POTA - ECOLI - GREMLIN Contacts

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POTA - Spermidine/putrescine import ATP-binding protein PotA

UniProt:	P69874	Sequences: MGQSKKLNKQPSSLSPLVQLAGIRKCFDGKEVIPQLDLTINNGEFLTLLGPSGCGKTTVLRLIAGLETVDSGRIMLDNEDITHVPAENRYVNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEITPRVMEALRMVQLETFAQRKPHQLSGGQQQRVAIARAVVNKPRLLLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVAGFIGEINMFNATVIERLDEQRVRANVEGRECNIYVNFAVEPGQKLHVLLRPEDLRVEEINDDNHAEGLIGYVRERNYKGMTLESVVELENGKMVMVSEFFNEDDPDFDHSLDQKMAINWVESWEVVLADEEHK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10749
Length:	378 (309)
Sequences:	12455 (9561)
Seq/√Len:	543.9

ECOLI - POTA POTG MALK YCJV CYSA PROV UGPC FBPC YDCT METN MODC DPPF RBSA OPPD OPPF DPPD YEHX SAPD ARAG YADG DDPD YHES MACB GSIA DDPF UUP CYDC MDLB MSBA MLAF MDLA FEPC LSRA TAUB YTFR SAPF HISP YECC CYDD FHUC SSUB NIKE YOJI YHDZ FECE ETTA LPTB PHNC GLNQ GLTL YPHE THIQ LIVG ZNUC PHNK PSTB ARTP SUFC MODF LOLD LIVF FTSE NIKD XYLG ALSA FETA YBBA BTUD MGLA YDDA YEJF CCMA PHNL YNJD YBHF YBIT
BACSU - MSMX OPUAA YURJ OPUCA OPUBA YVRA METN TAGH OPPD YKFD DPPD APPF YFIL YXLF YHCH APPD YHAQ YCBN YDBJ YVFR OPPF YHEH RBSA YDIF YFMR SUNT YFIC YTRB ECFA1 YFIB YKNU YKNV YUSV BMRA YKPA YFMM YGAD FHUC YFMF YHEI YLMA CYDD TCYN YWJA YCLP CYDC ECSA YKOD BCEA YVCR YTLC YXDL SKFE SUFC ECFA2 YXEO TCYC PSTB1 GLNQ PSTB2 NATA SSUB FTSE ARTM MNTB YJKB ALBC EXPZ YVRO YTHP YKNY YCLH ZNUC YYBJ YHCG YYDI YUFO YTRE
HALSA - Q9HHQ5 Q9HNZ9 Q9HMW0 Q9HR06 BTUDA Q9HMX3 Q9HMT3 Q9HMX2 Q9HMU8 Q9HMG1 Q9HRJ6 PSTB2 Q9HSQ7 Q9HRH8 PHNC Q9HHM2 Q9HMG6 Q9HNY3 Q9HRZ9 Q9HRV7 PSTB1 Y2317 Y1631 Q9HHR7 Q9HR96 Q9HS04 Q9HQA8 Q9HT03 Q9HR21 Q9HMC1 Q9HMW1
SULSO - Q97YY4 Q97UF2 Q97UY8 Q97ZC0 Q97VC1 Q7LX64 Q97VF5 Q97UH3 Q97UJ9 Q97VH6 Q97YP3 Q97VK8 Q97YK2 Q97X18 Q97VK9 Q97YP7 Q97VF4 Q97UD4 Q97YP8 Q97YQ7 Q980W0 Q97Z03 Q97U54 Q97UH4 PSTB Q97W42 Y1893 Q97V01 Q7LXM4 Q97V00 Q7LY07 Y2030 Q97VY4 Q97VM2 Q7LX80 Q97UG5 Q97Z56 Q97YP4 Q97Z96 Q97UC2 Q980K5 Q97ZU0 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
230_G	234_E	4.579	1.00
73_R	80_D	4.170	1.00
22_G	35_Q	4.094	1.00
44_E	217_R	3.967	1.00
47_T	215_S	3.839	1.00
19_Q	39_T	3.658	1.00
21_A	73_R	3.643	1.00
133_R	138_E	3.576	1.00
31_E	34_P	3.229	1.00
125_T	129_M	2.977	1.00
34_P	225_R	2.944	1.00
231_T	234_E	2.739	1.00
20_L	23_I	2.724	1.00
24_R	71_S	2.642	1.00
46_L	219_V	2.622	1.00
120_P	123_E	2.593	1.00
107_F	111_A	2.530	1.00
41_N	44_E	2.483	1.00
140_F	143_R	2.482	1.00
227_E	241_N	2.446	1.00
24_R	35_Q	2.424	1.00
22_G	37_D	2.351	1.00
24_R	31_E	2.269	1.00
19_Q	75_M	2.267	1.00
107_F	142_Q	2.255	1.00
21_A	75_M	2.238	1.00
26_C	31_E	2.235	1.00
23_I	69_V	2.226	1.00
107_F	125_T	2.200	1.00
25_K	62_L	2.167	1.00
127_R	165_K	2.156	1.00
77_D	167_R	2.082	1.00
90_Y	167_R	2.002	1.00
212_L	233_R	1.988	1.00
18_V	168_L	1.981	1.00
60_L	204_V	1.972	1.00
136_Q	185_Q	1.967	1.00
75_M	80_D	1.967	1.00
20_L	38_L	1.893	1.00
33_I	62_L	1.889	1.00
62_L	69_V	1.857	1.00
25_K	67_E	1.843	1.00
131_A	163_V	1.837	1.00
127_R	130_E	1.807	1.00
81_I	84_V	1.751	1.00
107_F	129_M	1.750	1.00
26_C	70_D	1.749	1.00
63_I	202_V	1.734	1.00
25_K	70_D	1.727	1.00
132_L	141_A	1.695	1.00
62_L	74_I	1.684	1.00
219_V	229_D	1.669	1.00
104_M	112_F	1.640	1.00
242_L	291_H	1.638	1.00
126_P	130_E	1.636	1.00
251_I	254_F	1.593	1.00
171_L	201_F	1.576	1.00
272_E	275_E	1.569	1.00
251_I	255_N	1.567	1.00
219_V	226_I	1.561	1.00
123_E	126_P	1.556	1.00
80_D	83_H	1.552	1.00
122_A	126_P	1.541	1.00
60_L	170_L	1.497	1.00
222_R	227_E	1.492	1.00
61_R	67_E	1.487	1.00
233_R	237_E	1.482	1.00
123_E	127_R	1.476	1.00
285_E	288_Q	1.462	1.00
33_I	36_L	1.461	1.00
40_I	46_L	1.445	1.00
130_E	133_R	1.432	1.00
220_V	235_I	1.398	1.00
20_L	63_I	1.398	1.00
273_G	276_C	1.396	1.00
69_V	74_I	1.394	1.00
111_A	128_V	1.390	1.00
246_G	253_M	1.366	1.00
266_R	269_A	1.364	1.00
119_T	123_E	1.362	1.00
26_C	71_S	1.355	1.00
76_L	81_I	1.353	1.00
33_I	59_V	1.351	1.00
73_R	82_T	1.328	1.00
36_L	59_V	1.312	1.00
119_T	124_I	1.296	1.00
103_H	146_H	1.284	1.00
302_E	306_D	1.282	1.00
24_R	34_P	1.281	1.00
105_T	108_E	1.278	1.00
21_A	37_D	1.276	1.00
302_E	305_N	1.256	1.00
38_L	219_V	1.252	1.00
265_Q	269_A	1.250	1.00
79_E	84_V	1.236	1.00
26_C	29_G	1.232	1.00
269_A	272_E	1.222	1.00
107_F	128_V	1.222	1.00
124_I	128_V	1.220	1.00
46_L	229_D	1.204	1.00
274_R	277_N	1.194	1.00
64_A	170_L	1.192	1.00
101_F	104_M	1.188	1.00
105_T	144_K	1.185	1.00
129_M	133_R	1.182	1.00
135_V	159_A	1.181	1.00
111_A	124_I	1.173	1.00
191_K	214_M	1.171	1.00
257_T	289_K	1.160	1.00
242_L	246_G	1.154	1.00
108_E	111_A	1.153	1.00
276_C	279_Y	1.148	1.00
194_Q	201_F	1.123	1.00
43_G	198_G	1.109	1.00
320_R	324_G	1.104	1.00
44_E	216_D	1.103	1.00
309_H	312_G	1.100	1.00
292_V	295_R	1.094	1.00
26_C	32_V	1.088	1.00
130_E	134_M	1.087	1.00
20_L	59_V	1.077	1.00
108_E	115_R	1.077	1.00
92_N	161_A	1.074	1.00
165_K	199_I	1.067	1.00
92_N	166_P	1.065	1.00
79_E	167_R	1.065	1.00
112_F	116_M	1.061	1.00
143_R	147_Q	1.060	1.00
252_N	255_N	1.060	1.00
49_L	220_V	1.058	1.00
59_V	221_M	1.056	1.00
268_R	271_V	1.054	1.00
22_G	71_S	1.052	1.00
275_E	278_I	1.049	1.00
84_V	88_N	1.048	1.00
144_K	147_Q	1.045	1.00
17_L	39_T	1.034	1.00
74_I	81_I	1.024	1.00
41_N	217_R	1.024	1.00
129_M	141_A	1.023	1.00
284_V	288_Q	1.023	1.00
23_I	62_L	1.022	1.00
106_V	148_L	1.021	1.00
242_L	253_M	1.020	1.00
46_L	217_R	1.019	1.00
47_T	211_A	1.016	1.00
309_H	317_V	1.013	1.00
251_I	256_A	0.994	1.00
104_M	108_E	0.992	1.00
322_Y	327_L	0.990	1.00
226_I	229_D	0.986	1.00
38_L	229_D	0.982	1.00
20_L	74_I	0.981	1.00
42_N	77_D	0.974	1.00
267_V	270_N	0.972	1.00
217_R	229_D	0.969	1.00
17_L	42_N	0.963	1.00
54_C	221_M	0.957	1.00
121_A	124_I	0.957	1.00
205_T	211_A	0.948	1.00
289_K	293_L	0.947	1.00
183_R	207_D	0.944	1.00
109_N	160_R	0.939	1.00
115_R	121_A	0.936	1.00
23_I	74_I	0.930	1.00
131_A	162_V	0.927	1.00
69_V	82_T	0.924	1.00
252_N	256_A	0.919	1.00
158_I	171_L	0.915	1.00
323_K	328_E	0.914	1.00
191_K	213_T	0.914	1.00
271_V	274_R	0.914	1.00
319_E	322_Y	0.912	1.00
27_F	32_V	0.910	1.00
85_P	88_N	0.909	1.00
316_Y	319_E	0.907	1.00
234_E	238_E	0.907	1.00
51_P	54_C	0.906	1.00
194_Q	199_I	0.903	1.00
269_A	273_G	0.901	1.00
17_L	77_D	0.896	1.00
45_F	214_M	0.894	1.00
19_Q	78_N	0.894	1.00
295_R	299_L	0.891	1.00
119_T	122_A	0.889	1.00
251_I	293_L	0.887	1.00
107_F	141_A	0.887	1.00
129_M	138_E	0.882	1.00
285_E	289_K	0.876	1.00
291_H	295_R	0.871	1.00
40_I	200_T	0.869	1.00
110_V	113_G	0.867	1.00
310_A	316_Y	0.866	1.00
270_N	274_R	0.866	1.00
294_L	299_L	0.864	1.00
48_L	219_V	0.863	1.00
320_R	323_K	0.856	1.00
299_L	302_E	0.856	1.00
121_A	125_T	0.855	1.00
130_E	165_K	0.855	1.00
62_L	67_E	0.852	1.00
317_V	324_G	0.849	1.00
113_G	160_R	0.844	1.00
287_G	291_H	0.843	1.00
245_A	249_G	0.841	1.00
110_V	159_A	0.837	1.00
117_Q	164_N	0.828	1.00
267_V	271_V	0.822	1.00
282_F	285_E	0.818	1.00
287_G	290_L	0.815	1.00
175_L	203_F	0.815	1.00
301_V	304_I	0.812	1.00
270_N	273_G	0.812	1.00
57_T	61_R	0.810	1.00
211_A	215_S	0.810	1.00
271_V	275_E	0.810	1.00
62_L	70_D	0.808	1.00
309_H	316_Y	0.807	1.00
111_A	115_R	0.805	1.00
284_V	287_G	0.804	1.00
315_G	318_R	0.803	1.00
100_L	145_P	0.801	1.00
277_N	280_V	0.799	1.00
106_V	156_V	0.796	1.00
321_N	324_G	0.792	1.00
273_G	278_I	0.791	1.00
290_L	294_L	0.786	1.00
253_M	291_H	0.786	1.00
222_R	225_R	0.784	1.00
61_R	66_L	0.784	1.00
17_L	41_N	0.781	1.00
113_G	164_N	0.781	1.00
283_A	286_P	0.780	1.00
281_N	285_E	0.779	1.00
303_E	306_D	0.778	1.00
42_N	167_R	0.778	1.00
271_V	278_I	0.777	1.00
110_V	132_L	0.777	1.00
180_Y	184_K	0.776	1.00
315_G	319_E	0.775	1.00
296_P	300_R	0.773	1.00
256_A	290_L	0.772	1.00
43_G	200_T	0.766	1.00
110_V	163_V	0.765	1.00
266_R	270_N	0.764	1.00
48_L	221_M	0.763	1.00
132_L	137_L	0.761	1.00
254_F	258_V	0.760	1.00
101_F	113_G	0.759	1.00
287_G	294_L	0.757	1.00
274_R	279_Y	0.754	1.00
203_F	215_S	0.753	1.00
274_R	278_I	0.752	1.00
254_F	260_E	0.752	1.00
27_F	67_E	0.751	1.00
104_M	109_N	0.748	1.00
167_R	199_I	0.747	1.00
290_L	293_L	0.745	1.00
275_E	280_V	0.743	1.00
314_I	317_V	0.742	1.00
292_V	296_P	0.741	1.00
190_L	201_F	0.740	1.00
294_L	298_D	0.736	1.00
100_L	109_N	0.736	1.00
269_A	274_R	0.734	1.00
175_L	190_L	0.734	1.00
289_K	296_P	0.732	1.00
272_E	277_N	0.731	1.00
295_R	298_D	0.729	1.00
40_I	202_V	0.728	1.00
25_K	58_T	0.723	1.00
294_L	297_E	0.719	1.00
145_P	156_V	0.719	1.00
316_Y	320_R	0.719	1.00
316_Y	324_G	0.718	1.00
169_L	199_I	0.714	1.00
300_R	306_D	0.703	1.00
109_N	145_P	0.698	1.00
18_V	76_L	0.698	1.00
237_E	322_Y	0.697	1.00
158_I	214_M	0.696	1.00
64_A	93_T	0.694	1.00
317_V	320_R	0.694	1.00
255_N	291_H	0.693	1.00
184_K	188_N	0.691	1.00
131_A	134_M	0.689	1.00
324_G	327_L	0.688	1.00
295_R	303_E	0.688	1.00
269_A	275_E	0.685	1.00
282_F	286_P	0.685	1.00
222_R	243_F	0.684	1.00
244_V	247_F	0.684	1.00
131_A	135_V	0.680	1.00
236_Y	297_E	0.680	1.00
288_Q	295_R	0.678	1.00
325_M	328_E	0.677	1.00
272_E	278_I	0.674	1.00
75_M	78_N	0.674	1.00
300_R	303_E	0.672	1.00
281_N	284_V	0.672	1.00
268_R	273_G	0.671	1.00
308_N	311_E	0.670	1.00
268_R	272_E	0.665	1.00
289_K	295_R	0.664	1.00
127_R	131_A	0.660	1.00
193_L	197_L	0.659	1.00
220_V	239_P	0.657	1.00
45_F	201_F	0.656	1.00
48_L	202_V	0.654	1.00
94_V	161_A	0.654	1.00
288_Q	292_V	0.654	1.00
105_T	142_Q	0.650	1.00
301_V	306_D	0.649	1.00
299_L	305_N	0.647	1.00
281_N	288_Q	0.645	1.00
278_I	281_N	0.644	1.00
261_R	264_E	0.643	1.00
289_K	303_E	0.641	1.00
293_L	296_P	0.641	1.00
283_A	287_G	0.639	1.00
245_A	248_I	0.638	1.00
173_E	206_H	0.638	1.00
129_M	137_L	0.637	1.00
155_R	178_L	0.636	1.00
94_V	154_Q	0.631	1.00
312_G	315_G	0.629	1.00
36_L	226_I	0.629	1.00
101_F	109_N	0.629	1.00
28_D	31_E	0.628	1.00
293_L	297_E	0.628	1.00
184_K	250_E	0.627	1.00
122_A	125_T	0.625	1.00
217_R	228_Q	0.623	1.00
282_F	289_K	0.623	1.00
273_G	279_Y	0.623	1.00
204_V	208_Q	0.623	1.00
309_H	313_L	0.622	1.00
317_V	321_N	0.620	1.00
46_L	202_V	0.620	1.00
313_L	321_N	0.619	1.00
286_P	289_K	0.619	1.00
193_L	199_I	0.617	1.00
282_F	288_Q	0.615	1.00
204_V	207_D	0.613	1.00
310_A	317_V	0.613	1.00
119_T	127_R	0.610	1.00
92_N	201_F	0.609	1.00
25_K	33_I	0.609	1.00
271_V	277_N	0.609	1.00
288_Q	296_P	0.608	1.00
166_P	169_L	0.605	1.00
273_G	277_N	0.604	1.00
311_E	314_I	0.602	1.00
316_Y	323_K	0.602	1.00
286_P	290_L	0.601	1.00
20_L	36_L	0.597	1.00
255_N	258_V	0.596	1.00
265_Q	268_R	0.595	1.00
54_C	59_V	0.593	1.00
296_P	299_L	0.593	1.00
296_P	302_E	0.593	1.00
323_K	326_T	0.590	1.00
301_V	305_N	0.589	1.00
296_P	301_V	0.589	1.00
315_G	324_G	0.589	1.00
274_R	280_V	0.589	1.00
254_F	257_T	0.589	1.00
171_L	203_F	0.587	1.00
308_N	314_I	0.585	0.99
287_G	295_R	0.584	0.99
323_K	327_L	0.583	0.99
313_L	317_V	0.582	0.99
278_I	286_P	0.582	0.99
268_R	274_R	0.578	0.99
255_N	289_K	0.577	0.99
295_R	302_E	0.576	0.99
285_E	292_V	0.576	0.99
125_T	128_V	0.574	0.99
209_E	213_T	0.573	0.99
274_R	281_N	0.572	0.99
272_E	276_C	0.571	0.99
280_V	284_V	0.570	0.99
189_E	192_A	0.569	0.99
266_R	271_V	0.567	0.99
221_M	226_I	0.565	0.99
92_N	164_N	0.565	0.99
132_L	135_V	0.564	0.99
44_E	229_D	0.563	0.99
115_R	124_I	0.563	0.99
128_V	131_A	0.562	0.99
280_V	283_A	0.559	0.99
312_G	316_Y	0.559	0.99
311_E	316_Y	0.558	0.99
279_Y	283_A	0.558	0.99
40_I	168_L	0.556	0.99
251_I	258_V	0.555	0.99
264_E	268_R	0.554	0.99
273_G	280_V	0.554	0.99
311_E	315_G	0.549	0.99
276_C	282_F	0.547	0.99
310_A	314_I	0.547	0.99
180_Y	187_Q	0.547	0.99
252_N	260_E	0.545	0.99
298_D	301_V	0.545	0.99
289_K	292_V	0.543	0.99
265_Q	271_V	0.543	0.99
45_F	194_Q	0.541	0.99
102_P	146_H	0.541	0.99
296_P	306_D	0.541	0.99
47_T	214_M	0.540	0.99
321_N	327_L	0.540	0.99
177_A	187_Q	0.540	0.99
263_D	266_R	0.539	0.99
311_E	317_V	0.539	0.99
276_C	280_V	0.539	0.99
169_L	201_F	0.538	0.99
150_G	155_R	0.538	0.99
314_I	318_R	0.534	0.99
94_V	157_A	0.534	0.99
318_R	322_Y	0.533	0.99
82_T	86_A	0.533	0.99
191_K	322_Y	0.533	0.99
266_R	274_R	0.531	0.99
308_N	312_G	0.531	0.99
170_L	202_V	0.531	0.99
27_F	58_T	0.531	0.99
112_F	115_R	0.530	0.99
205_T	210_E	0.530	0.99
264_E	267_V	0.530	0.99
278_I	285_E	0.530	0.99
296_P	303_E	0.529	0.99
203_F	214_M	0.527	0.99
113_G	116_M	0.524	0.99
265_Q	272_E	0.522	0.99
283_A	289_K	0.522	0.99
292_V	299_L	0.522	0.99
22_G	25_K	0.521	0.99
238_E	241_N	0.521	0.99
96_Q	177_A	0.521	0.99
279_Y	282_F	0.521	0.99
21_A	39_T	0.519	0.99
176_S	180_Y	0.519	0.99
261_R	266_R	0.518	0.99
287_G	299_L	0.516	0.99
232_P	236_Y	0.516	0.99
97_S	153_Q	0.516	0.99
120_P	124_I	0.515	0.99
18_V	40_I	0.514	0.99
287_G	296_P	0.512	0.99
246_G	250_E	0.511	0.99
322_Y	326_T	0.510	0.99
249_G	252_N	0.510	0.99
305_N	309_H	0.510	0.99
48_L	59_V	0.510	0.99
17_L	168_L	0.508	0.99
234_E	237_E	0.507	0.99
267_V	274_R	0.507	0.99
270_N	277_N	0.507	0.99
275_E	281_N	0.506	0.99
139_T	143_R	0.505	0.99
277_N	281_N	0.502	0.98
310_A	320_R	0.501	0.98
26_C	34_P	0.501	0.98
105_T	109_N	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yyzA	1	0.9365	100	0.259	Contact Map
2it1A	1	0.9392	100	0.262	Contact Map
1v43A	2	0.9127	100	0.262	Contact Map
1oxxK	1	0.8995	100	0.269	Contact Map
1g291	4	0.9392	100	0.272	Contact Map
3rlfA	2	0.9471	100	0.274	Contact Map
1z47A	2	0.8968	100	0.279	Contact Map
3d31A	2	0.9048	100	0.282	Contact Map
3tuiC	2	0.8862	100	0.288	Contact Map
3fvqA	2	0.9101	100	0.29	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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