DCEB - ECOLI - GREMLIN Contacts

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DCEB - Glutamate decarboxylase beta

UniProt:	P69910	Sequences: MDKKQVTDLRSELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11490
Length:	466 (356)
Sequences:	8318 (5164)
Seq/√Len:	273.7

ECOLI - DCEB DCEA ISCS CSDA
BACSU - ISCS ISCS1 ISCS2
HALSA - Q9HHV3 CSD MFNA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
219_F	222_P	4.340	1.00
195_I	235_G	4.180	1.00
352_Y	435_E	4.060	1.00
356_E	438_L	3.798	1.00
352_Y	431_M	3.456	1.00
205_V	227_L	3.440	1.00
161_P	181_P	3.361	1.00
209_F	247_G	3.164	1.00
183_R	188_F	2.879	1.00
183_R	186_Q	2.838	1.00
193_R	196_E	2.797	1.00
225_D	266_R	2.680	1.00
329_Y	332_L	2.556	1.00
224_H	240_M	2.510	1.00
360_L	442_K	2.462	1.00
130_C	165_C	2.451	1.00
61_A	64_C	2.411	1.00
191_P	226_A	2.381	1.00
207_P	223_L	2.357	1.00
356_E	435_E	2.332	1.00
224_H	266_R	2.307	1.00
156_N	178_R	2.282	1.00
348_Q	431_M	2.266	1.00
155_P	201_N	2.170	1.00
186_Q	368_T	2.159	1.00
180_I	197_A	2.151	1.00
274_G	327_Q	2.105	1.00
352_Y	356_E	2.060	1.00
181_P	193_R	2.058	1.00
364_E	381_K	2.030	1.00
221_Q	225_D	2.024	1.00
193_R	197_A	2.010	1.00
107_L	331_F	2.003	1.00
221_Q	262_F	1.967	1.00
355_D	359_K	1.964	1.00
221_Q	264_L	1.960	1.00
157_L	170_A	1.945	1.00
227_L	238_I	1.932	1.00
74_K	78_L	1.880	1.00
373_E	376_P	1.869	1.00
195_I	236_I	1.844	1.00
195_I	226_A	1.840	1.00
364_E	383_K	1.831	1.00
320_P	323_Q	1.813	1.00
356_E	359_K	1.811	1.00
190_D	193_R	1.768	1.00
102_N	106_D	1.767	1.00
234_T	266_R	1.764	1.00
103_M	332_L	1.762	1.00
277_F	327_Q	1.696	1.00
69_D	73_H	1.673	1.00
192_K	195_I	1.671	1.00
353_L	425_C	1.655	1.00
438_L	442_K	1.653	1.00
242_I	267_V	1.646	1.00
354_A	365_F	1.637	1.00
202_T	236_I	1.634	1.00
272_A	286_W	1.613	1.00
354_A	358_A	1.607	1.00
156_N	199_D	1.606	1.00
356_E	360_L	1.583	1.00
244_A	270_I	1.569	1.00
227_L	240_M	1.566	1.00
244_A	248_G	1.564	1.00
423_I	437_L	1.556	1.00
161_P	179_E	1.541	1.00
194_M	205_V	1.528	1.00
133_G	269_S	1.516	1.00
160_G	207_P	1.510	1.00
183_R	190_D	1.507	1.00
198_C	226_A	1.506	1.00
191_P	194_M	1.494	1.00
439_E	443_A	1.485	1.00
341_K	345_A	1.480	1.00
135_M	306_L	1.477	1.00
70_E	74_K	1.476	1.00
207_P	240_M	1.458	1.00
192_K	196_E	1.442	1.00
178_R	197_A	1.440	1.00
398_R	447_Y	1.438	1.00
109_H	263_R	1.416	1.00
109_H	261_D	1.412	1.00
129_A	271_S	1.409	1.00
158_V	201_N	1.407	1.00
440_D	443_A	1.400	1.00
205_V	238_I	1.399	1.00
342_V	345_A	1.394	1.00
103_M	328_Y	1.391	1.00
402_R	443_A	1.389	1.00
73_H	77_D	1.382	1.00
161_P	182_M	1.372	1.00
436_L	440_D	1.344	1.00
375_I	379_C	1.333	1.00
209_F	220_P	1.324	1.00
349_V	434_A	1.323	1.00
137_M	239_D	1.320	1.00
159_C	170_A	1.314	1.00
195_I	199_D	1.313	1.00
431_M	435_E	1.303	1.00
430_E	433_F	1.295	1.00
353_L	434_A	1.293	1.00
209_F	265_P	1.286	1.00
402_R	440_D	1.285	1.00
167_H	179_E	1.280	1.00
139_W	176_E	1.275	1.00
248_G	331_F	1.271	1.00
376_P	379_C	1.265	1.00
347_Y	351_A	1.262	1.00
159_C	179_E	1.258	1.00
71_N	74_K	1.244	1.00
345_A	348_Q	1.243	1.00
99_R	103_M	1.236	1.00
234_T	268_K	1.233	1.00
356_E	442_K	1.231	1.00
437_L	441_Y	1.229	1.00
96_I	325_I	1.228	1.00
198_C	238_I	1.226	1.00
107_L	336_R	1.221	1.00
261_D	264_L	1.220	1.00
398_R	401_L	1.220	1.00
142_R	155_P	1.211	1.00
172_Y	306_L	1.208	1.00
194_M	223_L	1.206	1.00
207_P	220_P	1.201	1.00
156_N	202_T	1.201	1.00
380_F	383_K	1.186	1.00
278_G	426_R	1.179	1.00
289_W	295_L	1.175	1.00
195_I	222_P	1.166	1.00
217_Y	251_A	1.165	1.00
356_E	439_E	1.160	1.00
127_S	305_Y	1.160	1.00
108_W	270_I	1.151	1.00
180_I	193_R	1.150	1.00
381_K	384_D	1.150	1.00
137_M	269_S	1.144	1.00
107_L	248_G	1.135	1.00
222_P	225_D	1.134	1.00
130_C	241_H	1.132	1.00
435_E	439_E	1.131	1.00
75_L	96_I	1.120	1.00
355_D	358_A	1.115	1.00
131_M	172_Y	1.115	1.00
351_A	355_D	1.113	1.00
66_T	70_E	1.112	1.00
180_I	189_M	1.109	1.00
121_T	132_L	1.107	1.00
97_D	324_V	1.106	1.00
71_N	329_Y	1.105	1.00
158_V	197_A	1.104	1.00
133_G	287_V	1.101	1.00
360_L	439_E	1.101	1.00
436_L	439_E	1.095	1.00
154_K	203_I	1.091	1.00
241_H	271_S	1.089	1.00
156_N	201_N	1.088	1.00
188_F	218_E	1.080	1.00
205_V	223_L	1.080	1.00
135_M	172_Y	1.077	1.00
97_D	321_A	1.071	1.00
340_T	344_N	1.070	1.00
104_V	286_W	1.064	1.00
253_F	261_D	1.061	1.00
120_G	288_I	1.060	1.00
338_G	341_K	1.059	1.00
345_A	349_V	1.058	1.00
123_T	129_A	1.057	1.00
223_L	240_M	1.056	1.00
374_G	378_V	1.053	1.00
106_D	336_R	1.053	1.00
357_I	363_Y	1.052	1.00
197_A	200_E	1.051	1.00
95_A	99_R	1.049	1.00
224_H	234_T	1.044	1.00
338_G	342_V	1.043	1.00
248_G	277_F	1.041	1.00
221_Q	266_R	1.040	1.00
126_S	245_A	1.040	1.00
397_E	401_L	1.039	1.00
194_M	226_A	1.038	1.00
374_G	379_C	1.034	1.00
350_A	354_A	1.022	1.00
158_V	178_R	1.022	1.00
368_T	373_E	1.022	1.00
227_L	234_T	1.021	1.00
170_A	177_L	1.012	1.00
69_D	77_D	1.012	1.00
380_F	384_D	1.012	1.00
134_G	204_G	1.011	1.00
210_G	374_G	1.011	1.00
191_P	222_P	1.010	1.00
429_F	433_F	1.007	1.00
424_M	428_G	1.004	1.00
71_N	75_L	0.999	1.00
248_G	272_A	0.998	1.00
135_M	139_W	0.996	1.00
158_V	180_I	0.989	1.00
349_V	431_M	0.987	1.00
277_F	331_F	0.985	1.00
206_V	241_H	0.985	1.00
254_V	344_N	0.982	1.00
358_A	363_Y	0.974	1.00
444_S	447_Y	0.973	1.00
362_P	383_K	0.971	1.00
97_D	319_R	0.969	1.00
262_F	266_R	0.967	1.00
111_P	263_R	0.966	1.00
191_P	195_I	0.966	1.00
225_D	235_G	0.964	1.00
69_D	74_K	0.963	1.00
189_M	194_M	0.961	1.00
358_A	368_T	0.956	1.00
191_P	223_L	0.956	1.00
344_N	348_Q	0.955	1.00
354_A	378_V	0.954	1.00
429_F	434_A	0.953	1.00
227_L	236_I	0.947	1.00
360_L	438_L	0.942	1.00
342_V	346_S	0.941	1.00
267_V	270_I	0.934	1.00
108_W	272_A	0.934	1.00
159_C	177_L	0.933	1.00
366_I	420_V	0.932	1.00
375_I	378_V	0.929	1.00
60_L	63_F	0.923	1.00
354_A	373_E	0.921	1.00
194_M	198_C	0.914	1.00
134_G	166_W	0.912	1.00
137_M	204_G	0.912	1.00
442_K	446_K	0.912	1.00
67_W	70_E	0.902	1.00
423_I	441_Y	0.900	1.00
168_K	171_R	0.898	1.00
336_R	340_T	0.894	1.00
353_L	437_L	0.893	1.00
159_C	162_V	0.888	1.00
135_M	173_W	0.886	1.00
227_L	235_G	0.876	1.00
126_S	130_C	0.876	1.00
379_C	382_L	0.872	1.00
199_D	202_T	0.871	1.00
342_V	427_R	0.870	1.00
73_H	76_M	0.870	1.00
376_P	380_F	0.867	1.00
357_I	365_F	0.867	1.00
307_G	311_G	0.866	1.00
60_L	64_C	0.865	1.00
188_F	368_T	0.864	1.00
366_I	381_K	0.863	1.00
210_G	375_I	0.862	1.00
359_K	442_K	0.862	1.00
163_Q	276_K	0.861	1.00
393_Y	397_E	0.857	1.00
343_Q	347_Y	0.857	1.00
404_W	412_G	0.855	1.00
319_R	324_V	0.851	1.00
425_C	434_A	0.850	1.00
134_G	169_F	0.850	1.00
362_P	442_K	0.849	1.00
223_L	227_L	0.849	1.00
180_I	194_M	0.843	1.00
220_P	242_I	0.841	1.00
172_Y	176_E	0.841	1.00
97_D	328_Y	0.838	1.00
374_G	377_A	0.838	1.00
70_E	73_H	0.837	1.00
155_P	199_D	0.835	1.00
72_V	326_A	0.826	0.99
373_E	379_C	0.825	0.99
70_E	281_P	0.818	0.99
221_Q	265_P	0.815	0.99
124_I	128_E	0.814	0.99
353_L	356_E	0.813	0.99
404_W	440_D	0.812	0.99
337_E	341_K	0.811	0.99
159_C	206_V	0.810	0.99
199_D	236_I	0.805	0.99
226_A	236_I	0.805	0.99
341_K	344_N	0.804	0.99
104_V	122_N	0.803	0.99
262_F	288_I	0.803	0.99
209_F	251_A	0.800	0.99
139_W	172_Y	0.799	0.99
284_C	323_Q	0.797	0.99
111_P	118_A	0.795	0.99
208_T	212_T	0.794	0.99
394_D	398_R	0.791	0.99
157_L	204_G	0.791	0.99
328_Y	331_F	0.788	0.99
221_Q	259_V	0.787	0.99
111_P	291_D	0.784	0.99
70_E	77_D	0.783	0.99
94_A	98_L	0.783	0.99
269_S	289_W	0.780	0.99
140_R	294_A	0.776	0.99
157_L	177_L	0.775	0.99
345_A	431_M	0.774	0.99
360_L	363_Y	0.774	0.99
81_N	84_W	0.774	0.99
390_Y	393_Y	0.773	0.99
262_F	265_P	0.768	0.99
158_V	198_C	0.764	0.99
398_R	444_S	0.763	0.99
348_Q	352_Y	0.757	0.99
220_P	240_M	0.757	0.99
445_L	449_S	0.756	0.99
72_V	76_M	0.754	0.99
169_F	306_L	0.747	0.99
350_A	378_V	0.746	0.99
87_K	90_Y	0.746	0.99
103_M	107_L	0.746	0.99
210_G	247_G	0.744	0.99
284_C	327_Q	0.738	0.99
66_T	77_D	0.736	0.99
432_D	435_E	0.735	0.99
140_R	144_R	0.733	0.99
130_C	166_W	0.732	0.99
69_D	76_M	0.731	0.99
274_G	284_C	0.730	0.99
340_T	343_Q	0.729	0.99
307_G	310_I	0.729	0.99
274_G	286_W	0.728	0.99
65_Q	68_D	0.726	0.99
119_V	291_D	0.725	0.99
407_P	412_G	0.725	0.99
268_K	290_R	0.722	0.99
133_G	204_G	0.722	0.99
332_L	337_E	0.721	0.99
227_L	237_D	0.715	0.98
213_Y	410_T	0.714	0.98
71_N	103_M	0.713	0.98
209_F	260_W	0.712	0.98
188_F	374_G	0.709	0.98
394_D	397_E	0.708	0.98
220_P	267_V	0.706	0.98
189_M	223_L	0.703	0.98
76_M	322_G	0.703	0.98
164_I	168_K	0.703	0.98
65_Q	427_R	0.701	0.98
166_W	206_V	0.697	0.98
280_A	330_E	0.697	0.98
225_D	234_T	0.696	0.98
399_L	406_V	0.694	0.98
309_Q	316_N	0.694	0.98
304_D	307_G	0.693	0.98
397_E	400_R	0.693	0.98
433_F	436_L	0.691	0.98
440_D	444_S	0.691	0.98
199_D	203_I	0.690	0.98
390_Y	394_D	0.688	0.98
423_I	426_R	0.688	0.98
104_V	331_F	0.686	0.98
208_T	211_V	0.683	0.98
385_G	390_Y	0.680	0.98
141_W	144_R	0.680	0.98
134_G	173_W	0.679	0.98
104_V	328_Y	0.678	0.98
432_D	436_L	0.677	0.98
170_A	179_E	0.675	0.98
274_G	279_L	0.674	0.98
283_G	320_P	0.673	0.98
377_A	380_F	0.672	0.98
80_I	83_N	0.669	0.98
404_W	407_P	0.665	0.98
188_F	216_N	0.665	0.98
108_W	288_I	0.660	0.97
126_S	271_S	0.660	0.97
181_P	197_A	0.657	0.97
291_D	294_A	0.656	0.97
404_W	436_L	0.656	0.97
108_W	262_F	0.655	0.97
65_Q	338_G	0.654	0.97
156_N	176_E	0.650	0.97
68_D	76_M	0.650	0.97
74_K	325_I	0.649	0.97
239_D	269_S	0.649	0.97
349_V	352_Y	0.646	0.97
128_E	316_N	0.645	0.97
382_L	385_G	0.645	0.97
103_M	331_F	0.644	0.97
406_V	412_G	0.643	0.97
84_W	319_R	0.642	0.97
254_V	261_D	0.642	0.97
68_D	72_V	0.642	0.97
349_V	425_C	0.640	0.97
110_A	119_V	0.636	0.97
391_T	394_D	0.636	0.97
248_G	260_W	0.635	0.97
362_P	449_S	0.635	0.97
157_L	175_V	0.633	0.97
66_T	69_D	0.633	0.97
67_W	73_H	0.629	0.97
196_E	200_E	0.626	0.97
131_M	173_W	0.625	0.97
395_L	444_S	0.624	0.96
134_G	170_A	0.621	0.96
283_G	322_G	0.616	0.96
373_E	381_K	0.614	0.96
105_A	118_A	0.612	0.96
379_C	383_K	0.607	0.96
334_L	339_Y	0.606	0.96
67_W	71_N	0.603	0.96
284_C	324_V	0.602	0.96
64_C	278_G	0.600	0.96
357_I	378_V	0.599	0.96
389_G	392_L	0.599	0.96
446_K	449_S	0.598	0.96
144_R	237_D	0.598	0.96
354_A	357_I	0.598	0.96
353_L	423_I	0.598	0.96
375_I	382_L	0.596	0.95
253_F	260_W	0.595	0.95
133_G	137_M	0.594	0.95
198_C	236_I	0.593	0.95
409_F	412_G	0.592	0.95
224_H	264_L	0.592	0.95
164_I	250_L	0.592	0.95
396_S	400_R	0.592	0.95
190_D	226_A	0.592	0.95
101_V	311_G	0.591	0.95
402_R	405_Q	0.590	0.95
286_W	327_Q	0.590	0.95
268_K	294_A	0.589	0.95
276_K	422_R	0.587	0.95
443_A	447_Y	0.586	0.95
66_T	71_N	0.586	0.95
110_A	120_G	0.583	0.95
407_P	411_L	0.582	0.95
93_S	321_A	0.581	0.95
74_K	96_I	0.581	0.95
130_C	271_S	0.580	0.95
404_W	411_L	0.580	0.95
209_F	242_I	0.580	0.95
379_C	420_V	0.579	0.95
124_I	127_S	0.579	0.95
250_L	343_Q	0.578	0.95
374_G	383_K	0.577	0.95
421_M	424_M	0.577	0.95
393_Y	411_L	0.573	0.94
144_R	154_K	0.573	0.94
108_W	251_A	0.572	0.94
125_G	285_G	0.569	0.94
352_Y	434_A	0.569	0.94
396_S	407_P	0.568	0.94
100_C	328_Y	0.567	0.94
64_C	426_R	0.567	0.94
198_C	202_T	0.566	0.94
110_A	262_F	0.566	0.94
160_G	189_M	0.565	0.94
226_A	238_I	0.563	0.94
185_G	190_D	0.563	0.94
158_V	205_V	0.563	0.94
174_D	179_E	0.562	0.94
398_R	402_R	0.562	0.94
373_E	377_A	0.561	0.94
135_M	169_F	0.561	0.94
404_W	413_G	0.561	0.94
373_E	378_V	0.560	0.94
393_Y	396_S	0.560	0.94
381_K	385_G	0.560	0.94
357_I	380_F	0.560	0.94
99_R	102_N	0.559	0.94
422_R	426_R	0.557	0.94
206_V	271_S	0.557	0.94
260_W	267_V	0.557	0.94
422_R	425_C	0.557	0.94
212_T	276_K	0.556	0.93
438_L	441_Y	0.555	0.93
441_Y	445_L	0.554	0.93
224_H	227_L	0.553	0.93
121_T	314_A	0.553	0.93
400_R	406_V	0.552	0.93
402_R	447_Y	0.547	0.93
74_K	77_D	0.547	0.93
79_S	92_Q	0.547	0.93
190_D	222_P	0.546	0.93
101_V	120_G	0.545	0.93
92_Q	95_A	0.544	0.93
83_N	318_S	0.543	0.93
191_P	219_F	0.543	0.93
76_M	326_A	0.543	0.93
376_P	383_K	0.543	0.93
389_G	418_I	0.542	0.93
74_K	80_I	0.541	0.93
248_G	327_Q	0.540	0.92
178_R	201_N	0.540	0.92
172_Y	315_I	0.538	0.92
392_L	397_E	0.538	0.92
181_P	190_D	0.537	0.92
190_D	194_M	0.537	0.92
337_E	340_T	0.534	0.92
374_G	381_K	0.533	0.92
247_G	251_A	0.533	0.92
379_C	384_D	0.529	0.92
210_G	217_Y	0.525	0.91
423_I	427_R	0.525	0.91
129_A	285_G	0.524	0.91
197_A	201_N	0.524	0.91
435_E	438_L	0.524	0.91
376_P	382_L	0.523	0.91
134_G	206_V	0.522	0.91
67_W	330_E	0.522	0.91
103_M	106_D	0.521	0.91
286_W	289_W	0.521	0.91
270_I	288_I	0.521	0.91
358_A	365_F	0.521	0.91
107_L	328_Y	0.521	0.91
239_D	268_K	0.519	0.91
160_G	208_T	0.519	0.91
373_E	383_K	0.518	0.91
327_Q	331_F	0.516	0.91
67_W	74_K	0.516	0.91
376_P	384_D	0.516	0.91
374_G	385_G	0.515	0.91
271_S	285_G	0.511	0.90
132_L	304_D	0.511	0.90
91_P	94_A	0.511	0.90
137_M	141_W	0.511	0.90
220_P	223_L	0.510	0.90
194_M	227_L	0.509	0.90
132_L	314_A	0.508	0.90
101_V	286_W	0.507	0.90
395_L	445_L	0.507	0.90
118_A	291_D	0.507	0.90
189_M	207_P	0.507	0.90
80_I	84_W	0.507	0.90
282_L	318_S	0.505	0.90
179_E	223_L	0.504	0.90
142_R	174_D	0.504	0.90
381_K	392_L	0.503	0.90
303_V	307_G	0.503	0.90
304_D	310_I	0.503	0.90
250_L	277_F	0.501	0.89
246_S	376_P	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4e1oA	2	0.927	100	0.422	Contact Map
4ritB	2	0.897	100	0.424	Contact Map
2jisA	2	0.9185	100	0.427	Contact Map
1js3A	2	0.9013	100	0.431	Contact Map
3vp6A	2	0.9206	100	0.432	Contact Map
2qmaA	2	0.8841	100	0.445	Contact Map
3k40A	2	0.8841	100	0.446	Contact Map
4obuE	2	0.912	100	0.446	Contact Map
2dgkA	3	0.927	100	0.498	Contact Map
3hbxA	5	0.9335	100	0.506	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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