GREMLIN Database
PTKC - Galactitol permease IIC component
UniProt: P69831 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12416
Length: 451 (432)
Sequences: 609 (383)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_K36_C5.1961.00
207_I354_F4.9601.00
189_P193_L4.7201.00
77_H328_Q4.4791.00
105_L109_A4.3891.00
229_F254_A4.3771.00
233_L250_A4.0971.00
237_I246_V3.8991.00
242_D245_G3.4581.00
313_F360_G3.4291.00
110_M115_M3.4211.00
324_V369_W3.4121.00
23_I33_A3.4021.00
196_A200_K3.2921.00
195_D199_E3.2130.99
33_A37_F3.1950.99
71_N240_G3.1730.99
38_K223_E3.1500.99
23_I40_G3.1350.99
312_I357_L3.1100.99
193_L197_I3.0880.99
55_G59_D3.0150.99
209_F354_F2.9040.99
329_V395_A2.8440.98
329_V371_A2.7830.98
198_I204_V2.7350.98
106_V151_V2.6830.98
195_D355_R2.6790.98
64_A249_L2.6780.98
295_L299_L2.6070.97
204_V358_I2.6020.97
316_L361_V2.5210.97
164_F178_A2.5120.97
26_S31_M2.4960.96
171_F303_H2.4410.96
118_V162_D2.3650.95
78_V372_T2.2980.94
78_V328_Q2.2930.94
320_I369_W2.2480.94
48_V251_V2.2060.93
114_R289_Q2.1880.93
41_L251_V2.1720.92
90_T96_A2.1470.92
243_V247_L2.1040.91
349_H359_S2.0660.90
317_T364_M2.0560.90
204_V354_F2.0560.90
165_A169_R2.0360.90
373_Q406_W2.0310.90
117_R290_E2.0240.89
120_N180_P2.0240.89
109_A112_L1.9970.89
30_G217_K1.9940.89
380_Q383_A1.9800.88
136_L149_G1.9530.88
110_M113_T1.8980.86
99_A150_V1.8900.86
45_I225_V1.8720.85
6_M10_L1.8580.85
89_M382_A1.8440.84
91_W94_Q1.8360.84
66_K70_E1.8140.83
37_F229_F1.8020.83
91_W96_A1.7890.83
30_G284_A1.7850.82
111_L291_F1.7790.82
34_G220_P1.7700.82
389_K392_G1.7400.81
144_M148_A1.6780.78
68_M140_T1.6560.77
52_L278_A1.6550.77
110_M155_A1.6480.77
108_V112_L1.6480.77
24_I28_I1.6480.77
422_I425_A1.6380.76
161_G251_V1.6250.76
211_A305_A1.6040.75
111_L205_N1.6030.75
62_G332_F1.6000.75
208_K213_D1.5820.74
199_E205_N1.5770.74
120_N158_Y1.5760.74
68_M238_L1.5730.73
195_D359_S1.5670.73
372_T395_A1.5650.73
189_P197_I1.5430.72
129_M157_V1.5390.72
236_G249_L1.5380.72
132_T153_H1.5340.71
309_A356_T1.5240.71
120_N299_L1.5010.70
41_L254_A1.5000.70
117_R289_Q1.4990.70
102_I197_I1.4960.70
179_I299_L1.4960.70
51_G55_G1.4940.69
68_M235_I1.4920.69
196_A199_E1.4770.69
321_A331_P1.4750.68
125_N158_Y1.4630.68
328_Q372_T1.4590.68
25_F29_L1.4560.67
357_L361_V1.4530.67
316_L357_L1.4400.66
160_L288_G1.4300.66
79_V385_A1.4300.66
165_A292_L1.4260.66
92_A134_A1.4130.65
407_L411_V1.4040.64
114_R135_L1.3900.64
43_I50_I1.3810.63
126_I168_T1.3720.63
170_N350_R1.3570.62
37_F254_A1.3500.61
30_G40_G1.3480.61
146_G149_G1.3380.61
78_V393_M1.2990.58
31_M36_C1.2950.58
30_G281_R1.2850.57
27_K33_A1.2790.57
267_I349_H1.2710.57
108_V190_I1.2630.56
133_G150_V1.2550.56
229_F250_A1.2520.55
91_W181_H1.2310.54
109_A170_N1.2250.54
43_I270_G1.2160.53
262_R265_K1.2160.53
53_V61_I1.2150.53
161_G178_A1.2140.53
156_F160_L1.2020.52
410_Q413_S1.2010.52
198_I355_R1.2000.52
70_E390_A1.2000.52
204_V207_I1.1950.52
100_I130_T1.1890.52
262_R266_P1.1840.51
23_I37_F1.1830.51
24_I383_A1.1750.51
90_T159_K1.1710.50
35_D254_A1.1690.50
211_A214_I1.1690.50
14_P36_C1.1610.50
193_L196_A1.1590.50
124_W268_M1.1550.49
81_V121_V1.1540.49
368_L372_T1.1530.49
431_I435_W1.1520.49
198_I358_I1.1510.49
270_G336_A1.1410.49
198_I349_H1.1360.48
24_I290_E1.1350.48
23_I27_K1.1340.48
373_Q410_Q1.1240.47
375_I393_M1.1210.47
198_I362_I1.1150.47
19_P44_G1.1090.47
203_G206_R1.1070.46
175_E394_V1.1030.46
41_L229_F1.0970.46
136_L145_I1.0950.46
197_I319_L1.0920.45
383_A388_L1.0900.45
18_L333_G1.0850.45
23_I26_S1.0830.45
419_G422_I1.0820.45
78_V358_I1.0770.45
333_G337_T1.0750.44
382_A394_V1.0610.44
169_R290_E1.0500.43
52_L332_F1.0480.43
96_A130_T1.0410.42
17_M119_V1.0400.42
195_D349_H1.0310.42
54_I287_G1.0260.41
18_L260_M1.0260.41
418_P421_I1.0250.41
233_L246_V1.0220.41
350_R361_V1.0140.41
203_G207_I1.0050.40
332_F340_F0.9790.39
194_V408_L0.9780.39
52_L319_L0.9780.39
238_L322_V0.9740.38
102_I151_V0.9720.38
61_I332_F0.9690.38
106_V112_L0.9680.38
345_A349_H0.9590.37
221_F314_I0.9580.37
70_E245_G0.9580.37
148_A155_A0.9570.37
140_T207_I0.9560.37
106_V155_A0.9540.37
91_W307_V0.9530.37
210_S354_F0.9510.37
420_F434_T0.9500.37
316_L320_I0.9500.37
33_A87_S0.9470.37
139_A380_Q0.9470.37
269_D277_Q0.9470.37
332_F371_A0.9460.37
124_W351_G0.9420.36
105_L108_V0.9400.36
425_A428_L0.9360.36
70_E220_P0.9350.36
32_K35_D0.9350.36
194_V198_I0.9330.36
7_R11_D0.9320.36
195_D231_M0.9300.36
129_M189_P0.9270.36
26_S40_G0.9260.36
119_V289_Q0.9260.36
345_A362_I0.9260.36
37_F348_V0.9250.35
52_L56_L0.9250.35
100_I401_G0.9230.35
231_M235_I0.9210.35
96_A101_P0.9200.35
199_E355_R0.9200.35
148_A151_V0.9190.35
74_L86_S0.9140.35
194_V322_V0.9130.35
93_S134_A0.9110.35
39_A276_K0.9070.34
60_S252_K0.9040.34
177_I180_P0.9040.34
50_I260_M0.9020.34
76_L330_L0.9000.34
120_N179_I0.8950.34
286_F382_A0.8950.34
93_S307_V0.8910.34
310_S350_R0.8900.34
43_I56_L0.8890.33
318_I330_L0.8880.33
20_I384_N0.8880.33
204_V410_Q0.8870.33
367_T401_G0.8850.33
26_S274_I0.8850.33
23_I30_G0.8820.33
283_Q287_G0.8810.33
287_G423_I0.8810.33
18_L96_A0.8780.33
260_M287_G0.8720.33
90_T154_A0.8710.32
177_I288_G0.8710.32
198_I359_S0.8700.32
17_M22_I0.8670.32
183_T306_V0.8660.32
161_G164_F0.8640.32
429_T435_W0.8610.32
20_I28_I0.8600.32
275_A299_L0.8600.32
39_A77_H0.8570.32
108_V230_V0.8520.31
114_R117_R0.8520.31
70_E240_G0.8520.31
81_V394_V0.8510.31
374_T381_L0.8440.31
142_S146_G0.8400.31
14_P84_P0.8370.31
141_G146_G0.8330.30
285_K319_L0.8330.30
57_M145_I0.8320.30
89_M394_V0.8280.30
9_I244_K0.8270.30
87_S406_W0.8260.30
7_R57_M0.8210.30
260_M300_L0.8200.30
18_L278_A0.8200.30
248_Q252_K0.8180.30
243_V246_V0.8170.30
260_M266_P0.8160.30
418_P425_A0.8160.30
64_A239_A0.8120.29
270_G298_A0.8100.29
231_M334_D0.8090.29
375_I388_L0.8040.29
288_G291_F0.8030.29
68_M239_A0.8020.29
117_R177_I0.8020.29
18_L50_I0.8010.29
185_A350_R0.8000.29
194_V362_I0.7990.29
214_I308_S0.7970.29
66_K242_D0.7950.28
181_H294_G0.7950.28
30_G388_L0.7950.28
326_G369_W0.7950.28
324_V368_L0.7910.28
93_S396_S0.7910.28
181_H401_G0.7910.28
167_D347_A0.7900.28
104_I108_V0.7900.28
240_G321_A0.7880.28
239_A330_L0.7870.28
172_F290_E0.7860.28
93_S133_G0.7810.28
30_G277_Q0.7790.28
429_T432_F0.7780.28
407_L425_A0.7780.28
227_V231_M0.7780.28
12_L54_I0.7760.28
53_V250_A0.7730.27
18_L342_V0.7700.27
267_I270_G0.7680.27
136_L382_A0.7640.27
17_M260_M0.7640.27
263_V267_I0.7630.27
11_D206_R0.7620.27
75_N413_S0.7610.27
61_I395_A0.7590.27
144_M394_V0.7580.27
329_V372_T0.7560.27
121_V295_L0.7560.27
288_G318_I0.7540.26
263_V387_A0.7520.26
20_I40_G0.7510.26
64_A241_Y0.7490.26
81_V369_W0.7490.26
17_M21_V0.7480.26
98_V147_M0.7480.26
61_I79_V0.7480.26
37_F342_V0.7470.26
310_S334_D0.7460.26
365_S369_W0.7460.26
121_V169_R0.7450.26
371_A395_A0.7430.26
153_H182_G0.7420.26
120_N178_A0.7420.26
179_I287_G0.7400.26
158_Y374_T0.7380.26
178_A299_L0.7370.26
416_N419_G0.7360.26
47_F271_L0.7360.26
243_V350_R0.7320.25
38_K250_A0.7300.25
166_R380_Q0.7290.25
50_I181_H0.7280.25
420_F428_L0.7270.25
90_T124_W0.7270.25
128_H387_A0.7270.25
14_P184_S0.7250.25
24_I230_V0.7250.25
90_T138_L0.7230.25
114_R410_Q0.7230.25
221_F312_I0.7220.25
86_S378_H0.7220.25
175_E359_S0.7210.25
267_I297_P0.7210.25
100_I402_S0.7200.25
172_F274_I0.7200.25
190_I194_V0.7200.25
263_V313_F0.7200.25
172_F307_V0.7200.25
327_N330_L0.7190.25
28_I357_L0.7170.25
89_M127_W0.7130.24
121_V310_S0.7120.24
418_P429_T0.7120.24
193_L227_V0.7090.24
200_K358_I0.7080.24
338_I342_V0.7070.24
110_M305_A0.7070.24
263_V395_A0.7060.24
214_I254_A0.7030.24
360_G396_S0.7030.24
422_I426_I0.7020.24
103_A339_G0.7010.24
142_S155_A0.7010.24
100_I270_G0.6960.24
107_N122_D0.6960.24
118_V178_A0.6950.24
172_F305_A0.6940.24
328_Q375_I0.6940.24
105_L197_I0.6940.24
205_N435_W0.6940.24
243_V362_I0.6930.24
20_I218_F0.6930.24
300_L343_A0.6930.24
298_A301_L0.6900.23
45_I408_L0.6890.23
267_I301_L0.6880.23
46_G270_G0.6860.23
47_F84_P0.6850.23
196_A390_A0.6840.23
331_P368_L0.6840.23
425_A434_T0.6820.23
145_I408_L0.6810.23
57_M310_S0.6810.23
257_M279_R0.6810.23
280_S284_A0.6790.23
162_D275_A0.6790.23
333_G401_G0.6780.23
70_E75_N0.6770.23
420_F426_I0.6770.23
146_G399_Q0.6760.23
66_K227_V0.6750.23
143_W189_P0.6740.23
346_V356_T0.6700.23
37_F62_G0.6700.23
105_L217_K0.6700.23
146_G391_G0.6700.23
225_V257_M0.6690.23
144_M251_V0.6690.23
136_L286_F0.6640.22
67_A285_K0.6640.22
108_V432_F0.6640.22
133_G188_G0.6640.22
87_S324_V0.6620.22
139_A377_L0.6620.22
230_V245_G0.6610.22
89_M355_R0.6610.22
262_R308_S0.6590.22
110_M159_K0.6570.22
333_G339_G0.6560.22
120_N125_N0.6560.22
36_C108_V0.6550.22
24_I33_A0.6550.22
9_I39_A0.6550.22
85_G96_A0.6520.22
214_I218_F0.6520.22
34_G227_V0.6510.22
162_D327_N0.6500.22
43_I295_L0.6500.22
115_M151_V0.6490.22
68_M334_D0.6480.22
126_I179_I0.6470.22
25_F393_M0.6470.22
208_K420_F0.6450.22
426_I429_T0.6440.21
380_Q384_N0.6440.21
37_F109_A0.6440.21
134_A147_M0.6430.21
111_L382_A0.6430.21
428_L432_F0.6420.21
92_A135_L0.6420.21
172_F353_L0.6410.21
76_L368_L0.6390.21
272_T276_K0.6390.21
62_G87_S0.6390.21
4_E254_A0.6380.21
12_L384_N0.6380.21
374_T377_L0.6370.21
87_S111_L0.6360.21
59_D63_P0.6350.21
275_A294_G0.6330.21
131_F399_Q0.6330.21
17_M83_W0.6320.21
195_D200_K0.6290.21
73_D282_L0.6290.21
127_W177_I0.6280.21
190_I295_L0.6280.21
146_G205_N0.6270.21
231_M295_L0.6260.21
137_H146_G0.6260.21
65_A332_F0.6260.21
39_A431_I0.6260.21
126_I303_H0.6240.21
123_I158_Y0.6240.21
93_S223_E0.6230.21
133_G236_G0.6220.21
34_G175_E0.6220.21
128_H181_H0.6220.21
61_I90_T0.6210.21
68_M215_Q0.6190.20
41_L178_A0.6180.20
14_P28_I0.6170.20
330_L372_T0.6160.20
234_I246_V0.6150.20
425_A429_T0.6150.20
29_L328_Q0.6130.20
8_Y295_L0.6130.20
164_F188_G0.6130.20
428_L431_I0.6110.20
53_V304_T0.6100.20
78_V287_G0.6100.20
46_G224_P0.6090.20
104_I345_A0.6090.20
50_I65_A0.6090.20
319_L322_V0.6080.20
236_G256_V0.6080.20
24_I102_I0.6080.20
9_I30_G0.6070.20
14_P87_S0.6060.20
163_W346_V0.6060.20
120_N146_G0.6050.20
179_I252_K0.6050.20
29_L284_A0.6030.20
337_T398_D0.6030.20
112_L285_K0.5990.20
312_I425_A0.5990.20
258_L262_R0.5980.20
45_I227_V0.5970.20
165_A225_V0.5970.20
41_L199_E0.5970.20
260_M264_I0.5970.20
146_G169_R0.5960.20
240_G291_F0.5940.19
22_I352_N0.5940.19
40_G214_I0.5930.19
349_H357_L0.5920.19
97_L307_V0.5920.19
368_L395_A0.5900.19
321_A368_L0.5900.19
33_A36_C0.5880.19
337_T405_T0.5880.19
159_K381_L0.5870.19
25_F60_S0.5870.19
29_L38_K0.5870.19
39_A355_R0.5860.19
126_I301_L0.5860.19
119_V134_A0.5840.19
119_V399_Q0.5840.19
152_I424_G0.5820.19
257_M291_F0.5820.19
207_I224_P0.5810.19
297_P340_F0.5810.19
11_D362_I0.5810.19
39_A60_S0.5800.19
374_T409_I0.5800.19
11_D245_G0.5770.19
33_A109_A0.5750.19
10_L356_T0.5730.19
142_S233_L0.5730.19
417_I423_I0.5720.19
170_N323_C0.5720.19
137_H353_L0.5710.19
20_I131_F0.5710.19
350_R436_R0.5690.18
30_G321_A0.5690.18
406_W410_Q0.5680.18
105_L246_V0.5680.18
120_N347_A0.5680.18
97_L356_T0.5670.18
28_I119_V0.5670.18
133_G199_E0.5660.18
107_N296_D0.5650.18
424_G428_L0.5650.18
89_M374_T0.5650.18
295_L302_G0.5620.18
68_M330_L0.5620.18
418_P422_I0.5620.18
87_S357_L0.5620.18
42_H281_R0.5610.18
208_K251_V0.5610.18
231_M308_S0.5590.18
190_I312_I0.5580.18
111_L286_F0.5560.18
100_I337_T0.5560.18
99_A142_S0.5550.18
234_I257_M0.5550.18
30_G126_I0.5540.18
84_P267_I0.5530.18
24_I250_A0.5530.18
325_P369_W0.5530.18
93_S96_A0.5520.18
421_I426_I0.5520.18
256_V380_Q0.5520.18
9_I223_E0.5510.18
204_V425_A0.5510.18
155_A383_A0.5500.18
268_M294_G0.5490.18
53_V245_G0.5490.18
170_N358_I0.5490.18
184_S267_I0.5480.18
168_T177_I0.5470.18
369_W373_Q0.5470.18
43_I356_T0.5460.18
25_F254_A0.5460.18
26_S71_N0.5450.18
83_W223_E0.5440.18
197_I358_I0.5440.18
95_I129_M0.5440.18
5_V358_I0.5420.17
249_L288_G0.5410.17
106_V349_H0.5410.17
217_K237_I0.5410.17
267_I307_V0.5390.17
138_L319_L0.5390.17
128_H336_A0.5390.17
9_I20_I0.5380.17
253_T398_D0.5370.17
58_L251_V0.5370.17
250_A411_V0.5360.17
279_R283_Q0.5360.17
17_M339_G0.5350.17
64_A403_P0.5340.17
48_V55_G0.5340.17
37_F251_V0.5340.17
324_V327_N0.5330.17
314_I339_G0.5320.17
148_A309_A0.5320.17
209_F312_I0.5310.17
83_W87_S0.5310.17
50_I310_S0.5310.17
83_W124_W0.5280.17
232_G315_P0.5270.17
297_P339_G0.5270.17
170_N432_F0.5270.17
173_E272_T0.5270.17
363_I369_W0.5260.17
145_I148_A0.5260.17
162_D294_G0.5250.17
337_T401_G0.5250.17
43_I299_L0.5250.17
172_F347_A0.5250.17
138_L306_V0.5210.17
175_E262_R0.5200.17
87_S257_M0.5200.17
21_V24_I0.5190.17
34_G243_V0.5180.17
181_H340_F0.5170.17
11_D208_K0.5160.17
34_G162_D0.5160.17
96_A348_V0.5150.17
108_V204_V0.5150.17
251_V266_P0.5140.17
314_I355_R0.5140.17
59_D208_K0.5120.16
144_M323_C0.5110.16
117_R292_L0.5110.16
120_N126_I0.5100.16
5_V155_A0.5100.16
13_G44_G0.5090.16
30_G144_M0.5090.16
115_M292_L0.5090.16
108_V286_F0.5090.16
98_V226_T0.5090.16
22_I234_I0.5080.16
268_M271_L0.5080.16
18_L172_F0.5070.16
117_R264_I0.5070.16
153_H314_I0.5070.16
197_I210_S0.5070.16
143_W147_M0.5070.16
242_D285_K0.5060.16
50_I191_A0.5040.16
144_M411_V0.5040.16
127_W131_F0.5030.16
75_N245_G0.5030.16
15_T48_V0.5030.16
79_V190_I0.5030.16
24_I108_V0.5030.16
22_I317_T0.5020.16
147_M311_L0.5020.16
206_R213_D0.5020.16
264_I278_A0.5000.16
44_G49_G0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rp9A 2 0.8869 100 0.474 Contact Map
2l2tA 2 0.0976 37.7 0.979 Contact Map
2m20A 2 0.0976 34.1 0.98 Contact Map
2kncA 1 0.1153 25.1 0.981 Contact Map
2jwaA 2 0.0976 23.8 0.981 Contact Map
2ks1B 1 0.0976 23.4 0.981 Contact Map
2rddB 1 0.0798 22.8 0.981 Contact Map
2kncB 1 0.122 17.1 0.982 Contact Map
3hb3B 1 0.1641 15.9 0.983 Contact Map
4r1iA 2 0.5055 15.8 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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