GREMLIN Database
FCTA - Formyl-CoA:oxalate CoA-transferase
UniProt: P69902 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14145
Length: 416 (376)
Sequences: 10449 (7039)
Seq/√Len: 363.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_T111_H3.7181.00
32_D68_R3.6771.00
23_T94_V3.2911.00
319_I323_E3.1241.00
122_G180_L3.0431.00
185_L188_E2.9651.00
122_G176_L2.9181.00
76_T79_G2.8991.00
88_R115_I2.7751.00
84_E115_I2.7481.00
103_D108_T2.7221.00
112_I119_L2.7101.00
262_T321_K2.6111.00
358_E366_K2.6041.00
80_K84_E2.5261.00
319_I324_A2.5081.00
72_L83_M2.4981.00
9_K32_D2.4621.00
263_D320_D2.4241.00
109_W113_Q2.3651.00
320_D323_E2.3531.00
186_H194_Q2.3511.00
319_I327_Y2.2881.00
261_E317_V2.2261.00
85_K88_R2.2251.00
81_E85_K2.2191.00
390_G393_T2.2001.00
82_V402_Y2.1381.00
13_F83_M2.1161.00
92_I180_L2.1011.00
315_Y318_T2.0531.00
358_E368_L2.0291.00
304_H307_D1.9941.00
392_H395_A1.9851.00
393_T397_L1.9791.00
9_K89_E1.9551.00
310_A314_K1.9211.00
129_E197_T1.9081.00
11_L87_I1.8831.00
113_Q192_R1.8831.00
68_R395_A1.8801.00
360_E366_K1.8641.00
111_H114_E1.8491.00
178_I181_L1.8391.00
168_G204_V1.8351.00
102_I107_F1.8321.00
186_H190_T1.8281.00
73_N76_T1.8131.00
29_F182_A1.8021.00
340_S343_E1.7911.00
286_K315_Y1.7891.00
311_E314_K1.7811.00
11_L90_A1.7741.00
3_T6_Q1.7621.00
186_H378_A1.7591.00
93_L119_L1.7551.00
68_R399_E1.7421.00
136_V329_T1.7311.00
133_Y347_D1.7221.00
12_D23_T1.7001.00
8_I184_L1.7001.00
286_K289_W1.6881.00
87_I112_I1.6861.00
388_L391_E1.6841.00
267_Y270_F1.6801.00
258_K309_F1.6751.00
294_A307_D1.6551.00
27_A66_N1.6541.00
133_Y136_V1.6401.00
186_H192_R1.6391.00
322_H326_A1.6381.00
72_L79_G1.6151.00
202_D353_S1.6081.00
77_A80_K1.5921.00
312_I316_T1.5881.00
123_S195_R1.5711.00
109_W121_F1.5541.00
282_K287_P1.5521.00
147_G204_V1.5471.00
315_Y324_A1.5461.00
155_F158_G1.5411.00
194_Q377_S1.5351.00
87_I116_N1.5211.00
283_A327_Y1.5211.00
70_I396_V1.4901.00
297_T300_A1.4901.00
326_A330_Q1.4771.00
70_I393_T1.4751.00
385_A391_E1.4681.00
321_K343_E1.4661.00
28_W65_S1.4611.00
72_L82_V1.4571.00
286_K311_E1.4491.00
201_Q350_L1.4391.00
261_E313_E1.4141.00
120_I187_R1.4071.00
179_G374_M1.4051.00
300_A303_P1.3841.00
316_T324_A1.3811.00
346_L351_R1.3711.00
394_A398_Q1.3691.00
387_P392_H1.3671.00
154_G241_R1.3651.00
280_T284_I1.3561.00
307_D310_A1.3561.00
171_N207_L1.3521.00
85_K402_Y1.3491.00
278_E291_T1.3431.00
349_S352_Q1.3361.00
323_E327_Y1.3341.00
124_I176_L1.3191.00
86_L400_L1.3161.00
321_K337_P1.3151.00
260_W309_F1.3141.00
289_W311_E1.3121.00
84_E107_F1.3071.00
282_K290_I1.3051.00
95_E123_S1.3001.00
192_R378_A1.2991.00
84_E111_H1.2971.00
118_R187_R1.2951.00
10_V92_I1.2861.00
133_Y146_A1.2781.00
8_I185_L1.2751.00
194_Q379_F1.2661.00
361_Q365_G1.2621.00
109_W195_R1.2601.00
279_N282_K1.2341.00
66_N384_K1.2311.00
283_A331_F1.2241.00
356_V368_L1.2241.00
140_E144_Q1.2181.00
278_E282_K1.2171.00
277_W281_C1.2111.00
205_L350_L1.2101.00
284_I315_Y1.2001.00
145_A268_I1.1981.00
78_E81_E1.1901.00
185_L189_K1.1851.00
266_A321_K1.1851.00
342_K346_L1.1831.00
199_S202_D1.1771.00
296_S300_A1.1691.00
13_F93_L1.1691.00
181_L185_L1.1671.00
261_E316_T1.1571.00
275_Q279_N1.1501.00
175_H206_N1.1481.00
274_E278_E1.1461.00
132_P352_Q1.1441.00
22_C177_L1.1421.00
101_A104_H1.1411.00
82_V400_L1.1341.00
39_P71_E1.1261.00
184_L188_E1.1221.00
325_V335_C1.1221.00
271_T280_T1.1171.00
87_I115_I1.1111.00
361_Q364_R1.1091.00
71_E393_T1.0991.00
102_I121_F1.0971.00
74_T105_M1.0951.00
132_P349_S1.0911.00
138_A200_M1.0871.00
339_L347_D1.0821.00
205_L344_I1.0811.00
323_E326_A1.0641.00
127_F146_A1.0631.00
144_Q168_G1.0631.00
190_T378_A1.0611.00
266_A270_F1.0551.00
179_G196_V1.0501.00
75_K105_M1.0481.00
69_S387_P1.0461.00
183_A194_Q1.0441.00
238_A342_K1.0441.00
4_P376_F1.0401.00
138_A143_A1.0391.00
146_A347_D1.0391.00
11_L83_M1.0321.00
91_D187_R1.0181.00
265_N321_K1.0161.00
13_F102_I1.0141.00
22_C176_L1.0141.00
294_A304_H1.0091.00
92_I120_I1.0071.00
9_K34_I1.0071.00
280_T312_I1.0051.00
208_C341_M1.0001.00
325_V337_P0.9971.00
112_I121_F0.9941.00
118_R188_E0.9911.00
9_K90_A0.9901.00
322_H325_V0.9881.00
194_Q378_A0.9881.00
295_Y304_H0.9871.00
177_L181_L0.9851.00
348_P352_Q0.9831.00
25_M178_I0.9721.00
307_D311_E0.9711.00
83_M107_F0.9701.00
314_K318_T0.9691.00
262_T267_Y0.9691.00
14_T19_G0.9631.00
95_E102_I0.9611.00
88_R116_N0.9581.00
277_W301_R0.9571.00
84_E88_R0.9551.00
9_K68_R0.9491.00
109_W193_G0.9491.00
80_K107_F0.9481.00
359_V369_T0.9471.00
82_V85_K0.9451.00
7_G185_L0.9451.00
5_L181_L0.9401.00
27_A33_V0.9391.00
245_A305_I0.9391.00
130_C134_V0.9391.00
32_D395_A0.9271.00
339_L343_E0.9251.00
83_M87_I0.9191.00
93_L112_I0.9191.00
37_E46_R0.9171.00
77_A81_E0.9171.00
328_L335_C0.9151.00
3_T384_K0.9111.00
326_A329_T0.9091.00
327_Y330_Q0.9081.00
175_H203_A0.9071.00
126_G138_A0.9061.00
24_Q65_S0.9041.00
282_K331_F0.9021.00
145_A336_A0.8951.00
261_E265_N0.8911.00
36_I83_M0.8891.00
184_L187_R0.8871.00
157_D241_R0.8861.00
202_D355_S0.8851.00
186_H379_F0.8851.00
24_Q28_W0.8851.00
129_E195_R0.8821.00
267_Y324_A0.8821.00
395_A399_E0.8811.00
295_Y307_D0.8811.00
351_R368_L0.8781.00
322_H337_P0.8751.00
82_V397_L0.8721.00
153_T164_A0.8691.00
16_V139_Y0.8671.00
130_C352_Q0.8631.00
83_M93_L0.8621.00
121_F195_R0.8591.00
313_E317_V0.8571.00
97_F101_A0.8561.00
298_A302_Q0.8551.00
238_A340_S0.8551.00
327_Y331_F0.8531.00
81_E84_E0.8531.00
14_T23_T0.8521.00
187_R190_T0.8511.00
29_F178_I0.8511.00
372_C381_P0.8471.00
36_I70_I0.8461.00
357_V371_G0.8421.00
215_Q342_K0.8411.00
93_L102_I0.8401.00
64_N67_K0.8401.00
79_G82_V0.8331.00
387_P391_E0.8321.00
278_E290_I0.8321.00
26_L180_L0.8301.00
92_I184_L0.8271.00
178_I185_L0.8261.00
21_S25_M0.8261.00
84_E87_I0.8241.00
321_K325_V0.8221.00
60_F64_N0.8221.00
279_N283_A0.8221.00
313_E316_T0.8211.00
93_L121_F0.8201.00
125_K128_D0.8131.00
151_S340_S0.8121.00
285_G327_Y0.8091.00
89_E399_E0.8091.00
35_K43_D0.8061.00
146_A339_L0.8021.00
84_E116_N0.8021.00
122_G196_V0.8001.00
215_Q238_A0.7971.00
71_E389_L0.7961.00
101_A105_M0.7941.00
320_D324_A0.7941.00
95_E129_E0.7931.00
18_S124_I0.7931.00
311_E315_Y0.7931.00
349_S353_S0.7921.00
34_I396_V0.7871.00
143_A168_G0.7841.00
79_G397_L0.7841.00
70_I82_V0.7811.00
355_S375_K0.7751.00
197_T353_S0.7731.00
98_H101_A0.7731.00
261_E266_A0.7721.00
350_L356_V0.7661.00
108_T121_F0.7651.00
371_G375_K0.7631.00
80_K106_G0.7631.00
79_G83_M0.7601.00
11_L93_L0.7601.00
131_S349_S0.7581.00
110_E113_Q0.7561.00
279_N331_F0.7551.00
263_D323_E0.7511.00
12_D15_G0.7501.00
152_T208_C0.7501.00
155_F159_P0.7501.00
145_A150_A0.7501.00
103_D110_E0.7491.00
269_Y336_A0.7481.00
32_D399_E0.7451.00
267_Y316_T0.7451.00
70_I397_L0.7421.00
109_W119_L0.7391.00
325_V329_T0.7391.00
42_G389_L0.7381.00
4_P379_F0.7371.00
103_D123_S0.7361.00
174_M178_I0.7351.00
36_I72_L0.7351.00
361_Q388_L0.7311.00
85_K89_E0.7301.00
194_Q376_F0.7301.00
12_D19_G0.7301.00
56_D361_Q0.7281.00
11_L89_E0.7271.00
120_I183_A0.7261.00
71_E390_G0.7251.00
263_D318_T0.7241.00
22_C94_V0.7221.00
80_K105_M0.7221.00
5_L8_I0.7201.00
155_F161_L0.7190.99
205_L355_S0.7190.99
111_H115_I0.7180.99
146_A337_P0.7170.99
40_G71_E0.7170.99
259_G338_V0.7160.99
267_Y321_K0.7160.99
17_Q63_L0.7140.99
115_I118_R0.7130.99
284_I312_I0.7130.99
178_I182_A0.7120.99
20_P169_D0.7110.99
329_T335_C0.7100.99
133_Y349_S0.7090.99
69_S390_G0.7080.99
168_G172_T0.7080.99
295_Y311_E0.7060.99
266_A269_Y0.7060.99
347_D350_L0.7050.99
281_C287_P0.7030.99
245_A309_F0.7000.99
118_R190_T0.6980.99
66_N383_I0.6970.99
363_L388_L0.6960.99
35_K42_G0.6950.99
120_I185_L0.6950.99
100_G103_D0.6950.99
87_I107_F0.6940.99
152_T341_M0.6930.99
318_T324_A0.6920.99
155_F258_K0.6900.99
357_V383_I0.6890.99
350_L355_S0.6890.99
309_F313_E0.6840.99
276_N334_P0.6830.99
293_P296_S0.6820.99
250_Q309_F0.6810.99
354_G375_K0.6810.99
310_A313_E0.6800.99
308_I312_I0.6790.99
186_H189_K0.6770.99
81_E115_I0.6750.99
212_L345_S0.6740.99
43_D46_R0.6730.99
345_S356_V0.6720.99
172_T203_A0.6700.99
337_P343_E0.6700.99
142_V336_A0.6700.99
56_D363_L0.6690.99
258_K313_E0.6680.99
173_G177_L0.6670.99
270_F335_C0.6670.99
306_F310_A0.6650.99
139_Y273_Q0.6640.99
82_V401_G0.6630.99
287_P290_I0.6630.99
28_W66_N0.6620.99
149_A163_S0.6610.99
61_T386_A0.6600.99
262_T265_N0.6600.99
69_S389_L0.6600.99
360_E365_G0.6560.99
79_G402_Y0.6560.99
15_G44_V0.6540.99
146_A336_A0.6530.99
74_T83_M0.6530.99
314_K317_V0.6530.99
95_E100_G0.6500.99
295_Y308_I0.6500.99
139_Y334_P0.6490.99
98_H137_K0.6490.99
377_S380_T0.6480.99
344_I350_L0.6480.99
130_C375_K0.6460.99
50_R53_P0.6430.99
29_F376_F0.6420.99
171_N174_M0.6410.99
130_C353_S0.6400.99
89_E400_L0.6390.99
116_N119_L0.6370.99
118_R192_R0.6370.99
72_L397_L0.6350.99
176_L180_L0.6340.99
110_E114_E0.6340.99
245_A258_K0.6330.99
25_M177_L0.6320.99
279_N332_D0.6310.99
92_I187_R0.6290.99
26_L177_L0.6270.99
34_I90_A0.6260.99
171_N203_A0.6260.99
69_S391_E0.6250.99
274_E301_R0.6230.99
125_K197_T0.6210.99
100_G108_T0.6200.99
85_K400_L0.6200.99
264_P322_H0.6190.99
201_Q349_S0.6180.98
198_M203_A0.6170.98
250_Q302_Q0.6160.98
283_A333_I0.6150.98
141_N268_I0.6150.98
273_Q276_N0.6150.98
261_E267_Y0.6130.98
100_G135_N0.6120.98
109_W123_S0.6120.98
302_Q305_I0.6110.98
21_S206_N0.6110.98
34_I89_E0.6080.98
110_E195_R0.6080.98
11_L86_L0.6070.98
17_Q166_A0.6060.98
42_G46_R0.6040.98
149_A208_C0.6020.98
128_D197_T0.6000.98
376_F380_T0.5980.98
299_H303_P0.5980.98
103_D111_H0.5980.98
149_A204_V0.5970.98
3_T379_F0.5970.98
21_S170_S0.5970.98
137_K332_D0.5950.98
159_P241_R0.5930.98
312_I315_Y0.5930.98
268_I316_T0.5930.98
19_G94_V0.5930.98
214_D248_G0.5920.98
4_P29_F0.5910.98
103_D195_R0.5880.98
280_T328_L0.5850.98
23_T67_K0.5840.98
262_T324_A0.5830.98
161_L244_N0.5830.98
38_R71_E0.5810.98
84_E106_G0.5810.98
176_L198_M0.5760.98
376_F379_F0.5760.98
215_Q236_G0.5750.98
87_I93_L0.5740.98
18_S172_T0.5740.98
292_D295_Y0.5740.98
376_F381_P0.5720.98
52_I55_I0.5690.97
362_P391_E0.5680.97
103_D129_E0.5670.97
246_G249_G0.5670.97
8_I187_R0.5660.97
95_E121_F0.5660.97
172_T200_M0.5660.97
168_G200_M0.5650.97
16_V44_V0.5650.97
300_A304_H0.5640.97
37_E42_G0.5620.97
123_S129_E0.5590.97
250_Q305_I0.5580.97
183_A196_V0.5560.97
359_V383_I0.5550.97
262_T316_T0.5550.97
266_A343_E0.5540.97
127_F142_V0.5530.97
99_P125_K0.5530.97
354_G357_V0.5530.97
8_I92_I0.5520.97
63_L170_S0.5510.97
362_P388_L0.5510.97
100_G104_H0.5510.97
21_S173_G0.5510.97
147_G201_Q0.5490.97
139_Y142_V0.5480.97
177_L182_A0.5450.97
297_T301_R0.5450.97
69_S392_H0.5440.97
22_C173_G0.5430.97
115_I119_L0.5420.97
23_T33_V0.5410.97
264_P320_D0.5410.97
170_S209_R0.5400.96
398_Q403_S0.5400.96
61_T361_Q0.5390.96
124_I172_T0.5380.96
263_D317_V0.5370.96
13_F74_T0.5350.96
98_H332_D0.5340.96
395_A398_Q0.5330.96
7_G32_D0.5310.96
396_V399_E0.5310.96
143_A200_M0.5290.96
92_I181_L0.5280.96
283_A330_Q0.5280.96
99_P129_E0.5280.96
172_T198_M0.5280.96
84_E102_I0.5270.96
182_A185_L0.5260.96
324_A327_Y0.5250.96
87_I90_A0.5250.96
153_T161_L0.5230.96
135_N329_T0.5220.96
140_E150_A0.5220.96
68_R392_H0.5210.96
196_V376_F0.5210.96
264_P321_K0.5210.96
6_Q189_K0.5180.96
182_A376_F0.5160.95
84_E112_I0.5140.95
282_K291_T0.5130.95
274_E277_W0.5130.95
393_T396_V0.5130.95
284_I287_P0.5100.95
76_T80_K0.5100.95
163_S167_L0.5090.95
144_Q150_A0.5090.95
19_G124_I0.5090.95
393_T398_Q0.5090.95
71_E82_V0.5080.95
12_D67_K0.5060.95
79_G401_G0.5050.95
245_A250_Q0.5020.95
212_L370_V0.5010.95
360_E385_A0.5010.95
108_T114_E0.5010.95
37_E69_S0.5000.95
295_Y300_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q7eA 2 0.9688 100 0.039 Contact Map
2vjqA 2 0.9832 100 0.04 Contact Map
3ubmA 2 0.9832 100 0.05 Contact Map
1xk7A 2 0.9255 100 0.06 Contact Map
4ed9A 2 0.8942 100 0.087 Contact Map
4hl6A 2 0.899 100 0.099 Contact Map
2yimA 2 0.8462 100 0.139 Contact Map
2g04A 2 0.8365 100 0.173 Contact Map
2a9fA 2 0.4567 87.8 0.958 Contact Map
1vl6A 4 0.4832 85.4 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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