GREMLIN Database
POTA - Spermidine/putrescine import ATP-binding protein PotA
UniProt: P69874 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10749
Length: 378 (309)
Sequences: 12455 (9561)
Seq/√Len: 543.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_G234_E4.5791.00
73_R80_D4.1701.00
22_G35_Q4.0941.00
44_E217_R3.9671.00
47_T215_S3.8391.00
19_Q39_T3.6581.00
21_A73_R3.6431.00
133_R138_E3.5761.00
31_E34_P3.2291.00
125_T129_M2.9771.00
34_P225_R2.9441.00
231_T234_E2.7391.00
20_L23_I2.7241.00
24_R71_S2.6421.00
46_L219_V2.6221.00
120_P123_E2.5931.00
107_F111_A2.5301.00
41_N44_E2.4831.00
140_F143_R2.4821.00
227_E241_N2.4461.00
24_R35_Q2.4241.00
22_G37_D2.3511.00
24_R31_E2.2691.00
19_Q75_M2.2671.00
107_F142_Q2.2551.00
21_A75_M2.2381.00
26_C31_E2.2351.00
23_I69_V2.2261.00
107_F125_T2.2001.00
25_K62_L2.1671.00
127_R165_K2.1561.00
77_D167_R2.0821.00
90_Y167_R2.0021.00
212_L233_R1.9881.00
18_V168_L1.9811.00
60_L204_V1.9721.00
136_Q185_Q1.9671.00
75_M80_D1.9671.00
20_L38_L1.8931.00
33_I62_L1.8891.00
62_L69_V1.8571.00
25_K67_E1.8431.00
131_A163_V1.8371.00
127_R130_E1.8071.00
81_I84_V1.7511.00
107_F129_M1.7501.00
26_C70_D1.7491.00
63_I202_V1.7341.00
25_K70_D1.7271.00
132_L141_A1.6951.00
62_L74_I1.6841.00
219_V229_D1.6691.00
104_M112_F1.6401.00
242_L291_H1.6381.00
126_P130_E1.6361.00
251_I254_F1.5931.00
171_L201_F1.5761.00
272_E275_E1.5691.00
251_I255_N1.5671.00
219_V226_I1.5611.00
123_E126_P1.5561.00
80_D83_H1.5521.00
122_A126_P1.5411.00
60_L170_L1.4971.00
222_R227_E1.4921.00
61_R67_E1.4871.00
233_R237_E1.4821.00
123_E127_R1.4761.00
285_E288_Q1.4621.00
33_I36_L1.4611.00
40_I46_L1.4451.00
130_E133_R1.4321.00
220_V235_I1.3981.00
20_L63_I1.3981.00
273_G276_C1.3961.00
69_V74_I1.3941.00
111_A128_V1.3901.00
246_G253_M1.3661.00
266_R269_A1.3641.00
119_T123_E1.3621.00
26_C71_S1.3551.00
76_L81_I1.3531.00
33_I59_V1.3511.00
73_R82_T1.3281.00
36_L59_V1.3121.00
119_T124_I1.2961.00
103_H146_H1.2841.00
302_E306_D1.2821.00
24_R34_P1.2811.00
105_T108_E1.2781.00
21_A37_D1.2761.00
302_E305_N1.2561.00
38_L219_V1.2521.00
265_Q269_A1.2501.00
79_E84_V1.2361.00
26_C29_G1.2321.00
269_A272_E1.2221.00
107_F128_V1.2221.00
124_I128_V1.2201.00
46_L229_D1.2041.00
274_R277_N1.1941.00
64_A170_L1.1921.00
101_F104_M1.1881.00
105_T144_K1.1851.00
129_M133_R1.1821.00
135_V159_A1.1811.00
111_A124_I1.1731.00
191_K214_M1.1711.00
257_T289_K1.1601.00
242_L246_G1.1541.00
108_E111_A1.1531.00
276_C279_Y1.1481.00
194_Q201_F1.1231.00
43_G198_G1.1091.00
320_R324_G1.1041.00
44_E216_D1.1031.00
309_H312_G1.1001.00
292_V295_R1.0941.00
26_C32_V1.0881.00
130_E134_M1.0871.00
20_L59_V1.0771.00
108_E115_R1.0771.00
92_N161_A1.0741.00
165_K199_I1.0671.00
92_N166_P1.0651.00
79_E167_R1.0651.00
112_F116_M1.0611.00
143_R147_Q1.0601.00
252_N255_N1.0601.00
49_L220_V1.0581.00
59_V221_M1.0561.00
268_R271_V1.0541.00
22_G71_S1.0521.00
275_E278_I1.0491.00
84_V88_N1.0481.00
144_K147_Q1.0451.00
17_L39_T1.0341.00
74_I81_I1.0241.00
41_N217_R1.0241.00
129_M141_A1.0231.00
284_V288_Q1.0231.00
23_I62_L1.0221.00
106_V148_L1.0211.00
242_L253_M1.0201.00
46_L217_R1.0191.00
47_T211_A1.0161.00
309_H317_V1.0131.00
251_I256_A0.9941.00
104_M108_E0.9921.00
322_Y327_L0.9901.00
226_I229_D0.9861.00
38_L229_D0.9821.00
20_L74_I0.9811.00
42_N77_D0.9741.00
267_V270_N0.9721.00
217_R229_D0.9691.00
17_L42_N0.9631.00
54_C221_M0.9571.00
121_A124_I0.9571.00
205_T211_A0.9481.00
289_K293_L0.9471.00
183_R207_D0.9441.00
109_N160_R0.9391.00
115_R121_A0.9361.00
23_I74_I0.9301.00
131_A162_V0.9271.00
69_V82_T0.9241.00
252_N256_A0.9191.00
158_I171_L0.9151.00
323_K328_E0.9141.00
191_K213_T0.9141.00
271_V274_R0.9141.00
319_E322_Y0.9121.00
27_F32_V0.9101.00
85_P88_N0.9091.00
316_Y319_E0.9071.00
234_E238_E0.9071.00
51_P54_C0.9061.00
194_Q199_I0.9031.00
269_A273_G0.9011.00
17_L77_D0.8961.00
45_F214_M0.8941.00
19_Q78_N0.8941.00
295_R299_L0.8911.00
119_T122_A0.8891.00
251_I293_L0.8871.00
107_F141_A0.8871.00
129_M138_E0.8821.00
285_E289_K0.8761.00
291_H295_R0.8711.00
40_I200_T0.8691.00
110_V113_G0.8671.00
310_A316_Y0.8661.00
270_N274_R0.8661.00
294_L299_L0.8641.00
48_L219_V0.8631.00
320_R323_K0.8561.00
299_L302_E0.8561.00
121_A125_T0.8551.00
130_E165_K0.8551.00
62_L67_E0.8521.00
317_V324_G0.8491.00
113_G160_R0.8441.00
287_G291_H0.8431.00
245_A249_G0.8411.00
110_V159_A0.8371.00
117_Q164_N0.8281.00
267_V271_V0.8221.00
282_F285_E0.8181.00
287_G290_L0.8151.00
175_L203_F0.8151.00
301_V304_I0.8121.00
270_N273_G0.8121.00
57_T61_R0.8101.00
211_A215_S0.8101.00
271_V275_E0.8101.00
62_L70_D0.8081.00
309_H316_Y0.8071.00
111_A115_R0.8051.00
284_V287_G0.8041.00
315_G318_R0.8031.00
100_L145_P0.8011.00
277_N280_V0.7991.00
106_V156_V0.7961.00
321_N324_G0.7921.00
273_G278_I0.7911.00
290_L294_L0.7861.00
253_M291_H0.7861.00
222_R225_R0.7841.00
61_R66_L0.7841.00
17_L41_N0.7811.00
113_G164_N0.7811.00
283_A286_P0.7801.00
281_N285_E0.7791.00
303_E306_D0.7781.00
42_N167_R0.7781.00
271_V278_I0.7771.00
110_V132_L0.7771.00
180_Y184_K0.7761.00
315_G319_E0.7751.00
296_P300_R0.7731.00
256_A290_L0.7721.00
43_G200_T0.7661.00
110_V163_V0.7651.00
266_R270_N0.7641.00
48_L221_M0.7631.00
132_L137_L0.7611.00
254_F258_V0.7601.00
101_F113_G0.7591.00
287_G294_L0.7571.00
274_R279_Y0.7541.00
203_F215_S0.7531.00
274_R278_I0.7521.00
254_F260_E0.7521.00
27_F67_E0.7511.00
104_M109_N0.7481.00
167_R199_I0.7471.00
290_L293_L0.7451.00
275_E280_V0.7431.00
314_I317_V0.7421.00
292_V296_P0.7411.00
190_L201_F0.7401.00
294_L298_D0.7361.00
100_L109_N0.7361.00
269_A274_R0.7341.00
175_L190_L0.7341.00
289_K296_P0.7321.00
272_E277_N0.7311.00
295_R298_D0.7291.00
40_I202_V0.7281.00
25_K58_T0.7231.00
294_L297_E0.7191.00
145_P156_V0.7191.00
316_Y320_R0.7191.00
316_Y324_G0.7181.00
169_L199_I0.7141.00
300_R306_D0.7031.00
109_N145_P0.6981.00
18_V76_L0.6981.00
237_E322_Y0.6971.00
158_I214_M0.6961.00
64_A93_T0.6941.00
317_V320_R0.6941.00
255_N291_H0.6931.00
184_K188_N0.6911.00
131_A134_M0.6891.00
324_G327_L0.6881.00
295_R303_E0.6881.00
269_A275_E0.6851.00
282_F286_P0.6851.00
222_R243_F0.6841.00
244_V247_F0.6841.00
131_A135_V0.6801.00
236_Y297_E0.6801.00
288_Q295_R0.6781.00
325_M328_E0.6771.00
272_E278_I0.6741.00
75_M78_N0.6741.00
300_R303_E0.6721.00
281_N284_V0.6721.00
268_R273_G0.6711.00
308_N311_E0.6701.00
268_R272_E0.6651.00
289_K295_R0.6641.00
127_R131_A0.6601.00
193_L197_L0.6591.00
220_V239_P0.6571.00
45_F201_F0.6561.00
48_L202_V0.6541.00
94_V161_A0.6541.00
288_Q292_V0.6541.00
105_T142_Q0.6501.00
301_V306_D0.6491.00
299_L305_N0.6471.00
281_N288_Q0.6451.00
278_I281_N0.6441.00
261_R264_E0.6431.00
289_K303_E0.6411.00
293_L296_P0.6411.00
283_A287_G0.6391.00
245_A248_I0.6381.00
173_E206_H0.6381.00
129_M137_L0.6371.00
155_R178_L0.6361.00
94_V154_Q0.6311.00
312_G315_G0.6291.00
36_L226_I0.6291.00
101_F109_N0.6291.00
28_D31_E0.6281.00
293_L297_E0.6281.00
184_K250_E0.6271.00
122_A125_T0.6251.00
217_R228_Q0.6231.00
282_F289_K0.6231.00
273_G279_Y0.6231.00
204_V208_Q0.6231.00
309_H313_L0.6221.00
317_V321_N0.6201.00
46_L202_V0.6201.00
313_L321_N0.6191.00
286_P289_K0.6191.00
193_L199_I0.6171.00
282_F288_Q0.6151.00
204_V207_D0.6131.00
310_A317_V0.6131.00
119_T127_R0.6101.00
92_N201_F0.6091.00
25_K33_I0.6091.00
271_V277_N0.6091.00
288_Q296_P0.6081.00
166_P169_L0.6051.00
273_G277_N0.6041.00
311_E314_I0.6021.00
316_Y323_K0.6021.00
286_P290_L0.6011.00
20_L36_L0.5971.00
255_N258_V0.5961.00
265_Q268_R0.5951.00
54_C59_V0.5931.00
296_P299_L0.5931.00
296_P302_E0.5931.00
323_K326_T0.5901.00
301_V305_N0.5891.00
296_P301_V0.5891.00
315_G324_G0.5891.00
274_R280_V0.5891.00
254_F257_T0.5891.00
171_L203_F0.5871.00
308_N314_I0.5850.99
287_G295_R0.5840.99
323_K327_L0.5830.99
313_L317_V0.5820.99
278_I286_P0.5820.99
268_R274_R0.5780.99
255_N289_K0.5770.99
295_R302_E0.5760.99
285_E292_V0.5760.99
125_T128_V0.5740.99
209_E213_T0.5730.99
274_R281_N0.5720.99
272_E276_C0.5710.99
280_V284_V0.5700.99
189_E192_A0.5690.99
266_R271_V0.5670.99
221_M226_I0.5650.99
92_N164_N0.5650.99
132_L135_V0.5640.99
44_E229_D0.5630.99
115_R124_I0.5630.99
128_V131_A0.5620.99
280_V283_A0.5590.99
312_G316_Y0.5590.99
311_E316_Y0.5580.99
279_Y283_A0.5580.99
40_I168_L0.5560.99
251_I258_V0.5550.99
264_E268_R0.5540.99
273_G280_V0.5540.99
311_E315_G0.5490.99
276_C282_F0.5470.99
310_A314_I0.5470.99
180_Y187_Q0.5470.99
252_N260_E0.5450.99
298_D301_V0.5450.99
289_K292_V0.5430.99
265_Q271_V0.5430.99
45_F194_Q0.5410.99
102_P146_H0.5410.99
296_P306_D0.5410.99
47_T214_M0.5400.99
321_N327_L0.5400.99
177_A187_Q0.5400.99
263_D266_R0.5390.99
311_E317_V0.5390.99
276_C280_V0.5390.99
169_L201_F0.5380.99
150_G155_R0.5380.99
314_I318_R0.5340.99
94_V157_A0.5340.99
318_R322_Y0.5330.99
82_T86_A0.5330.99
191_K322_Y0.5330.99
266_R274_R0.5310.99
308_N312_G0.5310.99
170_L202_V0.5310.99
27_F58_T0.5310.99
112_F115_R0.5300.99
205_T210_E0.5300.99
264_E267_V0.5300.99
278_I285_E0.5300.99
296_P303_E0.5290.99
203_F214_M0.5270.99
113_G116_M0.5240.99
265_Q272_E0.5220.99
283_A289_K0.5220.99
292_V299_L0.5220.99
22_G25_K0.5210.99
238_E241_N0.5210.99
96_Q177_A0.5210.99
279_Y282_F0.5210.99
21_A39_T0.5190.99
176_S180_Y0.5190.99
261_R266_R0.5180.99
287_G299_L0.5160.99
232_P236_Y0.5160.99
97_S153_Q0.5160.99
120_P124_I0.5150.99
18_V40_I0.5140.99
287_G296_P0.5120.99
246_G250_E0.5110.99
322_Y326_T0.5100.99
249_G252_N0.5100.99
305_N309_H0.5100.99
48_L59_V0.5100.99
17_L168_L0.5080.99
234_E237_E0.5070.99
267_V274_R0.5070.99
270_N277_N0.5070.99
275_E281_N0.5060.99
139_T143_R0.5050.99
277_N281_N0.5020.98
310_A320_R0.5010.98
26_C34_P0.5010.98
105_T109_N0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yyzA 1 0.9365 100 0.259 Contact Map
2it1A 1 0.9392 100 0.262 Contact Map
1v43A 2 0.9127 100 0.262 Contact Map
1oxxK 1 0.8995 100 0.269 Contact Map
1g291 4 0.9392 100 0.272 Contact Map
3rlfA 2 0.9471 100 0.274 Contact Map
1z47A 2 0.8968 100 0.279 Contact Map
3d31A 2 0.9048 100 0.282 Contact Map
3tuiC 2 0.8862 100 0.288 Contact Map
3fvqA 2 0.9101 100 0.29 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0142 seconds.