GREMLIN Database
NANC - Probable N-acetylneuraminic acid outer membrane channel protein NanC
UniProt: P69856 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12389
Length: 238 (222)
Sequences: 244 (171)
Seq/√Len: 11.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_A211_D4.9701.00
193_A209_E4.0350.99
169_W192_N3.7870.99
30_G41_T3.2420.97
132_D152_R2.8870.94
29_R231_R2.7600.92
97_G112_Y2.5880.90
212_Y228_N2.5680.89
29_R42_R2.4900.88
152_R191_E2.4060.86
154_D170_Q2.2310.81
154_D172_T2.1610.79
212_Y226_S2.1580.79
94_V115_L2.1470.78
30_G39_Y2.1230.77
184_N224_N2.0250.74
124_N158_T1.9850.72
115_L127_I1.9830.72
6_I9_G1.9710.72
152_R172_T1.9420.71
49_W54_W1.9320.70
111_P129_Y1.9310.70
8_S11_L1.8720.68
34_S228_N1.8610.67
189_A214_D1.8510.67
6_I10_V1.8270.66
97_G111_P1.8260.66
153_W232_I1.8130.65
42_R231_R1.8050.65
215_R223_D1.7810.64
76_N185_H1.7490.62
175_S187_K1.7470.62
6_I70_K1.7400.62
9_G18_P1.7200.61
8_S21_S1.6890.59
77_D101_H1.6420.57
86_I94_V1.6390.57
119_A124_N1.6260.56
79_Q97_G1.6150.56
54_W83_N1.6040.55
104_S232_I1.5990.55
192_N212_Y1.5750.54
29_R79_Q1.5610.53
8_S17_S1.5550.53
12_L203_D1.5530.53
101_H152_R1.5460.52
42_R128_R1.5300.52
6_I15_F1.4900.50
93_T116_S1.4860.50
183_A190_T1.4690.49
43_L80_V1.4660.49
28_V41_T1.4620.48
7_L12_L1.4540.48
27_D42_R1.4490.48
9_G17_S1.4470.48
89_D123_L1.4450.47
94_V223_D1.4370.47
119_A122_D1.3980.45
183_A189_A1.3820.44
117_W206_P1.3690.44
60_N77_D1.3590.43
24_A46_S1.3560.43
185_H208_I1.3490.43
129_Y151_H1.3430.43
101_H193_A1.3390.42
27_D231_R1.3340.42
154_D191_E1.2810.40
204_I234_V1.2760.39
12_L15_F1.2740.39
29_R229_S1.2710.39
7_L184_N1.2580.39
27_D207_Y1.2540.38
51_N121_K1.2510.38
13_L18_P1.2230.37
96_P113_V1.2130.36
156_Y168_A1.2110.36
212_Y227_E1.2060.36
211_D229_S1.2050.36
34_S212_Y1.2030.36
48_G54_W1.1870.35
109_Y213_L1.1680.34
214_D220_N1.1660.34
137_R140_D1.1260.33
109_Y226_S1.1220.32
132_D172_T1.1160.32
97_G128_R1.1150.32
120_T123_L1.1140.32
158_T168_A1.1130.32
65_I125_F1.1100.32
15_F18_P1.1030.32
167_F194_F1.0970.31
79_Q110_G1.0920.31
8_S18_P1.0860.31
106_G151_H1.0850.31
164_D223_D1.0830.31
87_K184_N1.0740.30
51_N131_Y1.0690.30
91_Q117_W1.0630.30
26_L39_Y1.0560.30
79_Q231_R1.0550.30
150_V154_D1.0450.29
7_L10_V1.0450.29
127_I154_D1.0440.29
42_R211_D1.0420.29
210_Y228_N1.0390.29
11_L20_I1.0390.29
58_E110_G1.0380.29
41_T227_E1.0250.28
101_H211_D1.0150.28
14_C208_I1.0110.28
105_N145_M1.0090.28
6_I223_D1.0040.28
25_T207_Y1.0040.28
72_N152_R1.0010.27
10_V15_F1.0000.27
132_D191_E0.9760.26
176_K193_A0.9680.26
57_M75_L0.9610.26
160_H194_F0.9600.26
77_D102_F0.9560.26
160_H166_T0.9530.26
34_S54_W0.9520.26
9_G70_K0.9520.26
12_L145_M0.9480.25
8_S45_V0.9450.25
209_E231_R0.9330.25
11_L16_S0.9300.25
28_V169_W0.9280.25
42_R58_E0.9270.25
66_H185_H0.9260.25
24_A47_E0.9230.24
197_Q205_T0.9220.24
24_A93_T0.9200.24
123_L200_M0.9180.24
55_A59_S0.9040.24
26_L102_F0.9040.24
28_V70_K0.8960.23
185_H222_R0.8950.23
33_R208_I0.8850.23
34_S230_Y0.8810.23
46_S58_E0.8800.23
54_W84_Y0.8780.23
40_E44_K0.8780.23
180_Y183_A0.8720.23
89_D186_K0.8680.23
154_D237_K0.8680.23
114_K171_T0.8640.22
39_Y169_W0.8570.22
223_D226_S0.8560.22
46_S60_N0.8550.22
76_N101_H0.8540.22
114_K170_Q0.8520.22
98_M109_Y0.8460.22
44_K56_S0.8390.22
31_G211_D0.8390.22
132_D226_S0.8370.21
53_W82_V0.8340.21
222_R234_V0.8330.21
124_N168_A0.8290.21
185_H226_S0.8280.21
95_R115_L0.8270.21
16_S235_S0.8270.21
94_V113_V0.8260.21
210_Y230_Y0.8260.21
23_A58_E0.8260.21
189_A226_S0.8230.21
181_R223_D0.8220.21
49_W55_A0.8200.21
7_L21_S0.8140.21
7_L13_L0.8120.21
172_T191_E0.8100.21
29_R128_R0.8090.21
8_S13_L0.8060.20
211_D231_R0.8050.20
83_N224_N0.7990.20
131_Y152_R0.7950.20
221_G225_L0.7920.20
117_W146_S0.7870.20
81_E156_Y0.7820.20
183_A214_D0.7810.20
205_T237_K0.7810.20
119_A123_L0.7810.20
23_A46_S0.7790.20
124_N171_T0.7780.20
184_N232_I0.7690.19
85_A168_A0.7650.19
99_L110_G0.7640.19
43_L95_R0.7620.19
156_Y170_Q0.7610.19
79_Q128_R0.7590.19
99_L112_Y0.7580.19
90_D222_R0.7570.19
135_A196_L0.7570.19
227_E236_F0.7530.19
10_V17_S0.7530.19
96_P130_R0.7530.19
11_L15_F0.7530.19
116_S119_A0.7500.19
160_H203_D0.7490.19
52_G199_H0.7460.19
195_V237_K0.7460.19
41_T236_F0.7440.19
56_S110_G0.7420.18
6_I20_I0.7410.18
207_Y235_S0.7400.18
9_G16_S0.7390.18
51_N84_Y0.7380.18
226_S236_F0.7360.18
13_L207_Y0.7330.18
33_R45_V0.7320.18
30_G190_T0.7310.18
9_G20_I0.7290.18
36_S92_W0.7290.18
20_I186_K0.7270.18
44_K114_K0.7270.18
26_L198_Y0.7270.18
131_Y170_Q0.7260.18
26_L207_Y0.7230.18
43_L104_S0.7210.18
109_Y196_L0.7200.18
27_D229_S0.7150.18
36_S70_K0.7120.18
131_Y151_H0.7040.17
105_N125_F0.6880.17
92_W165_F0.6870.17
13_L16_S0.6870.17
183_A223_D0.6860.17
32_Y78_V0.6800.17
176_K182_Y0.6750.17
92_W115_L0.6740.17
14_C18_P0.6720.17
113_V188_W0.6720.17
56_S81_E0.6710.16
148_D207_Y0.6700.16
87_K173_L0.6690.16
183_A215_R0.6680.16
99_L114_K0.6670.16
25_T160_H0.6670.16
33_R213_L0.6670.16
61_T204_I0.6650.16
134_K144_D0.6650.16
180_Y190_T0.6620.16
198_Y206_P0.6580.16
6_I12_L0.6580.16
206_P231_R0.6560.16
81_E99_L0.6510.16
167_F230_Y0.6500.16
55_A107_T0.6460.16
87_K90_D0.6450.16
8_S15_F0.6420.16
72_N180_Y0.6400.16
164_D179_D0.6390.16
130_R191_E0.6370.16
128_R206_P0.6290.15
126_G156_Y0.6280.15
15_F90_D0.6260.15
98_M123_L0.6210.15
49_W78_V0.6190.15
48_G69_K0.6190.15
131_Y191_E0.6180.15
70_K227_E0.6130.15
48_G58_E0.6110.15
7_L17_S0.6090.15
103_S134_K0.6060.15
187_K223_D0.6040.15
208_I230_Y0.5940.14
43_L225_L0.5940.14
153_W186_K0.5940.14
91_Q113_V0.5930.14
39_Y236_F0.5930.14
32_Y117_W0.5900.14
13_L90_D0.5890.14
66_H71_E0.5880.14
62_W65_I0.5830.14
169_W194_F0.5830.14
10_V164_D0.5820.14
73_A120_T0.5800.14
8_S12_L0.5780.14
28_V131_Y0.5760.14
97_G176_K0.5760.14
32_Y150_V0.5730.14
113_V208_I0.5730.14
139_Q232_I0.5730.14
18_P138_Q0.5720.14
15_F20_I0.5700.14
137_R196_L0.5690.14
51_N144_D0.5650.14
30_G236_F0.5620.14
29_R206_P0.5620.14
152_R170_Q0.5600.14
44_K49_W0.5570.14
29_R58_E0.5560.14
91_Q120_T0.5530.14
104_S203_D0.5490.13
10_V185_H0.5460.13
60_N154_D0.5440.13
43_L100_T0.5440.13
130_R233_G0.5430.13
129_Y226_S0.5400.13
16_S202_P0.5400.13
80_V102_F0.5320.13
127_I196_L0.5310.13
6_I14_C0.5310.13
56_S207_Y0.5300.13
120_T149_N0.5280.13
89_D224_N0.5270.13
166_T237_K0.5260.13
79_Q229_S0.5250.13
10_V90_D0.5240.13
62_W152_R0.5240.13
93_T192_N0.5230.13
9_G13_L0.5210.13
98_M111_P0.5210.13
206_P233_G0.5190.13
76_N132_D0.5180.13
43_L55_A0.5170.13
203_D232_I0.5170.13
50_Q114_K0.5170.13
43_L57_M0.5140.13
175_S178_N0.5130.13
98_M196_L0.5120.13
36_S112_Y0.5110.13
174_Y214_D0.5110.13
125_F191_E0.5110.13
6_I11_L0.5080.13
60_N211_D0.5080.13
42_R229_S0.5070.13
64_T215_R0.5050.12
27_D58_E0.5040.12
109_Y212_Y0.5030.12
96_P152_R0.5020.12
90_D189_A0.5010.12
17_S90_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fqeA 1 0.7059 100 0.189 Contact Map
2wjrA 1 0.8571 100 0.201 Contact Map
3nb3A 2 0.5504 98.7 0.852 Contact Map
2x9kA 1 0.8613 97.9 0.884 Contact Map
3pguA 1 0.9538 97.1 0.9 Contact Map
2k0lA 1 0.7185 96.8 0.904 Contact Map
3dwoX 1 0.9538 96.8 0.904 Contact Map
3qraA 1 0.5798 96.7 0.905 Contact Map
1qjpA 1 0.5126 96.7 0.905 Contact Map
1ormA 1 0.5504 96.7 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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