GREMLIN Database
DCEA - Glutamate decarboxylase alpha
UniProt: P69908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG50009
Length: 466 (373)
Sequences: 7664 (4808)
Seq/√Len: 248.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_F222_P4.7041.00
174_D177_L4.6501.00
195_I235_G4.5781.00
352_Y435_E4.1581.00
356_E438_L3.9631.00
205_V227_L3.8541.00
352_Y431_M3.4761.00
161_P181_P3.4581.00
209_F247_G3.0801.00
225_D266_R3.0311.00
61_A64_C3.0051.00
183_R188_F3.0031.00
183_R186_Q2.9431.00
193_R196_E2.8691.00
191_P226_A2.6801.00
130_C165_C2.6091.00
360_L442_K2.5791.00
224_H266_R2.4811.00
207_P223_L2.4461.00
224_H240_M2.4291.00
155_P201_N2.4291.00
348_Q431_M2.4121.00
356_E435_E2.3941.00
364_E381_K2.3421.00
180_I197_A2.2721.00
221_Q262_F2.2351.00
186_Q368_T2.2191.00
109_H261_D2.1741.00
156_N178_R2.1521.00
193_R197_A2.1371.00
221_Q264_L2.1361.00
221_Q225_D2.0711.00
157_L170_A2.0451.00
352_Y356_E2.0081.00
227_L238_I1.9901.00
181_P193_R1.9531.00
195_I236_I1.9451.00
364_E383_K1.9371.00
202_T236_I1.9121.00
234_T266_R1.8611.00
320_P323_Q1.8571.00
195_I226_A1.8471.00
190_D193_R1.8461.00
74_K78_L1.8411.00
353_L425_C1.8291.00
261_D264_L1.8081.00
355_D359_K1.7921.00
356_E359_K1.7831.00
354_A365_F1.7801.00
102_N106_D1.7791.00
192_K195_I1.7581.00
198_C226_A1.7431.00
356_E360_L1.7401.00
244_A248_G1.7381.00
373_E376_P1.7251.00
438_L442_K1.6621.00
354_A358_A1.6261.00
161_P179_E1.6031.00
307_G311_G1.6011.00
439_E443_A1.5811.00
69_D73_H1.5781.00
133_G269_S1.5641.00
274_G327_Q1.5491.00
227_L240_M1.5431.00
341_K345_A1.5281.00
160_G207_P1.5271.00
244_A270_I1.5021.00
109_H263_R1.4991.00
207_P240_M1.4771.00
398_R447_Y1.4611.00
242_I267_V1.4551.00
205_V238_I1.4501.00
158_V201_N1.4461.00
137_M239_D1.4381.00
329_Y332_L1.4371.00
183_R190_D1.4361.00
198_C238_I1.4351.00
440_D443_A1.4271.00
192_K196_E1.4161.00
272_A286_W1.4121.00
207_P220_P1.4101.00
330_E333_R1.4091.00
191_P194_M1.4091.00
431_M435_E1.3901.00
70_E74_K1.3851.00
328_Y331_F1.3821.00
194_M205_V1.3771.00
156_N199_D1.3661.00
195_I199_D1.3611.00
209_F220_P1.3511.00
107_L336_R1.3511.00
327_Q331_F1.3411.00
161_P182_M1.3411.00
342_V345_A1.3401.00
430_E433_F1.3351.00
256_P344_N1.3341.00
178_R197_A1.3321.00
304_D307_G1.3281.00
436_L440_D1.3261.00
56_A59_N1.3201.00
353_L434_A1.3131.00
222_P225_D1.3121.00
71_N74_K1.3091.00
307_G310_I1.3051.00
402_R443_A1.2981.00
423_I437_L1.2921.00
398_R401_L1.2911.00
356_E442_K1.2861.00
402_R440_D1.2831.00
129_A271_S1.2801.00
180_I193_R1.2791.00
349_V434_A1.2751.00
99_R103_M1.2601.00
73_H77_D1.2601.00
209_F265_P1.2481.00
347_Y351_A1.2461.00
142_R155_P1.2451.00
437_L441_Y1.2441.00
154_K203_I1.2421.00
375_I379_C1.2371.00
289_W295_L1.2321.00
356_E439_E1.2221.00
307_G312_T1.2161.00
205_V223_L1.2151.00
135_M306_L1.2131.00
224_H234_T1.2131.00
133_G287_V1.2081.00
131_M172_Y1.2071.00
167_H179_E1.1941.00
45_I332_L1.1871.00
108_W270_I1.1821.00
435_E439_E1.1771.00
195_I222_P1.1761.00
397_E401_L1.1751.00
221_Q266_R1.1721.00
197_A200_E1.1711.00
345_A348_Q1.1661.00
194_M223_L1.1661.00
351_A355_D1.1601.00
137_M269_S1.1571.00
340_T344_N1.1561.00
159_C179_E1.1521.00
217_Y251_A1.1411.00
158_V178_R1.1361.00
358_A363_Y1.1321.00
336_R340_T1.1301.00
357_I363_Y1.1281.00
376_P379_C1.1241.00
429_F433_F1.1221.00
107_L248_G1.1201.00
326_A330_E1.1091.00
95_A99_R1.0971.00
436_L439_E1.0961.00
69_D74_K1.0931.00
104_V286_W1.0911.00
123_T129_A1.0891.00
134_G204_G1.0881.00
159_C170_A1.0871.00
135_M139_W1.0831.00
135_M172_Y1.0821.00
188_F218_E1.0811.00
326_A329_Y1.0751.00
345_A349_V1.0721.00
107_L331_F1.0721.00
248_G277_F1.0721.00
254_V344_N1.0651.00
241_H271_S1.0641.00
338_G341_K1.0631.00
103_M332_L1.0581.00
360_L439_E1.0491.00
234_T268_K1.0461.00
71_N75_L1.0451.00
223_L227_L1.0431.00
325_I328_Y1.0391.00
350_A354_A1.0381.00
97_D321_A1.0361.00
227_L234_T1.0301.00
355_D358_A1.0281.00
191_P222_P1.0241.00
156_N202_T1.0181.00
137_M204_G1.0121.00
135_M173_W1.0111.00
337_E341_K1.0091.00
134_G169_F1.0081.00
180_I189_M1.0081.00
106_D336_R1.0071.00
358_A368_T1.0021.00
191_P223_L0.9961.00
349_V431_M0.9951.00
130_C241_H0.9941.00
120_G288_I0.9881.00
342_V346_S0.9871.00
75_L96_I0.9861.00
60_L63_F0.9831.00
381_K384_D0.9811.00
225_D235_G0.9781.00
194_M226_A0.9771.00
359_K442_K0.9771.00
354_A373_E0.9771.00
158_V180_I0.9761.00
66_T70_E0.9751.00
126_S245_A0.9701.00
134_G166_W0.9701.00
158_V197_A0.9651.00
121_T132_L0.9651.00
53_D59_N0.9621.00
429_F434_A0.9551.00
277_F327_Q0.9531.00
344_N348_Q0.9491.00
327_Q330_E0.9401.00
227_L236_I0.9381.00
157_L204_G0.9381.00
138_K175_V0.9371.00
108_W272_A0.9361.00
393_Y397_E0.9331.00
70_E281_P0.9311.00
390_Y394_D0.9301.00
97_D319_R0.9301.00
274_G328_Y0.9271.00
384_D388_P0.9261.00
274_G280_A0.9241.00
303_V307_G0.9211.00
159_C162_V0.9161.00
444_S447_Y0.9151.00
206_V241_H0.9151.00
156_N201_N0.9141.00
328_Y332_L0.9131.00
338_G342_V0.9111.00
191_P195_I0.9091.00
248_G272_A0.9081.00
368_T373_E0.9071.00
220_P242_I0.9061.00
209_F251_A0.9041.00
425_C434_A0.9031.00
189_M194_M0.8961.00
126_S130_C0.8951.00
399_L406_V0.8951.00
341_K344_N0.8911.00
360_L438_L0.8891.00
73_H76_M0.8891.00
199_D236_I0.8891.00
220_P267_V0.8891.00
163_Q276_K0.8881.00
345_A431_M0.8781.00
180_I194_M0.8771.00
172_Y306_L0.8741.00
442_K446_K0.8731.00
70_E73_H0.8690.99
394_D398_R0.8650.99
375_I378_V0.8630.99
103_M328_Y0.8620.99
353_L437_L0.8590.99
155_P199_D0.8590.99
304_D310_I0.8580.99
225_D234_T0.8570.99
374_G379_C0.8500.99
209_F260_W0.8460.99
111_P117_Q0.8450.99
254_V257_D0.8430.99
168_K171_R0.8420.99
50_L53_D0.8410.99
226_A236_I0.8400.99
267_V270_I0.8400.99
262_F266_R0.8390.99
210_G374_G0.8360.99
227_L235_G0.8360.99
223_L240_M0.8350.99
176_E199_D0.8330.99
291_D294_A0.8260.99
404_W412_G0.8250.99
284_C327_Q0.8250.99
348_Q352_Y0.8250.99
111_P263_R0.8250.99
342_V427_R0.8250.99
139_W172_Y0.8230.99
166_W206_V0.8210.99
55_N59_N0.8190.99
366_I420_V0.8190.99
188_F368_T0.8170.99
304_D312_T0.8130.99
260_W267_V0.8100.99
394_D397_E0.8070.99
353_L356_E0.8070.99
60_L64_C0.8030.99
376_P384_D0.8020.99
373_E379_C0.8020.99
306_L312_T0.7980.99
227_L237_D0.7960.99
67_W71_N0.7900.99
157_L175_V0.7890.99
397_E400_R0.7890.99
124_I128_E0.7890.99
127_S305_Y0.7860.99
256_P348_Q0.7860.99
376_P380_F0.7830.99
158_V198_C0.7820.99
67_W70_E0.7810.99
357_I365_F0.7810.99
50_L54_G0.7770.99
362_P383_K0.7720.99
134_G173_W0.7710.99
111_P118_A0.7710.99
362_P442_K0.7700.99
329_Y333_R0.7700.99
67_W74_K0.7700.99
53_D58_Q0.7680.99
87_K90_Y0.7680.99
188_F374_G0.7660.99
210_G247_G0.7620.99
390_Y393_Y0.7580.99
66_T71_N0.7570.99
134_G206_V0.7570.99
199_D202_T0.7570.99
53_D56_A0.7570.99
208_T212_T0.7560.99
66_T69_D0.7560.99
164_I168_K0.7550.99
108_W262_F0.7510.99
55_N58_Q0.7500.98
354_A378_V0.7490.98
220_P240_M0.7450.98
213_Y410_T0.7440.98
340_T343_Q0.7420.98
53_D57_R0.7370.98
350_A378_V0.7370.98
139_W176_E0.7360.98
103_M107_L0.7360.98
388_P392_L0.7350.98
133_G204_G0.7340.98
94_A98_L0.7340.98
105_A118_A0.7330.98
156_N176_E0.7320.98
360_L363_Y0.7310.98
140_R294_A0.7310.98
69_D77_D0.7270.98
376_P382_L0.7270.98
190_D194_M0.7270.98
128_E316_N0.7190.98
353_L423_I0.7170.98
304_D311_G0.7120.98
224_H264_L0.7120.98
374_G378_V0.7120.98
104_V122_N0.7100.98
398_R444_S0.7100.98
315_I318_S0.7080.98
283_G322_G0.7070.98
144_R237_D0.7070.98
239_D269_S0.7070.98
107_L332_L0.7070.98
314_A319_R0.7060.98
274_G286_W0.7060.98
343_Q347_Y0.7050.98
248_G260_W0.7020.98
189_M223_L0.6990.98
255_A258_I0.6960.98
70_E77_D0.6950.98
194_M198_C0.6950.98
51_Y54_G0.6950.98
443_A447_Y0.6940.98
391_T394_D0.6930.97
262_F265_P0.6930.97
433_F436_L0.6920.97
159_C206_V0.6910.97
108_W251_A0.6910.97
199_D203_I0.6910.97
389_G418_I0.6880.97
198_C202_T0.6870.97
221_Q265_P0.6870.97
446_K449_S0.6860.97
404_W440_D0.6860.97
124_I127_S0.6830.97
96_I325_I0.6750.97
131_M173_W0.6720.97
208_T211_V0.6700.97
379_C382_L0.6650.97
306_L310_I0.6630.97
221_Q259_V0.6610.97
373_E381_K0.6580.97
112_A117_Q0.6580.97
317_F320_P0.6580.97
140_R144_R0.6560.97
50_L58_Q0.6560.97
402_R405_Q0.6530.96
400_R406_V0.6530.96
407_P412_G0.6520.96
198_C236_I0.6520.96
440_D444_S0.6510.96
69_D76_M0.6510.96
326_A331_F0.6510.96
393_Y419_V0.6480.96
316_N319_R0.6470.96
133_G137_M0.6470.96
380_F384_D0.6450.96
422_R426_R0.6440.96
393_Y411_L0.6420.96
274_G284_C0.6420.96
71_N76_M0.6400.96
398_R402_R0.6400.96
313_F316_N0.6390.96
54_G58_Q0.6380.96
65_Q427_R0.6380.96
327_Q332_L0.6370.96
279_L342_V0.6370.96
67_W73_H0.6360.96
366_I381_K0.6340.96
269_S289_W0.6330.96
445_L449_S0.6320.96
283_G320_P0.6310.96
284_C323_Q0.6300.96
141_W144_R0.6290.96
423_I441_Y0.6270.95
432_D435_E0.6260.95
250_L343_Q0.6250.95
188_F216_N0.6250.95
125_G285_G0.6240.95
268_K294_A0.6230.95
197_A201_N0.6230.95
196_E200_E0.6210.95
119_V291_D0.6210.95
374_G384_D0.6210.95
282_L318_S0.6200.95
404_W413_G0.6200.95
404_W407_P0.6190.95
130_C166_W0.6170.95
375_I384_D0.6170.95
432_D436_L0.6160.95
74_K80_I0.6160.95
141_W239_D0.6150.95
51_Y57_R0.6150.95
134_G170_A0.6140.95
352_Y355_D0.6120.95
45_I48_D0.6120.95
101_V120_G0.6110.95
352_Y434_A0.6080.95
357_I378_V0.6050.95
54_G59_N0.6030.94
349_V352_Y0.6030.94
379_C383_K0.6030.94
212_T276_K0.6020.94
169_F306_L0.6010.94
335_G339_Y0.6000.94
191_P219_F0.6000.94
373_E382_L0.6000.94
276_K422_R0.5980.94
424_M428_G0.5980.94
257_D347_Y0.5970.94
373_E383_K0.5970.94
64_C426_R0.5970.94
224_H227_L0.5950.94
220_P223_L0.5950.94
189_M207_P0.5940.94
268_K290_R0.5910.94
374_G383_K0.5900.94
99_R102_N0.5870.94
160_G189_M0.5870.94
362_P382_L0.5860.94
65_Q68_D0.5860.94
406_V412_G0.5840.93
170_A177_L0.5840.93
108_W288_I0.5820.93
354_A376_P0.5820.93
129_A285_G0.5810.93
103_M106_D0.5770.93
396_S400_R0.5750.93
399_L441_Y0.5740.93
322_G326_A0.5710.93
181_P190_D0.5710.93
337_E340_T0.5680.93
410_T420_V0.5670.92
280_A330_E0.5650.92
209_F242_I0.5610.92
374_G377_A0.5590.92
110_A120_G0.5580.92
68_D76_M0.5580.92
375_I383_K0.5570.92
226_A238_I0.5560.92
351_A354_A0.5560.92
181_P197_A0.5560.92
399_L404_W0.5560.92
396_S407_P0.5560.92
82_K85_I0.5540.92
172_Y315_I0.5540.92
83_N318_S0.5530.92
439_E442_K0.5530.92
65_Q69_D0.5520.91
407_P411_L0.5510.91
185_G190_D0.5510.91
354_A357_I0.5500.91
262_F288_I0.5500.91
243_D276_K0.5480.91
68_D74_K0.5480.91
74_K96_I0.5470.91
388_P391_T0.5470.91
130_C245_A0.5470.91
362_P449_S0.5460.91
248_G331_F0.5450.91
68_D71_N0.5440.91
93_S321_A0.5430.91
51_Y59_N0.5420.91
130_C271_S0.5410.91
111_P291_D0.5400.91
71_N103_M0.5400.91
380_F383_K0.5380.90
165_C271_S0.5380.90
277_F346_S0.5350.90
121_T314_A0.5340.90
321_A325_I0.5340.90
76_M322_G0.5330.90
110_A262_F0.5320.90
134_G157_L0.5310.90
242_I264_L0.5310.90
402_R447_Y0.5300.90
358_A365_F0.5300.90
277_F331_F0.5290.90
190_D226_A0.5280.90
84_W319_R0.5280.90
373_E378_V0.5270.89
164_I250_L0.5270.89
54_G57_R0.5270.89
126_S271_S0.5260.89
81_N84_W0.5250.89
379_C384_D0.5250.89
183_R193_R0.5250.89
277_F343_Q0.5240.89
132_L314_A0.5240.89
346_S425_C0.5230.89
375_I380_F0.5220.89
66_T77_D0.5220.89
241_H269_S0.5210.89
349_V425_C0.5210.89
376_P381_K0.5190.89
83_N310_I0.5190.89
110_A267_V0.5180.89
101_V286_W0.5180.89
160_G208_T0.5170.89
123_T285_G0.5170.89
259_V339_Y0.5160.88
209_F240_M0.5140.88
125_G275_H0.5130.88
239_D268_K0.5130.88
392_L395_L0.5130.88
389_G392_L0.5120.88
47_N54_G0.5100.88
421_M441_Y0.5090.88
270_I288_I0.5090.88
271_S285_G0.5090.88
375_I382_L0.5070.88
51_Y56_A0.5060.88
67_W330_E0.5060.88
326_A332_L0.5060.88
357_I438_L0.5060.88
357_I380_F0.5050.87
178_R201_N0.5050.87
127_S316_N0.5050.87
392_L421_M0.5040.87
442_K445_L0.5030.87
395_L399_L0.5030.87
205_V226_A0.5020.87
246_S376_P0.5000.87
316_N320_P0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e1oA 2 0.927 100 0.419 Contact Map
4ritB 2 0.897 100 0.424 Contact Map
2jisA 2 0.9185 100 0.43 Contact Map
3vp6A 2 0.9227 100 0.433 Contact Map
1js3A 2 0.9013 100 0.433 Contact Map
4obuE 2 0.9142 100 0.445 Contact Map
3k40A 2 0.8841 100 0.446 Contact Map
2qmaA 2 0.8841 100 0.446 Contact Map
2dgkA 3 0.927 100 0.498 Contact Map
3hbxA 5 0.9335 100 0.505 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0117 seconds.