_E2.7971.00
225_D266_R2.6801.00
329_Y332_L2.5561.00
224_H240_M2.5101.00
360_L442_K2.4621.00
130_C165_C2.4511.00
61_A64_C2.4111.00
191_P226_A2.3811.00
207_P223_L2.3571.00
356_E435_E2.3321.00
224_H266_R2.3071.00
156_N178_R2.2821.00
348_Q431_M2.2661.00
155_P201_N2.1701.00
186_Q368_T2.1591.00
180_I197_A2.1511.00
274_G327_Q2.1051.00
352_Y356_E2.0601.00
181_P193_R2.0581.00
364_E381_K2.0301.00
221_Q225_D2.0241.00
193_R197_A2.0101.00
107_L331_F2.0031.00
221_Q262_F1.9671.00
355_D359_K1.9641.00
221_Q264_L1.9601.00
157_L170_A1.9451.00
227_L238_I1.9321.00
74_K78_L1.8801.00
373_E376_P1.8691.00
195_I236_I1.8441.00
195_I226_A1.8401.00
364_E383_K1.8311.00
320_P323_Q1.8131.00
356_E359_K1.8111.00
190_D193_R1.7681.00
102_N106_D1.7671.00
234_T266_R1.7641.00
103_M332_L1.7621.00
277_F327_Q1.6961.00
69_D73_H1.6731.00
192_K195_I1.6711.00
353_L425_C1.6551.00
438_L442_K1.6531.00
242_I267_V1.6461.00
354_A365_F1.6371.00
202_T236_I1.6341.00
272_A286_W1.6131.00
354_A358_A1.6071.00
156_N199_D1.6061.00
356_E360_L1.5831.00
244_A270_I1.5691.00
227_L240_M1.5661.00
244_A248_G1.5641.00
423_I437_L1.5561.00
161_P179_E1.5411.00
194_M205_V1.5281.00
133_G269_S1.5161.00
160_G207_P1.5101.00
183_R190_D1.5071.00
198_C226_A1.5061.00
191_P194_M1.4941.00
439_E443_A1.4851.00
341_K345_A1.4801.00
135_M306_L1.4771.00
70_E74_K1.4761.00
207_P240_M1.4581.00
192_K196_E1.4421.00
178_R197_A1.4401.00
398_R447_Y1.4381.00
109_H263_R1.4161.00
109_H261_D1.4121.00
129_A271_S1.4091.00
158_V201_N1.4071.00
440_D443_A1.4001.00
205_V238_I1.3991.00
342_V345_A1.3941.00
103_M328_Y1.3911.00
402_R443_A1.3891.00
73_H77_D1.3821.00
161_P182_M1.3721.00
436_L440_D1.3441.00
375_I379_C1.3331.00
209_F220_P1.3241.00
349_V434_A1.3231.00
137_M239_D1.3201.00
159_C170_A1.3141.00
195_I199_D1.3131.00
431_M435_E1.3031.00
430_E433_F1.2951.00
353_L434_A1.2931.00
209_F265_P1.2861.00
402_R440_D1.2851.00
167_H179_E1.2801.00
139_W176_E1.2751.00
248_G331_F1.2711.00
376_P379_C1.2651.00
347_Y351_A1.2621.00
159_C179_E1.2581.00
71_N74_K1.2441.00
345_A348_Q1.2431.00
99_R103_M1.2361.00
234_T268_K1.2331.00
356_E442_K1.2311.00
437_L441_Y1.2291.00
96_I325_I1.2281.00
198_C238_I1.2261.00
107_L336_R1.2211.00
261_D264_L1.2201.00
398_R401_L1.2201.00
142_R155_P1.2111.00
172_Y306_L1.2081.00
194_M223_L1.2061.00
207_P220_P1.2011.00
156_N202_T1.2011.00
380_F383_K1.1861.00
278_G426_R1.1791.00
289_W295_L1.1751.00
195_I222_P1.1661.00
217_Y251_A1.1651.00
356_E439_E1.1601.00
127_S305_Y1.1601.00
108_W270_I1.1511.00
180_I193_R1.1501.00
381_K384_D1.1501.00
137_M269_S1.1441.00
107_L248_G1.1351.00
222_P225_D1.1341.00
130_C241_H1.1321.00
435_E439_E1.1311.00
75_L96_I1.1201.00
355_D358_A1.1151.00
131_M172_Y1.1151.00
351_A355_D1.1131.00
66_T70_E1.1121.00
180_I189_M1.1091.00
121_T132_L1.1071.00
97_D324_V1.1061.00
71_N329_Y1.1051.00
158_V197_A1.1041.00
133_G287_V1.1011.00
360_L439_E1.1011.00
436_L439_E1.0951.00
154_K203_I1.0911.00
241_H271_S1.0891.00
156_N201_N1.0881.00
188_F218_E1.0801.00
205_V223_L1.0801.00
135_M172_Y1.0771.00
97_D321_A1.0711.00
340_T344_N1.0701.00
104_V286_W1.0641.00
253_F261_D1.0611.00
120_G288_I1.0601.00
338_G341_K1.0591.00
345_A349_V1.0581.00
123_T129_A1.0571.00
223_L240_M1.0561.00
374_G378_V1.0531.00
106_D336_R1.0531.00
357_I363_Y1.0521.00
197_A200_E1.0511.00
95_A99_R1.0491.00
224_H234_T1.0441.00
338_G342_V1.0431.00
248_G277_F1.0411.00
221_Q266_R1.0401.00
126_S245_A1.0401.00
397_E401_L1.0391.00
194_M226_A1.0381.00
374_G379_C1.0341.00
350_A354_A1.0221.00
158_V178_R1.0221.00
368_T373_E1.0221.00
227_L234_T1.0211.00
170_A177_L1.0121.00
69_D77_D1.0121.00
380_F384_D1.0121.00
134_G204_G1.0111.00
210_G374_G1.0111.00
191_P222_P1.0101.00
429_F433_F1.0071.00
424_M428_G1.0041.00
71_N75_L0.9991.00
248_G272_A0.9981.00
135_M139_W0.9961.00
158_V180_I0.9891.00
349_V431_M0.9871.00
277_F331_F0.9851.00
206_V241_H0.9851.00
254_V344_N0.9821.00
358_A363_Y0.9741.00
444_S447_Y0.9731.00
362_P383_K0.9711.00
97_D319_R0.9691.00
262_F266_R0.9671.00
111_P263_R0.9661.00
191_P195_I0.9661.00
225_D235_G0.9641.00
69_D74_K0.9631.00
189_M194_M0.9611.00
358_A368_T0.9561.00
191_P223_L0.9561.00
344_N348_Q0.9551.00
354_A378_V0.9541.00
429_F434_A0.9531.00
227_L236_I0.9471.00
360_L438_L0.9421.00
342_V346_S0.9411.00
267_V270_I0.9341.00
108_W272_A0.9341.00
159_C177_L0.9331.00
366_I420_V0.9321.00
375_I378_V0.9291.00
60_L63_F0.9231.00
354_A373_E0.9211.00
194_M198_C0.9141.00
134_G166_W0.9121.00
137_M204_G0.9121.00
442_K446_K0.9121.00
67_W70_E0.9021.00
423_I441_Y0.9001.00
168_K171_R0.8981.00
336_R340_T0.8941.00
353_L437_L0.8931.00
159_C162_V0.8881.00
135_M173_W0.8861.00
227_L235_G0.8761.00
126_S130_C0.8761.00
379_C382_L0.8721.00
199_D202_T0.8711.00
342_V427_R0.8701.00
73_H76_M0.8701.00
376_P380_F0.8671.00
357_I365_F0.8671.00
307_G311_G0.8661.00
60_L64_C0.8651.00
188_F368_T0.8641.00
366_I381_K0.8631.00
210_G375_I0.8621.00
359_K442_K0.8621.00
163_Q276_K0.8611.00
393_Y397_E0.8571.00
343_Q347_Y0.8571.00
404_W412_G0.8551.00
319_R324_V0.8511.00
425_C434_A0.8501.00
134_G169_F0.8501.00
362_P442_K0.8491.00
223_L227_L0.8491.00
180_I194_M0.8431.00
220_P242_I0.8411.00
172_Y176_E0.8411.00
97_D328_Y0.8381.00
374_G377_A0.8381.00
70_E73_H0.8371.00
155_P199_D0.8351.00
72_V326_A0.8260.99
373_E379_C0.8250.99
70_E281_P0.8180.99
221_Q265_P0.8150.99
124_I128_E0.8140.99
353_L356_E0.8130.99
404_W440_D0.8120.99
337_E341_K0.8110.99
159_C206_V0.8100.99
199_D236_I0.8050.99
226_A236_I0.8050.99
341_K344_N0.8040.99
104_V122_N0.8030.99
262_F288_I0.8030.99
209_F251_A0.8000.99
139_W172_Y0.7990.99
284_C323_Q0.7970.99
111_P118_A0.7950.99
208_T212_T0.7940.99
394_D398_R0.7910.99
157_L204_G0.7910.99
328_Y331_F0.7880.99
221_Q259_V0.7870.99
111_P291_D0.7840.99
70_E77_D0.7830.99
94_A98_L0.7830.99
269_S289_W0.7800.99
140_R294_A0.7760.99
157_L177_L0.7750.99
345_A431_M0.7740.99
360_L363_Y0.7740.99
81_N84_W0.7740.99
390_Y393_Y0.7730.99
262_F265_P0.7680.99
158_V198_C0.7640.99
398_R444_S0.7630.99
348_Q352_Y0.7570.99
220_P240_M0.7570.99
445_L449_S0.7560.99
72_V76_M0.7540.99
169_F306_L0.7470.99
350_A378_V0.7460.99
87_K90_Y0.7460.99
103_M107_L0.7460.99
210_G247_G0.7440.99
284_C327_Q0.7380.99
66_T77_D0.7360.99
432_D435_E0.7350.99
140_R144_R0.7330.99
130_C166_W0.7320.99
69_D76_M0.7310.99
274_G284_C0.7300.99
340_T343_Q0.7290.99
307_G310_I0.7290.99
274_G286_W0.7280.99
65_Q68_D0.7260.99
119_V291_D0.7250.99
407_P412_G0.7250.99
268_K290_R0.7220.99
133_G204_G0.7220.99
332_L337_E0.7210.99
227_L237_D0.7150.98
213_Y410_T0.7140.98
71_N103_M0.7130.98
209_F260_W0.7120.98
188_F374_G0.7090.98
394_D397_E0.7080.98
220_P267_V0.7060.98
189_M223_L0.7030.98
76_M322_G0.7030.98
164_I168_K0.7030.98
65_Q427_R0.7010.98
166_W206_V0.6970.98
280_A330_E0.6970.98
225_D234_T0.6960.98
399_L406_V0.6940.98
309_Q316_N0.6940.98
304_D307_G0.6930.98
397_E400_R0.6930.98
433_F436_L0.6910.98
440_D444_S0.6910.98
199_D203_I0.6900.98
390_Y394_D0.6880.98
423_I426_R0.6880.98
104_V331_F0.6860.98
208_T211_V0.6830.98
385_G390_Y0.6800.98
141_W144_R0.6800.98
134_G173_W0.6790.98
104_V328_Y0.6780.98
432_D436_L0.6770.98
170_A179_E0.6750.98
274_G279_L0.6740.98
283_G320_P0.6730.98
377_A380_F0.6720.98
80_I83_N0.6690.98
404_W407_P0.6650.98
188_F216_N0.6650.98
108_W288_I0.6600.97
126_S271_S0.6600.97
181_P197_A0.6570.97
291_D294_A0.6560.97
404_W436_L0.6560.97
108_W262_F0.6550.97
65_Q338_G0.6540.97
156_N176_E0.6500.97
68_D76_M0.6500.97
74_K325_I0.6490.97
239_D269_S0.6490.97
349_V352_Y0.6460.97
128_E316_N0.6450.97
382_L385_G0.6450.97
103_M331_F0.6440.97
406_V412_G0.6430.97
84_W319_R0.6420.97
254_V261_D0.6420.97
68_D72_V0.6420.97
349_V425_C0.6400.97
110_A119_V0.6360.97
391_T394_D0.6360.97
248_G260_W0.6350.97
362_P449_S0.6350.97
157_L175_V0.6330.97
66_T69_D0.6330.97
67_W73_H0.6290.97
196_E200_E0.6260.97
131_M173_W0.6250.97
395_L444_S0.6240.96
134_G170_A0.6210.96
283_G322_G0.6160.96
373_E381_K0.6140.96
105_A118_A0.6120.96
379_C383_K0.6070.96
334_L339_Y0.6060.96
67_W71_N0.6030.96
284_C324_V0.6020.96
64_C278_G0.6000.96
357_I378_V0.5990.96
389_G392_L0.5990.96
446_K449_S0.5980.96
144_R237_D0.5980.96
354_A357_I0.5980.96
353_L423_I0.5980.96
375_I382_L0.5960.95
253_F260_W0.5950.95
133_G137_M0.5940.95
198_C236_I0.5930.95
409_F412_G0.5920.95
224_H264_L0.5920.95
164_I250_L0.5920.95
396_S400_R0.5920.95
190_D226_A0.5920.95
101_V311_G0.5910.95
402_R405_Q0.5900.95
286_W327_Q0.5900.95
268_K294_A0.5890.95
276_K422_R0.5870.95
443_A447_Y0.5860.95
66_T71_N0.5860.95
110_A120_G0.5830.95
407_P411_L0.5820.95
93_S321_A0.5810.95
74_K96_I0.5810.95
130_C271_S0.5800.95
404_W411_L0.5800.95
209_F242_I0.5800.95
379_C420_V0.5790.95
124_I127_S0.5790.95
250_L343_Q0.5780.95
374_G383_K0.5770.95
421_M424_M0.5770.95
393_Y411_L0.5730.94
144_R154_K0.5730.94
108_W251_A0.5720.94
125_G285_G0.5690.94
352_Y434_A0.5690.94
396_S407_P0.5680.94
100_C328_Y0.5670.94
64_C426_R0.5670.94
198_C202_T0.5660.94
110_A262_F0.5660.94
160_G189_M0.5650.94
226_A238_I0.5630.94
185_G190_D0.5630.94
158_V205_V0.5630.94
174_D179_E0.5620.94
398_R402_R0.5620.94
373_E377_A0.5610.94
135_M169_F0.5610.94
404_W413_G0.5610.94
373_E378_V0.5600.94
393_Y396_S0.5600.94
381_K385_G0.5600.94
357_I380_F0.5600.94
99_R102_N0.5590.94
422_R426_R0.5570.94
206_V271_S0.5570.94
260_W267_V0.5570.94
422_R425_C0.5570.94
212_T276_K0.5560.93
438_L441_Y0.5550.93
441_Y445_L0.5540.93
224_H227_L0.5530.93
121_T314_A0.5530.93
400_R406_V0.5520.93
402_R447_Y0.5470.93
74_K77_D0.5470.93
79_S92_Q0.5470.93
190_D222_P0.5460.93
101_V120_G0.5450.93
92_Q95_A0.5440.93
83_N318_S0.5430.93
191_P219_F0.5430.93
76_M326_A0.5430.93
376_P383_K0.5430.93
389_G418_I0.5420.93
74_K80_I0.5410.93
248_G327_Q0.5400.92
178_R201_N0.5400.92
172_Y315_I0.5380.92
392_L397_E0.5380.92
181_P190_D0.5370.92
190_D194_M0.5370.92
337_E340_T0.5340.92
374_G381_K0.5330.92
247_G251_A0.5330.92
379_C384_D0.5290.92
210_G217_Y0.5250.91
423_I427_R0.5250.91
129_A285_G0.5240.91
197_A201_N0.5240.91
435_E438_L0.5240.91
376_P382_L0.5230.91
134_G206_V0.5220.91
67_W330_E0.5220.91
103_M106_D0.5210.91
286_W289_W0.5210.91
270_I288_I0.5210.91
358_A365_F0.5210.91
107_L328_Y0.5210.91
239_D268_K0.5190.91
160_G208_T0.5190.91
373_E383_K0.5180.91
327_Q331_F0.5160.91
67_W74_K0.5160.91
376_P384_D0.5160.91
374_G385_G0.5150.91
271_S285_G0.5110.90
132_L304_D0.5110.90
91_P94_A0.5110.90
137_M141_W0.5110.90
220_P223_L0.5100.90
194_M227_L0.5090.90
132_L314_A0.5080.90
101_V286_W0.5070.90
395_L445_L0.5070.90
118_A291_D0.5070.90
189_M207_P0.5070.90
80_I84_W0.5070.90
282_L318_S0.5050.90
179_E223_L0.5040.90
142_R174_D0.5040.90
381_K392_L0.5030.90
303_V307_G0.5030.90
304_D310_I0.5030.90
250_L277_F0.5010.89
246_S376_P0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e1oA 2 0.927 100 0.422 Contact Map
4ritB 2 0.897 100 0.424 Contact Map
2jisA 2 0.9185 100 0.427 Contact Map
1js3A 2 0.9013 100 0.431 Contact Map
3vp6A 2 0.9206 100 0.432 Contact Map
2qmaA 2 0.8841 100 0.445 Contact Map
3k40A 2 0.8841 100 0.446 Contact Map
4obuE 2 0.912 100 0.446 Contact Map
2dgkA 3 0.927 100 0.498 Contact Map
3hbxA 5 0.9335 100 0.506 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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