GREMLIN Database
DMSD - Tat proofreading chaperone DmsD
UniProt: P69853 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13847
Length: 204 (184)
Sequences: 1342 (1074)
Seq/√Len: 79.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_M134_M4.3351.00
21_F182_A3.4601.00
107_R125_E3.2831.00
71_A172_H3.1741.00
88_G154_H2.7901.00
162_F166_F2.7751.00
10_F189_W2.6741.00
163_L182_A2.6721.00
93_D100_G2.6651.00
14_A189_W2.5501.00
128_F159_S2.5351.00
167_I183_R2.5041.00
10_F147_C2.4201.00
22_Y129_G2.3681.00
10_F14_A2.3261.00
17_L182_A2.2901.00
135_A147_C2.1961.00
159_S186_L2.1831.00
73_Q77_V2.0911.00
167_I180_E2.0691.00
91_W165_V2.0111.00
68_H174_F1.9721.00
86_P162_F1.9511.00
20_L178_L1.8761.00
139_A147_C1.8461.00
88_G131_L1.8441.00
134_M150_L1.8341.00
152_A190_Q1.8141.00
173_P176_R1.8051.00
27_S31_A1.7701.00
15_R136_A1.7231.00
106_L110_M1.6961.00
88_G92_L1.6871.00
166_F179_G1.6831.00
135_A151_L1.6401.00
149_E153_W1.6391.00
21_F178_L1.6361.00
159_S163_L1.6081.00
106_L131_L1.6041.00
160_T183_R1.6011.00
88_G157_P1.5751.00
85_P90_V1.5550.99
115_I137_W1.5200.99
112_E149_E1.4930.99
71_A170_A1.4640.99
18_G133_L1.4560.99
79_P82_L1.4170.99
14_A147_C1.4150.99
136_A140_E1.4140.99
46_W49_P1.4130.99
15_R140_E1.3620.99
14_A185_T1.3530.99
51_A54_A1.3020.98
88_G106_L1.2920.98
69_A73_Q1.2880.98
155_L159_S1.2570.98
89_S124_P1.2190.97
128_F182_A1.2050.97
128_F162_F1.2030.97
103_T106_L1.2010.97
21_F76_F1.1960.97
103_T125_E1.1950.97
72_W127_H1.1880.97
79_P103_T1.1610.96
170_A173_P1.1600.96
55_P58_T1.1570.96
49_P52_S1.1560.96
131_L134_M1.1500.96
10_F185_T1.1460.96
86_P128_F1.1210.95
90_V97_V1.1140.95
132_L186_L1.1050.95
19_A26_E1.1050.95
71_A74_R1.1030.95
87_W99_F1.0880.94
135_A185_T1.0870.94
170_A176_R1.0820.94
24_A77_V1.0760.94
87_W123_E1.0750.94
78_G82_L1.0730.94
21_F128_F1.0710.94
106_L150_L1.0630.94
161_R165_V1.0600.94
14_A135_A1.0550.94
139_A189_W1.0490.93
164_D183_R1.0450.93
135_A189_W1.0440.93
91_W175_Y1.0380.93
139_A142_G1.0360.93
25_P29_E1.0260.93
183_R187_A1.0160.92
63_Q68_H1.0110.92
93_D102_S1.0100.92
156_F186_L0.9920.91
89_S98_L0.9860.91
22_Y130_S0.9860.91
77_V82_L0.9820.91
70_Q73_Q0.9790.91
108_Q112_E0.9740.90
87_W124_P0.9590.90
113_K134_M0.9500.89
10_F135_A0.9450.89
158_W162_F0.9430.89
127_H130_S0.9340.89
154_H157_P0.9330.88
99_F124_P0.9260.88
132_L182_A0.9230.88
163_L179_G0.9160.88
178_L182_A0.9080.87
27_S65_E0.9070.87
110_M131_L0.8960.86
56_L60_F0.8890.86
161_R164_D0.8840.86
25_P72_W0.8770.85
110_M130_S0.8770.85
18_G87_W0.8760.85
131_L155_L0.8730.85
20_L174_F0.8700.85
147_C189_W0.8680.85
88_G100_G0.8640.84
150_L158_W0.8520.83
24_A65_E0.8510.83
72_W76_F0.8500.83
106_L134_M0.8480.83
11_S140_E0.8420.83
128_F163_L0.8350.82
105_A153_W0.8350.82
177_A181_L0.8340.82
93_D97_V0.8250.81
20_L98_L0.8230.81
26_E50_E0.8190.81
65_E69_A0.8130.81
92_L157_P0.8120.80
10_F139_A0.7970.79
109_W150_L0.7940.79
84_S91_W0.7920.79
26_E32_P0.7880.78
151_L189_W0.7850.78
79_P87_W0.7810.78
99_F103_T0.7750.77
115_I140_E0.7670.77
164_D167_I0.7670.77
98_L103_T0.7670.77
109_W113_K0.7660.76
54_A191_S0.7520.75
131_L150_L0.7510.75
64_C67_T0.7500.75
18_G136_A0.7450.74
78_G124_P0.7370.74
14_A133_L0.7320.73
15_R133_L0.7320.73
49_P56_L0.7300.73
90_V103_T0.7300.73
24_A73_Q0.7300.73
103_T107_R0.7280.73
185_T189_W0.7250.72
151_L156_F0.7250.72
84_S90_V0.7220.72
97_V100_G0.7160.71
150_L157_P0.7140.71
147_C193_L0.7050.70
89_S99_F0.7050.70
155_L178_L0.7030.70
49_P177_A0.7030.70
89_S102_S0.6980.70
113_K138_L0.6890.69
133_L137_W0.6810.68
84_S166_F0.6810.68
76_F175_Y0.6810.68
72_W86_P0.6740.67
16_V20_L0.6710.66
191_S194_L0.6640.66
110_M125_E0.6640.66
167_I176_R0.6560.65
77_V127_H0.6510.64
52_S59_A0.6510.64
11_S19_A0.6490.64
31_A51_A0.6470.64
137_W140_E0.6430.63
109_W149_E0.6410.63
24_A100_G0.6370.62
141_N145_T0.6350.62
71_A176_R0.6340.62
66_E70_Q0.6330.62
18_G129_G0.6320.62
27_S35_A0.6310.62
75_L181_L0.6260.61
142_G146_E0.6250.61
165_V168_E0.6240.61
51_A153_W0.6240.61
101_D105_A0.6210.61
104_L125_E0.6180.60
15_R18_G0.6170.60
48_L61_Q0.6120.59
53_L177_A0.6100.59
98_L124_P0.6090.59
72_W162_F0.6080.59
152_A194_L0.6070.59
112_E119_M0.6060.59
70_Q107_R0.6050.59
74_R162_F0.6040.58
60_F63_Q0.6000.58
49_P53_L0.5990.58
13_A19_A0.5970.58
36_V39_S0.5960.57
90_V99_F0.5960.57
157_P160_T0.5940.57
13_A148_E0.5940.57
151_L186_L0.5930.57
127_H162_F0.5920.57
142_G145_T0.5870.56
71_A169_K0.5860.56
87_W96_S0.5860.56
19_A68_H0.5850.56
75_L169_K0.5840.56
53_L185_T0.5770.55
105_A108_Q0.5750.55
11_S136_A0.5740.55
48_L128_F0.5730.54
47_P51_A0.5710.54
143_R146_E0.5700.54
8_D12_V0.5700.54
100_G163_L0.5670.54
175_Y178_L0.5650.53
106_L139_A0.5650.53
80_W133_L0.5650.53
71_A166_F0.5650.53
13_A37_L0.5650.53
19_A22_Y0.5650.53
28_A32_P0.5640.53
180_E187_A0.5630.53
13_A185_T0.5620.53
98_L102_S0.5600.53
90_V98_L0.5560.52
55_P191_S0.5540.52
50_E57_V0.5540.52
86_P124_P0.5530.52
17_L185_T0.5510.52
183_R186_L0.5500.52
155_L190_Q0.5490.51
76_F166_F0.5480.51
106_L166_F0.5480.51
44_T48_L0.5480.51
37_L42_W0.5440.51
56_L59_A0.5430.51
160_T167_I0.5430.51
119_M122_N0.5430.51
67_T142_G0.5420.50
102_S106_L0.5420.50
45_Q180_E0.5410.50
55_P59_A0.5400.50
73_Q106_L0.5400.50
55_P167_I0.5390.50
73_Q110_M0.5380.50
87_W103_T0.5370.50
109_W185_T0.5350.50
80_W179_G0.5330.49
31_A63_Q0.5330.49
71_A171_E0.5330.49
86_P165_V0.5320.49
49_P57_V0.5290.49
47_P57_V0.5250.48
90_V93_D0.5220.48
51_A112_E0.5220.48
179_G182_A0.5220.48
57_V68_H0.5180.47
56_L177_A0.5150.47
83_P123_E0.5140.47
90_V101_D0.5120.47
128_F144_Q0.5120.47
54_A64_C0.5110.47
51_A58_T0.5100.46
25_P106_L0.5080.46
32_P58_T0.5080.46
50_E56_L0.5080.46
71_A83_P0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s9uA 1 0.9706 100 0.187 Contact Map
1n1cA 2 0.9559 100 0.218 Contact Map
2o9xA 2 0.7892 100 0.369 Contact Map
2xolA 2 0.7696 100 0.43 Contact Map
4jzaA 2 0.4118 8.4 0.949 Contact Map
2zqmA 5 0.3529 4.7 0.955 Contact Map
2vofA 1 0.6667 4.3 0.956 Contact Map
3lxuX 2 0.3137 2.9 0.959 Contact Map
4q86A 3 0.902 2.7 0.96 Contact Map
3gycA 1 0.8235 2.6 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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