GREMLIN Database
PTSN - Nitrogen regulatory protein
UniProt: P69829 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11682
Length: 163 (141)
Sequences: 7003 (5327)
Seq/√Len: 448.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_D141_R3.3611.00
16_R147_E2.5791.00
33_E51_F2.4041.00
145_S148_E2.3231.00
36_S51_F2.2081.00
37_E41_K2.1341.00
35_I109_A2.0631.00
20_R38_L2.0011.00
90_L107_L1.9661.00
54_I109_A1.9341.00
25_C34_I1.9291.00
138_R142_A1.9221.00
24_H91_E1.8981.00
27_S30_R1.8671.00
22_R91_E1.8611.00
18_C42_Q1.8401.00
40_A45_L1.8311.00
93_P105_D1.8251.00
44_S82_R1.7831.00
17_E42_Q1.7201.00
29_K58_E1.7091.00
23_V88_V1.6971.00
25_C31_A1.6701.00
44_S84_V1.6581.00
49_V78_E1.6111.00
22_R89_Q1.6111.00
52_E56_T1.5971.00
84_V111_L1.5881.00
83_A113_P1.5511.00
80_T111_L1.5501.00
35_I88_V1.5401.00
50_V111_L1.5301.00
31_A107_L1.4451.00
144_Q148_E1.4301.00
33_E55_L1.4191.00
143_A149_L1.3961.00
16_R150_Y1.3881.00
47_P81_L1.3871.00
56_T59_K1.3861.00
53_A74_G1.3851.00
26_Q30_R1.3841.00
53_A56_T1.3841.00
68_G105_D1.3831.00
90_L93_P1.3791.00
21_S89_Q1.3751.00
20_R34_I1.3371.00
147_E151_Q1.3331.00
95_A103_P1.3231.00
29_K55_L1.2811.00
57_R64_G1.2801.00
32_L54_I1.2631.00
38_L41_K1.2521.00
143_A148_E1.2411.00
67_N137_C1.2391.00
38_L42_Q1.2351.00
87_F149_L1.2341.00
37_E47_P1.2101.00
36_S54_I1.2031.00
104_V107_L1.1991.00
139_R155_D1.1951.00
77_E114_A1.1891.00
137_C141_R1.1651.00
150_Y154_T1.1341.00
15_N18_C1.1331.00
23_V34_I1.1301.00
16_R146_D1.1301.00
51_F55_L1.1261.00
96_F107_L1.1191.00
139_R152_I1.0991.00
28_K97_D1.0461.00
25_C90_L1.0401.00
93_P103_P1.0331.00
38_L86_V1.0291.00
143_A152_I1.0241.00
11_S154_T1.0221.00
29_K33_E1.0201.00
83_A112_V1.0181.00
32_L51_F1.0101.00
21_S149_L1.0091.00
19_T149_L1.0071.00
36_S109_A1.0021.00
34_I38_L0.9941.00
56_T60_M0.9911.00
58_E63_T0.9841.00
43_L81_L0.9821.00
20_R23_V0.9801.00
106_L141_R0.9781.00
19_T146_D0.9681.00
45_L50_V0.9631.00
40_A48_Q0.9571.00
130_R136_I0.9461.00
24_H92_T0.9421.00
125_S129_K0.9291.00
87_F106_L0.9261.00
133_D136_I0.9241.00
85_G123_T0.9211.00
37_E40_A0.9211.00
53_A78_E0.9191.00
90_L105_D0.9171.00
146_D150_Y0.9061.00
30_R33_E0.9041.00
39_A111_L0.9041.00
31_A90_L0.9001.00
89_Q149_L0.8991.00
148_E151_Q0.8861.00
48_Q52_E0.8841.00
39_A86_V0.8761.00
30_R34_I0.8691.00
40_A47_P0.8551.00
139_R142_A0.8501.00
26_Q92_T0.8451.00
50_V54_I0.8341.00
88_V109_A0.8221.00
128_A132_A0.8131.00
18_C44_S0.8081.00
89_Q106_L0.8071.00
136_I152_I0.8051.00
151_Q155_D0.7981.00
95_A101_N0.7861.00
21_S146_D0.7861.00
34_I37_E0.7811.00
40_A51_F0.7801.00
49_V53_A0.7801.00
120_H124_L0.7781.00
37_E51_F0.7711.00
57_R63_T0.7601.00
35_I86_V0.7501.00
127_V131_L0.7481.00
31_A94_I0.7441.00
53_A76_L0.7431.00
34_I88_V0.7421.00
90_L94_I0.7381.00
83_A119_T0.7361.00
71_I124_L0.7331.00
33_E37_E0.7321.00
33_E52_E0.7311.00
15_N82_R0.7281.00
125_S128_A0.7281.00
112_V123_T0.7261.00
66_G69_I0.7191.00
55_L59_K0.6991.00
139_R148_E0.6901.00
69_I131_L0.6871.00
39_A84_V0.6761.00
151_Q154_T0.6761.00
68_G141_R0.6711.00
86_V109_A0.6661.00
76_L80_T0.6581.00
121_L125_S0.6571.00
92_T105_D0.6511.00
25_C88_V0.6501.00
87_F108_F0.6501.00
57_R72_P0.6491.00
64_G99_I0.6420.99
28_K32_L0.6420.99
32_L55_L0.6370.99
134_K138_R0.6310.99
13_V123_T0.6290.99
69_I137_C0.6220.99
15_N44_S0.6140.99
22_R144_Q0.6120.99
19_T150_Y0.6090.99
130_R153_I0.6090.99
15_N42_Q0.6080.99
65_I128_A0.6030.99
85_G108_F0.5980.99
86_V111_L0.5980.99
24_H34_I0.5970.99
146_D149_L0.5900.99
33_E48_Q0.5840.99
114_A119_T0.5810.99
95_A98_A0.5800.99
114_A118_K0.5770.99
28_K57_R0.5770.99
23_V91_E0.5730.99
50_V109_A0.5730.99
20_R146_D0.5700.99
70_A104_V0.5680.99
62_S97_D0.5640.99
108_F127_V0.5630.99
97_D102_Q0.5610.99
36_S40_A0.5600.99
28_K55_L0.5590.99
121_L124_L0.5530.98
49_V52_E0.5500.98
39_A45_L0.5490.98
126_L130_R0.5450.98
129_K133_D0.5430.98
35_I107_L0.5420.98
128_A131_L0.5420.98
135_T138_R0.5410.98
39_A50_V0.5400.98
14_L87_F0.5390.98
12_S15_N0.5390.98
120_H128_A0.5380.98
138_R141_R0.5370.98
15_N150_Y0.5340.98
20_R88_V0.5300.98
89_Q144_Q0.5290.98
135_T139_R0.5290.98
32_L96_F0.5270.98
112_V120_H0.5250.98
80_T84_V0.5240.98
85_G127_V0.5230.98
28_K96_F0.5180.98
67_N102_Q0.5180.98
50_V74_G0.5140.98
89_Q140_L0.5090.97
140_L149_L0.5080.97
124_L128_A0.5020.97
75_K78_E0.5020.97
139_R143_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a6jA 4 0.9571 100 0.119 Contact Map
3urrA 2 0.9325 100 0.181 Contact Map
2a0jA 1 0.8957 100 0.181 Contact Map
1a3aA 2 0.8834 100 0.183 Contact Map
3oxpA 2 0.8896 100 0.193 Contact Map
2oq3A 1 0.8896 100 0.206 Contact Map
4m62S 1 0.908 100 0.217 Contact Map
3bjvA 2 0.9264 100 0.225 Contact Map
2oqtA 2 0.9325 100 0.226 Contact Map
3t43A 2 0.8221 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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